| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nora T Khanarian, Nora M Haney, Rachel A Burga, Helen H L. A functional agarose-hydroxyapatite scaffold for osteochondral interface regeneration. Biomaterials. vol 33. issue 21. 2012-09-17. PMID:22531222. |
it was observed that while deep zone chondrocyte (dzc) biosynthesis and hypertrophy remained unaffected, hypertrophic chondrocytes measured higher matrix deposition and mineralization potential with the addition of ha. |
2012-09-17 |
2023-08-12 |
Not clear |
| Nora T Khanarian, Nora M Haney, Rachel A Burga, Helen H L. A functional agarose-hydroxyapatite scaffold for osteochondral interface regeneration. Biomaterials. vol 33. issue 21. 2012-09-17. PMID:22531222. |
while cell hypertrophy was independent of ceramic size, matrix deposition was higher only with the addition of micron-sized ceramic particles. |
2012-09-17 |
2023-08-12 |
Not clear |
| F Wei, J Zhou, X Wei, J Zhang, B C Fleming, R Terek, M Pei, Q Chen, T Liu, L We. Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage. Osteoarthritis and cartilage. vol 20. issue 7. 2012-09-05. PMID:22469853. |
the objectives of this study were to (1) determine the correlation between osteoarthritis (oa) and indian hedgehog (ihh) expression, and (2) establish the effects of ihh on expression of markers of chondrocyte hypertrophy and matrix metalloprotease (mmp)-13 in human oa cartilage. |
2012-09-05 |
2023-08-12 |
human |
| Jack W Penn, Adriaan O Grobbelaar, Kerstin J Rolf. The role of the TGF-β family in wound healing, burns and scarring: a review. International journal of burns and trauma. vol 2. issue 1. 2012-08-30. PMID:22928164. |
other putative mechanisms which may underlie the pathogenesis of hypertrophic scars include excessive inflammation, excessive angiogenesis, altered levels of matrix metalloproteinases, growth factors, and delayed apoptosis of fibrotic myofibroblasts either due to p53 genetic alterations or tensile forces across the wound. |
2012-08-30 |
2023-08-12 |
human |
| Pia M Jungmann, Alexander T Mehlhorn, Hagen Schmal, Hermann Schillers, Hans Oberleithner, Norbert P Südkam. Nanomechanics of human adipose-derived stem cells: small GTPases impact chondrogenic differentiation. Tissue engineering. Part A. vol 18. issue 9-10. 2012-08-29. PMID:22195645. |
the aim of this study was to investigate the impact of small gtpases (rac1 and rhoa) on transforming growth factor (tgf)-β1-mediated chondrogenic differentiation of ascs and compare it with bmp-2-induced hypertrophy, by assessing effects on intracellular and extracellular matrix. |
2012-08-29 |
2023-08-12 |
human |
| Harel Dan, Stav Simsa-Maziel, Adi Reich, Dalit Sela-Donenfeld, Efrat Monsonego-Orna. The role of matrix gla protein in ossification and recovery of the avian growth plate. Frontiers in endocrinology. vol 3. 2012-08-23. PMID:22787455. |
extracellular matrix mineralization is an essential physiologic process in bone, teeth, and hypertrophic cartilage. |
2012-08-23 |
2023-08-12 |
Not clear |
| Martin Hellström, Anna Engström-Laurent, Stellan Mörner, Bengt Johansso. Hyaluronan and collagen in human hypertrophic cardiomyopathy: a morphological analysis. Cardiology research and practice. vol 2012. 2012-08-23. PMID:22900226. |
the hypertrophic cardiomyopathy (hcm) disease process is not only limited to cardiomyocyte abnormalities but also engages the extracellular matrix. |
2012-08-23 |
2023-08-12 |
human |
| C C van Donkelaar, W Wilso. Mechanics of chondrocyte hypertrophy. Biomechanics and modeling in mechanobiology. vol 11. issue 5. 2012-08-22. PMID:21847614. |
this paper shows that matrix turnover by metabolically active chondrocytes, together with externally applied mechanical conditions, can explain quantitatively the volumetric change of chondrocytes during hypertrophy. |
2012-08-22 |
2023-08-12 |
mouse |
| Thor Ueland, Arne Yndestad, Christen P Dahl, Lars Gullestad, Pål Aukrus. TNF revisited: osteoprotegerin and TNF-related molecules in heart failure. Current heart failure reports. vol 9. issue 2. 2012-08-14. PMID:22453763. |
by activating the nuclear factor-κb (nf-κb) and death-related pathways, tnf ligands can induce a variety of effects within the myocardium, including apoptosis, hypertrophy, inflammation, and extracellular matrix remodeling. |
2012-08-14 |
2023-08-12 |
Not clear |
| Muneaki Ishijima, Nobuharu Suzuki, Kentaro Hozumi, Tomoya Matsunobu, Keisuke Kosaki, Haruka Kaneko, John R Hassell, Eri Arikawa-Hirasawa, Yoshihiko Yamad. Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix biology : journal of the International Society for Matrix Biology. vol 31. issue 4. 2012-08-13. PMID:22421594. |
hypertrophic chondrocytes were differentiated in hspg2(-/-) growth plates; however, removal of the hypertrophic matrix and calcified cartilage was inhibited. |
2012-08-13 |
2023-08-12 |
