| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katie Bardsley, Agnieska Kwarciak, Christine Freeman, Ian Brook, Paul Hatton, Aileen Crawfor. Repair of bone defects in vivo using tissue engineered hypertrophic cartilage grafts produced from nasal chondrocytes. Biomaterials. vol 112. 2017-12-12. PMID:27770634. |
on subcutaneous implantation of the hypertrophic engineered constructs, the grafts became vascularised, cartilage mineralisation occurred and loss of the proteoglycan in the matrix was observed. |
2017-12-12 |
2023-08-13 |
rat |
| Christopher L Mendias, Andrew J Schwartz, Jeremy A Grekin, Jonathan P Gumucio, Kristoffer B Sug. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. Journal of applied physiology (Bethesda, Md. : 1985). vol 122. issue 3. 2017-12-12. PMID:27979985. |
changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. |
2017-12-12 |
2023-08-13 |
rat |
| Christopher L Mendias, Andrew J Schwartz, Jeremy A Grekin, Jonathan P Gumucio, Kristoffer B Sug. Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy. Journal of applied physiology (Bethesda, Md. : 1985). vol 122. issue 3. 2017-12-12. PMID:27979985. |
additionally, the extracellular matrix (ecm) stores and transmits forces from muscle fibers to tendons and bones, and determining how the ecm changes during hypertrophy is important in understanding the adaptation of muscle tissue to mechanical loading. |
2017-12-12 |
2023-08-13 |
rat |
| X Wang, Y Zhang, B H Jiang, Q Zhang, R P Zhou, L Zhang, Chen Wan. Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism. Experimental cell research. vol 361. issue 2. 2017-11-29. PMID:29056521. |
hypertrophic scar (hs) formation is associated with the fibrosis of fibrocytes caused by excessive extracellular matrix (ecm) synthesis and deposition, the initial event of hs formation. |
2017-11-29 |
2023-08-13 |
Not clear |
| Britta A Anderson, Audrey McAlinde. miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 11. 2017-11-20. PMID:28244607. |
while the in vivo expression patterns led us to hypothesize that mir-483 may enhance chondrogenesis or suppress hypertrophic marker expression, surprisingly, mir-483 overexpression reduced chondrocyte gene expression and cartilage matrix production. |
2017-11-20 |
2023-08-13 |
human |
| L C Lee, G S Kassab, J M Guccion. Mathematical modeling of cardiac growth and remodeling. Wiley interdisciplinary reviews. Systems biology and medicine. vol 8. issue 3. 2017-11-13. PMID:26952285. |
to facilitate the discussion, we have organized the g&r models in terms of (1) the physical focus (biochemical vs mechanical) and (2) the process that they describe (myocyte hypertrophy vs extracellular matrix remodeling). |
2017-11-13 |
2023-08-13 |
Not clear |
| Xiaoqian Ji, Changzheng Li, Yitao Ou, Ning Li, Kai Yuan, Guizhi Yang, Xiaoyan Chen, Zhicheng Yang, Bing Liu, Wai W Cheung, Lijing Wang, Ren Huang, Tian La. Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway. Molecular and cellular endocrinology. vol 437. 2017-11-07. PMID:27378149. |
diabetic nephropathy (dn) is characterized by proliferation of mesangial cells, mesangial hypertrophy and extracellular matrix (ecm) accumulation. |
2017-11-07 |
2023-08-13 |
mouse |
| Julia Münch, Maxim Avanesov, Peter Bannas, Dennis Säring, Elisabeth Krämer, Giulia Mearini, Lucie Carrier, Anna Suling, Gunnar Lund, Monica Patte. Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy. Journal of cardiac failure. vol 22. issue 10. 2017-11-02. PMID:27018569. |
serum matrix metalloproteinases as quantitative biomarkers for myocardial fibrosis and sudden cardiac death risk stratification in patients with hypertrophic cardiomyopathy. |
2017-11-02 |
2023-08-13 |
Not clear |
| Ling Chen, Jingyun Li, Qian Li, Hui Yan, Bei Zhou, Yanli Gao, Jun L. Non-Coding RNAs: The New Insight on Hypertrophic Scar. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:28067426. |
hypertrophic scarring (hs), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. |
2017-11-02 |
2023-08-13 |
Not clear |
| Hazel H Szeto, Shaoyi Liu, Yi Soong, Nazia Alam, Glen T Prusky, Surya V Sesha. Protection of mitochondria prevents high-fat diet-induced glomerulopathy and proximal tubular injury. Kidney international. vol 90. issue 5. 2017-10-31. PMID:27519664. |
the primary pathologic finding of obesity-related kidney disease is glomerulopathy, with glomerular hypertrophy, mesangial matrix expansion, and focal segmental glomerulosclerosis. |
2017-10-31 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
