| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Grimm, S R Holmer, G A Riegger, E P Krome. Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol-induced heart failure in the rat. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology vol 8 issue 6 2000 10615017 |
compared to ctrl, iso induced left ventricular hypertrophy (lvh), fibrosis, and overexpression of extracellular matrix proteins. |
2000-01-13 |
2023-01-24 |
rat |
| A Poliard, M C Ronzi\\xc3\\xa8re, A M Freyria, D Lamblin, D Herbage, O Kellerman. Lineage-dependent collagen expression and assembly during osteogenic or chondrogenic differentiation of a mesoblastic cell line. Experimental cell research vol 253 issue 2 2000 10585261 |
chondrogenic c1 cells first elaborate a type ii collagen network and then acquire hypertrophic chondrocyte properties while assembling a type x collagen matrix as in the growth plate. |
2000-01-11 |
2023-01-24 |
Not clear |
| K Yagami, J Y Suh, M Enomoto-Iwamoto, E Koyama, W R Abrams, I M Shapiro, M Pacifici, M Iwamot. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. The Journal of cell biology vol 147 issue 5 1999 10579728 |
matrix gla protein (mgp), a gamma-carboxyglutamic acid (gla)-rich, vitamin k-dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development. |
1999-12-30 |
2023-01-24 |
chicken |
| K Fukada, S Shibata, S Suzuki, K Ohya, T Kurod. In situ hybridisation study of type I, II, X collagens and aggrecan mRNas in the developing condylar cartilage of fetal mouse mandible. Journal of anatomy vol 195 ( Pt 3) issue 1999 10580848 |
the primarily formed chondrocytes in the cartilage matrix had already shown the appearance of hypertrophy and expressed types i, ii and x collagens and aggrecan mrnas simultaneously. |
1999-12-14 |
2023-01-24 |
mouse |
| A Cerr. Lectin histochemistry of the hyaline layer around the larvae of Patiriella species (Asteroidea) with different developmental modes. Journal of morphology vol 242 issue 2 1999 10521870 |
lectin labeling shows that hypertrophy of the hyaline layer of p. exigua, in particular the outer coarse meshwork, involves elaboration of the carbohydrate composition of the matrix. |
1999-12-08 |
2023-01-24 |
Not clear |
| A M Costa, S Peyrol, L C P\\xc3\\xb4rto, J P Comparin, J L Foyatier, A Desmouli\\xc3\\xa8r. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. The American journal of pathology vol 155 issue 5 1999 10550323 |
our results show that, in hypertrophic scars, pressure therapy restores in part the extracellular matrix organization observed in normal scar and induces the disappearance of alpha-smooth muscle actin-expressing myofibroblasts, probably by apoptosis. |
1999-11-30 |
2023-01-24 |
Not clear |
| M W Orth, J I Fenton, K A Chlebek-Brow. Biochemical characterization of cartilage degradation in embryonic chick tibial explant cultures. Poultry science vol 78 issue 11 1999 10560834 |
these results suggest that chondrocytes in the tibiae undergo hypertrophy, degrade the extracellular matrix, and die. |
1999-11-26 |
2023-01-24 |
chicken |
| E B Hunziker, E Kapfinger, C Saage. Hypertrophy of growth plate chondrocytes in vivo is accompanied by modulations in the activity state and surface area of their cytoplasmic organelles. Histochemistry and cell biology vol 112 issue 2 1999 10460464 |
the rate of longitudinal bone growth is regulated primarily by modulations in the activity of epiphyseal plate hypertrophic chondrocytes, these being manifested as changes in cell and matrix volume. |
1999-11-22 |
2023-01-24 |
rat |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs vol 165 issue 2 1999 10516421 |
quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. |
1999-11-16 |
2023-01-24 |
human |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs vol 165 issue 2 1999 10516421 |
a computer image analysis of immunostained extracellular matrix (ecm) proteins (collagen types i, ii, iii and v, fibronectin and tenascin) in hypertrophic layers in the mandibular condyle and temporal bone of human fetuses, which ranged in gestational age from 12 to 32 weeks, was performed. |
1999-11-16 |
2023-01-24 |
human |
| C Farquharson, D Lester, E Seawright, D Jefferies, B Housto. Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy. Bone vol 25 issue 4 1999 10511106 |
a partial failure of chondrocyte hypertrophy was observed, although collagen type x immunoreactivity was noted within the interstitial matrix. |
1999-11-02 |
