| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Suda, S Shibata, K Yamazaki, T Kuroda, P V Senior, F Beck, V E Hammon. Parathyroid hormone-related protein regulates proliferation of condylar hypertrophic chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 14. issue 11. 2000-03-07. PMID:10571683. |
immunolocalization of type x collagen, the extracellular matrix specifically expressed by hypertrophic chondrocytes, was greatly reduced in the condylar cartilage of homozygous pthrp-knockout mice compared with wild-type mice. |
2000-03-07 |
2023-08-12 |
mouse |
| J Higaki, M Aoki, R Morishita, I Kida, Y Taniyama, N Tomita, K Yamamoto, A Moriguchi, Y Kaneda, T Ogihar. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669640. |
angiotensin ii (ang ii) stimulates cardiac hypertrophy as well as the production of extracellular matrix. |
2000-03-03 |
2023-08-12 |
human |
| P J Duke, D Montufar-Soli. Exposure to altered gravity affects all stages of endochondral cartilage differentiation. Advances in space research : the official journal of the Committee on Space Research (COSPAR). vol 24. issue 6. 2000-02-29. PMID:11542628. |
once cartilage has developed, in rats, further differentiation (hypertrophy, matrix production) was also affected by spaceflight and hind limb suspension. |
2000-02-29 |
2023-08-12 |
rat |
| P Teofoli, S Barduagni, M Ribuffo, A Campanella, O De Pita', P Pudd. Expression of Bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars. Journal of dermatological science. vol 22. issue 1. 2000-02-25. PMID:10651227. |
keloids and hypertrophic scars represent a model of altered wound healing characterized by overproduction of extracellular matrix and dermal fibroblasts with high mitotic rate. |
2000-02-25 |
2023-08-12 |
Not clear |
| J Johnson, T Shinomura, H Eberspaecher, G Pinero, B Decrombrugghe, M Höö. Expression and localization of PG-Lb/epiphycan during mouse development. Developmental dynamics : an official publication of the American Association of Anatomists. vol 216. issue 4-5. 2000-02-22. PMID:10633869. |
our results show that pg-lb/epiphycan gene expression is an intermediate marker for chondrogenesis, and that the protein can be localized to the extracellular matrix surrounding resting, proliferating, and hypertrophic chondrocytes by immunofluorescence histochemistry. |
2000-02-22 |
2023-08-12 |
mouse |
| K Sebeková, J Dämmrich, Z Krivosíková, A Heidlan. The effect of oral protease administration in the rat remnant kidney model. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 199. issue 3. 2000-02-14. PMID:10639701. |
the protein/dna ratio in isolated glomeruli and tubules, as an estimate of glomerular matrix accumulation and hypertrophy of tubules, was enhanced in 5/6 nx groups and a tendency towards lower values was observed after e treatment. |
2000-02-14 |
2023-08-12 |
rat |
| J Alvarez, M Balbín, F Santos, M Fernández, S Ferrando, J M Lópe. Different bone growth rates are associated with changes in the expression pattern of types II and X collagens and collagenase 3 in proximal growth plates of the rat tibia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 1. 2000-02-11. PMID:10646117. |
an intimate relationship between morphological and kinetic changes associated with chondrocyte hypertrophy and changes in the expression pattern of matrix collagens and collagenase 3 was observed. |
2000-02-11 |
2023-08-12 |
rat |
| F De Luca, J A Uyeda, V Mericq, E E Mancilla, J A Yanovski, K M Barnes, M H Zile, J Baro. Retinoic acid is a potent regulator of growth plate chondrogenesis. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614657. |
in this system, ra inhibited longitudinal bone growth by three mechanisms: 1) decreased chondrocyte proliferation, (assessed by 3h-thymidine incorporation), particularly in the proliferative zone of the growth plate; 2) decreased matrix synthesis (assessed by 35so4 incorporation into glycosaminoglycans); and 3) decreased cell hypertrophy (determined histologically). |
2000-01-13 |
2023-08-12 |
rat |
| F De Luca, J A Uyeda, V Mericq, E E Mancilla, J A Yanovski, K M Barnes, M H Zile, J Baro. Retinoic acid is a potent regulator of growth plate chondrogenesis. Endocrinology. vol 141. issue 1. 2000-01-13. PMID:10614657. |
we conclude that ra, acting through rars, negatively regulates longitudinal bone growth by inhibiting growth plate chondrocyte proliferation, chondrocyte hypertrophy, and matrix synthesis. |
2000-01-13 |
2023-08-12 |
rat |
| D Grimm, S R Holmer, G A Riegger, E P Krome. Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol-induced heart failure in the rat. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 6. 2000-01-13. PMID:10615017. |
