| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malihe-Sadat Poormasjedi-Meibod, Ryan Hartwell, Ruhangiz Taghi Kilani, Aziz Ghahar. Anti-scarring properties of different tryptophan derivatives. PloS one. vol 9. issue 3. 2015-01-13. PMID:24637853. |
hypertrophic scars are associated with prolonged extracellular matrix (ecm) production, aberrant ecm degradation and high tissue cellularity. |
2015-01-13 |
2023-08-12 |
rabbit |
| Trevi A Ramirez, Rugmani Padmanabhan Iyer, Omid Ghasemi, Elizabeth F Lopez, Daniel B Levin, Jianhua Zhang, Rogelio Zamilpa, Youn-Min Chou, Yu-Fang Jin, Merry L Lindse. Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24768766. |
the treatments influenced systolic function and hypertrophy index, as well as extracellular matrix (ecm) and inflammatory genes in the remote region, indicating that primary effects were on the viable myocardium. |
2015-01-13 |
2023-08-13 |
mouse |
| Ana M Briones, Rosa Aras-López, María J Alonso, Mercedes Salaice. Small artery remodeling in obesity and insulin resistance. Current vascular pharmacology. vol 12. issue 3. 2015-01-05. PMID:24846232. |
in general, vascular remodeling of small arteries associated to cardiometabolic diseases seems to be hypertrophic and it is associated to increased extracellular matrix deposition, although specific vascular beds might show different structural patterns. |
2015-01-05 |
2023-08-13 |
Not clear |
| Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian W. Fibroblast growth factor 18 increases the trophic effects of bone marrow mesenchymal stem cells on chondrocytes isolated from late stage osteoarthritic patients. Stem cells international. vol 2014. 2014-12-29. PMID:25544847. |
results from transwell coculture study showed that expression of matrix producing genes in oa chondrocytes increased when cocultured with mscs with fgf18 in culture medium, while hypertrophic genes were not changed by coculture. |
2014-12-29 |
2023-08-13 |
Not clear |
| Nancy E Castro, Mitsuo Kato, Jung Tak Park, Rama Nataraja. Transforming growth factor β1 (TGF-β1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. The Journal of biological chemistry. vol 289. issue 42. 2014-12-22. PMID:25204661. |
increased expression of transforming growth factor-β1 (tgf-β1) in glomerular mesangial cells (mc) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (dn), a debilitating renal complication of diabetes. |
2014-12-22 |
2023-08-13 |
mouse |
| Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal. vol 4. issue 3. 2014-12-09. PMID:25489556. |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2014-12-09 |
2023-08-13 |
Not clear |
| Shigenori Miura, Jun Kondo, Aki Takimoto, Hiroko Sano-Takai, Long Guo, Chisa Shukunami, Hideyuki Tanaka, Yuji Hirak. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development. PloS one. vol 9. issue 4. 2014-12-03. PMID:24710035. |
taken together, our results suggest that intact 20-25 kda chm-i is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single n-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage. |
2014-12-03 |
2023-08-13 |
rat |
| Katsuhito Fujiu, Ryozo Naga. Fibroblast-mediated pathways in cardiac hypertrophy. Journal of molecular and cellular cardiology. vol 70. 2014-12-01. PMID:24492068. |
many growth factors and extracellular matrix components secreted by cardiac fibroblasts induce and modify cardiomyocyte hypertrophy. |
2014-12-01 |
2023-08-12 |
Not clear |
| William M Yarbrough, Catalin Baicu, Rupak Mukherjee, An Van Laer, William T Rivers, Richard A McKinney, Corey B Prescott, Robert E Stroud, Parker D Freels, Kia N Zellars, Michael R Zile, Francis G Spinal. Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy. American journal of physiology. Heart and circulatory physiology. vol 307. issue 5. 2014-11-07. PMID:24993046. |
cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy. |
2014-11-07 |
2023-08-13 |
mouse |
| Linda M Kock, Jos Malda, Wouter J A Dhert, Keita Ito, Debby Gawlitt. Flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells. Journal of biomechanics. vol 47. issue 9. 2014-11-06. PMID:24290176. |
flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells. |
2014-11-06 |
2023-08-12 |
human |
| Linda M Kock, Jos Malda, Wouter J A Dhert, Keita Ito, Debby Gawlitt. Flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells. Journal of biomechanics. vol 47. issue 9. 2014-11-06. PMID:24290176. |
