| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Y Chuang, Megan S Lord, James Melrose, Martin D Rees, Sarah M Knox, Craig Freeman, Renato V Iozzo, John M Whiteloc. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry vol 49 issue 26 2010 20507176 |
in this study, perlecan was localized in the pericellular matrix of hypertrophic chondrocytes in developing human cartilage rudiments. |
2010-07-21 |
2023-01-25 |
human |
| Takayoshi Suganami, Yoshihiro Ogaw. Adipose tissue macrophages: their role in adipose tissue remodeling. Journal of leukocyte biology vol 88 issue 1 2010 20360405 |
indeed, obese adipose tissue is characterized by adipocyte hypertrophy, followed by increased angiogenesis, immune cell infiltration, extracellular matrix overproduction, and thus, increased production of proinflammatory adipocytokines during the progression of chronic inflammation. |
2010-07-12 |
2023-01-25 |
Not clear |
| Ashley S Hammond, Jie Ning, Carol V Ward, Matthew J Ravos. Mammalian limb loading and chondral modeling during ontogeny. Anatomical record (Hoboken, N.J. : 2007) vol 293 issue 4 2010 20235322 |
moreover, chondrocyte hypertrophy and proliferation were found to be responsive to locomotor loading and thus more important factors in chondral modeling than the extracellular matrix variables that were examined herein. |
2010-07-07 |
2023-01-25 |
Not clear |
| Yun Wang, Erika Bella, Christopher S D Lee, Claudio Migliaresi, Linda Pelcastre, Zvi Schwartz, Barbara D Boyan, Antonella Mott. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials vol 31 issue 17 2010 20303584 |
a hydrodynamic environment was beneficial to chondrocyte proliferation, differentiation, and integrin gene expression in a pore size dependent manner with superior cartilage matrix production but limited hypertrophic differentiation obtained using chondrocyte-seeded sl500 scaffolds. |
2010-06-28 |
2023-01-25 |
Not clear |
| Taku Saito, Atsushi Fukai, Akihiko Mabuchi, Toshiyuki Ikeda, Fumiko Yano, Shinsuke Ohba, Nao Nishida, Toru Akune, Noriko Yoshimura, Takumi Nakagawa, Kozo Nakamura, Katsushi Tokunaga, Ung-Il Chung, Hiroshi Kawaguch. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nature medicine vol 16 issue 6 2010 20495570 |
chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type x collagen (col10a1), matrix metalloproteinase-13 (mmp-13) and vascular endothelial growth factor (vegf), respectively, are central steps of endochondral ossification during normal skeletal growth and osteoarthritis development. |
2010-06-22 |
2023-01-25 |
mouse |
| Claire G Jeong, Scott J Holliste. A comparison of the influence of material on in vitro cartilage tissue engineering with PCL, PGS, and POC 3D scaffold architecture seeded with chondrocytes. Biomaterials vol 31 issue 15 2010 20219243 |
pgs was seen as the least favorable material for cartilage based on its relatively high de-differentiation (col1), hypertrophic mrna expression (col10) and high matrix degradation (mmp13, mmp3) results. |
2010-06-15 |
2023-01-25 |
Not clear |
| Y Sun, V Gandhi, M Prasad, W Yu, X Wang, Q Zhu, J Q Feng, R J Hinton, C Qi. Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. International journal of oral and maxillofacial surgery vol 39 issue 3 2010 20097540 |
the nh(2)-terminal fragment of dmp1 is mainly detected in the matrix of the cartilage while the cooh-terminal fragment is primarily localized in the nuclei of cells in the chondroblastic and hypertrophic layers. |
2010-06-10 |
2023-01-25 |
rat |
| L J Mauro, S J Wenzel, G M Sindber. Regulation of chick bone growth by leptin and catecholamines. Poultry science vol 89 issue 4 2010 20308401 |
real-time pcr analysis showed that ne enhanced type x collagen mrna expression, a marker of mature hypertrophic chondrocytes, with no effect on type ii collagen mrna, the matrix protein secreted by proliferating chondrocytes. |
2010-06-03 |
2023-01-25 |
chicken |
| Kirk R Hutchinson, James A Stewart, Pamela A Lucches. Extracellular matrix remodeling during the progression of volume overload-induced heart failure. Journal of molecular and cellular cardiology vol 48 issue 3 2010 19524591 |
volume overload-induced heart failure results in progressive left ventricular remodeling characterized by chamber dilation, eccentric cardiac myocyte hypertrophy and changes in extracellular matrix (ecm) remodeling changes. |
2010-05-14 |
2023-01-25 |
Not clear |
| Hui Zhu, Andrew J Bendal. Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. PloS one vol 4 issue 11 2010 19956613 |
