| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timoklia Orfanidou, Dimitrios Iliopoulos, Konstantinos N Malizos, Aspasia Tsezo. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. Journal of cellular and molecular medicine vol 13 issue 9B 2011 20196777 |
chondrocytes' hypertrophy includes metabolic changes, matrix remodelling, proliferation and apoptosis, characteristics associated with the progression of osteoarthritis. |
2011-12-23 |
2023-01-25 |
human |
| E J Mackie, L Tatarczuch, M Miram. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. The Journal of endocrinology vol 211 issue 2 2011 21642379 |
chondrocytes play a central role in this process, contributing to longitudinal growth through a combination of proliferation, extracellular matrix (ecm) secretion and hypertrophy. |
2011-12-20 |
2023-01-25 |
Not clear |
| Esteban Orenes-Pi\\xc3\\xb1ero, Diana Hern\\xc3\\xa1ndez-Romero, Eva Jover, Gonzalo de la Morena, Mariano Vald\\xc3\\xa9s, Francisco Mar\\xc3\\xad. An insight of novel pharmacological therapies in hypertrophic cardiomyopathy. Medicinal chemistry (Shariqah (United Arab Emirates)) vol 7 issue 4 2011 21568880 |
during the evolvement of the hypertrophic disease, myocardium suffers a heterogeneous remodeling which includes enhancement of extracellular matrix. |
2011-12-20 |
2023-01-25 |
Not clear |
| Dwight J Klemm, Susan M Majka, Joseph T Crossno, John C Psilas, Jane E B Reusch, Chrystelle V Gara. Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells. Journal of cardiovascular pharmacology vol 58 issue 2 2011 21562428 |
remodeling of the pulmonary artery (pa) involves smooth muscle cell (smc) proliferation, hypertrophy, migration, and elevated extracellular matrix (ecm) production elicited by mitogens and oxidants produced in response to hypoxic insult. |
2011-12-19 |
2023-01-25 |
rat |
| Mathew Varkey, Jie Ding, Edward E Tredge. Differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar. Biomaterials vol 32 issue 30 2011 21802722 |
differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar. |
2011-12-12 |
2023-01-25 |
Not clear |
| Joel Thompson, Patricia Wilson, Katie Brandewie, Deepa Taneja, Liliana Schaefer, Bonnie Mitchell, Lisa R Tannoc. Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy. The American journal of pathology vol 179 issue 3 2011 21723246 |
diabetic mice on the high-cholesterol diet had accelerated development of diabetic nephropathy with elevations in urine albumin excretion, glomerular and renal hypertrophy, and mesangial matrix expansion. |
2011-12-09 |
2023-01-25 |
mouse |
| Johannes Lagethon Bj\\xc3\\xb8rnstad, Ivar Sjaastad, St\\xc3\\xa5le Nyg\\xc3\\xa5rd, Almira Hasic, Mohammad Shakil Ahmed, H\\xc3\\xa5vard Attramadal, Alexandra Vanessa Finsen, Geir Christensen, Theis T\\xc3\\xb8nnesse. Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload. European heart journal vol 32 issue 2 2011 20525982 |
aortic stenosis induces pressure overload and myocardial remodelling with concentric hypertrophy and alterations in extracellular matrix (ecm). |
2011-12-09 |
2023-01-25 |
Not clear |
| Phil Barnett, Maurice J B van den Hof. Cardiac regeneration: different cells same goal. Medical & biological engineering & computing vol 49 issue 7 2011 21499802 |
in most, if not all, pathologic cardiac ischemia ensues triggering a succession of events leading to massive death of cardiomyocytes, fibroblast and extracellular matrix accumulation, cardiomyocyte hypertrophy which culminates in heart failure and eventually death. |
2011-12-08 |
2023-01-25 |
Not clear |
| Carolyn L Buller, Charles W Heilig, Frank C Brosiu. GLUT1 enhances mTOR activity independently of TSC2 and AMPK. American journal of physiology. Renal physiology vol 301 issue 3 2011 21613414 |
similarly, enhanced mammalian target of rapamycin (mtor) activation has been implicated in mesangial matrix expansion and glomerular hypertrophy in diabetes. |
2011-12-07 |
2023-01-25 |
Not clear |
| Jinhu Xiong, Melda Onal, Robert L Jilka, Robert S Weinstein, Stavros C Manolagas, Charles A O'Brie. Matrix-embedded cells control osteoclast formation. Nature medicine vol 17 issue 10 2011 21909103 |
here we have used a mouse strain in which rankl can be conditionally deleted and a series of cre-deleter strains to demonstrate that hypertrophic chondrocytes and osteocytes, both of which are embedded in matrix, are essential sources of the rankl that controls mineralized cartilage resorption and bone remodeling, respectively. |
2011-12-07 |
2023-01-25 |
Not clear |
| Kevin L McFarland, Kathryn Glaser, Jennifer M Hahn, Steven T Boyce, Dorothy M Sup. Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association vol 32 issue 4 2011 21747336 |
