| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vijayakumar Sukumaran, Punniyakoti T Veeraveedu, Arun Prasath Lakshmanan, Narasimman Gurusamy, Ken'ichi Yamaguchi, Meilei Ma, Kenji Suzuki, Makoto Kodama, Kenichi Watanab. Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor. Free radical research. vol 46. issue 7. 2012-11-02. PMID:22497476. |
olmesartan treatment significantly reduced fibrosis, hypertrophy and their marker molecules (opn, ctgf, anp and gata-4, respectively), as well as matrix metalloproteinases compared with those of vehicle-treated dcm rats. |
2012-11-02 |
2023-08-12 |
rat |
| Cecelia C Yates, Diana Whaley, Alan Well. Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model. Cell transplantation. vol 21. issue 5. 2012-11-01. PMID:22236446. |
if this signaling is disrupted wounds continue to be active, resulting in a chronic hypercellular and hypertrophic state characterized by an immature matrix composition. |
2012-11-01 |
2023-08-12 |
mouse |
| Deborah Studer, Christopher Millan, Ece Öztürk, Katharina Maniura-Weber, Marcy Zenobi-Won. Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells. European cells & materials. vol 24. 2012-11-01. PMID:22828990. |
the extraordinary cell volume increase during hypertrophy is accompanied by an up-regulation of collagen x, matrix metalloproteinases (mmps), and vascular endothelial growth factor (vegf), all which are targets of the runt-related transcription factor 2 (runx2). |
2012-11-01 |
2023-08-12 |
Not clear |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
numerous studies demonstrated increased expression of extracellular matrix (ecm) proteins and activation of focal adhesion (fa) signaling pathways in models of pressure overload-induced cardiac hypertrophy. |
2012-10-31 |
2023-08-12 |
rat |
| Jing Huang, John H Wolk, Michael H Gewitz, Rajamma Mathe. Caveolin-1 expression during the progression of pulmonary hypertension. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 8. 2012-10-31. PMID:22890027. |
right ventricular (rv) systolic pressure, rv hypertrophy, pulmonary vascular histology, and the expression of caveolin-1 and endothelial membrane proteins (platelet/endothelial cell adhesion molecule-1 [pecam-1], both α and β subunits of soluble guanylate cyclase [sgc]), von willebrand factor (vwf), smooth muscle α-actin, proliferative and anti-apoptotic factors (py-stat3 and bcl-xl) and matrix metalloproteinase (mmp) 2 in the lungs were examined. |
2012-10-31 |
2023-08-12 |
human |
| Kannikar Wongdee, Nateetip Krishnamra, Narattaphol Charoenphandh. Endochondral bone growth, bone calcium accretion, and bone mineral density: how are they related? The journal of physiological sciences : JPS. vol 62. issue 4. 2012-10-29. PMID:22627708. |
endochondral bone growth in young growing mammals or adult mammals with persistent growth plates progresses from proliferation, maturation and hypertrophy of growth plate chondrocytes to mineralization of cartilaginous matrix to form an osseous tissue. |
2012-10-29 |
2023-08-12 |
rat |
| Andrew D Bries, Dennis S Weiner, Robin Jacquet, Mark J Adamczyk, Melanie A Morscher, Elizabeth Lowder, Michael J Askew, Richard P Steiner, Walter I Horne, William J Landi. A study in vivo of the effects of a static compressive load on the proximal tibial physis in rabbits. The Journal of bone and joint surgery. American volume. vol 94. issue 15. 2012-10-24. PMID:22855000. |
this investigation examined whether mechanically induced compression of rabbit physes causes changes in gene expression, cells, and extracellular components that promote physeal resilience and strength (type-ii collagen and aggrecan) and cartilage hypertrophy (type-x collagen and matrix metalloprotease-13). |
2012-10-24 |
2023-08-12 |
rabbit |
| Claudia Chavez-Muñoz, Ryan Hartwell, Reza B Jalili, Seyed Mehdi Jafarnejad, Amy Lai, Layla Nabai, Abdi Ghaffari, Peymon Hojabrpour, Natalia Kanaan, Vincent Duronio, Emma Guns, Artem Cherkasov, Aziz Ghahar. SPARC/SFN interaction, suppresses type I collagen in dermal fibroblasts. Journal of cellular biochemistry. vol 113. issue 8. 2012-10-19. PMID:22422640. |
in conclusion, this study describes for the first time an interaction between sparc and sfn that may have implications for the regulation of matrix deposition and prevention of dermal fibrotic conditions such as hypertrophic scars and keloid. |
2012-10-19 |
2023-08-12 |
human |
| E E Tredget, Y J Shen, G Liu, N Forsyth, C Smith, A Robertson Harrop, P G Scott, A Ghahar. Regulation of collagen synthesis and messenger RNA levels in normal and hypertrophic scar fibroblasts in vitro by interferon alfa-2b. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 1. issue 3. 2012-10-02. PMID:17163884. |
