| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Catal\\xc3\\xa1n, J G\\xc3\\xb3mez-Ambrosi, A Rodr\\xc3\\xadguez, G Fr\\xc3\\xbchbec. Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity. Histology and histopathology vol 27 issue 12 2013 23059882 |
adipose tissue responds dynamically to alterations in nutrient excess through adipocyte hypertrophy and hyperplasia, followed by increased angiogenesis, immune cell infiltration, extracellular matrix (ecm) overproduction, and thus, increased production of proinflammatory adipokines during the progression of chronic inflammation. |
2013-03-21 |
2023-01-25 |
human |
| Nikhil C Adi, Jennipher N Adi, Liliana Cesar, Arthur S Agatston, Paul Kurlansky, Keith A Webste. Influence of diet on visceral adipose remodeling in NONcNZO10 mice with polygenic susceptibility for type 2 diabetes. Obesity (Silver Spring, Md.) vol 20 issue 10 2013 22858798 |
expansion of vat involves adipocyte hyperplasia and hypertrophy and requires breakdown of the extracellular matrix and increased vascular outgrowth. |
2013-03-19 |
2023-01-25 |
mouse |
| Giuseppe Distefano, Pietro Sciacc. Molecular pathogenesis of myocardial remodeling and new potential therapeutic targets in chronic heart failure. Italian journal of pediatrics vol 38 issue 2013 22971785 |
typical features of myocardial remodeling are represented by cardiomyocytes hypertrophy and apoptosis, extracellular matrix alterations, mesenchymal fibrotic and phlogistic processes and by cardiac gene expression modifications with fetal genetic program reactivation. |
2013-03-12 |
2023-01-25 |
Not clear |
| Leonarda J van den Broek, Frank B Niessen, Rik J Scheper, Susan Gibb. Development, validation and testing of a human tissue engineered hypertrophic scar model. ALTEX vol 29 issue 4 2013 23138509 |
here we describe the development and validation of a tissue-engineered human hypertrophic scar (htscar) model based on reconstructed epidermis on a dermal matrix containing adipose derived mesenchymal stem cells (asc). |
2013-03-12 |
2023-01-25 |
human |
| Sundaravadivel Balasubramanian, Lakeya Quinones, Harinath Kasiganesan, Yuhua Zhang, Dorea L Pleasant, Kamala P Sundararaj, Michael R Zile, Amy D Bradshaw, Dhandapani Kuppuswam. \\xce\\xb23 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PloS one vol 7 issue 9 2013 22984613 |
\xce\xb23 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. |
2013-03-05 |
2023-01-25 |
mouse |
| Roger M Maso. Fell-Muir lecture: Connective tissue growth factor (CCN2) -- a pernicious and pleiotropic player in the development of kidney fibrosis. International journal of experimental pathology vol 94 issue 1 2013 23110747 |
connective tissue growth factor stimulates the development of fibrosis in the kidney in many ways including activating cells to increase extracellular matrix synthesis, inducing cell cycle arrest and hypertrophy, and prolonging survival of activated cells. |
2013-03-05 |
2023-01-25 |
human |
| Richard D Bagnall, Tatiana Tsoutsman, Rhian E Shephard, William Ritchie, Christopher Semsaria. Global microRNA profiling of the mouse ventricles during development of severe hypertrophic cardiomyopathy and heart failure. PloS one vol 7 issue 9 2013 23024758 |
time-course analysis revealed that decreased expression of mir-1 and mir-133a commences at a pre-disease stage, and precedes upregulation of target genes causal of cardiac hypertrophy and extracellular matrix remodelling, suggesting a role for mir-1 and mir-133a in early disease development. |
2013-02-15 |
2023-01-25 |
mouse |
| Anne M Fitzpatrick, Dean P Jones, Lou Ann S Brow. Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxidants & redox signaling vol 17 issue 2 2013 22304503 |
whereas inflammation is important for tissue regeneration and wound healing, the profound and sustained inflammatory response associated with asthma may result in airway remodeling that involves smooth muscle hypertrophy, epithelial goblet-cell hyperplasia, and permanent deposition of airway extracellular matrix proteins. |
2013-02-11 |
2023-01-25 |
human |
| Xun Tan, Juan Chai, Shi-Cheng Bi, Jun-Jun Li, Wen-Wen Li, Ji-Yong Zho. Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension. Veterinary journal (London, England : 1997) vol 193 issue 2 2013 22377328 |
involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension. |
2013-02-08 |
2023-01-25 |
Not clear |
| Frank Thiele, Christian M Cohrs, Armando Flor, Thomas S Lisse, Gerhard K H Przemeck, Marion Horsch, Anja Schrewe, Valerie Gailus-Durner, Boris Ivandic, Hugo A Katus, Wolfgang Wurst, Catherine Reisenberg, Hollis Chaney, Helmut Fuchs, Wolfgang Hans, Johannes Beckers, Joan C Marini, Martin Hrab\\xc3\\xa9 de Angeli. Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms. Human molecular genetics vol 21 issue 16 2013 22589248 |