the axial and appendicular skeleton of vertebrates develops by endochondral ossification, in which skeletogenic tissue is initially cartilaginous and the differentiation of chondrocytes via the hypertrophic pathway precedes the differentiation of osteoblasts and the deposition of a definitive bone matrix. |
2010-04-26 |
2023-01-25 |
Not clear |
| Kaneyuki Tsuchimochi, Miguel Otero, Cecilia L Dragomir, Darren A Plumb, Luiz F Zerbini, Towia A Libermann, Kenneth B Marcu, Setsuro Komiya, Kosei Ijiri, Mary B Goldrin. GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. The Journal of biological chemistry vol 285 issue 11 2010 20048163 |
previously, we reported that the hypertrophic zone of the gadd45beta(-/-) mouse embryonic growth plate is compressed, and expression of type x collagen (col10a1) and matrix metalloproteinase 13 (mmp13) genes is decreased. |
2010-04-15 |
2023-01-25 |
Not clear |
| A Gericke, C Qin, Y Sun, R Redfern, D Redfern, Y Fujimoto, H Taleb, W T Butler, A L Boske. Different forms of DMP1 play distinct roles in mineralization. Journal of dental research vol 89 issue 4 2010 20200415 |
dentin matrix protein-1 (dmp1) is a major synthetic product of hypertrophic chondrocytes and osteocytes. |
2010-04-08 |
2023-01-25 |
Not clear |
| Marcus Franz, Alexander Berndt, Annelore Altendorf-Hofmann, Nico Fiedler, Petra Richter, Julia Schumm, Michael Fritzenwanger, Hans Reiner Figulla, Bernhard R Breh. Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy. European journal of heart failure vol 11 issue 11 2010 19815660 |
serum levels of large tenascin-c variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy. |
2010-03-25 |
2023-01-25 |
Not clear |
| Gary Sweene. Cardiovascular effects of leptin. Nature reviews. Cardiology vol 7 issue 1 2010 19949425 |
accordingly, many studies have examined the contribution of leptin to cardiac remodeling in heart failure and whether the effects of leptin on metabolism, apoptosis, extracellular matrix remodeling, and hypertrophy could explain the so-called obesity paradox. |
2010-03-23 |
2023-01-25 |
human |
| Susan B Gurley, Carrie L Mach, Johannes Stegbauer, Jihong Yang, Kamie P Snow, Ann Hu, Timothy W Meyer, Thomas M Coffma. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. American journal of physiology. Renal physiology vol 298 issue 3 2010 20042456 |
renal and glomerular hypertrophy was seen in all of the lines, but significant increases in mesangial matrix compared with baseline nondiabetic controls were observed only in the 129 and c57bl/6 backgrounds. |
2010-03-19 |
2023-01-25 |
mouse |
| Hideo Orim. The mechanism of mineralization and the role of alkaline phosphatase in health and disease. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi vol 77 issue 1 2010 20154452 |
the first step of mineralization is the formation of hydroxyapatite crystals within matrix vesicles that bud from the surface membrane of hypertrophic chondrocytes, osteoblasts, and odontoblasts. |
2010-03-19 |
2023-01-25 |
mouse |
| J P White, J M Reecy, T A Washington, S Sato, M E Le, J M Davis, L B Wilson, J A Carso. Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6. Acta physiologica (Oxford, England) vol 197 issue 4 2010 19681796 |
overloading healthy skeletal muscle produces myofibre hypertrophy and extracellular matrix remodelling, and these processes are thought to be interdependent for producing muscle growth. |
2010-03-12 |
2023-01-25 |
mouse |
| Simon Doessing, Katja M Heinemeier, Lars Holm, Abigail L Mackey, Peter Schjerling, Michael Rennie, Kenneth Smith, S\\xc3\\xb8ren Reitelseder, Anne-Marie Kappelgaard, Michael H\\xc3\\xb8jby Rasmussen, Allan Flyvbjerg, Michael Kjae. Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. The Journal of physiology vol 588 issue Pt 2 2010 19933753 |
the results suggest that gh is more important in strengthening the matrix tissue than for muscle cell hypertrophy in adult human musculotendinous tissue. |
2010-03-02 |
2023-01-25 |
human |
| Robert C Olne. Mechanisms of impaired growth: effect of steroids on bone and cartilage. Hormone research vol 72 Suppl 1 issue 2010 19940493 |
local effects of gcs at the growth plate include reduction of igf-i production, inducing igf-i resistance and reducing production of c-type natriuretic peptide, which results in a reduction of chondrocyte proliferation, matrix synthesis and hypertrophy. |
2010-02-18 |
2023-01-25 |
Not clear |
| C B Little, A Barai, D Burkhardt, S M Smith, A J Fosang, Z Werb, M Shah, E W Thompso. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis and rheumatism vol 60 issue 12 2010 19950295 |
matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. |
2010-02-18 |
2023-01-25 |
mouse |