| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masahiro Iwamoto, Yoichi Ohta, Colleen Larmour, Motomi Enomoto-Iwamot. Toward regeneration of articular cartilage. Birth defects research. Part C, Embryo today : reviews vol 99 issue 3 2014 24078496 |
articular chondrocytes are restrictedly controlled not to differentiate into a hypertrophic stage by autocrine and paracrine factors and extracellular matrix microenvironment, but retain potential to undergo hypertrophy. |
2014-04-11 |
2023-01-25 |
Not clear |
| Takahiro Ushijima, Ken Okazaki, Hidetoshi Tsushima, Yukihide Iwamot. CCAAT/enhancer-binding protein \\xce\\xb2 regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. The Journal of biological chemistry vol 289 issue 5 2014 24344131 |
ccaat/enhancer-binding protein \xce\xb2 (c/ebp\xce\xb2) is a transcription factor that promotes hypertrophic differentiation by stimulating type x collagen and matrix metalloproteinase 13 during chondrocyte differentiation. |
2014-04-10 |
2023-01-25 |
mouse |
| Dong Huang, Kuan-Hong Shen, Hong-Gang Wan. Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. Chinese medical journal vol 126 issue 17 2014 24033957 |
pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. |
2014-04-07 |
2023-01-25 |
Not clear |
| Dong Huang, Kuan-Hong Shen, Hong-Gang Wan. Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. Chinese medical journal vol 126 issue 17 2014 24033957 |
we sought to investigate the differential expression of matrix metalloproteinases (mmps) and collagen in posttraumatic hypertrophic scar tissue with mechanical pressure and delineate the molecular mechanisms of pressure therapy for hypertrophic scars. |
2014-04-07 |
2023-01-25 |
Not clear |
| Eleonora Olivotto, Miguel Otero, Annalisa Astolfi, Daniela Platano, Annalisa Facchini, Stefania Pagani, Flavio Flamigni, Andrea Facchini, Mary B Goldring, Rosa Maria Borz\\xc3\\xac, Kenneth B Marc. IKK\\xce\\xb1/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PloS one vol 8 issue 9 2014 24023802 |
here, we have investigated the mechanism of action of ikk\xce\xb1 as a novel effector of human and murine chondrocyte extracellular matrix (ecm) homeostasis and differentiation towards hypertrophy. |
2014-04-02 |
2023-01-25 |
human |
| David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Bo-Qing Zhu, Zhu-Qiu Jin, Anthony J Baker, Joel S Karline. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PloS one vol 8 issue 7 2014 23874529 |
n-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. |
2014-02-19 |
2023-01-25 |
mouse |
| Guler Yavas, Rengin Elsurer, Cagdas Yavas, Cagdas Elsurer, Ozlem At. Does spironolactone ameliorate trastuzumab-induced cardiac toxicity? Medical hypotheses vol 81 issue 2 2014 23688742 |
genomic effect induces genomic up-regulation of the egfr protein expression via egfr promoter, whereas nongenotropic effect leads to the egfr transactivation resulting in persistent pathophysiological effects including formation of extracellular matrix and myocardial hypertrophy. |
2014-02-03 |
2023-01-25 |
Not clear |
| Stephen P O'Brien, Mandy Smith, Hong Ling, Lucy Phillips, William Weber, John Lydon, Colleen Maloney, Steven Ledbetter, Cynthia Arbeeny, Stefan Wawersi. Glomerulopathy in the KK.Cg-A(y) /J mouse reflects the pathology of diabetic nephropathy. Journal of diabetes research vol 2013 issue 2014 23710468 |
glomerular hypertrophy and hypercellularity, mesangial matrix expansion, podocyte effacement, and basement membrane thickening were present in both binephric and uninephrectomized cohorts. |
2014-01-28 |
2023-01-25 |
mouse |
| F Nutter, A Khwaja, J Haylo. Seliciclib inhibits renal hypertrophy but not fibrosis in the rat following subtotal nephrectomy. Nephron. Experimental nephrology vol 122 issue 3-4 2014 23689642 |
the ability of seliciclib, a cyclin-dependent kinase inhibitor, to reduce kidney hypertrophy and extracellular matrix (ecm) deposition has been examined in the snx rat. |
2014-01-22 |
2023-01-25 |
rat |
| Taku Kojima, Tomoka Hasegawa, Paulo Henrique Luiz de Freitas, Tomomaya Yamamoto, Muneteru Sasaki, Keisuke Horiuchi, Hiromi Hongo, Tamaki Yamada, Naoko Sakagami, Naoaki Saito, Michiko Yoshizawa, Tadaharu Kobayashi, Takeyasu Maeda, Chikara Saito, Norio Amizuk. Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice. Biomedical research (Tokyo, Japan) vol 34 issue 3 2014 23782745 |
we have histologically examined vascular invasion and calcification of the hypertrophic zone during endochondral ossification in matrix metalloproteinase (mmp)-9 deficient (mmp-9-/-) mice and in their littermates at 3 days, 3 weeks and 6 weeks after birth. |
2014-01-22 |
2023-01-25 |
mouse |
| Xianrong Zhang, Ji Zhu, Yumei Li, Tiao Lin, Valerie A Siclari, Abhishek Chandra, Elena M Candela, Eiki Koyama, Motomi Enomoto-Iwamoto, Ling Qi. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through \\xce\\xb2-catenin-dependent and -independent pathways. The Journal of biological chemistry vol 288 issue 45 2014 24047892 |
