| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brent E Bobick, William M Kuly. Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth defects research. Part C, Embryo today : reviews. vol 84. issue 2. 2008-08-06. PMID:18546337. |
endochondral ossification is a highly regulated, multistep cell specification program involving the initial differentiation of prechondrogenic mesenchymal cells into hyaline chondrocytes, terminal differentiation of hyaline chondrocytes into hypertrophic chondrocytes, and finally, apoptosis of hypertrophic chondrocytes followed by bone matrix deposition. |
2008-08-06 |
2023-08-12 |
Not clear |
| Xi-Qiao Wang, Ying-Kai Liu, Zhi-Gang Mao, Chun Qing, Shu-Liang Lu, Da-Zhong X. Isolation, culture and characterization of endothelial cells from human hypertrophic scar. Endothelium : journal of endothelial cell research. vol 15. issue 3. 2008-08-06. PMID:18568951. |
recently, the authors developed a reliable technique to obtain endothelial cells from hypertrophic scars that involved separation of cells from the scar tissue matrix and isolation from other cell types. |
2008-08-06 |
2023-08-12 |
human |
| Yongmei Liu, Barry I Freedman, Kathryn P Burdon, Carl D Langefeld, Timothy Howard, David Herrington, David C Goff, Donald W Bowden, Lynne E Wagenknecht, Catherine C Hedrick, Stephen S Ric. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 52. issue 2. 2008-08-05. PMID:18640486. |
these products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy. |
2008-08-05 |
2023-08-12 |
Not clear |
| Vanessa Roldán, Francisco Marín, Juan R Gimeno, Francisco Ruiz-Espejo, Josefa González, Eloisa Feliu, Antonio García-Honrubia, Daniel Saura, Gonzalo de la Morena, Mariano Valdés, Vicente Vicent. Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. American heart journal. vol 156. issue 1. 2008-07-31. PMID:18585501. |
matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. |
2008-07-31 |
2023-08-12 |
Not clear |
| Biao Feng, Shali Chen, Jane Chiu, Biju George, Subrata Chakrabart. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. American journal of physiology. Endocrinology and metabolism. vol 294. issue 6. 2008-07-22. PMID:18413674. |
diabetic cardiomyopathy, structurally characterized by cardiomyocyte hypertrophy and increased extracellular matrix (ecm) protein deposition, eventually leads to heart failure. |
2008-07-22 |
2023-08-12 |
rat |
| Michihiko Usui, Lianping Xing, Hicham Drissi, Michael Zuscik, Regis O'Keefe, Di Chen, Brendan F Boyc. Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 23. issue 3. 2008-06-24. PMID:17967138. |
we report that hypertrophic chondrocytes induce osteoclast formation through rankl production stimulated by bmp2 and runx2/smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates. |
2008-06-24 |
2023-08-12 |
chicken |
| Mylène Pezet, Marie-Paule Jacob, Brigitte Escoubet, Dealba Gheduzzi, Emmanuelle Tillet, Pascale Perret, Philippe Huber, Daniela Quaglino, Roger Vranckx, Dean Y Li, Barry Starcher, Walter A Boyle, Robert P Mecham, Gilles Faur. Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation research. vol 11. issue 1. 2008-06-16. PMID:18173368. |
in young adult eln+/- mice, some features resemble vascular aging of wild-type animals: cardiac hypertrophy, loss of elasticity of the arterial wall through enhanced fragmentation of the elastic fibers, and extracellular matrix accumulation in the aortic wall, in particular in the intima. |
2008-06-16 |
2023-08-12 |
mouse |
| Luciana Ribeiro Garzoni, Daniel Adesse, Maurilio José Soares, Maria Isabel Doria Rossi, Radovan Borojevic, Maria de Nazareth Leal de Meirelle. Fibrosis and hypertrophy induced by Trypanosoma cruzi in a three-dimensional cardiomyocyte-culture system. The Journal of infectious diseases. vol 197. issue 6. 2008-06-05. PMID:18279074. |
t. cruzi infection induced an increase in both the cellular area and the extracellular matrix components in cardiac spheroids, which contributed to an increase in total microtissue volume, making this a powerful 3-dimensional in vitro model for the study of cardiac-tissue hypertrophy, fibrosis, and remodeling. |
2008-06-05 |
2023-08-12 |
Not clear |
| A Serra, R Romero, D Lopez, M Navarro, A Esteve, N Perez, A Alastrue, A Ariz. Renal injury in the extremely obese patients with normal renal function. Kidney international. vol 73. issue 8. 2008-06-04. PMID:18216780. |
increased mesangial matrix, podocyte hypertrophy, mesangial cell proliferation, and glomerulomegaly were more frequent in the obese cohort than in the control group. |
2008-06-04 |
2023-08-12 |
Not clear |
| Gopala K Rangan, Greg H Tesc. Quantification of renal pathology by image analysis. Nephrology (Carlton, Vic.). vol 12. issue 6. 2008-05-30. PMID:17995580. |
our explanations indicate how these methods can be used to evaluate glomerular hypertrophy, tubular and vascular injury, accumulation of inflammatory cells and myofibroblasts, deposition of extracellular matrix, and the development of renal scarring. |
2008-05-30 |