abundant matrix was formed in the constructs, but production of chondrogenic and hypertrophic matrix components was affected by flow-perfusion. |
2014-11-06 |
2023-08-12 |
human |
| Heiani Touaitahuata, Gaelle Cres, Sylvain de Rossi, Virginie Vives, Anne Blang. The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth. Developmental biology. vol 393. issue 1. 2014-11-06. PMID:24992711. |
in the primary spongiosa, osteoclasts degrade the mineralized cartilage produced by hypertrophic chondrocytes to generate cartilage trabeculae that osteoblasts embed in bone matrix. |
2014-11-06 |
2023-08-13 |
mouse |
| E V Tchetina, F Mwale, A R Pool. Changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. Acta naturae. vol 6. issue 3. 2014-10-28. PMID:25349717. |
changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. |
2014-10-28 |
2023-08-13 |
cattle |
| E V Tchetina, F Mwale, A R Pool. Changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. Acta naturae. vol 6. issue 3. 2014-10-28. PMID:25349717. |
with the onset of hypertrophy expression of proteinases and their inhibitors, extracellular matrix molecules, as well as activity associated with vascularization and apoptosis were significantly upregulated. |
2014-10-28 |
2023-08-13 |
cattle |
| E V Tchetina, F Mwale, A R Pool. Changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. Acta naturae. vol 6. issue 3. 2014-10-28. PMID:25349717. |
this study reveals the complex interrelationships of gene expression in the physis that accompany matrix assembly, resorption, chondrocyte proliferation, hypertrophy, vascularization and cell death while principal zones of the growth plate are characterized by a distinct signature profile of gene expression. |
2014-10-28 |
2023-08-13 |
cattle |
| E V Privalova, V Iu Kaplunova, M V Kozhevnikova, N V Khabarova, G A Shakar'iants, Iu N Belenko. [Matrix metalloproteinases and hypertrophic cardiomyopathy]. Kardiologiia. vol 54. issue 5. 2014-10-16. PMID:25177880. |
[matrix metalloproteinases and hypertrophic cardiomyopathy]. |
2014-10-16 |
2023-08-13 |
human |
| P Anil Kumar, Gavin I Welsh, Moin A Saleem, Ram K Meno. Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus. Frontiers in endocrinology. vol 5. 2014-10-13. PMID:25309512. |
histological alterations in dm include early hypertrophy of glomerular and tubular components, subsequent thickening of basement membrane in glomeruli and tubules, progressive accumulation of extracellular matrix proteins in the glomerular mesangium and loss of podocytes, together constituting a clinical condition referred to as diabetic nephropathy (dn). |
2014-10-13 |
2023-08-13 |
Not clear |
| Mathew Varkey, Jie Ding, Edward E Tredge. Fibrotic remodeling of tissue-engineered skin with deep dermal fibroblasts is reduced by keratinocytes. Tissue engineering. Part A. vol 20. issue 3-4. 2014-10-10. PMID:24090416. |
tissue-engineered skin is a very promising model for the elucidation of the role of matrix microenvironment and biomechanical characteristics and could help in the identification of new therapeutic targets for hypertrophic scars. |
2014-10-10 |
2023-08-12 |
Not clear |
| Florian Gembardt, Christoph Bartaun, Natalia Jarzebska, Eric Mayoux, Vladimir T Todorov, Bernd Hohenstein, Christian Hug. The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. American journal of physiology. Renal physiology. vol 307. issue 3. 2014-10-06. PMID:24944269. |
however, empagliflozin treatment affected diabetes-related glomerular hypertrophy, markers of renal inflammation, and mesangial matrix expansion only in btbr ob/ob mice without hypertension. |
2014-10-06 |
2023-08-13 |
mouse |
| Mareike Derks, Theresa Sturm, Axel Haverich, Andres Hilfike. Isolation and chondrogenic differentiation of porcine perichondrial progenitor cells for the purpose of cartilage tissue engineering. Cells, tissues, organs. vol 198. issue 3. 2014-10-02. PMID:24157487. |
potential chondrogenic differentiation was investigated by histology and immunohistology in addition to gene expression analysis of the cartilage markers collagen ii, aggrecan, cartilage oligomeric matrix protein (comp), the precartilage marker collagen i, and the hypertrophic cartilage marker collagen x. ppc showed a proliferative behavior comparable to that of msc. |
2014-10-02 |
2023-08-12 |
Not clear |