| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norikazu Hinamoto, Yohei Maeshima, Hiroko Yamasaki, Tatsuyo Nasu, Daisuke Saito, Hiroyuki Watatani, Haruyo Ujike, Katsuyuki Tanabe, Kana Masuda, Yuka Arata, Hitoshi Sugiyama, Yasufumi Sato, Hirofumi Makin. Exacerbation of diabetic renal alterations in mice lacking vasohibin-1. PloS one vol 9 issue 9 2015 25255225 |
furthermore, the renal and glomerular hypertrophy, glomerular accumulation of mesangial matrix and type iv collagen and activation of renal tgf-\xce\xb21/smad3 signaling, a key mediator of renal fibrosis, were exacerbated in the diabetic vash1(+/-) mice compared with the diabetic wild-type littermates. |
2015-06-22 |
2023-01-25 |
mouse |
| Jennifer Fischer, Antje Aulmann, Verena Dexheimer, Tobias Grossner, Wiltrud Richte. Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells. Stem cells and development vol 23 issue 20 2015 24836507 |
pulsed pthrp exposure of mscs stimulated chondrogenesis and reduced endochondral differentiation apparently uncoupling chondrogenic matrix deposition from hypertrophic marker expression. |
2015-06-12 |
2023-01-25 |
human |
| Samy L Habi. Alterations in tubular epithelial cells in diabetic nephropathy. Journal of nephrology vol 26 issue 5 2015 24052469 |
renal hypertrophy, matrix protein accumulation and tubulointerstitial fibrosis are major pathological features of diabetic nephropathy (dn) that eventuate in renal failure. |
2015-06-04 |
2023-01-25 |
rat |
| Shao-Qing Zhang, Yi-Ting Sun, Tian-Hua Xu, Xue-Feng Zhang, Ying-Zhong Liu, Ma Jian-Fei Ma, Li-Ning Wang, Li Ya. Protective effect of metformin on renal injury of C57BL/6J mouse treated with high fat diet. Die Pharmazie vol 69 issue 12 2015 25951664 |
at the end of 12th week, compared with mice on low fat diet (lfd), body weight (bw), the levels of fasting insulin (fins), plasma and renal triglyceride (tg) were higher and plasma high density lipoprotein (hdl) and insulin sensitivity index (isi) were significantly lower, but the levels of fasting blood glycemia (fbg), plasma total cholesterol (tc) and renal tc had no changes; oil red o staining revealed renal lipids deposition, masson staining and he staining revealed glomerular hypertrophy, matrix increasing, and inflammatory cells infiltration in glomerular; the expression of p-ampk\xce\xb1 protein decreased and the expression of srebp-1c, tnf-\xce\xb1, nox4 mrna increased significantly in mouse treated with high fat diet (hfd). |
2015-06-02 |
2023-01-25 |
mouse |
| Meiling Zhu, Qian Feng, Liming Bia. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels. Acta biomaterialia vol 10 issue 3 2015 24342044 |
in addition, at a constant high ha concentration, increasing hydrogel crosslinking density promoted hmsc hypertrophy and matrix calcification. |
2015-05-12 |
2023-01-25 |
human |
| Chenyu Huang, Rei Ogaw. The link between hypertension and pathological scarring: does hypertension cause or promote keloid and hypertrophic scar pathogenesis? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol 22 issue 4 2015 24899409 |
pathological scars, namely, keloids and hypertrophic scars (hss), are caused by excessive cutaneous wound healing that is characterized by histological extracellular matrix (ecm) accumulation, clinically relevant irritating symptoms, and frequent recurrence after surgical excision. |
2015-05-12 |
2023-01-25 |
Not clear |
| Laura C O'Brien, Eleonora Mezzaroma, Benjamin W Van Tassell, Carlo Marchetti, Salvatore Carbone, Antonio Abbate, Stefano Told. Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Molecular medicine (Cambridge, Mass.) vol 20 issue 2015 24804827 |
in animal models of acute myocardial infarction (ami), pressure overload, and lps-induced dysfunction, il-18 regulates cardiomyocyte hypertrophy and induces cardiac contractile dysfunction and extracellular matrix remodeling. |
2015-05-11 |
2023-01-25 |
human |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. \\xce\\xb21-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine vol 73 issue 2015 24933619 |
\xce\xb21-adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. |
2015-05-11 |
2023-01-25 |
rat |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. \\xce\\xb21-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine vol 73 issue 2015 24933619 |
hypertension induces left-ventricular hypertrophy (lvh) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (mmp) activity. |
2015-05-11 |
2023-01-25 |
rat |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3\\xce\\xb2 ameliorates diabetes-induced kidney injury. The Journal of biological chemistry vol 289 issue 51 2015 25339176 |
