| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dylan O'Toole, Ali Abdullah I Zaeri, Stuart A Nicklin, Anne T French, Christopher M Loughrey, Tamara P Marti. Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular signalling vol 76 issue 2021 32891693 |
cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ecm), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. |
2021-11-29 |
2023-01-26 |
Not clear |
| Weipeng Ge, Cuiliu Hou, Wei Zhang, Xiaoxiao Guo, Pan Gao, Xiaomin Song, Ran Gao, Ying Liu, Wenjun Guo, Bolun Li, Hongmei Zhao, Jing Wan. Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation. Journal of molecular and cellular cardiology vol 152 issue 2021 33301800 |
pathological cardiac remodeling, characterized by excessive deposition of extracellular matrix proteins and cardiac hypertrophy, leads to the development of heart failure. |
2021-11-23 |
2023-01-26 |
Not clear |
| Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamur. Biglycan expression and its function in human ligamentum flavum. Scientific reports vol 11 issue 1 2021 33649499 |
to investigate the involvement of bgn in the pathomechanism of human ligamentum hypertrophy, first we confirmed increased expression of bgn by immunohistochemistry in the extracellular matrix of hypertrophied lf of lss patients compared to lf without hypertrophy. |
2021-11-22 |
2023-01-26 |
human |
| Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang, Birong Don. Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis. Bioengineered vol 12 issue 1 2021 33977869 |
silencing of long noncoding inhba antisense rna1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microrna-141-3p/myeloid cell leukemia 1 axis. |
2021-11-10 |
2023-01-26 |
human |
| Xiaodong Li, Zeliang He, Julei Zhang, Yan Ha. Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. FEBS open bio vol 11 issue 6 2021 33932142 |
hypertrophic scarring (hs) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. |
2021-11-08 |
2023-01-26 |
human |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology vol issue 2021 34137454 |
hypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (vegf), receptor activator of nuclear factor kappa-b ligand (rankl) and matrix metallopeptidases-9/13 (mmp-9/13). |
2021-11-03 |
2023-01-26 |
Not clear |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology vol issue 2021 34137454 |
hypertrophic chondrocytes also indirectly regulate resorption of the cartilaginous extracellular matrix, by controlling formation of a special subtype of osteoclasts termed "chondroclasts". |
2021-11-03 |
2023-01-26 |
Not clear |
| Sijia Xu, Wenxin Dong, Yu Sh. LncRNA PICSAR binds to miR-485-5p and activates TGF-\\xce\\xb21/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM). Medical molecular morphology vol 54 issue 4 2021 34255190 |
lncrna picsar binds to mir-485-5p and activates tgf-\xce\xb21/smad to promote abnormal proliferation of hypertrophic scar fibroblasts (hsfs) and excessive deposition of extracellular matrix (ecm). |
2021-11-01 |
2023-01-26 |
Not clear |
| Alan Christhian Bahr, Julia Paim DA Luz, Rayane Brinck Teixeira, Patrick T\\xc3\\xbcrck, Alexsandra Zimmer, Alexandre Luz DE Castro, Eduardo Echer Dos Reis, Fernanda Visioli, Adriane Bell\\xc3\\xb3-Klein, Alex Sander DA Rosa Araujo, Paulo Cavalheiro Schenke. The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction. Anais da Academia Brasileira de Ciencias vol 93 issue suppl 4 2021 34706009 |
methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. |
2021-10-29 |
2023-01-26 |
rat |
| Jan M Leerink, Mabel van de Ruit, Elizabeth A M Feijen, Leontien C M Kremer, Annelies M C Mavinkurve-Groothuis, Yigal M Pinto, Esther E Creemers, Wouter E M Ko. Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis. Journal of molecular medicine (Berlin, Germany) vol 99 issue 9 2021 34052857 |
collagens, matrix metalloproteinases (mmps), inflammation markers, transforming growth factor \xc3\x9f signaling markers, and markers for cardiac hypertrophy were upregulated, whereas the protein kinase b (akt) pro-survival pathway was downregulated. |
