| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| G P Sidgwick, A Baya. Extracellular matrix molecules implicated in hypertrophic and keloid scarring. Journal of the European Academy of Dermatology and Venereology : JEADV vol 26 issue 2 2012 21838832 |
extracellular matrix molecules implicated in hypertrophic and keloid scarring. |
2012-05-14 |
2023-01-25 |
Not clear |
| Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition) vol 4 issue 2012 22202021 |
cartilage calcification is carried out by chondrocytes as they hypertrophy and begin to secrete matrix vesicles. |
2012-05-14 |
2023-01-25 |
Not clear |
| Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition) vol 4 issue 2012 22202021 |
hypertrophic chondrocytes secrete vesicles in the cartilaginous matrix of intercolumnar septae only, forming well-calcified longitudinal septae and poorly-calcified transverse partitions. |
2012-05-14 |
2023-01-25 |
Not clear |
| Geert W Schmid-Sch\\xc3\\xb6nbei. An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavage. Current hypertension reports vol 14 issue 1 2012 22081429 |
an emerging body of evidence suggests that human and experimental hypertensives may exhibit uncontrolled activity of proteinases, including the family of matrix metalloproteinases, recognized for their ability to restructure the extracellular matrix proteins and to play a role in hypertrophy. |
2012-05-01 |
2023-01-25 |
human |
| P S Skagen, T Horn, H A Kruse, B Staergaard, M M Rapport, T Nicolaise. Osteochondritis dissecans (OCD), an endoplasmic reticulum storage disease?: a morphological and molecular study of OCD fragments. Scandinavian journal of medicine & science in sports vol 21 issue 6 2012 20561273 |
further, von kossa staining and tem showed empty lacunae close to mineralized "islands" in the cartilage and hypertrophic chondrocytes containing accumulated matrix proteins. |
2012-05-01 |
2023-01-25 |
Not clear |
| Kirk R Hutchinson, Anuradha Guggilam, Mary J Cismowski, Maarten L Galantowicz, Thomas A West, James A Stewart, Xiaojin Zhang, Kevin C Lord, Pamela A Lucches. Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure. Journal of applied physiology (Bethesda, Md. : 1985) vol 111 issue 6 2012 21885799 |
structural and functional changes were correlated to lv collagen content, extracellular matrix (ecm) proteins, and hypertrophic markers. |
2012-04-30 |
2023-01-25 |
rat |
| Maurizio Mandala, George Oso. Physiological remodelling of the maternal uterine circulation during pregnancy. Basic & clinical pharmacology & toxicology vol 110 issue 1 2012 21902814 |
the process of maternal gestational uterine vascular remodelling involves a number of cellular processes and mechanisms, including trophoblast invasion, hyperplasia and hypertrophy, and changes in extracellular matrix composition. |
2012-04-30 |
2023-01-25 |
rat |
| Anna Leychenko, Eugene Konorev, Mayumi Jijiwa, Michelle L Matte. Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes. PloS one vol 6 issue 12 2012 22174951 |
it is characterized by extracellular matrix remodeling and hypertrophic growth of adult cardiomyocytes. |
2012-04-23 |
2023-01-25 |
rat |
| Maria C Guido, Carolina F Clemente, Ana I Moretti, Hermes V Barbeiro, Victor Debbas, Elia G Caldini, Kleber G Franchini, Francisco G Sorian. Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia. Shock (Augusta, Ga.) vol 37 issue 1 2012 21921830 |
the hearts of lipopolysaccharide-injected rats showed collagen deposition, increased matrix metalloproteinase 2 activity, and myocyte hypertrophy, as well as reduced 24-h +dp/dt and -dp/dt, together with hypotension, increased left ventricular end-diastolic pressure, and elevated levels of fak (phosphorylated and unphosphorylated). |
2012-04-16 |
2023-01-25 |
rat |
| Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. The Journal of biological chemistry vol 287 issue 7 2012 22158625 |
high glucose stimulation of global protein synthesis, cellular hypertrophy, and matrix laminin and type iv collagen content was inhibited by sodium hydrosulfide (nahs), an h(2)s donor. |
2012-04-16 |
2023-01-25 |
mouse |
| Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. The Journal of biological chemistry vol 287 issue 7 2012 22158625 |
renal cortical content of cystathionine \xce\xb2-synthase and cystathionine \xce\xb3-lyase, hydrogen sulfide-generating enzymes, was significantly reduced in mice with type 1 diabetes or type 2 diabetes, coinciding with renal hypertrophy and matrix accumulation. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
calcineurin a-\xce\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
previously, we found that inhibition of calcineurin with cyclosporine reduced renal hypertrophy and blocked glomerular matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
therefore, we examined the role of calcineurin \xce\xb2 in diabetic renal hypertrophy and glomerular matrix expansion. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
type i diabetes was induced in wild-type and \xce\xb2(-/-) mice and then renal function, extracellular matrix expansion and hypertrophy were evaluated. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
in conclusion, loss of the \xce\xb2 isoform of calcineurin is sufficient to reproduce beneficial aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion. |
2012-04-16 |
2023-01-25 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine vol 15 issue 2 2012 19778355 |
therefore, while multiple signals appear to regulate matrix, calcineurin \xce\xb2 appears to be a central mechanism involved in organ hypertrophy. |
2012-04-16 |
2023-01-25 |
mouse |
| Carlos E de Andrea, Malgorzata I Wiweger, Judith V M G Bov\\xc3\\xa9e, Salvatore Romeo, Pancras C W Hogendoor. Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Archiv : an international journal of pathology vol 460 issue 1 2012 22116208 |
endochondral chondrocytes undergo sequences of cell division, matrix secretion, cell hypertrophy, apoptosis, and matrix calcification/mineralisation. |
2012-04-12 |
2023-01-25 |
Not clear |
| William M Yarbrough, Rupak Mukherjee, John S Ikonomidis, Michael R Zile, Francis G Spinal. Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications. The Journal of thoracic and cardiovascular surgery vol 143 issue 3 2012 21762938 |
aortic valve stenosis is a common cause of left ventricular pressure overload, a pathologic process that elicits myocyte hypertrophy and alterations in extracellular matrix composition, both of which contribute to increases in left ventricular stiffness. |
2012-04-04 |
2023-01-25 |
Not clear |
| Nikolaos Donos, Filippo Graziani, Nikos Mardas, Lambros Kostopoulo. The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. Clinical oral implants research vol 22 issue 12 2012 21382090 |
the use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. |
2012-04-03 |
2023-01-25 |
human |