| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoyan Wang, Anita Woods, Shalev Sabari, Luca Pagnotta, Lee-Anne Stanton, Frank Beie. RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. The Journal of biological chemistry. vol 279. issue 13. 2004-05-07. PMID:14726536. |
rhoa overexpression in chondrogenic atdc5 cells results in increased proliferation and a marked delay of hypertrophic differentiation, as shown by decreased induction of alkaline phosphatase activity, mineralization, and expression of the hypertrophic markers collagen x, bone sialoprotein, and matrix metalloproteinase 13. |
2004-05-07 |
2023-08-12 |
Not clear |
| Cornelia Piper, Heinz-Peter Schultheiss, Daniel Akdemir, Joern Rudolf, Dieter Horstkotte, Matthias Pauschinge. Remodeling of the cardiac extracellular matrix differs between volume- and pressure-overloaded ventricles and is specific for each heart valve lesion. The Journal of heart valve disease. vol 12. issue 5. 2004-04-27. PMID:14565712. |
different patterns of fibroblast-mediated remodeling of the extracellular matrix (ecm) might be expected between patients with pressure- and volume-induced left ventricular hypertrophy. |
2004-04-27 |
2023-08-12 |
Not clear |
| Lee-Anne Stanton, Shalev Sabari, Arthur V Sampaio, T Michael Underhill, Frank Beie. p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. The Biochemical journal. vol 378. issue Pt 1. 2004-04-22. PMID:14594450. |
in addition, p38 inhibition causes reduced expression of hypertrophic marker genes such as collagen x, matrix metalloproteinase 13 and bone sialoprotein. |
2004-04-22 |
2023-08-12 |
mouse |
| Rethinasamy Prabhakar, Natalia Petrashevskaya, Arnold Schwartz, Bruce Aronow, Greg P Boivin, Jeffery D Molkentin, David F Wieczore. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Molecular and cellular biochemistry. vol 251. issue 1-2. 2004-04-16. PMID:14575301. |
a dna hybridization microarray analysis of the transgenic vs. control ventricular rnas shows that 50 transcripts are differentially expressed by more than 100% during the onset of the hypertrophic process, many of which are associated with the extracellular matrix. |
2004-04-16 |
2023-08-12 |
mouse |
| Mohammed Shakil Ahmed, Erik Øie, Leif Erik Vinge, Arne Yndestad, Geir Øystein Andersen G, Yvonne Andersson, Toril Attramadal, Håvard Attramada. Induction of myocardial biglycan in heart failure in rats--an extracellular matrix component targeted by AT(1) receptor antagonism. Cardiovascular research. vol 60. issue 3. 2004-04-16. PMID:14659801. |
cardiac remodelling associated with congestive heart failure typically involves dilatation of the ventricular cavities, cardiomyocyte hypertrophy and alterations of extracellular matrix. |
2004-04-16 |
2023-08-12 |
rat |
| Kwong Man Lee, Alfred Sze Lok Cheng, Wing Hoi Cheung, Pauline Po Yee Lui, Vincent Ooi, Kwok Pui Fung, Ping Chung Leung, Kwok Sui Leun. Bioengineering and characterization of physeal transplant with physeal reconstruction potential. Tissue engineering. vol 9. issue 4. 2004-04-07. PMID:13678448. |
they synthesized and deposited cartilaginous matrix and differentiated into hypertrophic chondrocytes marked by increases in cell size and alkaline phosphatase activity. |
2004-04-07 |
2023-08-12 |
Not clear |
| Dengshun Miao, Hanlong Liu, Paul Plut, Meijuan Niu, Rujuan Huo, David Goltzman, Janet E Henderso. Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Experimental cell research. vol 294. issue 1. 2004-03-30. PMID:14980515. |
the growth plates of tibiae and vertebrae exhibited increased numbers of proliferating and hypertrophic chondrocytes with no apparent alteration in matrix mineralisation. |
2004-03-30 |
2023-08-12 |
mouse |
| Shunichi Shibata, Naoto Suda, Kenji Fukada, Kimie Ohyama, Yasuo Yamashita, Vicki E Hammon. Mandibular coronoid process in parathyroid hormone-related protein-deficient mice shows ectopic cartilage formation accompanied by abnormal bone modeling. Anatomy and embryology. vol 207. issue 1. 2004-03-24. PMID:12768421. |
in situ hybridization of matrix proteins showed that this coronoid cartilage had characteristics of the lower hypertrophic cell zone usually present at the site of endochondral bone formation and/or "chondroid bone" occasionally found in distraction osteogenesis. |
2004-03-24 |
2023-08-12 |
mouse |
| Sheldon Chen, Belinda Jim, Fuad N Ziyade. Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Seminars in nephrology. vol 23. issue 6. 2004-03-24. PMID:14631561. |
prominent among these is transforming growth factor beta (tgf-beta) because it promotes renal cell hypertrophy and stimulates extracellular matrix accumulation, the 2 hallmarks of diabetic renal disease. |
2004-03-24 |
2023-08-12 |
human |
| Sheldon Chen, Belinda Jim, Fuad N Ziyade. Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Seminars in nephrology. vol 23. issue 6. 2004-03-24. PMID:14631561. |
in tissue culture studies, cellular hypertrophy and matrix production are stimulated by high glucose concentrations in the culture media. |
2004-03-24 |
2023-08-12 |
human |
| M I Pavlov, J-M Sautier, M Oboeuf, A Asselin, A Berda. Chondrogenic differentiation during midfacial development in the mouse: in vivo and in vitro studies. Biology of the cell. vol 95. issue 2. 2004-03-17. PMID:12799063. |
