| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hitomi Kataoka Usui, Kenichi Shikata, Motofumi Sasaki, Shinichi Okada, Mitsuhiro Matsuda, Yasushi Shikata, Daisuke Ogawa, Yuichi Kido, Ryo Nagase, Kosuke Yozai, Sakiko Ohga, Atsuhito Tone, Jun Wada, Motohiro Takeya, Masahiro Takeya, Seikoh Horiuchi, Tatsuhiko Kodama, Hirofumi Makin. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes. vol 56. issue 2. 2007-04-09. PMID:17259380. |
diabetic sr-a(+/+) mice presented characteristic features of diabetic nephropathy: albuminuria, glomerular hypertrophy, mesangial matrix expansion, and overexpression of transforming growth factor-beta at 6 months after induction of diabetes. |
2007-04-09 |
2023-08-12 |
mouse |
| Mara Brancaccio, Emilio Hirsch, Antonella Notte, Giulio Selvetella, Giuseppe Lembo, Guido Taron. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovascular research. vol 70. issue 3. 2007-04-02. PMID:16466704. |
in fact, integrins, together with a number of associated cytoskeletal proteins, connect the sarcomeric contractile apparatus to the extracellular matrix across the plasma membrane and trigger intracellular signaling pathways activating the cardiomyocyte hypertrophy program. |
2007-04-02 |
2023-08-12 |
Not clear |
| P Boutouyri. [Arterial ageing and coronary artery disease: physiopathological and epidemiological data]. Archives des maladies du coeur et des vaisseaux. vol 99 Spec No 4. 2007-03-29. PMID:17236465. |
the increase in rigidity depends on the arterial territory: it is important in the aorta, moderate for elastic arteries but paradoxically decreased for muscular arteries, reflecting the combined effect of vascular smooth muscle hypertrophy ( mainly in the periphery) and changes in the extracellular matrix (mainly in the elastic arteries). |
2007-03-29 |
2023-08-12 |
Not clear |
| Yi-Chiang Hsu, Leng-Fang Wang, Yie W Chien, Woan-Ruoh Le. Induction of TIMP-1 and HSP47 synthesis in primary keloid fibroblasts by exogenous nitric oxide. Journal of dermatological science. vol 45. issue 1. 2007-03-20. PMID:17145168. |
the excessive accumulation of extracellular matrix is a hallmark of many fibrotic diseases, including the hypertrophic scar and keloid. |
2007-03-20 |
2023-08-12 |
Not clear |
| Hongmei Peng, Oscar A Carretero, Tang-Dong Liao, Edward L Peterson, Nour-Eddine Rhale. Role of N-acetyl-seryl-aspartyl-lysyl-proline in the antifibrotic and anti-inflammatory effects of the angiotensin-converting enzyme inhibitor captopril in hypertension. Hypertension (Dallas, Tex. : 1979). vol 49. issue 3. 2007-03-06. PMID:17283252. |
these hypertensive rats had the following: (1) left ventricular and renal hypertrophy, as well as increased collagen deposition in the left ventricular and the kidney; (2) glomerular matrix expansion; and (3) increased ed1-positive cells and enhanced phosphorylated-p42/44 mitogen-activated protein kinase in the left ventricle and kidney. |
2007-03-06 |
2023-08-12 |
rat |
| X-C Shen, Y-Lu, Z-Y Qia. Effects of crocetin on the matrix metalloproteinases in cardiac hypertrophy induced by norepinephrine in rats. Journal of Asian natural products research. vol 8. issue 3. 2007-03-05. PMID:16864425. |
effects of crocetin on the matrix metalloproteinases in cardiac hypertrophy induced by norepinephrine in rats. |
2007-03-05 |
2023-08-12 |
rat |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
cardiomyocyte hypertrophy and extracellular matrix remodeling, primarily mediated by inflammatory cytokine-stimulated cardiac fibroblasts, are critical cellular events in cardiac pathology. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
the molecular components governing these processes remain nebulous, and few genes have been linked to both hypertrophy and matrix remodeling. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
here we show that p8, a small stress-inducible basic helix-loop-helix protein, is required for endothelin- and alpha-adrenergic agonist-induced cardiomyocyte hypertrophy and for tumor necrosis factor-stimulated induction, in cardiac fibroblasts, of matrix metalloproteases (mmps) 9 and 13-mmps linked to general inflammation and to adverse ventricular remodeling in heart failure. |
2007-03-05 |
2023-08-12 |