reciprocal regulation of mir-214 and pten by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. |
2017-10-16 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
aberrant expression of micrornas (mirs) contributes to diabetic renal complications, including renal hypertrophy and matrix protein accumulation. |
2017-10-16 |
2023-08-13 |
mouse |
| Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion. American journal of physiology. Cell physiology. vol 313. issue 4. 2017-10-16. PMID:28701356. |
in addition, neutralization of high-glucose-stimulated mir-214 expression significantly inhibited cell hypertrophy and expression of the matrix protein fibronectin. |
2017-10-16 |
2023-08-13 |
mouse |
| E Fernlund, T Gyllenhammar, R Jablonowski, M Carlsson, A Larsson, J Ärnlöv, P Liub. Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young. Pediatric cardiology. vol 38. issue 4. 2017-10-10. PMID:28361263. |
this is the first study demonstrating adverse changes in biomarkers reflecting myocardial matrix remodeling, microfibrosis, and vascular endotheliopathy in early stage of hypertrophic cardiomyopathy in the young. |
2017-10-10 |
2023-08-13 |
Not clear |
| Jun-Ichi Suzuki, Hiroki Sato, Makoto Kaneko, Asuka Yoshida, Norio Aoyama, Shouta Akimoto, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Yuichi Izumi, Mitsuaki Isobe, Issei Komur. Periodontitis and myocardial hypertrophy. Hypertension research : official journal of the Japanese Society of Hypertension. vol 40. issue 4. 2017-09-26. PMID:27829660. |
in murine transverse aortic constriction models, a periodontal pathogen, aggregatibacter actinomycetemcomitans markedly enhanced cardiac hypertrophy with matrix metalloproteinase-2 activation, while another pathogen porphyromonas gingivalis (p.g.) |
2017-09-26 |
2023-08-13 |
Not clear |
| Jibo Han, Chunpeng Zou, Liqin Mei, Yali Zhang, Yuanyuan Qian, Shengban You, Yong Pan, Zheng Xu, Bin Bai, Weijian Huang, Guang Lian. MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway. Basic research in cardiology. vol 112. issue 1. 2017-09-26. PMID:28013347. |
in rat cardiomyocyte-like h9c2 cells as well as rat primary cardiomyocytes, inhibition of md2 by l6h21 or sirna knockdown suppressed the ang ii-induced tlr4 signaling pathway activation including myd88 recruitment, and reduced cardiomyocyte hypertrophy and matrix protein expression. |
2017-09-26 |
2023-08-13 |
mouse |
| Siva S V P Sakamuri, Anthony J Valente, Jalahalli M Siddesha, Patrice Delafontaine, Ulrich Siebenlist, Jason D Gardner, Chandrasekar Bysan. TRAF3IP2 mediates aldosterone/salt-induced cardiac hypertrophy and fibrosis. Molecular and cellular endocrinology. vol 429. 2017-09-25. PMID:27040306. |
however, traf3ip2 gene deletion attenuated aldosterone/salt-induced (i) p65 and c-jun activation, (ii) extracellular matrix (collagen iα1 and collagen iiiα1), matrix metalloproteinase (mmp2), lysyl oxidase (lox), inflammatory cytokine (il-6 and il-18), chemokine (cxcl1 and cxcl2), and adhesion molecule (icam1) mrna expression in hearts, (iii) il-6, il-18, and mmp2 protein levels, (iv) systemic il-6 and il-18 levels, and (iv) cardiac hypertrophy and fibrosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Slava Malatiali, Issam Francis, Mario Barac-Niet. Insulin Prevents Hyperfiltration and Proteinuria but Not Glomerular Hypertrophy and Increases Mesangial Matrix Expansion in Diabetic Rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 26. issue 1. 2017-09-25. PMID:27643698. |
insulin prevents hyperfiltration and proteinuria but not glomerular hypertrophy and increases mesangial matrix expansion in diabetic rats. |
2017-09-25 |
2023-08-13 |
rat |
| Q Li, Q Yu, R Na, B Li. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 50. issue 6. 2017-09-25. PMID:28513772. |
the mrna levels of myocardial hypertrophy marker genes, including atrial natriuretic factor (anf), matrix metalloproteinase (mmp)-9 and mmp-13, were detected by qrt-pcr, and the expressions of apoptosis-related proteins (bcl-2 and bax) were measured by western blotting. |
2017-09-25 |
2023-08-13 |
rat |
| Fen Shi, Xiaoling Cao, Zhicheng Hu, Da Ma, Dong Guo, Jian Zhang, Changlin Zhang, Peng Liu, Shanqiang Qu, Jiayuan Zhu, Wuguo Deng, Bing Tan. Pleiotropic FTY720 Is a Specific and Potent Therapy for Hypertrophic Scars. The Journal of investigative dermatology. vol 137. issue 7. 2017-09-13. PMID:28288846. |
hypertrophic scarring (hs) is a fibrotic skin condition characterized by aberrant fibroblast phenotypes and excessive deposition of extracellular matrix components. |
2017-09-13 |
2023-08-13 |
rabbit |