| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ernestina Schipan. Hypoxia and HIF-1 alpha in chondrogenesis. Seminars in cell & developmental biology. vol 16. issue 4-5. 2006-07-14. PMID:16144691. |
in endochondral bone development chondrocytes undergo well-ordered and controlled phases of proliferation, hypertrophic differentiation, mineralization of the surrounding matrix, death, blood vessel invasion, and finally replacement of cartilage with bone. |
2006-07-14 |
2023-08-12 |
Not clear |
| Xiangsheng Feng, Jiaju Tan, Yingen Pan, Qiuhe Wu, Shubin Ruan, Rui Shen, Xiaodong Chen, Yongjun D. Control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (ADM) to cover deep second degree burn. Burns : journal of the International Society for Burn Injuries. vol 32. issue 3. 2006-06-29. PMID:16487662. |
control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (adm) to cover deep second degree burn. |
2006-06-29 |
2023-08-12 |
Not clear |
| C W Park, Y Zhang, X Zhang, J Wu, L Chen, D R Cha, D Su, M-T Hwang, X Fan, L Davis, G Striker, F Zheng, M Breyer, Y Gua. PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney international. vol 69. issue 9. 2006-06-21. PMID:16672921. |
this was accompanied by dramatically reduced glomerular hypertrophy and mesangial matrix expansion. |
2006-06-21 |
2023-08-12 |
mouse |
| Shintaro Kinugawa, Hiroyuki Tsutsu. [Oxidative stress and heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 64. issue 5. 2006-06-15. PMID:16689364. |
the excessive reactive oxygen species (ros), produced by the electron leak in mitochondria of failing myocardium, play an important role in development and progression of heart failure (hf) and cardiac remodeling, which is associated with induction of myocyte hypertrophy and apoptosis and activation of matrix metalloproteinases. |
2006-06-15 |
2023-08-12 |
Not clear |
| T Pantsulai. Role of TGF-beta in pathogenesis of diabetic nephropathy. Georgian medical news. issue 131. 2006-06-12. PMID:16575121. |
diabetic nephropathy, a major long-term complication of diabetes mellitus is characterized by hypertrophy of the glomerular and tubuloepithelial structures and thickening of glomerular and tubular basement membranes and progressive accumulation of extracellular matrix proteins (fibronectin, collagens and laminin) in the mesangium and the interstitium. |
2006-06-12 |
2023-08-12 |
Not clear |
| T Pantsulai. Role of TGF-beta in pathogenesis of diabetic nephropathy. Georgian medical news. issue 131. 2006-06-12. PMID:16575121. |
of these, the cytokine transforming growth factor (tgf-beta) has emerged as having a key role in the development of renal hypertrophy and accumulation of extracellular matrix in diabetes. |
2006-06-12 |
2023-08-12 |
Not clear |
| Joji Ishikawa, Kazuomi Kario, Yoshio Matsui, Seiichi Shibasaki, Masato Morinari, Ruri Kaneda, Satoshi Hoshide, Kazuo Eguchi, Yukihiro Hojo, Kazuyuki Shimad. Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. Hypertension research : official journal of the Japanese Society of Hypertension. vol 28. issue 12. 2006-06-05. PMID:16671339. |
collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. |
2006-06-05 |
2023-08-12 |
Not clear |
| Hsiu-Wen Chan, Nicola J Smith, Ross D Hannan, Walter G Thoma. Tackling the EGFR in pathological tissue remodelling. Pulmonary pharmacology & therapeutics. vol 19. issue 1. 2006-05-11. PMID:15979363. |
tissue remodelling is an adaptive physiological event initiated by physical and/or hormonal stimuli and characterised by extracellular matrix modifications, inflammation, cellular hypertrophy, proliferation and/or apoptosis. |
2006-05-11 |
2023-08-12 |
Not clear |
| John V Bonacci, Alastair G Stewar. Regulation of human airway mesenchymal cell proliferation by glucocorticoids and beta2-adrenoceptor agonists. Pulmonary pharmacology & therapeutics. vol 19. issue 1. 2006-05-11. PMID:16286235. |
one of the most consistently observed changes in asthmatic airways is an increased volume of airway smooth muscle (asm), that has been explained by proliferation, hypertrophy, extracellular matrix deposition within the smooth muscle bundles, and more recently, the migration of mesenchymal precursor cells to the airways. |
2006-05-11 |
2023-08-12 |
human |
| V J Karthikeyan, Gregory Y H Li. Matrix metalloproteinases and hypertension: a link between left ventricular hypertrophy and diastolic dysfunction? The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434829. |
matrix metalloproteinases and hypertension: a link between left ventricular hypertrophy and diastolic dysfunction? |
2006-05-10 |