2023-01-24 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 14 issue 8 1999 10457260 |
chick embryo hypertrophic chondrocytes maintained in suspension synthesized type ii and type x collagen and organized their extracellular matrix, forming a tissue highly reminiscent of true cartilage, which eventually mineralized. |
1999-09-30 |
2023-01-24 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 14 issue 8 1999 10457260 |
hypertrophic chondrocytes cultured in adherent conditions in the presence of retinoic acid underwent further differentiation to osteoblast-like cells (i.e., they resumed cell proliferation, switched to type i collagen synthesis, and produced a mineralizing bone-like matrix). |
1999-09-30 |
2023-01-24 |
chicken |
| B Zerega, S Cermelli, P Bianco, R Cancedda, F D Cancedd. Parathyroid hormone [PTH(1-34)] and parathyroid hormone-related protein [PTHrP(1-34)] promote reversion of hypertrophic chondrocytes to a prehypertrophic proliferating phenotype and prevent terminal differentiation of osteoblast-like cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 14 issue 8 1999 10457260 |
these data indicate that pth/pthrp inhibit both the mineralization of a cartilage-like matrix and apoptosis (mimicked in the suspension culture) and the production of a mineralizing bone-like matrix, characterizing further differentiation of hypertrophic chondrocytes to osteoblasts like cells (mimicked in adhesion culture). |
1999-09-30 |
2023-01-24 |
chicken |
| M Lajemi, S Gautier, A Beneto. [Rigidity of large arteries and cardiovascular risk. epidemiological aspects and genetic determinants]. Pathologie-biologie vol 47 issue 6 1999 10472072 |
aging, environmental and genetic factors are responsible for structural and functional changes of the arterial wall media (hypertrophy, extracellular matrix accumulation, calcium deposits) and of the vascular endothelium (decrease in the release of vasodilators and increased synthesis of vasoconstrictors), all that leading to a diminution of elasticity and increased stiffness. |
1999-09-23 |
2023-01-24 |
human |
| N Nishijo, S Takamine, F Sugiyama, K Kimoto, K Taniguchi, H Horiguchi, T Ogata, K Murakami, A Fukamizu, K Yagam. Vascular remodeling in hypertensive transgenic mice. Experimental animals vol 48 issue 3 1999 10480026 |
they progressively developed remarkable vascular hypertrophy composed of dedifferentiation of vascular smooth muscle cells (vsmcs) and extracellular matrix accumulation in the thoracic aorta, and vsmc hyperplasia was predominant in the abdominal aorta. |
1999-09-23 |
2023-01-24 |
mouse |
| M Polo, P D Smith, Y J Kim, X Wang, F Ko, M C Robso. Effect of TGF-beta2 on proliferative scar fibroblast cell kinetics. Annals of plastic surgery vol 43 issue 2 1999 10454327 |
keloids, hypertrophic scars, and burn hypertrophic scars are all forms of proliferative scarring characterized by overabundant matrix formation. |
1999-09-20 |
2023-01-24 |
rat |
| A N Neely, C E Clendening, J Gardner, D G Greenhalgh, G D Warde. Gelatinase activity in keloids and hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol 7 issue 3 1999 10417752 |
ten hypertrophic scar samples, 9 keloid samples, and 10 donor skin samples were frozen, pulverized, homogenized, clarified by centrifugation, and analyzed for matrix metalloproteinases by quantitative zymography. |
1999-09-10 |
2023-01-24 |
Not clear |
| A N Neely, C E Clendening, J Gardner, D G Greenhalgh, G D Warde. Gelatinase activity in keloids and hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol 7 issue 3 1999 10417752 |
however, matrix metalloproteinase-2 activity was significantly elevated in keloids and hypertrophic scars vs. donor samples: 2.6 and 3.9-fold increases for latent matrix metalloproteinase-2, 7.8 and 6.9-fold increases for active matrix metalloproteinase-2, respectively. |
1999-09-10 |
2023-01-24 |
Not clear |
| A N Neely, C E Clendening, J Gardner, D G Greenhalgh, G D Warde. Gelatinase activity in keloids and hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol 7 issue 3 1999 10417752 |
we conclude that little matrix metalloproteinase-9 activity (the gelatinase involved in early tissue repair) is present in keloids and hypertrophic scars, while matrix metalloproteinase-2 activity (the gelatinase involved in prolonged tissue remodeling) is present in donor skin and is significantly increased in hypertrophic scars and keloids. |
1999-09-10 |
2023-01-24 |
Not clear |