| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng Feng, Anna Rita Plati, Qing-li Cheng, Mariana Berho, Anita Banerjee, Mylene Potier, Wen-che Jy, Andrew Koff, Liliane J Striker, Gary E Strike. Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. The American journal of pathology. vol 167. issue 2. 2005-09-29. PMID:16049323. |
the altered phenotype included increased extracellular matrix synthesis and decreased matrix metalloproteinase-2 levels as well as cell hypertrophy. |
2005-09-29 |
2023-08-12 |
mouse |
| Gerold Untergasser, Stephan Madersbacher, Peter Berge. Benign prostatic hyperplasia: age-related tissue-remodeling. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763388. |
prostate tissue-remodeling in the transition zone is characterized by: (i) hypertrophic basal cells, (ii) altered secretions of luminal cells leading to calcification, clogged ducts and inflammation, (iii) lymphocytic infiltration with production of proinflammatory cytokines, (iv) increased radical oxygen species (ros) production that damages epithelial and stromal cells, (v) increased basic fibroblast (bfgf) and transforming growth factor beta (tgf-beta 1) production leading to stromal proliferation, transdifferentiation and extracellular matrix production, (vi) altered autonomous innervation that decreases relaxation and leads to a high adrenergic tonus, (vii) and altered neuroendocine cell function and release of neuroendocrine peptides (nep). |
2005-08-25 |
2023-08-12 |
human |
| Tetsuro Wakatsuki, Joseph Schlessinger, Elliot L Elso. The biochemical response of the heart to hypertension and exercise. Trends in biochemical sciences. vol 29. issue 11. 2005-08-23. PMID:15501680. |
chronic hypertension also causes hypertrophy, but in addition it causes an excessive increase in fibroblasts and extracellular matrix (fibrosis), death of cardiomyocytes and ultimately heart failure. |
2005-08-23 |
2023-08-12 |
Not clear |
| Elena V Tchetina, Ginette Squires, A Robin Pool. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. The Journal of rheumatology. vol 32. issue 5. 2005-08-09. PMID:15868625. |
articular cartilage degeneration in osteoarthritis (oa) involves excessive degradation of extracellular matrix (ecm) and chondrocyte differentiation (hypertrophy). |
2005-08-09 |
2023-08-12 |
human |
| Kurt D Hankenson, Sheriar G Hormuzdi, Jeffrey A Meganck, Paul Bornstei. Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Molecular and cellular biology. vol 25. issue 13. 2005-08-02. PMID:15964815. |
thus, vascular invasion and ossification start in the femoral heads of tsp3-null mice at 9 weeks, whereas the wild-type femoral head is still composed of hypertrophic chondroctyes in a calcified matrix at 15 weeks. |
2005-08-02 |
2023-08-12 |
mouse |
| Jürgen Pauluhn, Ulrich Moh. Experimental approaches to evaluate respiratory allergy in animal models. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 56. issue 4-5. 2005-07-26. PMID:15816351. |
the pathology of asthma is associated with reversible narrowing of airways, associated with prominent features that involve structural changes in the airway walls and extracellular matrix remodeling including abnormalities of bronchial smooth muscle, eosinophilic inflammation of the bronchial wall, hyperplasia and hypertrophy of mucous glands. |
2005-07-26 |
2023-08-12 |
human |
| Claes C Strøm, Mark Aplin, Thorkil Ploug, Tue E H Christoffersen, Jozef Langfort, Michael Viese, Henrik Galbo, Stig Haunsø, Søren P Sheik. Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. The FEBS journal. vol 272. issue 11. 2005-07-21. PMID:15943803. |
expression changes in genes encoding extracellular matrix proteins, cytoskeletal elements, signalling factors and ribosomal proteins mimicked changes previously described in maladaptive hypertrophy. |
2005-07-21 |
2023-08-12 |
rat |
| Elangovan Vellaichamy, Madan L Khurana, Jude Fink, Kailash N Pande. Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15710627. |
the findings of this study demonstrate that disruption of npra/cgmp signaling promotes hypertrophic growth and extracellular matrix remodeling, leading to the development of cardiac hypertrophy, myocardial fibrosis, and congestive heart failure. |
2005-07-12 |
2023-08-12 |
mouse |
| Yoshihiro Tamamura, Tomohiro Otani, Naoko Kanatani, Eiki Koyama, Jirota Kitagaki, Toshihisa Komori, Yoshihiko Yamada, Frank Costantini, Satoshi Wakisaka, Maurizio Pacifici, Masahiro Iwamoto, Motomi Enomoto-Iwamot. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15760903. |
activation in mature cells instead stimulated hypertrophy, matrix mineralization, and expression of terminal markers such as metalloprotease (mmp)-13 and vascular endothelial growth factor. |
