| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelei Chen, Kian Siang Ng, Sujata Ravi, James C H Goh, Siew Lok To. In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells, employing a two-chambered co-culture well design. Journal of tissue engineering and regenerative medicine vol 10 issue 4 2016 23495238 |
the cells in the intermediate region were found to be hypertrophic chondrocytes, embedded in a calcified extracellular matrix containing glycosaminoglycans and collagen types i, ii and x. |
2016-12-26 |
2023-01-25 |
rabbit |
| Hung-Wen Liu, Chu-Chun Wei, Sue-Joan Chan. Low-molecular-weight polyphenols protect kidney damage through suppressing NF-\\xce\\xbaB and modulating mitochondrial biogenesis in diabetic db/db mice. Food & function vol 7 issue 4 2016 26960417 |
oligonol attenuated serum resistin and il-6 levels and reduced glomerular hypertrophy and mesangial matrix expansion caused by diabetes. |
2016-12-22 |
2023-01-25 |
mouse |
| Alessia Arcaro, Flora Pirozzi, Annalisa Angelini, Cristina Chimenti, Lia Crotti, Carla Giordano, Daniele Mancardi, Daniele Torella, Carlo G Tocchett. Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology. Oxidative medicine and cellular longevity vol 2016 issue 2016 26881035 |
myocardial redox imbalance is a hallmark of this syndrome, since excessive reactive oxygen and nitrogen species can behave as signaling molecules in the pathogenesis of hypertrophy and heart failure, leading to dysregulation of cellular calcium handling, of the contractile machinery, of myocardial energetics and metabolism, and of extracellular matrix deposition. |
2016-12-14 |
2023-01-25 |
human |
| H D Amin, C R Ethie. Differential effects of tyrosine-rich amelogenin peptide on chondrogenic and osteogenic differentiation of adult chondrocytes. Cell and tissue research vol 364 issue 1 2016 26404401 |
thus, a long-term aci strategy should ideally incorporate methods to 'prime' autologous chondrocytes to form a cartilage-specific matrix and suppress hypertrophic mineralization. |
2016-12-13 |
2023-01-25 |
human |
| Carina Prein, Niklas Warmbold, Zsuzsanna Farkas, Matthias Schieker, Attila Aszodi, Hauke Clausen-Schauman. Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy. Matrix biology : journal of the International Society for Matrix Biology vol 50 issue 2016 26454027 |
the growth plate (gp) is a dynamic tissue driving bone elongation through chondrocyte proliferation, hypertrophy and matrix production. |
2016-12-13 |
2023-01-25 |
Not clear |
| G Zaman, K A Staines, C Farquharson, P T Newton, J Dudhia, C Chenu, A A Pitsillides, G K Dhoo. Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and cell biology vol 145 issue 1 2016 26464246 |
sulf2 expression unlike sulf1 also spread to the calcifying matrix around the hypertrophic chondrocytes indicating its possible ligand inhibiting role through hspg desulphation. |
2016-12-13 |
2023-01-25 |
rat |
| Traci L Parry, Gopal Desai, Jonathan C Schisler, Luge Li, Megan T Quintana, Natalie Stanley, Pamela Lockyer, Cam Patterson, Monte S Willi. Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology vol 25 issue 2 2016 26764147 |
in addition to pathological hypertrophy, murf1-/- mice had an unexpected differential expression in genes associated with the pleiotropic effects of fenofibrate involved in the extracellular matrix, protease inhibition, hemostasis, and the sarcomere. |
2016-12-13 |
2023-01-25 |
mouse |
| Maria-Teresa Piccoli, Christian B\\xc3\\xa4r, Thomas Thu. Non-coding RNAs as modulators of the cardiac fibroblast phenotype. Journal of molecular and cellular cardiology vol 92 issue 2016 26764220 |
cardiac fibroblasts are the principal orchestrators of matrix formation and degradation and indirectly regulate cardiac hypertrophy and inflammation. |
2016-12-13 |
2023-01-25 |
Not clear |
| A Piek, R A de Boer, H H W Sillj\\xc3\\xa. The fibrosis-cell death axis in heart failure. Heart failure reviews vol 21 issue 2 2016 26883434 |
whereas pathological and physiological (exercise, pregnancy) overload both stimulate cardiomyocyte growth (hypertrophy), only pathological remodeling is characterized by increased deposition of extracellular matrix proteins, termed fibrosis, and loss of cardiomyocytes by necrosis, apoptosis and/or phagocytosis. |
2016-12-13 |
2023-01-25 |
Not clear |
| Wafa Bouaziz, Johanna Sigaux, Dominique Modrowski, Claire-Sophie Devignes, Thomas Funck-Brentano, Pascal Richette, Hang-Korng Ea, Sylvain Provot, Martine Cohen-Solal, Eric Ha\\xc3\\xb. Interaction of HIF1\\xce\\xb1 and \\xce\\xb2-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proceedings of the National Academy of Sciences of the United States of America vol 113 issue 19 2016 27122313 |
the major metalloproteinase matrix metalloproteinase 13 (mmp13) is also associated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from cartilage degradation and osteoarthritis (oa) in mice. |
2016-12-13 |
2023-01-25 |
mouse |