2021-10-29 |
2023-01-26 |
rat |
| Keshvad Hedayatyanfard, Nazgol-Sadat Haddadi, Seyed Ali Ziai, Hossein Karim, Feizollah Niazi, Ulrike Muscha Steckelings, Behnam Habibi, Ali Modarressi, Ahmad-Reza Dehpou. The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation. Experimental dermatology vol 29 issue 9 2021 32678966 |
hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. |
2021-10-28 |
2023-01-26 |
Not clear |
| Aykhan Yusifov, Vikram E Chhatre, Jacob M Zumo, Ross F Cook, Benjamin D McNair, Emily E Schmitt, Kathleen C Woulfe, Danielle R Brun. Cardiac response to adrenergic stress differs by sex and across the lifespan. GeroScience vol 43 issue 4 2021 33651247 |
adults increased myocyte cell size and deposited fibrotic matrix in response to iso, while juvenile and aged animals did not show evidence of hypertrophy or fibrosis. |
2021-10-28 |
2023-01-26 |
mouse |
| Natalya Bildyu. Integrins in cardiac hypertrophy: lessons learned from culture systems. ESC heart failure vol 8 issue 5 2021 34232557 |
the lessons learned from culture experiments on the models of hypertrophy induced by stretch, stimulating factors, and/or extracellular matrix components are summarized, demonstrating the major involvement of integrin-mediated signalling in cardiac hypertrophic response and its apparent crosstalk with signal pathways induced by stretch or hypertrophy stimulating factors. |
2021-10-28 |
2023-01-26 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology vol 99 issue 4 2021 32726570 |
p75ntr silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the pi3k/akt/mtor pathway. |
2021-10-27 |
2023-01-26 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology vol 99 issue 4 2021 32726570 |
hypertrophic scar (hs) results from abnormal wound healing, accompanied by excessive hypercellularity, migration, and extracellular matrix (ecm) deposition. |
2021-10-27 |
2023-01-26 |
Not clear |
| Susumu Horikoshi, Mikihito Kajiya, Souta Motoike, Mai Yoshino, Shin Morimoto, Hiroki Yoshii, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihar. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification. Biomedicines vol 9 issue 10 2021 34680525 |
c-mscs generated with xf-cim showed enlarged round cells, cartilage matrix, and hypertrophic chondrocytes genes elevation in vitro. |
2021-10-26 |
2023-01-26 |
mouse |
| Florian A Wenzl, Samuele Ambrosini, Shafeeq A Mohammed, Simon Kraler, Thomas F L\\xc3\\xbcscher, Sarah Costantino, Francesco Panen. Inflammation in Metabolic Cardiomyopathy. Frontiers in cardiovascular medicine vol 8 issue 2021 34671656 |
at the cellular level, inflammation-induced oxidative stress, mitochondrial dysfunction, impaired calcium handling, and lipotoxicity contribute to cardiomyocyte hypertrophy and dysfunction, extracellular matrix accumulation and microvascular disease. |
2021-10-22 |
2023-01-26 |
Not clear |
| Zhi Cong Wang, Hui Jun Sun, Kai Hua Li, Chao Fu, Mo Zhen Li. Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy Experimental and therapeutic medicine vol 8 issue 5 2021 25289054 |
icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy icariin (ica), a traditional chinese medicine, has been demonstrated to be a promoting compound for extracellular matrix synthesis and gene expression of chondrocytes. |
2021-10-21 |
2023-01-25 |
rat |
| Donghong Fang, Xuesi Wan, Wanping Deng, Hongyu Guan, Weijian Ke, Haipeng Xiao, Yanbing L. Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and therapeutic medicine vol 4 issue 5 2021 23226741 |
however, only middle and high doses of fxst prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. |
2021-10-21 |
2023-01-25 |
rat |
| Ning Wang, Lu Lu, Qi Feng Cao, Subo Qian, Jie Ding, Chen Wang, Huangqi Duan, Haibo Shen, Jun Q. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction. Experimental cell research vol 406 issue 1 2021 34237300 |
the bladder undergoes profound structural alterations after bladder outlet obstruction (boo), characterized by hypertrophy of the bladder wall and accumulation of extracellular matrix (ecm). |
2021-10-19 |
2023-01-26 |
mouse |