2005-07-12 |
2023-08-12 |
mouse |
| Jürgen Kopp, Ellen Preis, Harun Said, Bernd Hafemann, Lucia Wickert, Axel M Gressner, Norbert Pallua, Steven Doole. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15788410. |
human fibroproliferative disorders like hypertrophic scarring of the skin are characterized by increased contractility and excess extracellular matrix synthesis. |
2005-07-12 |
2023-08-12 |
human |
| Jürgen Kopp, Ellen Preis, Harun Said, Bernd Hafemann, Lucia Wickert, Axel M Gressner, Norbert Pallua, Steven Doole. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15788410. |
in summary, our data indicate that autocrine tgf-beta/smad signaling is involved in contractility and matrix gene expression of fibroblasts from normal and hypertrophic scars. |
2005-07-12 |
2023-08-12 |
human |
| A D Hodgkinson, T Page, B A Millward, A G Demain. A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. Journal of diabetes and its complications. vol 19. issue 2. 2005-06-30. PMID:15745834. |
glucose transporter 1 (glut1) activity has been implicated in renal hypertrophy and extracellular matrix formation in mesangial cells. |
2005-06-30 |
2023-08-12 |
Not clear |
| Young-Sook Kim, Zhong-Gao Xu, Marpadga A Reddy, Shu-Lian Li, Linda Lanting, Kumar Sharma, Sharon G Adler, Rama Nataraja. Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells. Journal of the American Society of Nephrology : JASN. vol 16. issue 2. 2005-06-28. PMID:15615821. |
diabetic nephropathy (dn) is characterized by mesangial cell (mc) hypertrophy and progressive accumulation of glomerular extracellular matrix (ecm). |
2005-06-28 |
2023-08-12 |
mouse |
| Kristen A Johnson, Robert A Terkeltau. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15691824. |
chondrocyte maturation to hypertrophy, associated with up-regulated transglutaminase 2 (tg2) expression, mediates not only physiologic growth plate mineralization but also pathologic matrix calcification and dys-regulated matrix repair in osteoarthritic articular cartilage. |
2005-06-07 |
2023-08-12 |
mouse |
| Kristen A Johnson, Robert A Terkeltau. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15691824. |
following transfection of tg2 site-directed mutants into chondrocytic cells, we observed that wild type tg2, and tg catalytic site and fibronectin-binding mutants promoted type x collagen expression and matrix calcification consistent with chondrocyte hypertrophic differentiation. |
2005-06-07 |
2023-08-12 |
mouse |
| P Pacaud, V Sauzeau, G Loiran. Rho proteins and vascular diseases. Archives des maladies du coeur et des vaisseaux. vol 98. issue 3. 2005-05-26. PMID:15816329. |
typically, arterial diseases are associated with functional and structural wall alterations including modified contractile properties, smooth muscle cell hypertrophy and proliferation, endothelial dysfunction, excessive extracellular matrix accumulation and inflammation. |
2005-05-26 |
2023-08-12 |
Not clear |
| Yan Wang, Frank Middleton, Jason A Horton, Lee Reichel, Cornelia E Farnum, Timothy A Damro. Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone. vol 35. issue 6. 2005-05-19. PMID:15589209. |
longitudinal bone growth results from coordination of proliferation and hypertrophy of chondrocytes, calcification of the matrix, vascular invasion, and completion of endochondral bone formation in the growth plate. |
2005-05-19 |
2023-08-12 |
rat |
| Anke Schnapper, Wilfried Meye. Osteopontin distribution in the canine skeleton during growth and structural maturation. Cells, tissues, organs. vol 178. issue 3. 2005-05-19. PMID:15655333. |
opn was expressed in hypertrophic chondrocytes of epiphyseal cartilage and in chondrocytes of the deep zone of mature articular cartilage, where extracellular matrix was also stained. |
2005-05-19 |
2023-08-12 |
Not clear |
| Judith Bellemare, Charles J Roberge, Danielle Bergeron, Carlos A Lopez-Vallé, Michel Roy, Véronique J Mouli. Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars. The Journal of pathology. vol 206. issue 1. 2005-05-17. PMID:15772942. |
hypertrophic scarring is a pathological process characterized by fibroblastic hyperproliferation and by excessive deposition of extracellular matrix components. |
2005-05-17 |
2023-08-12 |
Not clear |
| Björn Samnegård, Stefan H Jacobson, Georg Jaremko, Bo-Lennart Johansson, Karin Ekberg, Britta Isaksson, Linda Eriksson, John Wahren, Mats Sjöquis. C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 20. issue 3. 2005-05-16. PMID:15665028. |
c-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. |
2005-05-16 |
2023-08-12 |
rat |