| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandro Goruppi, Joseph V Bonventre, John M Kyriaki. Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. The EMBO journal. vol 21. issue 20. 2002-11-26. PMID:12374743. |
diabetic nephropathy begins with mesangial cell hypertrophy and hyperplasia, combined with excess matrix deposition. |
2002-11-26 |
2023-08-12 |
Not clear |
| Gareth R John, Sai Latha Shankar, Bridget Shafit-Zagardo, Aldo Massimi, Sunhee C Lee, Cedric S Raine, Celia F Brosna. Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nature medicine. vol 8. issue 10. 2002-11-22. PMID:12357247. |
within and around active ms plaques lacking remyelination, jagged1 was expressed at high levels by hypertrophic astrocytes, whereas notch1 and hes5 localized to cells with an immature oligodendrocyte phenotype, and tgf-beta 1 was associated with perivascular extracellular matrix in the same areas. |
2002-11-22 |
2023-08-12 |
human |
| Motohide Isono, Sheldon Chen, Soon Won Hong, M Carmen Iglesias-de la Cruz, Fuad N Ziyade. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochemical and biophysical research communications. vol 296. issue 5. 2002-10-24. PMID:12207925. |
activation of the transforming growth factor-beta (tgf-beta) system has been implicated in the pathological changes of diabetic nephropathy such as renal hypertrophy and accumulation of extracellular matrix. |
2002-10-24 |
2023-08-12 |
mouse |
| C William Wu, Elena V Tchetina, Fackson Mwale, Karen Hasty, Isabelle Pidoux, Agnes Reiner, Jeffrey Chen, Harold E Van Wart, A Robin Pool. Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 4. 2002-10-03. PMID:11918221. |
using bovine fetal chondrocytes isolated from physeal cartilages and separated into a distinct prehypertrophic subpopulation, we show that in serum-free culture they elaborate an extracellular matrix and differentiate into hypertrophic chondrocytes. |
2002-10-03 |
2023-08-12 |
cattle |
| Gary M Williams, Michael J Iatropoulo. Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicologic pathology. vol 30. issue 1. 2002-09-26. PMID:11890475. |
they can also be graded or continuous (nonbinary), as with enzyme induction, organelle hypertrophy, and extracellular matrix elaboration, occurring either at the intra- or extra (supra) cellular level. |
2002-09-26 |
2023-08-12 |
Not clear |
| Takashi Miyazawa, Yoshihiro Ogawa, Hideki Chusho, Akihiro Yasoda, Naohisa Tamura, Yasato Komatsu, Alexander Pfeifer, Franz Hofmann, Kazuwa Naka. Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193576. |
using cultured fetal mouse tibias, an in vitro model system of endochondral ossification, we also demonstrated that cnp cannot increase the longitudinal bone growth, and chondrocytic proliferation and hypertrophy, and cartilage matrix synthesis in prkg2(-/-) mice. |
2002-09-23 |
2023-08-12 |
mouse |
| Yuri Akiyama-Uchida, Naoto Ashizawa, Akira Ohtsuru, Shinji Seto, Tomoo Tsukazaki, Hiroshi Kikuchi, Shunichi Yamashita, Katsusuke Yan. Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts. Hypertension (Dallas, Tex. : 1979). vol 40. issue 2. 2002-08-16. PMID:12154105. |
cardiac fibrosis results from proliferation of interstitial fibroblasts and concomitant increased biosynthesis of extracellular matrix (ecm) components and is often complicated by cardiac hypertrophy. |
2002-08-16 |
2023-08-12 |
rat |
| Amanda Miller, Vibhas Mujumdar, Lena Palmer, John D Bower, Suresh C Tyag. Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats. American journal of hypertension. vol 15. issue 2 Pt 1. 2002-08-14. PMID:11863251. |
the hypothesis is that hcy decreases ee cell density by activating matrix metalloproteinase (mmp) and by inducing left ventricular hypertrophy (lvh) in homocysteinemic hypertensive rats (hhr). |
2002-08-14 |
2023-08-12 |
rat |
| Fackson Mwale, Elena Tchetina, C William Wu, A Robin Pool. The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 2. 2002-08-02. PMID:11811558. |
the assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens ii and ix and proteoglycan. |
2002-08-02 |
2023-08-12 |
cattle |
| Fackson Mwale, Elena Tchetina, C William Wu, A Robin Pool. The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 2. 2002-08-02. PMID:11811558. |
at hypertrophy, when mineral content was maximal, type ii collagen was reduced maximally in content coincident with a peak of cleavage of this molecule by collagenase when matrix metalloproteinase 13 (mmp-13) expression was maximal. |
