| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica Bertrand, Christoph Cromme, Daniel Umlauf, Svetlana Frank, Thomas Pa. Molecular mechanisms of cartilage remodelling in osteoarthritis. The international journal of biochemistry & cell biology vol 42 issue 10 2011 20603225 |
the loss of proteoglycans, the mineralization of the extracellular matrix (ecm) and the hypertrophic differentiation of the chondrocytes constitute hallmarks of the disease. |
2011-03-09 |
2023-01-25 |
Not clear |
| Julie A Williams, Maureen Kane, Takahiro Okabe, Motomi Enomoto-Iwamoto, Joseph L Napoli, Maurizio Pacifici, Masahiro Iwamot. Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. The Journal of biological chemistry vol 285 issue 47 2011 20843807 |
retinoid signaling was previously found to be nearly absent in ugp, but to be much stronger in lgp coincident with hypertrophy, extracellular matrix turnover and endochondral bone formation. |
2011-02-28 |
2023-01-25 |
rabbit |
| Ulrich Schotten, Sander Verheule, Paulus Kirchhof, Andreas Goett. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiological reviews vol 91 issue 1 2011 21248168 |
aging, neurohumoral activation, and chronic atrial stretch due to structural heart disease activate a variety of signaling pathways leading to histological changes in the atria including myocyte hypertrophy, fibroblast proliferation, and complex alterations of the extracellular matrix including tissue fibrosis. |
2011-02-28 |
2023-01-25 |
Not clear |
| Meenalakshmi M Mariappan, Kristin D'Silva, Myung Ja Lee, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells. American journal of physiology. Renal physiology vol 300 issue 1 2011 20943765 |
diabetes promotes protein synthesis to induce kidney hypertrophy and increase renal matrix proteins. |
2011-02-09 |
2023-01-25 |
rat |
| Meenalakshmi M Mariappan, Kristin D'Silva, Myung Ja Lee, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells. American journal of physiology. Renal physiology vol 300 issue 1 2011 20943765 |
renal cortex from type 1 diabetic rats and type 2 diabetic db/db mice showed increased phosphorylation of ubf, erk, and p70s6 kinase coinciding with renal hypertrophy and onset of matrix accumulation. |
2011-02-09 |
2023-01-25 |
rat |
| Mona Hedayat, Mohammad Jafar Mahmoudi, Noel R Rose, Nima Rezae. Proinflammatory cytokines in heart failure: double-edged swords. Heart failure reviews vol 15 issue 6 2011 20405319 |
cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. |
2011-02-08 |
2023-01-25 |
Not clear |
| Riccardo Lacchini, Anna L B Jacob-Ferreira, Marcelo R Luizon, Fernanda B Coeli, Tatiane C Izidoro-Toledo, Sandra Gasparini, Maria C Ferreira-Sae, Roberto Schreiber, Wilson Nadruz, Jose E Tanus-Santo. Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients. Clinica chimica acta; international journal of clinical chemistry vol 411 issue 23-24 2011 20707992 |
matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients. |
2011-01-19 |
2023-01-25 |
Not clear |
| S Giovannini, J Diaz-Romero, T Aigner, P Heini, P Mainil-Varlet, D Nesi. Micromass co-culture of human articular chondrocytes and human bone marrow mesenchymal stem cells to investigate stable neocartilage tissue formation in vitro. European cells & materials vol 20 issue 2011 20925023 |
msc produced cartilage-specific matrix only in +t+d but underwent hypertrophy in all pellet cultures. |
2011-01-19 |
2023-01-25 |
human |
| Elizabeth Sweeney, Douglas Roberts, Tina Corbo, Olena Jacenk. Congenic mice confirm that collagen X is required for proper hematopoietic development. PloS one vol 5 issue 3 2011 20209091 |
disrupted function of collagen x, a major hypertrophic cartilage matrix protein, resulted in skeletal and hematopoietic defects in endochondrally derived tissues. |
2011-01-11 |
2023-01-25 |
mouse |
| Doris Allerstorfer, Stefano Longato, Christoph Schwarzer, Reiner Fischer-Colbrie, Alison R Hayman, Michael J F Blume. VEGF and its role in the early development of the long bone epiphysis. Journal of anatomy vol 216 issue 5 2011 20525089 |
epiphyseal development further involves maturation of the resting chondrocytes into hypertrophic ones, associated with the mineralization of the cartilage matrix and eventual death of the latter cells. |
2011-01-05 |
2023-01-25 |
mouse |
| Cecelia C Yates, Priya Krishna, Diana Whaley, Richard Bodnar, Timothy Turner, Alan Well. Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. The American journal of pathology vol 176 issue 4 2010 20203286 |
these in vivo studies establish that the absence of cxcr3(-/-) signaling network results in hypertrophic and hypercellular scarring characterized by on-going wound regeneration, cellular proliferation, and scars in which immature matrix components are undergoing increased turnover resulting in a chronic inflammatory process. |
