| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Itay Israel Shemesh, Benaya Rozen-Zvi, Yona Kalechman, Uzi Gafter, Benjamin Sredn. AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway. PloS one vol 9 issue 12 2015 25474550 |
diabetic nephropathy (dn) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. |
2015-12-14 |
2023-01-25 |
rat |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology vol 309 issue 3 2015 26041445 |
hyperglycemic culture conditions, similar to that present in diabetes, were sufficient to elevate mesangial cell hexcers and increase markers of fibrosis, extracellular matrix proteins, and cellular hypertrophy. |
2015-12-04 |
2023-01-25 |
mouse |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology vol 309 issue 3 2015 26041445 |
inhibition of glucosylceramide synthase or lowering glucose levels decreased markers of fibrosis and extracellular matrix proteins and reversed mesangial cell hypertrophy. |
2015-12-04 |
2023-01-25 |
mouse |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology vol 309 issue 3 2015 26041445 |
thus, hyperglycemia in type ii diabetes leads to renal dysfunction at least in part by inducing accumulation of hexcers and laccers in mesangial cells, resulting in fibrosis, extracellular matrix production, and hypertrophy. |
2015-12-04 |
2023-01-25 |
mouse |
| M F N Feres, A Alhadlaq, T El-Bial. Adjunctive techniques for enhancing mandibular growth in Class II malocclusion. Medical hypotheses vol 84 issue 4 2015 25648662 |
the rationale for the use of these methods as adjunctive therapies for mandibular underdevelopment is attributed to their abilities on stimulating angiogenesis, cell differentiation, proliferation, and hypertrophy, as well as enhancing matrix production and endochondoral bone formation, especially on the condyle of growing animals. |
2015-12-03 |
2023-01-25 |
Not clear |
| Hui Wang, Zhao Chen, Xiao-Jing Li, Li Ma, Yue-Ling Tan. Anti-inflammatory cytokine TSG-6 inhibits hypertrophic scar formation in a rabbit ear model. European journal of pharmacology vol 751 issue 2015 25661977 |
hypertrophic scars are characterized by excessive fibrosis and extracellular matrix (ecm) deposition and can be functionally and cosmetically problematic; however, there are few satisfactory treatments for controlling hypertrophic scars. |
2015-12-01 |
2023-01-25 |
rabbit |
| F Kristek, M Drobna, S Cacanyiov. Different effects of 7-nitroindazole and L-NAME administered both individually and together on the cardiovascular system of the rat. Physiological research vol 64 issue 1 2015 25194127 |
in wistar rats, l-name evoked an increase of sbp; hypertrophy of the heart and arterial walls; an increase in cross-sectional areas (csa) of endothelial cells (ec), muscle cells (smc), extracellular matrix (ecm), and a decrease in acetylcholine-induced endothelial-dependent relaxation (edr). |
2015-11-30 |
2023-01-25 |
rat |
| Sophie Portron, Vincent Hivernaud, Christophe Merceron, Julie Lesoeur, Martial Masson, Olivier Gauthier, Claire Vinatier, Laurent Beck, J\\xc3\\xa9r\\xc3\\xb4me Guicheu. Inverse regulation of early and late chondrogenic differentiation by oxygen tension provides cues for stem cell-based cartilage tissue engineering. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology vol 35 issue 3 2015 25632940 |
to prevent the production of this calcified matrix at the articular site, the late hypertrophic differentiation of mscs must be carefully controlled. |
2015-11-25 |
2023-01-25 |
Not clear |
| Xu Chen, Daishan Jiang, Jing Wang, Xiaolan Chen, Xiaolin Xu, Peipei Xi, Yaping Fan, Xiaoyan Zhang, Youfei Gua. Prostaglandin E2 EP1 receptor enhances TGF-\\xce\\xb21-induced mesangial cell injury. International journal of molecular medicine vol 35 issue 1 2015 25352206 |
studies have found that the expression level of prostaglandin e2 (pge2) in mcs increases under high glucose conditions, that pge2 affects the proliferation and hypertrophy of mcs mainly through the ep1 pathway, and that the proliferation of mcs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. |
2015-11-09 |
2023-01-25 |
mouse |
| Julian C Lui, Ola Nilsson, Jeffrey Baro. Recent research on the growth plate: Recent insights into the regulation of the growth plate. Journal of molecular endocrinology vol 53 issue 1 2015 24740736 |
this process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion, and it is carefully orchestrated by complex networks of local paracrine factors and modulated by endocrine factors. |
2015-10-26 |
2023-01-25 |
human |
| Shouan Zhu, Jun Dai, Huanhuan Liu, Xiaoxia Cong, Yishan Chen, Yan Wu, Hu Hu, Boon Chin Heng, Hong Wei Ouyang, Yiting Zho. Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis & rheumatology (Hoboken, N.J.) vol 67 issue 8 2015 25917196 |
