| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gopala K Rangan, Greg H Tesc. Quantification of renal pathology by image analysis. Nephrology (Carlton, Vic.) vol 12 issue 6 2008 17995580 |
our explanations indicate how these methods can be used to evaluate glomerular hypertrophy, tubular and vascular injury, accumulation of inflammatory cells and myofibroblasts, deposition of extracellular matrix, and the development of renal scarring. |
2008-05-30 |
2023-01-24 |
Not clear |
| Cordula Surmann-Schmitt, Uwe Dietz, Trayana Kireva, Nadia Adam, Jung Park, Andreas Tagariello, Patrik Onnerfjord, Dick Heineg\\xc3\\xa5rd, Ursula Schl\\xc3\\xb6tzer-Schrehardt, Rainer Deutzmann, Klaus von der Mark, Michael Stoc. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. The Journal of biological chemistry vol 283 issue 11 2008 18156182 |
in contrast, antibodies prepared against the processed c-terminal fragment located ucma-c in the entire cartilage matrix, indicating that it either diffuses or is retained until chondrocytes reach hypertrophy. |
2008-05-20 |
2023-01-24 |
rat |
| Venkatapuram Seenu Reddy, Ralf Egan Harskamp, Margreet Willie van Ginkel, John Calhoon, Clinton Eugene Baisden, In-San Kim, Anthony J Valente, Bysani Chandraseka. Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation. Journal of cellular physiology vol 215 issue 3 2008 18064631 |
fibronectin (fn), a key component of the extracellular matrix, is upregulated in cardiac tissue during myocardial hypertrophy and failure. |
2008-04-29 |
2023-01-24 |
human |
| Lluis Martorell, Jos\\xc3\\xa9 Mart\\xc3\\xadnez-Gonz\\xc3\\xa1lez, Cristina Rodr\\xc3\\xadguez, Maurizio Gentile, Olivier Calvayrac, Lina Badimo. Thrombin and protease-activated receptors (PARs) in atherothrombosis. Thrombosis and haemostasis vol 99 issue 2 2008 18278179 |
endothelial pars participate in the regulation of vascular tone, vascular permeability and endothelial secretory activity while in vsmc they mediate contraction, migration, proliferation, hypertrophy and production of extracellular matrix. |
2008-04-22 |
2023-01-24 |
Not clear |
| Eun Seok Kang, Geun Taek Lee, Beom Seok Kim, Chul Hoon Kim, Gi Ho Seo, Seung Jin Han, Kyu Yeon Hur, Chul Woo Ahn, Hunjoo Ha, Mankil Jung, Young Soo Ahn, Bong Soo Cha, Hyun Chul Le. Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. European journal of pharmacology vol 579 issue 1-3 2008 18031723 |
in addition, lab inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. |
2008-04-15 |
2023-01-24 |
rat |
| Olga Ganeshina, Sergei A Kuznetsov, Misha Vorobye. The contractile segment of the abneural limbus in the gecko cochlea is enriched in vimentin. Cell and tissue research vol 330 issue 3 2008 17922145 |
our data indicate that the nal represents a previously unknown specialization of connective tissue, characterized by the reduction of extracellular matrix and a hypertrophy of the vimentin-based intracellular cytoskeleton. |
2008-04-11 |
2023-01-24 |
Not clear |
| Hironobu Suzuki, Norio Amizuka, Kimimitsu Oda, Masaki Noda, Hayato Ohshima, Takeyasu Maed. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. Journal of anatomy vol 212 issue 3 2008 18248363 |
the wild-type mice displayed the mineralized matrix at the zone of hypertrophic chondrocyte of the growth plate and well-mineralized metaphyseal trabeculae parallel to the longitudinal axis of the bone. |
2008-04-11 |
2023-01-24 |
mouse |
| Veena Raizada, Betty Skipper, Wentao Luo, Jeffrey Griffit. Intracardiac and intrarenal renin-angiotensin systems: mechanisms of cardiovascular and renal effects. Journal of investigative medicine : the official publication of the American Federation for Clinical Research vol 55 issue 7 2008 18062896 |
the principal effects of an overactive ras include the generation of reactive oxygen species, which leads to "oxidative stress," activation of the nuclear transcription factor kappab, and stimulation of pathways and genes that promote vasoconstriction, endothelial dysfunction, cell hypertrophy, fibroblast proliferation, inflammation, excess extracellular matrix deposition, atherosclerosis, and thrombosis. |
2008-04-10 |
2023-01-24 |
Not clear |
| Elena V Tchetina, John A Di Battista, David J Zukor, John Antoniou, A Robin Pool. Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis research & therapy vol 9 issue 4 2008 17683641 |
real-time pcr analysis of articular cartilage from five patients with oa revealed that pge2 at 10 pg/ml suppressed the expression of matrix metalloproteinase (mmp)-13 and to a smaller extent mmp-1, as well as the proinflammatory cytokines il-1beta and tnf-alpha and type x collagen (col10a1), the last of these being a marker of chondrocyte hypertrophy. |
2008-04-03 |
2023-01-24 |
human |
| Marcin Balcerzak, Agata Malinowska, Cyril Thouverey, Anna Sekrecka, Michal Dadlez, Rene Buchet, Slawomir Pikul. Proteome analysis of matrix vesicles isolated from femurs of chicken embryo. Proteomics vol 8 issue 1 2008 18095356 |
mvs are released into the extracellular matrix from osseous cells such as osteoblasts and hypertrophic chondrocytes. |
