| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung Bin Cho, Jun-Sub Kim, Zhenlong Zheng, Min Ju Choi, Ihn Geun Choi, Hong Shik Oh, Keun Jae Ah. Decreased tissue and serum expression of galectin-7 in patients with hypertrophic scars. Acta dermato-venereologica. vol 93. issue 6. 2014-06-18. PMID:23493985. |
hypertrophic scars (hs) result from an imbalance between collagen biosynthesis and matrix degradation during wound healing. |
2014-06-18 |
2023-08-12 |
Not clear |
| Anna J Meredith, Bruce M McManu. Vitamin D in heart failure. Journal of cardiac failure. vol 19. issue 10. 2014-05-26. PMID:24125108. |
evidence linking vitamin d to cardiovascular (cv) health has accumulated in recent years: numerous epidemiologic studies report deficiency as a significant cv risk factor, and rodent models suggest that active vitamin d can modulate critical remodeling processes, including cardiac hypertrophy and extracellular matrix remodeling. |
2014-05-26 |
2023-08-12 |
human |
| Bao-Heng Liu, Liang Chen, Shi-Rong Li, Zhen-Xiang Wang, Wen-Guang Chen. Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts. International journal of molecular medicine. vol 32. issue 3. 2014-05-12. PMID:23857156. |
in abnormal skin wound healing, hypertrophic scars (hs) are characterized by excessive fibroblast hypercellularity and an overproduction of collagen, leading to atypical extracellular matrix (ecm) remodeling. |
2014-05-12 |
2023-08-12 |
human |
| Jing Yu, Jill Urba. Immunolocalisation of fibrillin microfibrils in the calf metacarpal and vertebral growth plate. Journal of anatomy. vol 223. issue 6. 2014-05-05. PMID:24117386. |
fibrillin-1 was more abundant in the extracellular matrix of the resting and proliferative zones of the growth plate than in the hypertrophic zone. |
2014-05-05 |
2023-08-12 |
Not clear |
| Stephanie Eid, Rita Maalouf, Ayad A Jaffa, Joseph Nassif, Ahmed Hamdy, Awad Rashid, Fuad N Ziyadeh, Assaad A Ei. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PloS one. vol 8. issue 8. 2014-04-28. PMID:23936373. |
diabetic nephropathy (dn), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria leading to loss of renal function. |
2014-04-28 |
2023-08-12 |
rat |
| Stephanie Eid, Rita Maalouf, Ayad A Jaffa, Joseph Nassif, Ahmed Hamdy, Awad Rashid, Fuad N Ziyadeh, Assaad A Ei. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PloS one. vol 8. issue 8. 2014-04-28. PMID:23936373. |
in our study, we show that exposure of rats proximal tubular epithelial cells to high glucose (hg) resulted in increased extracellular matrix accumulation and hypertrophy. |
2014-04-28 |
2023-08-12 |
rat |
| Elizabeth Sweeney, Douglas Roberts, Angela Lin, Robert Guldberg, Olena Jacenk. Defective endochondral ossification-derived matrix and bone cells alter the lymphopoietic niche in collagen X mouse models. Stem cells and development. vol 22. issue 19. 2014-04-22. PMID:23656481. |
utilizing mice with disrupted function of collagen x (colx), a major hypertrophic cartilage matrix protein associated with endochondral ossification, our data identified a cytokine defect in trabecular bone cells at the chondro-osseous hematopoietic niche as a cause for aberrant b lymphopoiesis in these mice. |
2014-04-22 |
2023-08-12 |
mouse |
| Clintoria R Williams, Jennifer L Gooc. Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. The Journal of biological chemistry. vol 289. issue 8. 2014-04-22. PMID:24371139. |
calcineurin aβ is required for hypertrophy but not matrix expansion in the diabetic kidney. |
2014-04-22 |
2023-08-12 |
Not clear |
| Florence Legendre, David Ollitrault, Magalie Hervieu, Catherine Baugé, Laure Maneix, Didier Goux, Hanane Chajra, Frédéric Mallein-Gerin, Karim Boumediene, Philippe Galera, Magali Demoo. Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia. Tissue engineering. Part C, Methods. vol 19. issue 7. 2014-04-16. PMID:23270543. |
in our conditions, under bmp-2 treatment, redifferentiated and metabolically active chondrocytes synthesized a hyaline-like cartilage matrix characterized by type iib collagen and aggrecan molecules without any sign of hypertrophy or osteogenesis. |
2014-04-16 |
2023-08-12 |
human |
| Masahiro Iwamoto, Yoichi Ohta, Colleen Larmour, Motomi Enomoto-Iwamot. Toward regeneration of articular cartilage. Birth defects research. Part C, Embryo today : reviews. vol 99. issue 3. 2014-04-11. PMID:24078496. |
articular chondrocytes are restrictedly controlled not to differentiate into a hypertrophic stage by autocrine and paracrine factors and extracellular matrix microenvironment, but retain potential to undergo hypertrophy. |
2014-04-11 |
2023-08-12 |
Not clear |
| Takahiro Ushijima, Ken Okazaki, Hidetoshi Tsushima, Yukihide Iwamot. CCAAT/enhancer-binding protein β regulates the repression of type II collagen expression during the differentiation from proliferative to hypertrophic chondrocytes. The Journal of biological chemistry. vol 289. issue 5. 2014-04-10. PMID:24344131. |
