| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Yoshihiro Dogaki, Etsuko Okumachi, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosak. In vitro hypertrophy and calcification of human fracture haematoma-derived cells in chondrogenic differentiation. International orthopaedics vol 37 issue 5 2013 23446329 |
in this study, we investigated whether haematoma-derived cells (hcs) could differentiate into hypertrophic chondrocytes and finally induce calcification of the extracellular matrix in vitro. |
2013-11-14 |
2023-01-25 |
human |
| Yusuke Kaida, Kei Fukami, Takanori Matsui, Yuichiro Higashimoto, Yuri Nishino, Nana Obara, Yosuke Nakayama, Ryotaro Ando, Maki Toyonaga, Seiji Ueda, Masayoshi Takeuchi, Hiroyoshi Inoue, Seiya Okuda, Sho-ichi Yamagish. DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy. Diabetes vol 62 issue 9 2013 23630304 |
urinary albumin and 8-hydroxy-2'-deoxy-guanosine levels were increased, and glomerular hypertrophy and enhanced extracellular matrix accumulation were observed in kkay/ta mice, all of which were prevented by ages-aptamer. |
2013-11-12 |
2023-01-25 |
mouse |
| William T Gerthoffer, Dedmer Schaafsma, Pawan Sharma, Saeid Ghavami, Andrew J Halayk. Motility, survival, and proliferation. Comprehensive Physiology vol 2 issue 1 2013 23728975 |
however, terminally differentiated smooth muscle cells are phenotypically plastic and have multifunctional capacity for proliferation, cellular hypertrophy, migration, and the synthesis of extracellular matrix and inflammatory mediators. |
2013-11-04 |
2023-01-25 |
Not clear |
| Xiao Hu, Huo Ran, Wang Dechang, Wang Yibing, Feng Yongqiang, Li Qian. Absence of the adenosine A(2A) receptor attenuates hypertrophic scarring in mice. Journal of burn care & research : official publication of the American Burn Association vol 34 issue 3 2013 23412328 |
hypertrophic scar following cutaneous wounding is the result of the body overproducing collagen, and it has been shown that the activation of the adenosine a(2a) receptor promotes tissue repair, wound healing, and extracellular matrix production. |
2013-10-31 |
2023-01-25 |
mouse |
| Otavio R Coelho-Filho, Ravi V Shah, Richard Mitchell, Tomas G Neilan, Heitor Moreno, Bridget Simonson, Raymond Kwong, Anthony Rosenzweig, Saumya Das, Michael Jerosch-Herol. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation vol 128 issue 11 2013 23912910 |
the goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. |
2013-10-31 |
2023-01-25 |
Not clear |
| Mathias H Konstandin, Mirko V\\xc3\\xb6lkers, Brett Collins, Pearl Quijada, Mercedes Quintana, Andrea De La Torre, Lucy Ormachea, Shabana Din, Natalie Gude, Haruhiro Toko, Mark A Sussma. Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic research in cardiology vol 108 issue 5 2013 23912225 |
while substantial information has been published on the nature of the fundamental molecular signaling involved in hypertrophy, the role of extracellular matrix protein fibronectin (fn) in hypertrophic signaling is unclear. |
2013-10-17 |
2023-01-25 |
Not clear |
| Yasumoto Matsui, Atsushi Harad. [Aging of joint]. Clinical calcium vol 23 issue 1 2013 23268297 |
in oa cartilage, increased degradation and decreased production of major matrix components, like type ii collagen and aggrecan occur, as well as chondrocyte hypertrophy or apoptosis. |
2013-09-25 |
2023-01-25 |
Not clear |
| Biljana Skrbic, Johannes L Bj\\xc3\\xb8rnstad, Henriette S Marstein, Cathrine R Carlson, Ivar Sjaastad, St\\xc3\\xa5le Nyg\\xc3\\xa5rd, Sigrid Bj\\xc3\\xb8rnstad, Geir Christensen, Theis T\\xc3\\xb8nnesse. Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload. Matrix biology : journal of the International Society for Matrix Biology vol 32 issue 2 2013 23220517 |
thus, we examined potential differences in the regulation of myocardial extracellular matrix (ecm) constituents in mice with hypertrophy only (abnonhf) and with hf (abhf) as response to comparable pressure overload. |
2013-09-23 |
2023-01-25 |
mouse |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials vol 34 issue 17 2013 23489925 |
cells were cultured for six weeks within porous scaffolds, and their cellularity, cartilaginous matrix production (collagen ii/i expression ratio, hydroxyproline and gag content) and hypertrophy markers (collagen x expression, alp activity, calcium accumulation) were analyzed. |
2013-09-12 |
2023-01-25 |
Not clear |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials vol 34 issue 17 2013 23489925 |