2010-12-14 |
2023-01-25 |
mouse |
| Marc Fajardo, Chuan-Ju Liu, Kirill Ilalov, Kenneth A Ego. Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. Journal of orthopaedic trauma vol 24 issue 9 2010 20736794 |
matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. |
2010-12-07 |
2023-01-25 |
Not clear |
| Venkatapuram Seenu Reddy, Sumanth D Prabhu, Srinivas Mummidi, Anthony J Valente, Balachandar Venkatesan, Prakashsrinivasan Shanmugam, Patrice Delafontaine, Bysani Chandraseka. Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation. American journal of physiology. Heart and circulatory physiology vol 299 issue 4 2010 20693392 |
il-18 and the extracellular matrix metalloproteinase (mmp) inducer (emmprin) stimulate the expression of proinflammatory cytokines and mmps and are elevated in myocardial hypertrophy, remodeling, and failure. |
2010-11-30 |
2023-01-25 |
Not clear |
| Wenjian Dai, Weiqing He, Guangdong Shang, Jiandong Jiang, Yiguang Wang, Weijia Kon. Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. American journal of physiology. Heart and circulatory physiology vol 299 issue 5 2010 20802139 |
in ang ii-infused mice, mr-1 silencing also blocked the upregulation of other genes related to cardiac hypertrophy or metabolism of the extracellular matrix. |
2010-11-29 |
2023-01-25 |
mouse |
| J Yanni, J O Tellez, P V Sutyagin, M R Boyett, H Dobrzynsk. Structural remodelling of the sinoatrial node in obese old rats. Journal of molecular and cellular cardiology vol 48 issue 4 2010 19729016 |
it is concluded that the age- (and/or obesity-) dependent decline in san function is associated with a structural remodelling of the san: an enlargement of the san, a hypertrophy of the san cells, and a remodelling of the extracellular matrix. |
2010-11-16 |
2023-01-25 |
rat |
| Mitsuo Kato, Lin Wang, Sumanth Putta, Mei Wang, Hang Yuan, Guangdong Sun, Linda Lanting, Ivan Todorov, John J Rossi, Rama Nataraja. Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. The Journal of biological chemistry vol 285 issue 44 2010 20713358 |
increased accumulation of extracellular matrix proteins and hypertrophy induced by transforming growth factor-\xce\xb21 (tgf-\xce\xb2) in renal mesangial cells (mc) are hallmark features of diabetic nephropathy. |
2010-11-16 |
2023-01-25 |
mouse |
| Kazuyo Yamaji-Kegan, Qingning Su, Daniel J Angelini, Allen C Myers, Chris Cheadle, Roger A John. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950) vol 185 issue 9 2010 20889544 |
we also found that himf-induced proliferative activity, hypertrophy, collagen, and extracellular matrix deposition in the pulmonary arteries are significantly less in il-4 ko mice than in wt mice. |
2010-11-12 |
2023-01-25 |
mouse |
| Wen-Hsiang Su, Ming-Huei Cheng, Wen-Ling Lee, Tsung-Shan Tsou, Wen-Hsun Chang, Chien-Sheng Chen, Peng-Hui Wan. Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation? Mediators of inflammation vol 2010 issue 2010 20671960 |
hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. |
2010-11-04 |
2023-01-25 |
Not clear |
| Zhaohui Pei, Rongsen Meng, Guangwei Li, Guangmei Yan, Changqing Xu, Zhiqiang Zhuang, Jun Ren, Zhenbiao W. Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. Toxicology letters vol 199 issue 2 2010 20837116 |
mean arterial pressure, left ventricular geometry, expression of the hypertrophic markers anp and \xce\xb2-mhc, collagen contents (type i and iii), collagenase (mmp-1), matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of mmps-1 (timp-1) were evaluated in wky and shr rats with or without treatment. |
2010-11-04 |
2023-01-25 |
rat |
| D Saura, F Mar\\xc3\\xadn, V Climent, J Gonz\\xc3\\xa1lez, V Rold\\xc3\\xa1n, D Hern\\xc3\\xa1ndez-Romero, M J Oliva, M Sabater, G de la Morena, G Y H Lip, M Vald\\xc3\\xa9. Left atrial remodelling in hypertrophic cardiomyopathy: relation with exercise capacity and biochemical markers of tissue strain and remodelling. International journal of clinical practice vol 63 issue 10 2010 19769703 |
the aim of this study was to analyse the influence of lav on exercise performance in hypertrophic cardiomyopathy (hcm), and in a subset of subjects, assess the relation of lav and exercise performance to four biomarkers of disease pathophysiology: matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) (as indices of tissue remodelling), n-terminal portion of pro b-type natriuretic peptide (nt-pro-bnp) (associated with ventricular dysfunction) and c-reactive protein (crp, an index of inflammation). |
2010-11-01 |
2023-01-25 |
human |