| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harumi Kawaki, Satoshi Kubota, Masanao Minato, Norifumi H Moritani, Takako Hattori, Hiroshi Hanagata, Mamoru Kubota, Akira Miyauchi, Tohru Nakanishi, Masaharu Takigaw. Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line. DNA and cell biology vol 22 issue 10 2003 14611685 |
it stimulates proliferation, migration, and extracellular matrix production of mesenchymal cells, and is highly expressed in hypertrophic chondrocytes. |
2003-12-09 |
2023-01-24 |
human |
| Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, Daisuke Ogawa, Hitomi Usui, Yuichi Kido, Ryo Nagase, Jun Wada, Yasushi Shikata, Hirofumi Makin. Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes vol 52 issue 10 2003 14514644 |
urinary albumin excretion, glomerular hypertrophy, and mesangial matrix expansion were significantly lower in diabetic icam-1(-/-) mice than in diabetic icam-1(+/+) mice. |
2003-12-03 |
2023-01-24 |
mouse |
| Maria Angelica Binotto, Maria de Lourdes Higuchi, Vera Demarchi Aiell. Left ventricular remodeling in hearts with tricuspid atresia: morphologic observations and possible basis for ventricular dysfunction after surgery. The Journal of thoracic and cardiovascular surgery vol 126 issue 4 2003 14566242 |
this study was undertaken to assess the pattern of left ventricular hypertrophy, the myocardial capillary network, and the extracellular matrix in hearts with tricuspid atresia. |
2003-12-02 |
2023-01-24 |
Not clear |
| Tam\\xc3\\xa1s Husz\\xc3\\xa1r, Andr\\xc3\\xa1s Masszi, Istv\\xc3\\xa1n Mucsi, L\\xc3\\xa1szl\\xc3\\xb3 Rosival. [Role of mitogen-activated protein kinase cascade in the intracellular signaling of angiotensin II]. Orvosi hetilap vol 144 issue 31 2003 14502868 |
it has been recently recognized that angiotensin ii (ang ii), in addition to its role in the regulation of the salt-fluid homeostasis is also a growth factor and contributes to the regulation of cellular hypertrophy or proliferation and extracellular matrix (ecm) formation. |
2003-11-05 |
2023-01-24 |
Not clear |
| Richard L Lieber, Eva Runesson, Fredrik Einarsson, Jan Frid\\xc3\\xa9. Inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material. Muscle & nerve vol 28 issue 4 2003 14506719 |
inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material. |
2003-10-29 |
2023-01-24 |
Not clear |
| Andrey Sorokin, Donald E Koha. Physiology and pathology of endothelin-1 in renal mesangium. American journal of physiology. Renal physiology vol 285 issue 4 2003 12954590 |
mcs also express et receptors, activation of which leads to a complex signaling cascade with resultant stimulation of mc hypertrophy, proliferation, contraction, and extracellular matrix accumulation. |
2003-10-10 |
2023-01-24 |
Not clear |
| X H Guo, Z H Liu, C S Dai, H Li, D Liu, L S L. Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. Acta pharmacologica Sinica vol 22 issue 10 2003 11749778 |
rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. |
2003-10-02 |
2023-01-24 |
Not clear |
| X H Guo, Z H Liu, C S Dai, H Li, D Liu, L S L. Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. Acta pharmacologica Sinica vol 22 issue 10 2003 11749778 |
to investigate the effects of rhein on cell hypertrophy and accumulation of extracellular matrix (ecm) in the renal tubular epithelial cells. |
2003-10-02 |
2023-01-24 |
Not clear |
| Dae Joong Kim, Sang Hee Park, Chol Seung Lim, Jang-Soo Chun, Jin-Kyu Kim, Woo Keun Son. Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes. Cell biochemistry and function vol 21 issue 1 2003 12579520 |
cardiac hypertrophy is characterized by remodeling of the extracellular matrix (ecm). |
2003-09-16 |
2023-01-24 |
Not clear |
| J Bauersachs, D Fraccaroll. Aldosterone antagonism in addition to angiotensin-converting enzyme inhibitors in heart failure. Minerva cardioangiologica vol 51 issue 2 2003 12783071 |
while reduction of excessive extracellular matrix turnover leading to decreased fibrosis appears to be the most important effect of spironolactone in heart failure, other mechanisms such as regression of hypertrophy, improvement of endothelial function, enhanced renal sodium excretion and antiarrhythmic actions may contribute. |
2003-09-09 |
2023-01-24 |
Not clear |
| Rennolds S Ostrom, Jennifer E Naugle, Miki Hase, Caroline Gregorian, James S Swaney, Paul A Insel, Laurence L Brunton, J Gary Meszaro. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. The Journal of biological chemistry vol 278 issue 27 2003 12711600 |
cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. |
2003-08-18 |
2023-01-24 |
Not clear |
| A K Rosenthal, D Heinkel, C M Goh. Thyroxine stimulates transglutaminase activity in articular chondrocytes. Osteoarthritis and cartilage vol 11 issue 6 2003 12801486 |
hypertrophic chondrocytes are responsible for extracellular matrix mineralization, with formation of bone mineral in growth plate cartilage and pathologic calcium crystals in aging articular cartilage. |
2003-08-12 |
2023-01-24 |
Not clear |
| Tsutomu Yoshikaw. [Alterations in sympathoadrenal system in congestive heart failure]. Nihon rinsho. Japanese journal of clinical medicine vol 61 issue 5 2003 12754996 |
mechanisms underlying such adverse effects involve multiple biological events including production of oxygen free radicals, cytokines, matrix metalloproteinase, apoptosis, cardiac hypertrophy, and chamber remodeling as well as energy expenditure. |
2003-08-08 |
2023-01-24 |
Not clear |
| E Grimaud, F Blanchard, C Charrier, F Gouin, F Redini, D Heyman. Leukaemia inhibitory factor (lif) is expressed in hypertrophic chondrocytes and vascular sprouts during osteogenesis. Cytokine vol 20 issue 5 2003 12550107 |
avascular cartilage is replaced by highly vascularized bone tissue during endochondral ossification, a process involving capillary invasion of calcified hypertrophic cartilage in association with apoptosis of hypertrophic chondrocytes, degradation of cartilage matrix and deposition of bone matrix. |
2003-08-01 |
2023-01-24 |
rat |
| Sanja Ivkovic, Byeong S Yoon, Steven N Popoff, Fayez F Safadi, Diana E Libuda, Robert C Stephenson, Aaron Daluiski, Karen M Lyon. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (Cambridge, England) vol 130 issue 12 2003 12736220 |
ctgf deficiency leads to skeletal dysmorphisms as a result of impaired chondrocyte proliferation and extracellular matrix composition within the hypertrophic zone. |
2003-07-31 |
2023-01-24 |
mouse |
| Sanja Ivkovic, Byeong S Yoon, Steven N Popoff, Fayez F Safadi, Diana E Libuda, Robert C Stephenson, Aaron Daluiski, Karen M Lyon. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (Cambridge, England) vol 130 issue 12 2003 12736220 |
decreased expression of specific extracellular matrix components and matrix metalloproteinases suggests that matrix remodeling within the hypertrophic zones in ctgf mutants is defective. |
2003-07-31 |
2023-01-24 |
mouse |
| Miriam S Domowicz, Melissa M Mueller, Todd E Novak, Lauren E Schwartz, Nancy B Schwart. Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis. Developmental dynamics : an official publication of the American Association of Anatomists vol 226 issue 1 2003 12508223 |
this finding was verified by using an aggrecan-deficient mutant, the nanomelic chick, which lacks hnk-1 immunostaining in the extracellular matrix of dividing and hypertrophic chondrocytes as late as embryonic day 12. |
2003-07-29 |
2023-01-24 |
chicken |
| Miriam S Domowicz, Melissa M Mueller, Todd E Novak, Lauren E Schwartz, Nancy B Schwart. Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis. Developmental dynamics : an official publication of the American Association of Anatomists vol 226 issue 1 2003 12508223 |
localization changes with development and the hnk-1-aggrecan matrix becomes restricted to dividing and hypertrophic chondrocytes and is particularly concentrated in the intraterritorial matrix. |
2003-07-29 |
2023-01-24 |
chicken |
| Nathalie Ortega, Danielle Behonick, Dominique Stickens, Zena Wer. How proteases regulate bone morphogenesis. Annals of the New York Academy of Sciences vol 995 issue 2003 12814943 |
apoptosis of the terminal hypertrophic chondrocytes, degradation of the cartilage matrix, and deposition of bone matrix by osteoblasts accompanies neovascularization of the growth plate. |
2003-07-22 |
2023-01-24 |
Not clear |
| Russell L Prewitt, Darian C Rice, Anca D Dobria. Adaptation of resistance arteries to increases in pressure. Microcirculation (New York, N.Y. : 1994) vol 9 issue 4 2003 12152105 |
during the development of hypertension, hypertrophy of smooth muscle cells and deposition of extracellular matrix thicken the walls of large arteries without reducing the size of the lumen. |
2003-07-16 |
2023-01-24 |
Not clear |