immunohistochemical analyses demonstrated that inactivation of chondrocyte-specific egfr signaling reduced the amounts of matrix metalloproteinases (mmp9, -13, and -14) and rankl (receptor activator of nf-\xce\xbab ligand) in the hypertrophic chondrocytes close to the marrow space and decreased the cartilage matrix degradation in the soc. |
2014-01-20 |
2023-01-25 |
mouse |
| Wei Zhang, Jialin Chen, Jiadong Tao, Changchang Hu, Longkun Chen, Hongshi Zhao, Guowei Xu, Boon C Heng, Hong Wei Ouyan. The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold. Biomaterials vol 34 issue 25 2013 23702148 |
defects treated with pthrp at the 4-6 weeks time window exhibited better regeneration (reconstitution of cartilage and subchondral bone) with minimal terminal differentiation (hypertrophy, ossification and matrix degradation), as well as enhanced chondrogenesis (cell shape, col2 and gag accumulation) compared with treatment at other time windows. |
2013-12-31 |
2023-01-25 |
rabbit |
| Zhonglin Chai, Aozhi Dai, Yugang Tu, Jiaze Li, Tieqiao Wu, Yu Wang, Lorna J Hale, Frank Koentgen, Merlin C Thomas, Mark E Coope. Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury. Journal of the American Society of Nephrology : JASN vol 24 issue 11 2013 23929772 |
notably, cda1 deletion significantly reduced diabetes-associated renal matrix accumulation and immunohistochemical staining for collagens iii and iv and attenuated glomerular and tubulointerstitial injury indices, despite the presence of persistent hyperglycemia, polyuria, renal hypertrophy, and hyperfiltration. |
2013-12-23 |
2023-01-25 |
mouse |
| Vivek Gupta, Nilesh Gupta, Imam H Shaik, Reza Mehvar, Eva Nozik-Grayck, Ivan F McMurtry, Masahiko Oka, Masanobu Komatsu, Fakhrul Ahsa. Inhaled PLGA particles of prostaglandin E\\xe2\\x82\\x81 ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Molecular pharmaceutics vol 10 issue 5 2013 23485062 |
the influence of formulations on disease progression was studied by measuring the mean pulmonary arterial pressure (mpap), evaluating right ventricular hypertrophy and assessing various molecular and cellular makers including the degree of muscularization, platelet aggregation, matrix metalloproteinase-2 (mmp-2), and proliferating cell nuclear antigen (pcna). |
2013-12-16 |
2023-01-25 |
rat |
| Zhensen Zhu, Jie Ding, Heather A Shankowsky, Edward E Tredge. The molecular mechanism of hypertrophic scar. Journal of cell communication and signaling vol 7 issue 4 2013 23504443 |
hypertrophic scar (hts) is a dermal form of fibroproliferative disorder which often develops after thermal or traumatic injury to the deep regions of the skin and is characterized by excessive deposition and alterations in morphology of collagen and other extracellular matrix (ecm) proteins. |
2013-12-16 |
2023-01-25 |
Not clear |
| Tatiana Tsoutsman, Xiaoyu Wang, Kendra Garchow, Bruce Riser, Stephen Twigg, Christopher Semsaria. CCN2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. Journal of molecular and cellular cardiology vol 62 issue 2013 23756156 |
ccn2 plays a key role in extracellular matrix gene expression in severe hypertrophic cardiomyopathy and heart failure. |
2013-12-11 |
2023-01-25 |
Not clear |
| S Eid, W Abou-Kheir, R Sabra, G Daoud, A Jaffa, F N Ziyadeh, L Roman, A A Ei. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. Journal of biological regulators and homeostatic agents vol 27 issue 3 2013 24152838 |
dn is characterized by hyperfiltration, hypertrophy, extracellular matrix accumulation, and proteinuria. |
2013-11-27 |
2023-01-25 |
rat |
| Hyo-Bum Kwa. Aging, exercise, and extracellular matrix in the heart. Journal of exercise rehabilitation vol 9 issue 3 2013 24278882 |
the cardiac remodeling involves loss of cardiac myocytes, reactive hypertrophy of the remaining cells, and increased extracellular matrix (ecm) and fibrosis in the aging heart, especially left ventricles. |
2013-11-26 |
2023-01-25 |
Not clear |
| Yi Lin, Makoto Kuro-o, Zhongjie Su. Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology vol 154 issue 10 2013 23928372 |
klotho deficiency in kl(+/-) mutant mice exacerbated stz-induced increases in urine albumin, blood urea nitrogen, expansion of mesangial matrix in renal glomeruli, and kidney hypertrophy, suggesting a protective role of klotho in kidney function and structure. |
2013-11-25 |
2023-01-25 |
mouse |
| E Kupidlowska, K Dobrzynska, E Parys, A M Zobe. Effect of coumarin and xanthotoxin on mitochondrial structure, oxygen uptake, and succinate dehydrogenase activity in onion root cells. Journal of chemical ecology vol 20 issue 10 2013 24241824 |
they caused changes in the structure of the mitochondrial matrix to become dense, and protrusions of mitochondrial membranes were visible parallelling their hypertrophy, indicating alteration in the structure and physiology of these organelles. |
2013-11-19 |
2023-01-25 |
Not clear |