| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroaki Kitaoka, Toru Kubo, Makoto Okawa, Nana Takenaka, Yuichi Baba, Naohito Yamasaki, Yoshihisa Matsumura, Takashi Furuno, Yoshinori L Do. Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation. Journal of cardiology. vol 58. issue 3. 2012-03-05. PMID:21890325. |
although it has been reported that matrix metalloproteinases (mmps) are associated with left ventricular (lv) remodeling in patients with hypertrophic cardiomyopathy (hcm), the impact of plasma mmp levels in patients with hcm is somewhat vague. |
2012-03-05 |
2023-08-12 |
Not clear |
| Aida Martinez-Sanchez, Katarzyna A Dudek, Chris L Murph. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). The Journal of biological chemistry. vol 287. issue 2. 2012-02-27. PMID:22102413. |
specifically, increased mir-145 levels cause greatly reduced expression of critical cartilage extracellular matrix genes (col2a1 and aggrecan) and tissue-specific micrornas (mir-675 and mir-140) and increased levels of the hypertrophic markers runx2 and mmp13, characteristic of changes occurring in osteoarthritis. |
2012-02-27 |
2023-08-12 |
mouse |
| Xiang-Ming Qi, Yong-Gui Wu, Chao Liang, Pei Zhang, Jing Dong, Ke-Jun Ren, Wei Zhang, Fang Fang, Ji-Jia She. FK506 ameliorates renal injury in early experimental diabetic rats induced by streptozotocin. International immunopharmacology. vol 11. issue 10. 2012-02-13. PMID:21640200. |
calcineurin (can) plays an important role in glomerular hypertrophy and extracellular matrix accumulation in early diabetic nephropathy. |
2012-02-13 |
2023-08-12 |
rat |
| Ling Yan, Xiang Wei, Qi-Zhu Tang, Jinghua Feng, Yan Zhang, Chen Liu, Zhou-Yan Bian, Lian-Feng Zhang, Manyin Chen, Xue Bai, Ai-Bing Wang, John Fassett, Yingjie Chen, You-Wen He, Qinglin Yang, Peter P Liu, Hongliang L. Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. Cardiovascular research. vol 92. issue 1. 2012-01-23. PMID:21632881. |
mindin is a secreted extracellular matrix protein, an integrin ligand, and an angiogenesis inhibitor, other examples of which are all key players in the progression of cardiac hypertrophy. |
2012-01-23 |
2023-08-12 |
Not clear |
| B Frank Eames, Yi-Lin Yan, Mary E Swartz, Daniel S Levic, Ela W Knapik, John H Postlethwait, Charles B Kimme. Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. PLoS genetics. vol 7. issue 8. 2012-01-12. PMID:21901110. |
ultrastructural analyses demonstrated aberrant matrix organization and also early cellular features of chondrocyte hypertrophy in mutants. |
2012-01-12 |
2023-08-12 |
zebrafish |
| Marcin Dobaczewski, Wei Chen, Nikolaos G Frangogianni. Transforming growth factor (TGF)-β signaling in cardiac remodeling. Journal of molecular and cellular cardiology. vol 51. issue 4. 2012-01-06. PMID:21059352. |
endogenous tgf-β plays an important role in the pathogenesis of cardiac fibrotic and hypertrophic remodeling, and modulates matrix metabolism in the pressure-overloaded heart. |
2012-01-06 |
2023-08-12 |
mouse |
| Elizabeth Sweeney, Douglas Roberts, Olena Jacenk. Altered matrix at the chondro-osseous junction leads to defects in lymphopoiesis. Annals of the New York Academy of Sciences. vol 1237. 2012-01-05. PMID:22082369. |
together, these data expand the current hematopoietic niche model by including the eo-derived extracellular matrix, for example, the collagen x/hspg network, as well as the eo-derived hypertrophic chondrocytes and trabecular osteoblasts as hematopoietic signal mediating cells. |
2012-01-05 |
2023-08-12 |
mouse |
| Rajamma Mathe. Pulmonary hypertension: current therapy and future prospects. Cardiovascular & hematological agents in medicinal chemistry. vol 9. issue 3. 2012-01-03. PMID:21838666. |
the main effects are loss of vascular relaxation response, increased cell proliferation and impaired apoptosis, matrix deposition, obstruction in the small pulmonary arteries, right ventricular hypertrophy; and eventually leading to right heart failure and death. |
2012-01-03 |
2023-08-12 |
Not clear |
| Serban P Georgescu, Mark J Aronovitz, Juan L Iovanna, Richard D Patten, John M Kyriakis, Sandro Gorupp. Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. American journal of physiology. Cell physiology. vol 301. issue 5. 2011-12-27. PMID:21775709. |
the stress-inducible transcriptional regulator p8 is increased in failing human hearts and is required both for agonist-stimulated cardiomyocyte hypertrophy and for cardiac fibroblasts matrix metalloprotease-9 (mmp9) induction. |
2011-12-27 |
2023-08-12 |
mouse |
| Timoklia Orfanidou, Dimitrios Iliopoulos, Konstantinos N Malizos, Aspasia Tsezo. Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196777. |