in addition, dysregulated gene expression of nppa, different types of collagen and agt in heart and lung tissue support a bone-independent vicious cycle of heart dysfunction, including hypertrophy, loss of myocardial matrix integrity, pulmonary hypertension, pneumonia and hypoxia leading to death in aga2. |
2013-02-06 |
2023-01-25 |
mouse |
| Shaojiang Tian, Junming Tang, Huihui Liu, Liping Wang, Jianming Shen, Junfeng Li, Yanjie Ga. Propyl gallate plays a nephroprotective role in early stage of diabetic nephropathy associated with suppression of glomerular endothelial cell proliferation and angiogenesis. Experimental diabetes research vol 2012 issue 2013 22988451 |
we found that glomerular hypertrophy, glomerular mesangial matrix expansion, and albuminuria were significantly increased in dn rats. |
2013-01-30 |
2023-01-25 |
rat |
| Xiaofeng Cui, Akihiko Hasegawa, Martin Lotz, Darryl D'Lim. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy. Biotechnology and bioengineering vol 109 issue 9 2013 22422555 |
the meniscal and hypertrophic gene expression, gross appearance and structure of the pellets, meniscus extracellular matrix (ecm), histology and immunohistochemistry of proteoglycan and collagen were evaluated. |
2013-01-28 |
2023-01-25 |
Not clear |
| Ratnadeep Basu, Jiwon Lee, Zuocheng Wang, Vaibhav B Patel, Dong Fan, Subhash K Das, George C Liu, Rohan John, James W Scholey, Gavin Y Oudit, Zamaneh Kassir. Loss of TIMP3 selectively exacerbates diabetic nephropathy. American journal of physiology. Renal physiology vol 303 issue 9 2013 22896043 |
however, timp3 levels increased in akita kidneys and deletion of timp3 exacerbated the diabetic renal injury in the akita mouse, characterized by increased albuminuria, mesangial matrix expansion, and kidney hypertrophy. |
2013-01-24 |
2023-01-25 |
mouse |
| Pietro Francia, Arianna Uccellini, Alessandra Frattari, Anna Modestino, Agnese Ricotta, Cristina Balla, Ludovica Scialla, Massimo Volp. Extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension vol 16 issue 4 2013 23334911 |
extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. |
2013-01-23 |
2023-01-25 |
rat |
| Pietro Francia, Arianna Uccellini, Alessandra Frattari, Anna Modestino, Agnese Ricotta, Cristina Balla, Ludovica Scialla, Massimo Volp. Extracellular matrix remodelling in myocardial hypertrophy and failure : focus on osteopontin. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension vol 16 issue 4 2013 23334911 |
in general, evidence supports the concept that osteopontin plays a crucial role in extracellular matrix remodelling following myocardial adaptation to hypertrophic, inflammatory and neurohormonal stimuli in the overloaded heart. |
2013-01-23 |
2023-01-25 |
rat |
| Hong Zhang, Yan Zhang, Yi-Ping Jiang, Lan-Ke Zhang, Cheng Peng, Kun He, Khalid Rahman, Lu-Ping Qi. Curative effects of oleanolic Acid on formed hypertrophic scars in the rabbit ear model. Evidence-based complementary and alternative medicine : eCAM vol 2012 issue 2013 23326292 |
hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ecm). |
2013-01-18 |
2023-01-25 |
rabbit |
| Kelei Chen, Thomas Kok Hiong Teh, Sujata Ravi, Siew Lok Toh, James Cho Hong Go. Osteochondral interface generation by rabbit bone marrow stromal cells and osteoblasts coculture. Tissue engineering. Part A vol 18 issue 17-18 2013 22721548 |
more importantly, chondrogenic rbmscs in the coculture system were shown to form the osteochondral interface layer by expressing calcified cartilage zone specific extracellular matrix marker collagen x and the hypertrophic chondrocyte marker mmp-13, which were not observed in the control group. |
2013-01-16 |
2023-01-25 |
rabbit |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGF\\xce\\xb2-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one vol 7 issue 8 2013 22879939 |
tgf\xce\xb2-stimulated microrna-21 utilizes pten to orchestrate akt/mtorc1 signaling for mesangial cell hypertrophy and matrix expansion. |
2013-01-10 |
2023-01-25 |
Not clear |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGF\\xce\\xb2-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one vol 7 issue 8 2013 22879939 |
transforming growth factor-\xce\xb2 (tgf\xce\xb2) promotes glomerular hypertrophy and matrix expansion, leading to glomerulosclerosis. |
2013-01-10 |
2023-01-25 |
Not clear |
| Nirmalya Dey, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. TGF\\xce\\xb2-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion. PloS one vol 7 issue 8 2013 22879939 |
specific mir-21 targets downstream of tgf\xce\xb2 receptor activation that control cell hypertrophy and matrix protein expression have not been studied. |
2013-01-10 |
2023-01-25 |
Not clear |