increase in protein synthesis contributes to kidney hypertrophy and matrix protein accumulation in diabetes. |
2015-04-21 |
2023-01-25 |
mouse |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3\\xce\\xb2 ameliorates diabetes-induced kidney injury. The Journal of biological chemistry vol 289 issue 51 2015 25339176 |
snp administered for 3 weeks to mice with streptozotocin-induced type 1 diabetes ameliorated kidney hypertrophy, accumulation of matrix proteins, and albuminuria without changing blood glucose levels. |
2015-04-21 |
2023-01-25 |
mouse |
| Tetsuya Enishi, Kiminori Yukata, Mitsuhiko Takahashi, Ryosuke Sato, Koichi Sairyo, Natsuo Yasu. Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter. PloS one vol 9 issue 8 2015 25121501 |
at the terminal end of the growth plate, hypertrophic chondrocytes extruded from their territorial matrix into the open cavity on the surface of the membrane filter. |
2015-04-17 |
2023-01-25 |
rabbit |
| Chao Li, Hua-Yu Zhu, Wen-Dong Bai, Lin-Lin Su, Jia-Qi Liu, Wei-Xia Cai, Bin Zhao, Jian-Xin Gao, Shi-Chao Han, Jun Li, Da-Hai H. MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA. FEBS letters vol 589 issue 3 2015 25554417 |
urokinase type plasminogen activator (upa) and plasminogen activator inhibitor-1 (pai-1) have been proposed to play key roles in extracellular matrix (ecm) deposition in hypertrophic scars (hs). |
2015-04-10 |
2023-01-25 |
Not clear |
| Guido Tarone, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon De Windt, Stephane Heymans, Denise Hilfiker-Kleiner, Emilio Hirsch, Guido Iaccarino, Ralph Kn\\xc3\\xb6ll, Adelino F Leite-Moreira, Andr\\xc3\\xa9 P Louren\\xc3\\xa7o, Manuel Mayr, Thomas Thum, Carlo G Tocchett. Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure vol 16 issue 5 2015 24639064 |
these include potentiating cardiomyocyte contractility, increasing cardiomyocyte survival and adaptive hypertrophy, increasing oxygen and nutrition supply by sustaining vessel formation, and reducing ventricular stiffness by favourable extracellular matrix remodelling. |
2015-04-10 |
2023-01-25 |
Not clear |
| Sebastian Winocour, Joshua Vorstenbosch, Alissa Trzeciak, Lucie Lessard, Anie Phili. CD109, a novel TGF-\\xce\\xb2 antagonist, decreases fibrotic responses in a hypoxic wound model. Experimental dermatology vol 23 issue 7 2015 24815824 |
excessive extracellular matrix deposition that occurs in many fibrotic skin disorders such as hypertrophic scarring and scleroderma is often associated with hypoxia. |
2015-04-07 |
2023-01-25 |
mouse |
| M Mathieu, S Vigier, M N Labour, C Jorgensen, E Belamie, D No\\xc3\\xab. Induction of mesenchymal stem cell differentiation and cartilage formation by cross-linker-free collagen microspheres. European cells & materials vol 28 issue 2015 25179212 |
human msc rapidly adhered to tgf-\xce\xb23-loaded microspheres and, after 21\xc2\xa0d of culture, exhibited typical chondrocyte morphology and produced an uncalcified matrix made of the predominant cartilage components, aggrecan and type ii collagen, but devoid of the hypertrophic marker type x collagen. |
2015-04-02 |
2023-01-25 |
mouse |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR vol 28 issue 10 2015 24706573 |
hypertrophic scarring is characterized by collagen overproduction and excessive deposition of extracellular matrix. |
2015-03-31 |
2023-01-25 |
Not clear |
| Maria Adele Alberelli, Erica De Candi. Functional role of protease activated receptors in vascular biology. Vascular pharmacology vol 62 issue 2 2015 24924409 |
however, in conditions associated with endothelial dysfunction, pars mediate contraction, proliferation, migration, hypertrophy of vsmcs and their production of extracellular matrix, thereby contributing to the pathophysiology of atherosclerosis and hypertension. |
2015-03-31 |
2023-01-25 |
Not clear |
| Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert T Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal vol 4 issue 4 2015 25767782 |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2015-03-13 |
2023-01-25 |
Not clear |
| Moses B Ekong, Mine D Peter, Aniekan I Peter, Mokutima A Eluwa, Idorenyin U Umoh, Anozeng O Igiri, Theresa B Ekane. Cerebellar neurohistology and behavioural effects of gongronema latifolium and Rauwolfia vomitoria in mice. Metabolic brain disease vol 29 issue 2 2015 24254993 |
neurohistology of the cerebellum showed slight hypertrophy of purkinje cells, with brain matrix loss in treatment groups 2 and 3, but group 4 showed no apparent histopathology. |
2015-03-05 |
2023-01-25 |
mouse |