ccaat/enhancer-binding protein β (c/ebpβ) is a transcription factor that promotes hypertrophic differentiation by stimulating type x collagen and matrix metalloproteinase 13 during chondrocyte differentiation. |
2014-04-10 |
2023-08-12 |
mouse |
| Dong Huang, Kuan-Hong Shen, Hong-Gang Wan. Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. Chinese medical journal. vol 126. issue 17. 2014-04-07. PMID:24033957. |
pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. |
2014-04-07 |
2023-08-12 |
Not clear |
| Dong Huang, Kuan-Hong Shen, Hong-Gang Wan. Pressure therapy upregulates matrix metalloproteinase expression and downregulates collagen expression in hypertrophic scar tissue. Chinese medical journal. vol 126. issue 17. 2014-04-07. PMID:24033957. |
we sought to investigate the differential expression of matrix metalloproteinases (mmps) and collagen in posttraumatic hypertrophic scar tissue with mechanical pressure and delineate the molecular mechanisms of pressure therapy for hypertrophic scars. |
2014-04-07 |
2023-08-12 |
Not clear |
| Eleonora Olivotto, Miguel Otero, Annalisa Astolfi, Daniela Platano, Annalisa Facchini, Stefania Pagani, Flavio Flamigni, Andrea Facchini, Mary B Goldring, Rosa Maria Borzì, Kenneth B Marc. IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation. PloS one. vol 8. issue 9. 2014-04-02. PMID:24023802. |
here, we have investigated the mechanism of action of ikkα as a novel effector of human and murine chondrocyte extracellular matrix (ecm) homeostasis and differentiation towards hypertrophy. |
2014-04-02 |
2023-08-12 |
human |
| David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Bo-Qing Zhu, Zhu-Qiu Jin, Anthony J Baker, Joel S Karline. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PloS one. vol 8. issue 7. 2014-02-19. PMID:23874529. |
n-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. |
2014-02-19 |
2023-08-12 |
mouse |
| Guler Yavas, Rengin Elsurer, Cagdas Yavas, Cagdas Elsurer, Ozlem At. Does spironolactone ameliorate trastuzumab-induced cardiac toxicity? Medical hypotheses. vol 81. issue 2. 2014-02-03. PMID:23688742. |
genomic effect induces genomic up-regulation of the egfr protein expression via egfr promoter, whereas nongenotropic effect leads to the egfr transactivation resulting in persistent pathophysiological effects including formation of extracellular matrix and myocardial hypertrophy. |
2014-02-03 |
2023-08-12 |
Not clear |
| Stephen P O'Brien, Mandy Smith, Hong Ling, Lucy Phillips, William Weber, John Lydon, Colleen Maloney, Steven Ledbetter, Cynthia Arbeeny, Stefan Wawersi. Glomerulopathy in the KK.Cg-A(y) /J mouse reflects the pathology of diabetic nephropathy. Journal of diabetes research. vol 2013. 2014-01-28. PMID:23710468. |
glomerular hypertrophy and hypercellularity, mesangial matrix expansion, podocyte effacement, and basement membrane thickening were present in both binephric and uninephrectomized cohorts. |
2014-01-28 |
2023-08-12 |
mouse |
| F Nutter, A Khwaja, J Haylo. Seliciclib inhibits renal hypertrophy but not fibrosis in the rat following subtotal nephrectomy. Nephron. Experimental nephrology. vol 122. issue 3-4. 2014-01-22. PMID:23689642. |
the ability of seliciclib, a cyclin-dependent kinase inhibitor, to reduce kidney hypertrophy and extracellular matrix (ecm) deposition has been examined in the snx rat. |
2014-01-22 |
2023-08-12 |
rat |
| Taku Kojima, Tomoka Hasegawa, Paulo Henrique Luiz de Freitas, Tomomaya Yamamoto, Muneteru Sasaki, Keisuke Horiuchi, Hiromi Hongo, Tamaki Yamada, Naoko Sakagami, Naoaki Saito, Michiko Yoshizawa, Tadaharu Kobayashi, Takeyasu Maeda, Chikara Saito, Norio Amizuk. Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice. Biomedical research (Tokyo, Japan). vol 34. issue 3. 2014-01-22. PMID:23782745. |
we have histologically examined vascular invasion and calcification of the hypertrophic zone during endochondral ossification in matrix metalloproteinase (mmp)-9 deficient (mmp-9-/-) mice and in their littermates at 3 days, 3 weeks and 6 weeks after birth. |
2014-01-22 |
2023-08-12 |
mouse |
| Xianrong Zhang, Ji Zhu, Yumei Li, Tiao Lin, Valerie A Siclari, Abhishek Chandra, Elena M Candela, Eiki Koyama, Motomi Enomoto-Iwamoto, Ling Qi. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways. The Journal of biological chemistry. vol 288. issue 45. 2014-01-20. PMID:24047892. |
immunohistochemical analyses demonstrated that inactivation of chondrocyte-specific egfr signaling reduced the amounts of matrix metalloproteinases (mmp9, -13, and -14) and rankl (receptor activator of nf-κb ligand) in the hypertrophic chondrocytes close to the marrow space and decreased the cartilage matrix degradation in the soc. |
2014-01-20 |
2023-08-12 |
mouse |