disruption of either production or degradation of extracellular matrix can lead to abnormal scarring, resulting in hypertrophic scar or keloid scar. |
2011-11-23 |
2023-01-25 |
cattle |
| T A Washington, J P White, J M Davis, L B Wilson, L L Lowe, S Sato, J A Carso. Skeletal muscle mass recovery from atrophy in IL-6 knockout mice. Acta physiologica (Oxford, England) vol 202 issue 4 2011 21418148 |
the loss of il-6 can alter skeletal muscle's growth and extracellular matrix remodelling response to overload-induced hypertrophy. |
2011-11-22 |
2023-01-25 |
mouse |
| I-Min Liu, Thing-Fong Tzeng, Shorong-Shii Liou, Chia Ju Chan. Beneficial effect of traditional chinese medicinal formula danggui-shaoyao-san on advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats. Evidence-based complementary and alternative medicine : eCAM vol 2012 issue 2011 21837246 |
diabetic-dependent alterations in urinary albumin, 24-hour urinary albumin excretion rate, and creatinine clearance as well as the kidney hypertrophy (kidney weight/body weight ratio) and glomerular mesangial matrix expansion were ameliorated after 12 weeks of dss treatment. |
2011-11-10 |
2023-01-25 |
rat |
| Norifumi Takeda, Ichiro Manab. Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling. International journal of inflammation vol 2011 issue 2011 21941677 |
cardiac hypertrophy entails complex structural remodeling involving rearrangement of muscle fibers, interstitial fibrosis, accumulation of extracellular matrix, and angiogenesis. |
2011-11-10 |
2023-01-25 |
Not clear |
| Elena V Tchetin. Developmental mechanisms in articular cartilage degradation in osteoarthritis. Arthritis vol 2011 issue 2011 22046522 |
the most intriguing is the growing evidence indicating that extracellular matrix destruction in osteoarthritic articular cartilage resembles that in the hypertrophic zone of fetal growth plate during endochondral ossification. |
2011-11-10 |
2023-01-25 |
Not clear |
| M Victoria Conde, M Carmen Gonzalez, Bego\\xc3\\xb1a Quintana-Villamandos, Fatima Abderrahim, Ana M Briones, Luis Condezo-Hoyos, Javier Regadera, Cristina Susin, Jose J Gomez de Diego, Emilio Delgado-Baeza, Juan J Diaz-Gil, Silvia M Arriba. Liver growth factor treatment restores cell-extracellular matrix balance in resistance arteries and improves left ventricular hypertrophy in SHR. American journal of physiology. Heart and circulatory physiology vol 301 issue 3 2011 21642499 |
liver growth factor treatment restores cell-extracellular matrix balance in resistance arteries and improves left ventricular hypertrophy in shr. |
2011-11-01 |
2023-01-25 |
rat |
| Eric E Essick, Noriyuki Ouchi, Richard M Wilson, Koji Ohashi, Joanna Ghobrial, Rei Shibata, David R Pimentel, Flora Sa. Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. American journal of physiology. Heart and circulatory physiology vol 301 issue 3 2011 21666115 |
reactive oxygen species (ros) induce matrix metalloproteinase (mmp) activity that mediates hypertrophy and cardiac remodeling. |
2011-11-01 |
2023-01-25 |
rat |
| Karen E Porter, Neil A Turne. Statins and myocardial remodelling: cell and molecular pathways. Expert reviews in molecular medicine vol 13 issue 2011 21718586 |
this review examines evidence for the cellular effects of statins in the heart, and discusses the underlying molecular mechanisms at the level of the cardiomyocyte (hypertrophy, cell death and contractile function) and the cardiac fibroblast (differentiation, proliferation, migration and extracellular matrix synthesis). |
2011-10-05 |
2023-01-25 |
Not clear |
| Amber P Sanchez, JingHong Zhao, Young You, Anne-Emilie Decl\\xc3\\xa8ves, Maggie Diamond-Stanic, Kumar Sharm. Role of the USF1 transcription factor in diabetic kidney disease. American journal of physiology. Renal physiology vol 301 issue 2 2011 21543418 |
the degree of hyperglycemia and kidney hypertrophy were similar in all groups of diabetic mice; however, the usf1 -/- diabetic mice had significantly less albuminuria and mesangial matrix expansion than the wt diabetic mice. |
2011-10-03 |
2023-01-25 |
mouse |
| Toshiyuki Inoue, Kiichi Suzuki, Hideaki Maehara, Katsuji Shimiz. Human growth plate contains aggrecan fragments that can be generated by m-calpain. Connective tissue research vol 52 issue 3 2011 21117903 |
confocal immunostaining demonstrated colocalization of m-calpain and the aggrecan product within the lower hypertrophic chondrocytes and in limited region of the pericellular matrix. |
2011-09-30 |
2023-01-25 |
human |