mouse |
| Jochen G Hofstaetter, Stephane Blouin, Ingeborg Friehs, Klaus Klaushofer, Paul Roschge. No effect of short-term hypertension on bone matrix mineralization in a surgical animal model in immature rabbits. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 34. issue 2. 2012-08-09. PMID:21967032. |
our study indicates that short-term elevation of blood pressure has no effects on bone matrix mineralization in this surgical model of pressure-overload cardiac hypertrophy in immature rabbits. |
2012-08-09 |
2023-08-12 |
Not clear |
| Alan L James, John G Elliot, Robyn L Jones, Mark L Carroll, Thais Mauad, Tony R Bai, Michael J Abramson, Karen O McKay, Francis H Gree. Airway smooth muscle hypertrophy and hyperplasia in asthma. American journal of respiratory and critical care medicine. vol 185. issue 10. 2012-07-27. PMID:22403800. |
increased thickness of the airway smooth muscle (asm) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ecm). |
2012-07-27 |
2023-08-12 |
Not clear |
| Meenalakshmi M Mariappa. Signaling mechanisms in the regulation of renal matrix metabolism in diabetes. Experimental diabetes research. vol 2012. 2012-07-26. PMID:22454628. |
renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. |
2012-07-26 |
2023-08-12 |
Not clear |
| Liming Bian, David Y Zhai, Emily C Zhang, Robert L Mauck, Jason A Burdic. Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue engineering. Part A. vol 18. issue 7-8. 2012-07-23. PMID:21988555. |
dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hmsc-laden hyaluronic acid hydrogels. |
2012-07-23 |
2023-08-12 |
human |
| Liming Bian, David Y Zhai, Emily C Zhang, Robert L Mauck, Jason A Burdic. Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue engineering. Part A. vol 18. issue 7-8. 2012-07-23. PMID:21988555. |
in this study we investigated the effect of dynamic compressive loading on chondrogenesis, the production and distribution of cartilage specific matrix, and the hypertrophic differentiation of human mscs encapsulated in hyaluronic acid (ha) hydrogels during long term culture. |
2012-07-23 |
2023-08-12 |
human |
| Alexandra V Finsen, Ida G Lunde, Ivar Sjaastad, Even K Østli, Marianne Lyngra, Hilde O Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A Wilcox-Adelman, Paul F Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E Louch, Srdjan Djurovic, Cathrine R Carlson, Geir Christense. Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PloS one. vol 6. issue 12. 2012-07-20. PMID:22164265. |
we have investigated the hypothesis that the transmembrane z-disc proteoglycan syndecan-4, a co-receptor for integrins, connecting extracellular matrix proteins to the cytoskeleton, is an important signal transducer in cardiomyocytes during development of concentric myocardial hypertrophy following pressure overload. |
2012-07-20 |
2023-08-12 |
mouse |
| Shaoping Xu, Amy S Shriver, Dammanahalli K Jagadeesha, Ali H Chamseddine, Katalin Szőcs, Neal L Weintraub, Kathy K Griendling, Ramesh C Bhalla, Francis J Mille. Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9. Journal of vascular research. vol 49. issue 3. 2012-07-19. PMID:22433789. |
vascular injury causes neointimal hypertrophy, which is characterized by redox-mediated matrix degradation and smooth muscle cell (smc) migration and proliferation. |
2012-07-19 |
2023-08-12 |
Not clear |
| Hanna E Abbou. Mesangial cell biology. Experimental cell research. vol 318. issue 9. 2012-07-13. PMID:22414873. |
in response to metabolic, immunologic or hemodynamic injury, these cells undergo apoptosis or acquire an activated phenotype and undergo hypertrophy, proliferation with excessive production of matrix proteins, growth factors, chemokines and cytokines. |
2012-07-13 |
2023-08-12 |
Not clear |
| Mitsuo Kato, Jung Tak Park, Rama Nataraja. MicroRNAs and the glomerulus. Experimental cell research. vol 318. issue 9. 2012-07-13. PMID:22421514. |
increased expansion (hypertrophy) and accumulation of extracellular matrix (ecm) proteins such as collagen (fibrosis) in the glomerular mesangium along with glomerular podocyte dysfunction are major features of dn. |
2012-07-13 |
2023-08-12 |
human |
| John P Burand, Woojin Kim, Claudio L Afonso, Edan R Tulman, Gerald F Kutish, Zhiqiang Lu, Daniel L Roc. Analysis of the genome of the sexually transmitted insect virus Helicoverpa zea nudivirus 2. Viruses. vol 4. issue 1. 2012-07-10. PMID:22355451. |
these included a presumed juvenile hormone esterase gene, a gene coding for a putative zinc-dependent matrix metalloprotease, and a major facilitator superfamily protein gene; all of which are believed to play a role in the cellular proliferation and the tissue hypertrophy observed in the malformation of reproductive organs observed in hznv-2 infected corn earworm moths, helicoverpa zea. |
2012-07-10 |
2023-08-12 |
Not clear |