acs and co-cultures showed similarly high collagen ii/i expression ratio and gag rich matrix formation, whereas mscs produced the least hyaline cartilage-like matrix and obtained a hypertrophic phenotype with eventual calcification. |
2013-09-12 |
2023-01-25 |
Not clear |
| Indira Prasadam, Xinzhan Mao, Wei Shi, Ross Crawford, Yin Xia. Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment. Journal of molecular medicine (Berlin, Germany) vol 91 issue 3 2013 22965193 |
histology, immunostaining, rt-qpcr, western blotting and zymography were performed to assess the expression of cartilage matrix proteins and hypertrophic markers. |
2013-09-03 |
2023-01-25 |
rat |
| Simona Hefetz-Sela, Philipp E Schere. Adipocytes: impact on tumor growth and potential sites for therapeutic intervention. Pharmacology & therapeutics vol 138 issue 2 2013 23353703 |
obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. |
2013-08-27 |
2023-01-25 |
Not clear |
| Nahoko Shintani, Klaus A Siebenrock, Ernst B Hunzike. TGF-\\xc3\\x9f1 enhances the BMP-2-induced chondrogenesis of bovine synovial explants and arrests downstream differentiation at an early stage of hypertrophy. PloS one vol 8 issue 1 2013 23301025 |
furthermore, the downstream differentiation of chondrocytes proceeds to the stage of terminal hypertrophy, which is inextricably coupled with undesired matrix mineralization. |
2013-08-20 |
2023-01-25 |
cattle |
| Pingping Chen-An, Kim Vietz Andreassen, Kim Henriksen, Morten Asser Karsdal, Anne-Christine Bay-Jense. Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model. Rheumatology international vol 33 issue 2 2013 22453523 |
we speculated that this can become an important investigatory tool for investigation of matrix turnover, chondrocyte hypertrophy and cartilage calcification that are associated with djd pathogenesis. |
2013-08-05 |
2023-01-25 |
cattle |
| Ichiro Tsukamoto, Shinji Inoue, Takeshi Teramura, Toshiyuki Takehara, Kazuhiro Ohtani, Masao Akag. Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes. FEBS open bio vol 3 issue 2013 23905010 |
activation of at1r suppressed and activation of at2r enhanced the expression of markers of hypertrophic differentiation, including type x collagen, matrix metalloproteinase 13 and runt-related transcription factor 2. |
2013-08-01 |
2023-01-25 |
Not clear |
| Kristina Rydell-T\\xc3\\xb6rm\\xc3\\xa4nen, Paul-Andr\\xc3\\xa9 Risse, Varsha Kanabar, Rushita Bagchi, Michael P Czubryt, Jill R Johnso. Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries. Pulmonary pharmacology & therapeutics vol 26 issue 1 2013 22561160 |
these diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. |
2013-07-22 |
2023-01-25 |
Not clear |
| J Julie Kim, Takeshi Kurita, Serdar E Bulu. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocrine reviews vol 34 issue 1 2013 23303565 |
in uterine fibroids, progesterone promotes growth by increasing proliferation, cellular hypertrophy, and deposition of extracellular matrix. |
2013-07-22 |
2023-01-25 |
human |
| Annette Schr\\xc3\\xb6der, Tyler P Kirwan, Jia-Xin Jiang, Karen J Aitken, Darius J B\\xc3\\xa4gl. Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. The Journal of urology vol 189 issue 6 2013 23313213 |
rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights. |
2013-07-17 |
2023-01-25 |
Not clear |
| Shunichi Shimizu, Masaaki Ishibashi, Sumito Kumagai, Teruaki Wajima, Toshihito Hiroi, Tatsuya Kurihara, Masakazu Ishii, Yuji Kiuch. Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload. International journal of molecular medicine vol 31 issue 3 2013 23313998 |
moreover, continuous administration of bh4 to rats with pressure overload increased mitochondrial bh4 levels and reduced cardiac fibrosis and matrix metallopeptidase activity, but not cardiac hypertrophy. |
2013-07-10 |
2023-01-25 |
rat |
| Kurt D Marshall, Brittany N Muller, Maike Krenz, Laurin M Hanft, Kerry S McDonald, Kevin C Dellsperger, Craig A Emte. Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function. Journal of applied physiology (Bethesda, Md. : 1985) vol 114 issue 1 2013 23104696 |
in conclusion, chronic low-intensity interval exercise training attenuates diastolic impairment by promoting compliant extracellular matrix fibrotic components and preserving extracellular matrix regulatory mechanisms, preserves myocardial oxygen balance, and promotes a physiological molecular hypertrophic signaling phenotype in a large animal model resembling heart failure with preserved ejection fraction. |
2013-07-08 |
2023-01-25 |
Not clear |