compared to ctrl, iso induced left ventricular hypertrophy (lvh), fibrosis, and overexpression of extracellular matrix proteins. |
2000-01-13 |
2023-08-12 |
rat |
| A Poliard, M C Ronzière, A M Freyria, D Lamblin, D Herbage, O Kellerman. Lineage-dependent collagen expression and assembly during osteogenic or chondrogenic differentiation of a mesoblastic cell line. Experimental cell research. vol 253. issue 2. 2000-01-11. PMID:10585261. |
chondrogenic c1 cells first elaborate a type ii collagen network and then acquire hypertrophic chondrocyte properties while assembling a type x collagen matrix as in the growth plate. |
2000-01-11 |
2023-08-12 |
Not clear |
| K Yagami, J Y Suh, M Enomoto-Iwamoto, E Koyama, W R Abrams, I M Shapiro, M Pacifici, M Iwamot. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. The Journal of cell biology. vol 147. issue 5. 1999-12-30. PMID:10579728. |
matrix gla protein (mgp), a gamma-carboxyglutamic acid (gla)-rich, vitamin k-dependent and apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during development. |
1999-12-30 |
2023-08-12 |
chicken |
| K Fukada, S Shibata, S Suzuki, K Ohya, T Kurod. In situ hybridisation study of type I, II, X collagens and aggrecan mRNas in the developing condylar cartilage of fetal mouse mandible. Journal of anatomy. vol 195 ( Pt 3). 1999-12-14. PMID:10580848. |
the primarily formed chondrocytes in the cartilage matrix had already shown the appearance of hypertrophy and expressed types i, ii and x collagens and aggrecan mrnas simultaneously. |
1999-12-14 |
2023-08-12 |
mouse |
| A Cerr. Lectin histochemistry of the hyaline layer around the larvae of Patiriella species (Asteroidea) with different developmental modes. Journal of morphology. vol 242. issue 2. 1999-12-08. PMID:10521870. |
lectin labeling shows that hypertrophy of the hyaline layer of p. exigua, in particular the outer coarse meshwork, involves elaboration of the carbohydrate composition of the matrix. |
1999-12-08 |
2023-08-12 |
Not clear |
| A M Costa, S Peyrol, L C Pôrto, J P Comparin, J L Foyatier, A Desmoulièr. Mechanical forces induce scar remodeling. Study in non-pressure-treated versus pressure-treated hypertrophic scars. The American journal of pathology. vol 155. issue 5. 1999-11-30. PMID:10550323. |
our results show that, in hypertrophic scars, pressure therapy restores in part the extracellular matrix organization observed in normal scar and induces the disappearance of alpha-smooth muscle actin-expressing myofibroblasts, probably by apoptosis. |
1999-11-30 |
2023-08-12 |
Not clear |
| M W Orth, J I Fenton, K A Chlebek-Brow. Biochemical characterization of cartilage degradation in embryonic chick tibial explant cultures. Poultry science. vol 78. issue 11. 1999-11-26. PMID:10560834. |
these results suggest that chondrocytes in the tibiae undergo hypertrophy, degrade the extracellular matrix, and die. |
1999-11-26 |
2023-08-12 |
chicken |
| E B Hunziker, E Kapfinger, C Saage. Hypertrophy of growth plate chondrocytes in vivo is accompanied by modulations in the activity state and surface area of their cytoplasmic organelles. Histochemistry and cell biology. vol 112. issue 2. 1999-11-22. PMID:10460464. |
the rate of longitudinal bone growth is regulated primarily by modulations in the activity of epiphyseal plate hypertrophic chondrocytes, these being manifested as changes in cell and matrix volume. |
1999-11-22 |
2023-08-12 |
rat |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs. vol 165. issue 2. 1999-11-16. PMID:10516421. |
quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. |
1999-11-16 |
2023-08-12 |
human |
| I Sato, M Sunohara, T Sat. Quantitative analysis of extracellular matrix proteins in hypertrophic layers of the mandibular condyle and temporal bone during human fetal development. Cells, tissues, organs. vol 165. issue 2. 1999-11-16. PMID:10516421. |
a computer image analysis of immunostained extracellular matrix (ecm) proteins (collagen types i, ii, iii and v, fibronectin and tenascin) in hypertrophic layers in the mandibular condyle and temporal bone of human fetuses, which ranged in gestational age from 12 to 32 weeks, was performed. |
1999-11-16 |
2023-08-12 |
human |
| C Farquharson, D Lester, E Seawright, D Jefferies, B Housto. Microtubules are potential regulators of growth-plate chondrocyte differentiation and hypertrophy. Bone. vol 25. issue 4. 1999-11-02. PMID:10511106. |
a partial failure of chondrocyte hypertrophy was observed, although collagen type x immunoreactivity was noted within the interstitial matrix. |
1999-11-02 |
2023-08-12 |
chicken |