chondrocytes' hypertrophy includes metabolic changes, matrix remodelling, proliferation and apoptosis, characteristics associated with the progression of osteoarthritis. |
2011-12-23 |
2023-08-12 |
human |
| Esteban Orenes-Piñero, Diana Hernández-Romero, Eva Jover, Gonzalo de la Morena, Mariano Valdés, Francisco Marí. An insight of novel pharmacological therapies in hypertrophic cardiomyopathy. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 7. issue 4. 2011-12-20. PMID:21568880. |
during the evolvement of the hypertrophic disease, myocardium suffers a heterogeneous remodeling which includes enhancement of extracellular matrix. |
2011-12-20 |
2023-08-12 |
Not clear |
| E J Mackie, L Tatarczuch, M Miram. The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification. The Journal of endocrinology. vol 211. issue 2. 2011-12-20. PMID:21642379. |
chondrocytes play a central role in this process, contributing to longitudinal growth through a combination of proliferation, extracellular matrix (ecm) secretion and hypertrophy. |
2011-12-20 |
2023-08-12 |
Not clear |
| Dwight J Klemm, Susan M Majka, Joseph T Crossno, John C Psilas, Jane E B Reusch, Chrystelle V Gara. Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells. Journal of cardiovascular pharmacology. vol 58. issue 2. 2011-12-19. PMID:21562428. |
remodeling of the pulmonary artery (pa) involves smooth muscle cell (smc) proliferation, hypertrophy, migration, and elevated extracellular matrix (ecm) production elicited by mitogens and oxidants produced in response to hypoxic insult. |
2011-12-19 |
2023-08-12 |
rat |
| Mathew Varkey, Jie Ding, Edward E Tredge. Differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar. Biomaterials. vol 32. issue 30. 2011-12-12. PMID:21802722. |
differential collagen-glycosaminoglycan matrix remodeling by superficial and deep dermal fibroblasts: potential therapeutic targets for hypertrophic scar. |
2011-12-12 |
2023-08-12 |
Not clear |
| Johannes Lagethon Bjørnstad, Ivar Sjaastad, Ståle Nygård, Almira Hasic, Mohammad Shakil Ahmed, Håvard Attramadal, Alexandra Vanessa Finsen, Geir Christensen, Theis Tønnesse. Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload. European heart journal. vol 32. issue 2. 2011-12-09. PMID:20525982. |
aortic stenosis induces pressure overload and myocardial remodelling with concentric hypertrophy and alterations in extracellular matrix (ecm). |
2011-12-09 |
2023-08-12 |
Not clear |
| Joel Thompson, Patricia Wilson, Katie Brandewie, Deepa Taneja, Liliana Schaefer, Bonnie Mitchell, Lisa R Tannoc. Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy. The American journal of pathology. vol 179. issue 3. 2011-12-09. PMID:21723246. |
diabetic mice on the high-cholesterol diet had accelerated development of diabetic nephropathy with elevations in urine albumin excretion, glomerular and renal hypertrophy, and mesangial matrix expansion. |
2011-12-09 |
2023-08-12 |
mouse |
| Phil Barnett, Maurice J B van den Hof. Cardiac regeneration: different cells same goal. Medical & biological engineering & computing. vol 49. issue 7. 2011-12-08. PMID:21499802. |
in most, if not all, pathologic cardiac ischemia ensues triggering a succession of events leading to massive death of cardiomyocytes, fibroblast and extracellular matrix accumulation, cardiomyocyte hypertrophy which culminates in heart failure and eventually death. |
2011-12-08 |
2023-08-12 |
Not clear |
| Carolyn L Buller, Charles W Heilig, Frank C Brosiu. GLUT1 enhances mTOR activity independently of TSC2 and AMPK. American journal of physiology. Renal physiology. vol 301. issue 3. 2011-12-07. PMID:21613414. |
similarly, enhanced mammalian target of rapamycin (mtor) activation has been implicated in mesangial matrix expansion and glomerular hypertrophy in diabetes. |
2011-12-07 |
2023-08-12 |
mouse |
| Jinhu Xiong, Melda Onal, Robert L Jilka, Robert S Weinstein, Stavros C Manolagas, Charles A O'Brie. Matrix-embedded cells control osteoclast formation. Nature medicine. vol 17. issue 10. 2011-12-07. PMID:21909103. |
here we have used a mouse strain in which rankl can be conditionally deleted and a series of cre-deleter strains to demonstrate that hypertrophic chondrocytes and osteocytes, both of which are embedded in matrix, are essential sources of the rankl that controls mineralized cartilage resorption and bone remodeling, respectively. |
2011-12-07 |
2023-08-12 |
mouse |
| Kevin L McFarland, Kathryn Glaser, Jennifer M Hahn, Steven T Boyce, Dorothy M Sup. Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association. vol 32. issue 4. 2011-11-23. PMID:21747336. |
disruption of either production or degradation of extracellular matrix can lead to abnormal scarring, resulting in hypertrophic scar or keloid scar. |
2011-11-23 |
2023-08-12 |
human |