2023-08-12 |
Not clear |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. |
2006-05-10 |
2023-08-12 |
human |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
matrix metalloproteinases (mmps) are involved in the regulation of the extracellular matrix (ecm) of the myocardium and thus the pathogenesis of vascular and cardiac hypertrophy. |
2006-05-10 |
2023-08-12 |
human |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
in this study, we investigated contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy (lvh) and diastolic dysfunction in hypertensive subjects. |
2006-05-10 |
2023-08-12 |
human |
| Darko Bosnakovski, Morimichi Mizuno, Gonhyung Kim, Satoshi Takagi, Masahiro Okumur, Toru Fujina. Gene expression profile of bovine bone marrow mesenchymal stem cell during spontaneous chondrogenic differentiation in pellet culture system. The Japanese journal of veterinary research. vol 53. issue 3-4. 2006-05-08. PMID:16544933. |
of sox9 messenger ribonucleic acid (mrna), followed by high transcription of chondrocyte specific genes, collagen type ii and ix, biglycan and cartilage oligomeric matrix protein, and the final prehypertrophic and/or hypertrophic stage was distinguished by increased expression of collagen type x. |
2006-05-08 |
2023-08-12 |
cattle |
| Volker Roenicke, Stéphane Leclair, Anke Hoffmann, Michael Becker, Tania Szado, Thomas Kirsch, Oliver Stoss, Barbara T Navé, Thomas Henke. Emerging therapeutic targets in chronic heart failure: part II. Expert opinion on therapeutic targets. vol 7. issue 1. 2006-05-01. PMID:12556202. |
increased expression and activity of matrix metalloproteinases lead to altered composition and arrangement of the extracellular matrix, which is accompanied by eccentric hypertrophy of cardiomyocytes. |
2006-05-01 |
2023-08-12 |
Not clear |
| I Villemure, M A Chung, C S Seck, M H Kimm, J R Matyas, N A Dunca. Static compressive loading reduces the mRNA expression of type II and X collagen in rat growth-plate chondrocytes during postnatal growth. Connective tissue research. vol 46. issue 4-5. 2006-04-14. PMID:16546824. |
this suggests that mechanical compression influences chondrocytes of the hypertrophic zone to alter their expression of specific genes encoding proteins of the extracellular matrix, while pth-pthrp receptor mrna, a regulatory protein, remained unaffected by loading. |
2006-04-14 |
2023-08-12 |
rat |
| Timothy A Damron, Jason A Horton, Asghar Naqvi, Richard M Loomis, Bryan S Margulies, Judith A Strauss, Cornelia E Farnum, Joseph A Spadar. Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation. Radiation research. vol 165. issue 3. 2006-04-12. PMID:16494524. |
by 2 weeks, positive findings unique to the combination-treatment animals included greater mean proliferation in the irradiated growth plate than on the contralateral side, smaller limb length discrepancies, reversal of the increased overall matrix area fraction, and reversal of the usual deficiency in indian hedgehog staining in the irradiated hypertrophic zone. |
2006-04-12 |
2023-08-12 |
rat |
| Melanie C Fisher, Carissa Meyer, Graham Garber, Caroline N Deal. Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth. Bone. vol 37. issue 6. 2006-03-17. PMID:16183342. |
together, our results suggest that the mechanism of action whereby igfbp2 excess impairs long bone development is to inhibit igf-mediated proliferation and matrix synthesis by the cartilage model; reduce the proliferation and progression to hypertrophy by the maturing chondrocytes; and attenuate proliferation and formation of the periosteal bony collar. |
2006-03-17 |
2023-08-12 |
chicken |
| Keiichiro Kizaki, Muneyoshi Okada, Ryoichi Ito, Kazuki Yoshioka, Kazuyoshi Hashizume, Ken-ichiro Mutoh, Yukio Har. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Biological & pharmaceutical bulletin. vol 28. issue 12. 2006-03-09. PMID:16327176. |
gene expression of heparanase, matrix metalloproteinases (mmp)-2 and mmp-9 were examined in ventricles after chronic treatment with isoproterenol (iso) induced cardiac hypertrophy in rats. |
2006-03-09 |
2023-08-12 |
rat |
| Masako Baba, Jun Wada, Jun Eguchi, Izumi Hashimoto, Tatsuo Okada, Akihiro Yasuhara, Kenichi Shikata, Yashpal S Kanwar, Hirofumi Makin. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. Journal of the American Society of Nephrology : JASN. vol 16. issue 11. 2006-03-02. PMID:16177004. |
the injection of gal-9 into db/db mice significantly inhibited glomerular hypertrophy and mesangial matrix expansion and reduced urinary albumin excretion. |
2006-03-02 |
2023-08-12 |
mouse |