2008-03-31 |
2023-01-24 |
chicken |
| Mounir Errami, Cristi L Galindo, Amina T Tassa, John M Dimaio, Joseph A Hill, Harold R Garne. Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice. The Journal of pharmacology and experimental therapeutics vol 324 issue 3 2008 18089841 |
the united states food and drug administration-approved antibiotic doxycycline (dox) inhibits matrix metalloproteases, which contribute to the development of cardiac hypertrophy (ch). |
2008-03-24 |
2023-01-24 |
mouse |
| H Zreiqat, C R Howlett, S Gronthos, D Hume, C L Gecz. S100A8/S100A9 and their association with cartilage and bone. Journal of molecular histology vol 38 issue 5 2008 17636430 |
s100a8 was expressed in alkaline phosphatase-positive hypertrophic chondrocytes, but not in proliferating chondrocytes within the growth plate where the cartilaginous matrix was calcifying. |
2008-03-17 |
2023-01-24 |
human |
| Andrea C Aragon, Phillip G Kopf, Matthew J Campen, Janice K Huwe, Mary K Walke. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicological sciences : an official journal of the Society of Toxicology vol 101 issue 2 2008 17975115 |
tcdd induced mrna expression of genes associated with ecm remodeling (matrix metalloproteinase 9 and 13, preproendothelin-1 [preproet-1]), cardiac hypertrophy (atrial natriuretic peptide, beta-myosin heavy chain, osteopontin), and aryl hydrocarbon receptor (ahr) activation (cytochrome p4501a1, ahr repressor). |
2008-03-07 |
2023-01-24 |
mouse |
| Lars Gullestad, Erik Oie, Thor Ueland, Arne Yndestad, P\\xc3\\xa5l Aukrus. The role of statins in heart failure. Fundamental & clinical pharmacology vol 21 Suppl 2 issue 2008 18001320 |
beneficial effects include attenuation of cardiac hypertrophy, improvement in endothelial function, anti-inflammatory effects, reduction in the activity of matrix metalloproteinases, reduction in apoptosis, interference with neurohormones, and improved homeostasis. |
2008-03-06 |
2023-01-24 |
human |
| Osman K\\xc3\\xb6se, Ahmad Wasee. Keloids and hypertrophic scars: are they two different sides of the same coin? Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] vol 34 issue 3 2008 18177398 |
keloids and hypertrophic scars are the results of increased fibroblast density and extracellular matrix substances. |
2008-03-06 |
2023-01-24 |
Not clear |
| Yee H Looi, David J Grieve, Anjana Siva, Simon J Walker, Narayana Anilkumar, Alison C Cave, Michael Marber, Mark J Monaghan, Ajay M Sha. Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction. Hypertension (Dallas, Tex. : 1979) vol 51 issue 2 2008 18180403 |
nox2(-/-) mice exhibited less cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis; reduced increases in expression of connective tissue growth factor and procollagen 1 mrna; and smaller increases in myocardial matrix metalloproteinase-2 activity than wt mice. |
2008-02-26 |
2023-01-24 |
mouse |
| Wojciech Jachec, Ala Foremny, Dorota Domal-Kwiatkowska, Slawomir Smolik, Andrzej Tomasik, Urszula Mazurek, Jan Wodnieck. Expression of TGF-beta1 and its receptor genes (TbetaR I, TbetaR II, and TbetaR III-betaglycan) in peripheral blood leucocytes in patients with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome. International journal of molecular medicine vol 21 issue 1 2008 18097622 |
idiopathic pulmonary arterial hypertension (ipah) is characterized by smooth muscle cell, endothelial cell, and fibroblast hypertrophy and an increase in extracellular matrix volume in pulmonary precapillary arterioles. |
2008-02-25 |
2023-01-24 |
Not clear |
| Halil Ibrahim Canter, Ersoy Konas, Onder Bozdogan, Ibrahim Vargel, Bilgen Ozbatir, Filiz Oner, Yucel Er. Effect of slow-release 5-Fluorouracil on capsule formation around silicone breast implants: an experimental study with mice. Aesthetic plastic surgery vol 31 issue 6 2008 17578639 |
capsule formation around breast implants, development of tendon adhesions after tendon repair, intestinal brits after laparatomies, hypertrophic scars in skin incisions all are the results of excessive collagen synthesis to the extracellular matrix by fibroblasts. |
2008-02-21 |
2023-01-24 |
mouse |
| Sabine Rehm, Roberta A Thomas, Kim S Smith, Rosanna C Mirabile, Tracy L Gales, Scot L Eustis, Rogely W Boyc. Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. Toxicologic pathology vol 35 issue 7 2008 18098042 |
vascular smooth muscle cell (vsmc) necrosis was observed in aorta and renal hilar arteries approximately 6 hours after dosing followed by loss of vsmc, adaptive medial thickening by vsmc hypertrophy and deposition of pas-positive matrix and collagen. |
2008-02-21 |
2023-01-24 |
mouse |
| Lyudmila Mikhaylova, Jennifer Malmquist, Maria Nurminskay. Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a. Calcified tissue international vol 81 issue 5 2008 17982705 |
in this study we demonstrate that factors secreted by the hypertrophic chondrocytes induce matrix mineralization and osteoblastic transformation in cultured mouse vascular smooth muscle cells (vsmcs). |
2008-02-19 |
2023-01-24 |
mouse |