2023-08-12 |
Not clear |
| Cordula Surmann-Schmitt, Uwe Dietz, Trayana Kireva, Nadia Adam, Jung Park, Andreas Tagariello, Patrik Onnerfjord, Dick Heinegård, Ursula Schlötzer-Schrehardt, Rainer Deutzmann, Klaus von der Mark, Michael Stoc. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18156182. |
in contrast, antibodies prepared against the processed c-terminal fragment located ucma-c in the entire cartilage matrix, indicating that it either diffuses or is retained until chondrocytes reach hypertrophy. |
2008-05-20 |
2023-08-12 |
mouse |
| Venkatapuram Seenu Reddy, Ralf Egan Harskamp, Margreet Willie van Ginkel, John Calhoon, Clinton Eugene Baisden, In-San Kim, Anthony J Valente, Bysani Chandraseka. Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation. Journal of cellular physiology. vol 215. issue 3. 2008-04-29. PMID:18064631. |
fibronectin (fn), a key component of the extracellular matrix, is upregulated in cardiac tissue during myocardial hypertrophy and failure. |
2008-04-29 |
2023-08-12 |
human |
| Lluis Martorell, José Martínez-González, Cristina Rodríguez, Maurizio Gentile, Olivier Calvayrac, Lina Badimo. Thrombin and protease-activated receptors (PARs) in atherothrombosis. Thrombosis and haemostasis. vol 99. issue 2. 2008-04-22. PMID:18278179. |
endothelial pars participate in the regulation of vascular tone, vascular permeability and endothelial secretory activity while in vsmc they mediate contraction, migration, proliferation, hypertrophy and production of extracellular matrix. |
2008-04-22 |
2023-08-12 |
Not clear |
| Eun Seok Kang, Geun Taek Lee, Beom Seok Kim, Chul Hoon Kim, Gi Ho Seo, Seung Jin Han, Kyu Yeon Hur, Chul Woo Ahn, Hunjoo Ha, Mankil Jung, Young Soo Ahn, Bong Soo Cha, Hyun Chul Le. Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:18031723. |
in addition, lab inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. |
2008-04-15 |
2023-08-12 |
rat |
| Olga Ganeshina, Sergei A Kuznetsov, Misha Vorobye. The contractile segment of the abneural limbus in the gecko cochlea is enriched in vimentin. Cell and tissue research. vol 330. issue 3. 2008-04-11. PMID:17922145. |
our data indicate that the nal represents a previously unknown specialization of connective tissue, characterized by the reduction of extracellular matrix and a hypertrophy of the vimentin-based intracellular cytoskeleton. |
2008-04-11 |
2023-08-12 |
Not clear |
| Hironobu Suzuki, Norio Amizuka, Kimimitsu Oda, Masaki Noda, Hayato Ohshima, Takeyasu Maed. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. Journal of anatomy. vol 212. issue 3. 2008-04-11. PMID:18248363. |
the wild-type mice displayed the mineralized matrix at the zone of hypertrophic chondrocyte of the growth plate and well-mineralized metaphyseal trabeculae parallel to the longitudinal axis of the bone. |
2008-04-11 |
2023-08-12 |
mouse |
| Veena Raizada, Betty Skipper, Wentao Luo, Jeffrey Griffit. Intracardiac and intrarenal renin-angiotensin systems: mechanisms of cardiovascular and renal effects. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 55. issue 7. 2008-04-10. PMID:18062896. |
the principal effects of an overactive ras include the generation of reactive oxygen species, which leads to "oxidative stress," activation of the nuclear transcription factor kappab, and stimulation of pathways and genes that promote vasoconstriction, endothelial dysfunction, cell hypertrophy, fibroblast proliferation, inflammation, excess extracellular matrix deposition, atherosclerosis, and thrombosis. |
2008-04-10 |
2023-08-12 |
Not clear |
| Elena V Tchetina, John A Di Battista, David J Zukor, John Antoniou, A Robin Pool. Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17683641. |
real-time pcr analysis of articular cartilage from five patients with oa revealed that pge2 at 10 pg/ml suppressed the expression of matrix metalloproteinase (mmp)-13 and to a smaller extent mmp-1, as well as the proinflammatory cytokines il-1beta and tnf-alpha and type x collagen (col10a1), the last of these being a marker of chondrocyte hypertrophy. |
2008-04-03 |
2023-08-12 |
human |
| Marcin Balcerzak, Agata Malinowska, Cyril Thouverey, Anna Sekrecka, Michal Dadlez, Rene Buchet, Slawomir Pikul. Proteome analysis of matrix vesicles isolated from femurs of chicken embryo. Proteomics. vol 8. issue 1. 2008-03-31. PMID:18095356. |
mvs are released into the extracellular matrix from osseous cells such as osteoblasts and hypertrophic chondrocytes. |
2008-03-31 |
2023-08-12 |
chicken |
| Mounir Errami, Cristi L Galindo, Amina T Tassa, John M Dimaio, Joseph A Hill, Harold R Garne. Doxycycline attenuates isoproterenol- and transverse aortic banding-induced cardiac hypertrophy in mice. The Journal of pharmacology and experimental therapeutics. vol 324. issue 3. 2008-03-24. PMID:18089841. |
the united states food and drug administration-approved antibiotic doxycycline (dox) inhibits matrix metalloproteases, which contribute to the development of cardiac hypertrophy (ch). |
2008-03-24 |
2023-08-12 |
mouse |