2002-08-02 |
2023-08-12 |
cattle |
| Fackson Mwale, Elena Tchetina, C William Wu, A Robin Pool. The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 17. issue 2. 2002-08-02. PMID:11811558. |
taken together with earlier studies, these findings show that matrix remodeling after assembly is linked closely to initial changes in ca2+ and pi to subsequent cellular hypertrophy and mineralization. |
2002-08-02 |
2023-08-12 |
cattle |
| W Petersen, M Rafi. Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice. Archives of orthopaedic and trauma surgery. vol 121. issue 7. 2002-07-15. PMID:11510908. |
within the zone of hypertrophic chondrocytes, immunolabelling for ptn was positive in the pericellular matrix of hypertrophic chondrocytes and within the opened lacunae of the apoptotic hypertrophic chondrocytes. |
2002-07-15 |
2023-08-12 |
mouse |
| Olena Jacenko, Douglas W Roberts, Michelle R Campbell, Patricia M McManus, Catherine J Gress, Zhuliang Ta. Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. The American journal of pathology. vol 160. issue 6. 2002-07-15. PMID:12057907. |
during this process of endochondral ossification, hypertrophic cartilage expresses a unique matrix molecule, collagen x. |
2002-07-15 |
2023-08-12 |
mouse |
| Giordano Stabellini, Francesco Carinci, Pier Luigi Bedani, Carla Calastrini, Monica De Mattei, Luca Scapoli, Angelo Caruso, Mario Calvitti, Paola Locc. Cyclosporin A and transforming growth factor beta modify the pattern of extracellular glycosaminoglycans without causing cytoskeletal changes in human gingival fibroblasts. Transplantation. vol 73. issue 10. 2002-06-26. PMID:12042659. |
our data suggest that the biochemical changes in the extracellular matrix are caused more by cytokine, and that cyclosporin a does not induce any morphological changes in fibroblast cultures derived from hypertrophic and normal gingiva. |
2002-06-26 |
2023-08-12 |
human |
| Jacek Rozg. Hepatocyte proliferation in health and in liver failure. Medical science monitor : international medical journal of experimental and clinical research. vol 8. issue 2. 2002-06-24. PMID:11859294. |
in normal animals and humans, it is a tightly regulated process of both hypertrophy and hyperplasia involving different liver cell populations and a finely tuned interplay between growth factors, cytokines, extracellular matrix components and other regulators. |
2002-06-24 |
2023-08-12 |
rat |
| Filippo Renò, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology. vol 138. issue 4. 2002-06-04. PMID:11939809. |
release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. |
2002-06-04 |
2023-08-12 |
Not clear |
| Filippo Renò, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology. vol 138. issue 4. 2002-06-04. PMID:11939809. |
to investigate induction of matrix metalloproteinases (mmps) during mechanical compression of hypertrophic scars. |
2002-06-04 |
2023-08-12 |
Not clear |
| Filippo Renò, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology. vol 138. issue 4. 2002-06-04. PMID:11939809. |
mechanical pressure blocks hypertrophy inducted on extracellular matrix in scars by a mechanism that involves mmp-2 (gelatinase a) and mmp-9 (gelatinase b). |
2002-06-04 |
2023-08-12 |
Not clear |
| M Dangelo, D P Sarment, P C Billings, M Pacific. Activation of transforming growth factor beta in chondrocytes undergoing endochondral ossification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 12. 2002-06-03. PMID:11760850. |
zymography of gelatin gels revealed that matrix metalloprotease 2 (mmp-2) and mmp-9 were expressed by each population and that mmp-13 characterized hypertrophic chondrocytes and to a lesser extent proliferating chondrocytes in late cultures. |
2002-06-03 |
2023-08-12 |
chicken |
| M V Nurminskaya, B Recheis, J Nimpf, Cordula Magee, T F Linsenmaye. Transglutaminase factor XIIIA in the cartilage of developing avian long bones. Developmental dynamics : an official publication of the American Association of Anatomists. vol 223. issue 1. 2002-05-24. PMID:11803567. |
by immunohistochemical analysis, the protein is detected in the zone of maturation, where it is mostly intracellular, and in the hypertrophic zone, where it is present both intracellularly and in the extracellular matrix. |
2002-05-24 |
2023-08-12 |
chicken |