| Xiuqin Yang, Yangang Wang, Guanqi Ga. High glucose induces rat mesangial cells proliferation and MCP-1 expression via ROS-mediated activation of NF-\\xce\\xbaB pathway, which is inhibited by eleutheroside E. Journal of receptor and signal transduction research vol 36 issue 2 2016 26644089 |
high glucose induces rat mesangial cells proliferation and mcp-1 expression via ros-mediated activation of nf-\xce\xbab pathway, which is inhibited by eleutheroside e. glomerular hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy (dn). |
2016-11-14 |
2023-01-25 |
rat |
| J Shi, H Wang, H Guan, S Shi, Y Li, X Wu, N Li, C Yang, X Bai, W Cai, F Yang, X Wang, L Su, Z Zheng, D H. IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways. Cell death & disease vol 7 issue 2016 26962683 |
hypertrophic scar (hs) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ecm) component deposition. |
2016-11-14 |
2023-01-25 |
Not clear |
| Matthew E Deren, Xu Yang, Yingjie Guan, Qian Che. Biological and Chemical Removal of Primary Cilia Affects Mechanical Activation of Chondrogenesis Markers in Chondroprogenitors and Hypertrophic Chondrocytes. International journal of molecular sciences vol 17 issue 2 2016 26861287 |
cyclic loading (1 hz, 10% matrix deformation) of atdc5 cells in three-dimensional (3d) culture stimulates the mrna levels of chondrogenesis marker type ii collagen (col ii), hypertrophic chondrocyte marker type x collagen (col x), and a molecular regulator of chondrogenesis and chondrocyte hypertrophy bone morphogenetic protein 2 (bmp-2). |
2016-11-04 |
2023-01-25 |
Not clear |
| Jonathan A Kirk, Oscar H Cingolan. Thrombospondins in the transition from myocardial infarction to heart failure. Journal of molecular and cellular cardiology vol 90 issue 2016 26686988 |
in the present review, we provide basic as well as clinical evidence linking the thrombospondin proteins with the post myocardial infarction response, including inflammation, fibrotic matrix remodeling, angiogenesis, as well as myocyte hypertrophy, apoptosis, and contractile dysfunction in heart failure. |
2016-10-11 |
2023-01-25 |
Not clear |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology vol 767 issue 2016 26481166 |
recent studies have shown that calcineurin plays a central role in hypertrophy and extracellular matrix (ecm) accumulation in glomeruli at the early stages of diabetic nephropathy. |
2016-10-05 |
2023-01-25 |
rat |
| Chris J Watson, Stephen Horgan, Roisin Neary, Nadezhda Glezeva, Isaac Tea, Niamh Corrigan, Ken McDonald, Mark Ledwidge, John Baug. Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis. Journal of cardiovascular pharmacology and therapeutics vol 21 issue 1 2016 26130616 |
these pathological changes involve excessive extracellular matrix deposition within the myocardial interstitium and myocyte hypertrophy. |
2016-09-26 |
2023-01-25 |
Not clear |
| Li Ma, Chengjun Gan, Yong Huang, Ying Wang, Gaoxing Luo, Jun W. Comparative proteomic analysis of extracellular matrix proteins secreted by hypertrophic scar with normal skin fibroblasts. Burns & trauma vol 2 issue 2 2016 27602365 |
comparative proteomic analysis of extracellular matrix proteins secreted by hypertrophic scar with normal skin fibroblasts. |
2016-09-07 |
2023-01-25 |
Not clear |
| Ewelyne Miranda Lima, Andrews Marques Nascimento, Girlandia Alexandre Brasil, Ieda Carneiro Kalil, Dominik Lenz, Denise Coutinho Endringer, Tadeu Uggere Andrade, Nazar\\xc3\\xa9 Souza Bissol. Cardiopulmonary reflex, cardiac cytokines, and nandrolone decanoate: response to resistance training in rats. Canadian journal of physiology and pharmacology vol 93 issue 11 2016 26335603 |
myocyte hypertrophy and matrix collagen deposition were determined by morphometric analysis of h&e and picrosirius red-stained samples, respectively. |
2016-08-18 |
2023-01-25 |
rat |
| Ewelyne Miranda Lima, Andrews Marques Nascimento, Girlandia Alexandre Brasil, Ieda Carneiro Kalil, Dominik Lenz, Denise Coutinho Endringer, Tadeu Uggere Andrade, Nazar\\xc3\\xa9 Souza Bissol. Cardiopulmonary reflex, cardiac cytokines, and nandrolone decanoate: response to resistance training in rats. Canadian journal of physiology and pharmacology vol 93 issue 11 2016 26335603 |
the association of nd with rt increased myocyte hypertrophy, deposition of matrix type i collagen, tnf-\xce\xb1 and acea; decreased il-10, and impairment in the bjr were observed in nd+exerc compared with cont and exerc. |
2016-08-18 |
2023-01-25 |
rat |
| Neethu Mohan, Jijo Wilson, Dexy Joseph, Dhanesh Vaikkath, Prabha D Nai. Biomimetic fiber assembled gradient hydrogel to engineer glycosaminoglycan enriched and mineralized cartilage: An in vitro study. Journal of biomedical materials research. Part A vol 103 issue 12 2016 26014103 |
chondrocytes cultured on these fibers secreted a mineralized matrix that consisted of sgag, hypertrophic proteins, collagen type x, and osteocalcin. |
2016-08-11 |
2023-01-25 |
Not clear |