human |
| Balakuntalam S Kasinath, Meenalakshmi M Mariappan, Kavithalakshmi Sataranatarajan, Myung Ja Lee, Denis Felier. mRNA translation: unexplored territory in renal science. Journal of the American Society of Nephrology : JASN. vol 17. issue 12. 2007-02-27. PMID:16959824. |
ongoing work suggests an important role for mrna translation in compensatory renal growth, hypertrophy and extracellular matrix synthesis in diabetic nephropathy, growth factor synthesis by kidney cells, and glomerulonephritis. |
2007-02-27 |
2023-08-12 |
Not clear |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
chondrocyte hypertrophy and apoptosis induced by groalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin b. cxcr2 ligands contribute to chondrocyte hypertrophy and apoptosis, important determinants in cartilage pathophysiology. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
gene expression of key markers of hypertrophy (mmp-13, runx-2) and matrix synthesis (aggrecan), and of cathepsin b isoform cb(-2,3) was evaluated by real time pcr. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
this caused the downstream triggering of chondrocyte hypertrophy (mmp-13 and runx-2 upregulation, and calcium deposition) and apoptosis/anoikis following concurrence of matrix degrading activity, and inhibition of matrix synthesis which also involved the induction of cb(-2,3). |
2007-02-09 |
2023-08-12 |
human |
| Xiaoqiu Liu, Shu Qiang Sun, Aviv Hassid, Rennolds S Ostro. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Molecular pharmacology. vol 70. issue 6. 2007-01-30. PMID:16959941. |
cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. |
2007-01-30 |
2023-08-12 |
Not clear |
| Katsuya Hiran. The roles of proteinase-activated receptors in the vascular physiology and pathophysiology. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 1. 2007-01-22. PMID:17095716. |
in smooth muscle cells, pars mediate contraction, migration, proliferation, hypertrophy, and production of the extracellular matrix, thereby contributing to the development of vascular lesions and the pathophysiology of such vascular diseases as atherosclerosis. |
2007-01-22 |
2023-08-12 |
Not clear |
| Hiroyuki Tsutsui, Tomomi Ide, Shintaro Kinugaw. Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxidants & redox signaling. vol 8. issue 9-10. 2007-01-04. PMID:16987026. |
reactive oxygen species induce myocyte hypertrophy, apoptosis, and interstitial fibrosis by activating matrix metalloproteinases. |
2007-01-04 |
2023-08-12 |
Not clear |
| Yiu-Fai Chen, Ji-An Feng, Peng Li, Dongqi Xing, Yun Zhang, Rosa Serra, Namasivayam Ambalavanan, Erum Majid-Hassan, Suzanne Opari. Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling. Journal of applied physiology (Bethesda, Md. : 1985). vol 100. issue 2. 2006-12-28. PMID:16223981. |
these data support the hypothesis that endogenous tgf-beta plays an important role in pulmonary vascular adaptation to chronic hypoxia and that disruption of tgf-beta signaling attenuates hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, pulmonary arterial hypertrophy and muscularization, alveolar remodeling, and expression of extracellular matrix mrna in whole lung. |
2006-12-28 |
2023-08-12 |
mouse |
| Elodie Masson, Michel Lagarde, Nicolas Wiernsperger, Samer El Bawa. Hyperglycemia and glucosamine-induced mesangial cell cycle arrest and hypertrophy: Common or independent mechanisms? IUBMB life. vol 58. issue 7. 2006-12-22. PMID:16801212. |
while it is well accepted that the hp promotes extracellular matrix accumulation in the context of diabetic nephropathy, its involvement in the perturbations of cell cycle progression and hypertrophy of renal cells has been poorly investigated. |
2006-12-22 |
2023-08-12 |
Not clear |
| Tahir Durmus, Renée J LeClair, Kyoung-Sook Park, Aleksandra Terzic, Jeong K Yoon, Volkhard Lindne. Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene expression patterns : GEP. vol 6. issue 8. 2006-12-20. PMID:16678498. |
abundant expression of cthrc1 was observed in the developing skeleton, i.e., in cartilage primordia, in growth plate cartilage with exclusion of the hypertrophic zone, in the bone matrix and periostium. |
2006-12-20 |
2023-08-12 |
mouse |