we previously reported that rac1 was aberrantly activated to promote chondrocyte hypertrophy, mineralization, and expression of matrix metalloproteinase 13 and adamts in oa. |
2015-10-13 |
2023-01-25 |
Not clear |
| Justin Crawford, Karen Nygard, Bing Siang Gan, David Brian O'Gorma. Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring. Experimental dermatology vol 24 issue 2 2015 25421393 |
periostin induced significant increases in supermature focal adhesion formation, \xce\xb1 smooth muscle actin levels and collagen contraction in fibroblasts cultured from hypertrophic scars under conditions of increased matrix tension in three-dimensional type-i collagen lattices. |
2015-10-08 |
2023-01-25 |
Not clear |
| Justin Crawford, Karen Nygard, Bing Siang Gan, David Brian O'Gorma. Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring. Experimental dermatology vol 24 issue 2 2015 25421393 |
depletion of endogenous periostin expression in hypertrophic scar myofibroblasts resulted in a sustained decrease in \xce\xb1 smooth muscle actin levels under conditions of reducing matrix tension, while matrix-associated periostin levels caused the cells to retain high levels of a smooth muscle actin under these conditions. |
2015-10-08 |
2023-01-25 |
Not clear |
| Andreea Iren Serban, Loredana Stanca, Ovidiu Ionut Geicu, Maria Cristina Munteanu, Marieta Costache, Anca Dinischiot. Extracellular matrix is modulated in advanced glycation end products milieu via a RAGE receptor dependent pathway boosted by transforming growth factor-\\xce\\xb21 RAGE. Journal of diabetes vol 7 issue 1 2015 24666836 |
we set out to identify the role of ages in producing alterations leading to matrix hypertrophy and the pathway through which aminoguanidine, as well as anti-rage and anti-transforming growth factor (tgf)-\xce\xb21 antibody treatments could prevent these modifications. |
2015-09-22 |
2023-01-25 |
Not clear |
| Anna Filip, Arnaud Bianchi, Didier Mainard, Patrick Lacolley, Jacques Magdalou, Nathalie Mercie. A simple two dimensional culture method to study the hypertrophic differentiation of rat articular chondrocytes. Bio-medical materials and engineering vol 25 issue 1 Suppl 2015 25538060 |
hypertrophic chondrocytes synthesise collagen x and express matrix metalloproteinase 13 and alkaline phosphatase. |
2015-09-21 |
2023-01-25 |
rat |
| Jingming Zhou, Qian Chen, Beate Lanske, Braden C Fleming, Richard Terek, Xiaochun Wei, Ge Zhang, Shaowei Wang, Kai Li, Lei We. Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis research & therapy vol 16 issue 1 2015 24428864 |
previous observations implicate indian hedgehog (ihh) signaling in osteoarthritis (oa) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (mmp-13) expression. |
2015-09-16 |
2023-01-25 |
mouse |
| Hongrui Liu, Jie Guo, Shanliang Wei, Shengyu Lv, Wei Feng, Jian Cui, Tomoka Hasegawa, Hiromi Hongo, Yang Yang, Xiangzhi Li, Kimimitsu Oda, Norio Amizuka, Minqi L. Expression of matrix Gla protein and osteocalcin in the developing tibial epiphysis of mice. Histology and histopathology vol 30 issue 1 2015 24956112 |
subsequently, mgp reactivity was seen on the cartilaginous lacunar walls of hypertrophic chondrocytes, while ocn reactivity was evenly found not only in the bone matrix, but also in the cartilaginous lacunar walls and on the bone surfaces. |
2015-09-02 |
2023-01-25 |
mouse |
| Yves Gorin, Rita C Cavaglieri, Khaled Khazim, Doug-Yoon Lee, Francesca Bruno, Sachin Thakur, Paolo Fanti, C\\xc3\\xa9dric Szyndralewiez, Jeffrey L Barnes, Karen Block, Hanna E Abbou. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes. American journal of physiology. Renal physiology vol 308 issue 11 2015 25656366 |
gkt137831 significantly reduced glomerular hypertrophy, mesangial matrix expansion, urinary albumin excretion, and podocyte loss in ove26 mice. |
2015-08-13 |
2023-01-25 |
mouse |
| Dylan E Lee, Ryan M Trowbridge, Nagi T Ayoub, Devendra K Agrawa. High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scars. Plastic and reconstructive surgery. Global open vol 3 issue 6 2015 26180726 |
high-mobility group box protein-1, matrix metalloproteinases, and vitamin d in keloids and hypertrophic scars. |
2015-07-16 |
2023-01-25 |
Not clear |
| Dong Huang, Yingping Liu, Yongjun Huang, Youfu Xie, Kuanhong Shen, Dawei Zhang, Yong Mo. Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connective tissue research vol 55 issue 5-6 2015 25166894 |
activation of transforming growth factor-\xce\xb2 (tgf-\xce\xb2) signaling and matrix metalloproteinases are involved in hypertrophic scar (hs) formation. |
2015-07-08 |
2023-01-25 |
Not clear |