| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
together our results provide the first evidence for the involvement of mir-26a in high glucose-induced mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |
| Ilja L Krugliko. Microstructural inhomogeneity of electrical conductivity in subcutaneous fat tissue. PloS one. vol 10. issue 3. 2016-01-27. PMID:25734656. |
this effect is connected with different electrical conductivities of pathways inside (triglycerides in adipocytes) and outside (extra-cellular matrix) the cells and to the different weighting of these pathways in hypertrophic and hyperplastic types of swat. |
2016-01-27 |
2023-08-13 |
Not clear |
| Ilja L Krugliko. Microstructural inhomogeneity of electrical conductivity in subcutaneous fat tissue. PloS one. vol 10. issue 3. 2016-01-27. PMID:25734656. |
the application of the rf current to hypertrophic swat, which normally has a strongly developed extracellular matrix with high concentrations of hyaluronan and collagen in a peri-cellular space of adipocytes, can produce, micro-structurally, a highly inhomogeneous temperature distribution, characterized by strong temperature gradients between the peri-cellular sheath of the extra-cellular matrix around the hypertrophic adipocytes and their volumes. |
2016-01-27 |
2023-08-13 |
Not clear |
| Jenny Y Y Ooi, Natasha K Tuano, Haloom Rafehi, Xiao-Ming Gao, Mark Ziemann, Xiao-Jun Du, Assam El-Ost. HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes. Epigenetics. vol 10. issue 5. 2016-01-25. PMID:25941940. |
pressure overload-induced cardiac hypertrophy was associated with histone acetylation of genes implicated in cardiac contraction, collagen deposition, inflammation, and extracellular matrix identified by chip-seq. |
2016-01-25 |
2023-08-13 |
human |
| Amaia Rodríguez, Silvia Ezquerro, Leire Méndez-Giménez, Sara Becerril, Gema Frühbec. Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism. American journal of physiology. Endocrinology and metabolism. vol 309. issue 8. 2016-01-25. PMID:26330344. |
the mechanisms underlying the development of obesity and its associated comorbidities include the hypertrophy and/or hyperplasia of adipocytes, adipose tissue inflammation, impaired extracellular matrix remodeling, and fibrosis together with an altered secretion of adipokines. |
2016-01-25 |
2023-08-13 |
Not clear |
| Laura Cinque, Alison Forrester, Rosa Bartolomeo, Maria Svelto, Rossella Venditti, Sandro Montefusco, Elena Polishchuk, Edoardo Nusco, Antonio Rossi, Diego L Medina, Roman Polishchuk, Maria Antonietta De Matteis, Carmine Settembr. FGF signalling regulates bone growth through autophagy. Nature. vol 528. issue 7581. 2016-01-15. PMID:26595272. |
we investigated the role of autophagy during bone growth, which is mediated by chondrocyte rate of proliferation, hypertrophic differentiation and extracellular matrix (ecm) deposition in growth plates. |
2016-01-15 |
2023-08-13 |
mouse |
| Christopher L Mendias, Evan B Lynch, Jonathan P Gumucio, Michael D Flood, Danielle S Rittman, Douglas W Van Pelt, Stuart M Roche, Carol S Davi. Changes in skeletal muscle and tendon structure and function following genetic inactivation of myostatin in rats. The Journal of physiology. vol 593. issue 8. 2016-01-12. PMID:25640143. |
this large rodent model of myostatin deficiency did not have the negative consequences to muscle fibres and extracellular matrix observed in mouse models, and suggests that the greatest impact of myostatin in the regulation of muscle mass may not be to induce atrophy directly, but rather to block hypertrophy signalling. |
2016-01-12 |
2023-08-13 |
mouse |
| Na Mi, Xiu Juan Zhang, Yan Ding, Guo Hua Li, Wei Dong Wang, Hui Xia Xian, Jin X. Branched-chain amino acids attenuate early kidney injury in diabetic rats. Biochemical and biophysical research communications. vol 466. issue 2. 2016-01-08. PMID:26362188. |
elevated reactive oxygen species (ros) levels activate various signaling pathways and influence the activities of transforming growth factor-β (tgf-β) and matrix metalloproteinase-9 (mmp-9), which contributes to glomerular hypertrophy. |
2016-01-08 |
2023-08-13 |
mouse |
| Wei-Jian Ni, Li-Qin Tang, Wei We. Research progress in signalling pathway in diabetic nephropathy. Diabetes/metabolism research and reviews. vol 31. issue 3. 2015-12-15. PMID:24898554. |
diabetic nephropathy, a lethal diabetic complication, is a leading cause of end-stage renal disease, which is pathologically characterized by thickened tubular basal and glomerular membranes, accumulated extracellular matrix, and progressive mesangial hypertrophy. |
2015-12-15 |
2023-08-13 |
Not clear |
| Itay Israel Shemesh, Benaya Rozen-Zvi, Yona Kalechman, Uzi Gafter, Benjamin Sredn. AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction: regulation of the AKT downstream pathway. PloS one. vol 9. issue 12. 2015-12-14. PMID:25474550. |
diabetic nephropathy (dn) is characterized by proliferation of mesangial cells, mesangial expansion, hypertrophy and extracellular matrix accumulation. |