hypertrophic scars, which commonly occur after thermal and traumatic injury of the skin, are a fibroproliferative disorder of the dermal matrix wherein components of the inflammatory process, including the fibrotic growth factor, transforming growth factor-beta, appear to activate dormant fibroblasts leading to cellular proliferation and excessive matrix synthesis. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Ghahary, Y J Shen, P G Scott, E E Tredge. Expression of fibronectin messenger RNA in hypertrophic and normal dermal tissues and in vitro regulation by interferon alfa-2b. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 1. issue 3. 2012-10-02. PMID:17163885. |
after severe thermal injury, hypertrophic scarring which is associated with accumulation of extracellular matrix proteins including fibronectin, frequently develops. |
2012-10-02 |
2023-08-12 |
human |
| J C Sible, E Eriksson, S P Smith, N Smit. Fibronectin gene expression differs in normal and abnormal human wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 2. issue 1. 2012-10-02. PMID:17168907. |
the overproduction of fibronectin and type i collagen in keloids and hypertrophic scars implicates altered regulation of extracellular matrix components as an important aspect of these wound healing pathologies. |
2012-10-02 |
2023-08-12 |
human |
| J Steinhagen, B Kurz, O Niggemeyer, J Brun. The pathophysiology of cartilage diseases. Ortopedia, traumatologia, rehabilitacja. vol 3. issue 2. 2012-10-02. PMID:17986978. |
a hypertrophic phase in the beginning of osteoarthrosis does not lead to an accumulation of extracellular matrix because catabolic processes occur. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lina Nordquist, John Wahre. C-Peptide: the missing link in diabetic nephropathy? The review of diabetic studies : RDS. vol 6. issue 3. 2012-10-02. PMID:20039009. |
the glomerular hypertrophy and mesangial matrix expansion seen in early diabetes can be reduced or prevented by c-peptide administration, possibly via interference with tgf-beta1 and tnfalpha signaling. |
2012-10-02 |
2023-08-12 |
human |
| Chorong Jang, Ji Hee Lim, Cheol Whee Park, Young-Jin Ch. Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 15. issue 5. 2012-10-02. PMID:22128263. |
calcineurin (can) is activated in diabetes and plays a role in glomerular hypertrophy and extracellular matrix (ecm) accumulation. |
2012-10-02 |
2023-08-12 |
mouse |
| Kiyotaka Nakamagoe, Ai Hosaka, Yuzuru Kondo, Eiichi Ishikawa, Akira Tamaok. A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase. BMJ case reports. vol 2010. 2012-10-02. PMID:22368690. |
a case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jingyuan Li, Soban Umar, Marjan Amjedi, Andrea Iorga, Salil Sharma, Rangarajan D Nadadur, Vera Regitz-Zagrosek, Mansoureh Eghbal. New frontiers in heart hypertrophy during pregnancy. American journal of cardiovascular disease. vol 2. issue 3. 2012-10-02. PMID:22937489. |
cardiac hypertrophy during pregnancy is a complex process that involves many changes including in the signalling pathways, composition of extracellular matrix as well as the levels of sex hormones. |
2012-10-02 |
2023-08-12 |
Not clear |
| Jingyuan Li, Soban Umar, Marjan Amjedi, Andrea Iorga, Salil Sharma, Rangarajan D Nadadur, Vera Regitz-Zagrosek, Mansoureh Eghbal. New frontiers in heart hypertrophy during pregnancy. American journal of cardiovascular disease. vol 2. issue 3. 2012-10-02. PMID:22937489. |
in particular we focus on structural and extracellular matrix remodelling as well as signalling pathways in pregnancy-induced physiological heart hypertrophy. |
2012-10-02 |
2023-08-12 |
Not clear |
| Qian Zhang, Xinhua Xiao, Ming Li, Wenhui Li, Miao Yu, Huabing Zhang, Xiaofang Sun, Lili Mao, Hongding Xian. Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats. Journal of molecular endocrinology. vol 49. issue 1. 2012-09-26. PMID:22591908. |
kidney hypertrophy and glomerular mesangial matrix expansion were ameliorated. |
2012-09-26 |
2023-08-12 |
rat |
| A Ray Dillon, Louis J Dell'Italia, Michael Tillson, Cheryl Killingsworth, Thomas Denney, John Hathcock, Logan Botzma. Left ventricular remodeling in preclinical experimental mitral regurgitation of dogs. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. vol 14. issue 1. 2012-09-25. PMID:22386719. |
remodeling with loss of collagen weave and extracellular matrix (ecm) is accompanied by stretching and hypertrophy of the cross-sectional area and length of the cardiomyocyte. |
2012-09-25 |
2023-08-12 |
Not clear |
| Justin P Zachariah, Steven D Colan, Peter Lang, John K Triedman, Mark E Alexander, Edward P Walsh, Charles I Berul, Frank Cecchi. Circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia. Circulation. Heart failure. vol 5. issue 4. 2012-09-25. PMID:22628530. |
circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia. |
2012-09-25 |
2023-08-12 |
Not clear |