the purpose of this second part was to assess if chondrocytes could further differentiate in vitro until the hypertrophic phase and matrix mineralization. |
2004-03-17 |
2023-08-12 |
mouse |
| Yoshiko Sawae, Takako Sahara, Takahisa Sasak. Osteoclast differentiation at growth plate cartilage-trabecular bone junction in newborn rat femur. Journal of electron microscopy. vol 52. issue 6. 2004-03-12. PMID:14756237. |
in the growth plate cartilage, thin mineralized areas were detected solely in the longitudinal septal cartilage matrix in the hypertrophic zone, but the transverse septal cartilage matrix between adjacent chondrocytic lacunae within a row of chondrocytes remained unmineralized. |
2004-03-12 |
2023-08-12 |
rat |
| Michelle R Campbell, Catherine J Gress, Elizabeth H Appleman, Olena Jacenk. Chicken collagen X regulatory sequences restrict transgene expression to hypertrophic cartilage in mice. The American journal of pathology. vol 164. issue 2. 2004-03-11. PMID:14742255. |
nature 1993, 365:56-61; jacenko o, chan d, franklin a, ito s, underhill cb, bateman jf, campbell mr: a dominant interference collagen x mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice. |
2004-03-11 |
2023-08-12 |
mouse |
| Haruhito Azuma, Teruo Inamoto, Takeshi Sakamoto, Satoshi Kiyama, Takanobu Ubai, Yuko Shinohara, Kentaro Maemura, Motomu Tsuji, Naoki Segawa, Hiroshi Masuda, Kiyoshi Takahara, Yoji Katsuoka, Masahito Watanab. Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer research. vol 63. issue 23. 2004-02-27. PMID:14678958. |
we investigated expression of gamma-aminobutyric acid (gaba), glutamate decarboxylase, and matrix metalloproteinase (mmp) in the prostates of patients with cancer or benign prostatic hypertrophy by immunohistochemical study. |
2004-02-27 |
2023-08-12 |
human |
| Karima Et-Taouil, Michel Safar, Gérard E Plant. Mechanisms and consequences of large artery rigidity. Canadian journal of physiology and pharmacology. vol 81. issue 3. 2004-02-23. PMID:12733819. |
the structural characteristics responsible for large artery rigidity include smooth muscle cell hypertrophy, matrix collagen deposition, and recently described, dysfunction in proteoglycan metabolism. |
2004-02-23 |
2023-08-12 |
Not clear |
| Laura Masuelli, Roberto Bei, Pamela Sacchetti, Ilaria Scappaticci, Paola Francalanci, Loredana Albonici, Anna Coletti, Camilla Palumbo, Marilena Minieri, Roberta Fiaccavento, Felicia Carotenuto, Cristina Fantini, Luciana Carosella, Andrea Modesti, Paolo Di Nard. Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts. Cardiovascular research. vol 60. issue 2. 2004-02-13. PMID:14613867. |
to evaluate whether cardiomyocyte membrane structure and cell/extracellular matrix adhesion alterations perturb the cadherin/catenin complex in the hypertrophic cardiomyopathy (hcm). |
2004-02-13 |
2023-08-12 |
Not clear |
| Shinya Mizuno, Toshikazu Nakamur. Suppressions of chronic glomerular injuries and TGF-beta 1 production by HGF in attenuation of murine diabetic nephropathy. American journal of physiology. Renal physiology. vol 286. issue 1. 2004-02-10. PMID:14519594. |
growing evidence shows that transforming growth factor-beta 1 (tgf-beta 1) plays a key role in this process, especially in eliciting hypertrophy and matrix overaccumulation. |
2004-02-10 |
2023-08-12 |
mouse |
| Matthias Chiquet, Ana Sarasa Renedo, François Huber, Martin Flüc. How do fibroblasts translate mechanical signals into changes in extracellular matrix production? Matrix biology : journal of the International Society for Matrix Biology. vol 22. issue 1. 2004-02-02. PMID:12714044. |
our recent experiments in vivo indicate that externally applied mechanical load can lead to the rapid and sequential induction of distinct extracellular matrix (ecm) components in fibroblasts, rather than to a generalized hypertrophic response. |
2004-02-02 |
2023-08-12 |
Not clear |
| A Yamasaki, M Itabashi, Y Sakai, H Ito, Y Ishiwari, H Nagatsuka, N Naga. Expression of type I, type II, and type X collagen genes during altered endochondral ossification in the femoral epiphysis of osteosclerotic (oc/oc) mice. Calcified tissue international. vol 68. issue 1. 2004-01-29. PMID:12037624. |
the disorder is morphologically characterized by an abnormal extension of hypertrophic cartilage at 10 days after birth, which is later (21 days after birth) incorporated into the metaphyseal woven bone without breakdown of the cartilage matrix following vascular invasion of chondrocyte lacunae. |
2004-01-29 |
2023-08-12 |
mouse |
| E Tchetina, F Mwale, A R Pool. Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 18. issue 5. 2004-01-16. PMID:12733723. |
specifically, we studied the expression of genes encoding col2a1 and col10a1, the latter a marker of cellular hypertrophy, the matrix metalloproteinases (mmp), mmp-13 and mmp-9, as well as the transcriptional factors, sox9 and cbfa1, the growth factors basic fibroblast growth factor (bfgf), parathyroid hormone-related peptide (pthrp), transforming growth factor (tgf)beta1, and beta2, indian hedgehog (ihh), and the matrix protein osteocalcin. |
2004-01-16 |
2023-08-12 |
mouse |