2015-12-14 |
2023-08-13 |
rat |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology. vol 309. issue 3. 2015-12-04. PMID:26041445. |
hyperglycemic culture conditions, similar to that present in diabetes, were sufficient to elevate mesangial cell hexcers and increase markers of fibrosis, extracellular matrix proteins, and cellular hypertrophy. |
2015-12-04 |
2023-08-13 |
mouse |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology. vol 309. issue 3. 2015-12-04. PMID:26041445. |
inhibition of glucosylceramide synthase or lowering glucose levels decreased markers of fibrosis and extracellular matrix proteins and reversed mesangial cell hypertrophy. |
2015-12-04 |
2023-08-13 |
mouse |
| Marimuthu Subathra, Midhun Korrapati, Lauren A Howell, John M Arthur, James A Shayman, Rick G Schnellmann, Leah J Siskin. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. American journal of physiology. Renal physiology. vol 309. issue 3. 2015-12-04. PMID:26041445. |
thus, hyperglycemia in type ii diabetes leads to renal dysfunction at least in part by inducing accumulation of hexcers and laccers in mesangial cells, resulting in fibrosis, extracellular matrix production, and hypertrophy. |
2015-12-04 |
2023-08-13 |
mouse |
| M F N Feres, A Alhadlaq, T El-Bial. Adjunctive techniques for enhancing mandibular growth in Class II malocclusion. Medical hypotheses. vol 84. issue 4. 2015-12-03. PMID:25648662. |
the rationale for the use of these methods as adjunctive therapies for mandibular underdevelopment is attributed to their abilities on stimulating angiogenesis, cell differentiation, proliferation, and hypertrophy, as well as enhancing matrix production and endochondoral bone formation, especially on the condyle of growing animals. |
2015-12-03 |
2023-08-13 |
Not clear |
| Hui Wang, Zhao Chen, Xiao-Jing Li, Li Ma, Yue-Ling Tan. Anti-inflammatory cytokine TSG-6 inhibits hypertrophic scar formation in a rabbit ear model. European journal of pharmacology. vol 751. 2015-12-01. PMID:25661977. |
hypertrophic scars are characterized by excessive fibrosis and extracellular matrix (ecm) deposition and can be functionally and cosmetically problematic; however, there are few satisfactory treatments for controlling hypertrophic scars. |
2015-12-01 |
2023-08-13 |
rabbit |
| F Kristek, M Drobna, S Cacanyiov. Different effects of 7-nitroindazole and L-NAME administered both individually and together on the cardiovascular system of the rat. Physiological research. vol 64. issue 1. 2015-11-30. PMID:25194127. |
in wistar rats, l-name evoked an increase of sbp; hypertrophy of the heart and arterial walls; an increase in cross-sectional areas (csa) of endothelial cells (ec), muscle cells (smc), extracellular matrix (ecm), and a decrease in acetylcholine-induced endothelial-dependent relaxation (edr). |
2015-11-30 |
2023-08-13 |
rat |
| Sophie Portron, Vincent Hivernaud, Christophe Merceron, Julie Lesoeur, Martial Masson, Olivier Gauthier, Claire Vinatier, Laurent Beck, Jérôme Guicheu. Inverse regulation of early and late chondrogenic differentiation by oxygen tension provides cues for stem cell-based cartilage tissue engineering. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 3. 2015-11-25. PMID:25632940. |
to prevent the production of this calcified matrix at the articular site, the late hypertrophic differentiation of mscs must be carefully controlled. |
2015-11-25 |
2023-08-13 |
Not clear |
| Xu Chen, Daishan Jiang, Jing Wang, Xiaolan Chen, Xiaolin Xu, Peipei Xi, Yaping Fan, Xiaoyan Zhang, Youfei Gua. Prostaglandin E2 EP1 receptor enhances TGF-β1-induced mesangial cell injury. International journal of molecular medicine. vol 35. issue 1. 2015-11-09. PMID:25352206. |
studies have found that the expression level of prostaglandin e2 (pge2) in mcs increases under high glucose conditions, that pge2 affects the proliferation and hypertrophy of mcs mainly through the ep1 pathway, and that the proliferation of mcs and the accumulation of extracellular matrix are the main events leading to glomerular fibrosis. |
2015-11-09 |
2023-08-13 |
mouse |
| Julian C Lui, Ola Nilsson, Jeffrey Baro. Recent research on the growth plate: Recent insights into the regulation of the growth plate. Journal of molecular endocrinology. vol 53. issue 1. 2015-10-26. PMID:24740736. |
this process results from chondrocyte proliferation, hypertrophy, and extracellular matrix secretion, and it is carefully orchestrated by complex networks of local paracrine factors and modulated by endocrine factors. |
2015-10-26 |
2023-08-13 |
human |
| Shouan Zhu, Jun Dai, Huanhuan Liu, Xiaoxia Cong, Yishan Chen, Yan Wu, Hu Hu, Boon Chin Heng, Hong Wei Ouyang, Yiting Zho. Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis & rheumatology (Hoboken, N.J.). vol 67. issue 8. 2015-10-13. PMID:25917196. |
we previously reported that rac1 was aberrantly activated to promote chondrocyte hypertrophy, mineralization, and expression of matrix metalloproteinase 13 and adamts in oa. |
2015-10-13 |
2023-08-13 |
Not clear |