| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junmin Lee, Oju Jeon, Ming Kong, Amr A Abdeen, Jung-Youn Shin, Ha Neul Lee, Yu Bin Lee, Wujin Sun, Praveen Bandaru, Daniel S Alt, KangJu Lee, Han-Jun Kim, Sang Jin Lee, Somali Chaterji, Su Ryon Shin, Eben Alsberg, Ali Khademhossein. Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering. Science advances vol 6 issue 21 2021 32494742 |
here, by using engineered biomaterials and a high-throughput system for screening of combinatorial cues in cartilage microenvironments, we demonstrate that biomaterial cross-linking density that regulates matrix degradation and stiffness-together with defined presentation of growth factors, mechanical stimulation, and arginine-glycine-aspartic acid (rgd) peptides-can guide human mesenchymal stem cell (hmsc) differentiation into articular or hypertrophic cartilage phenotypes. |
2021-06-30 |
2023-01-26 |
human |
| Xiaomin Kang, Zhuang Qian, Jiali Liu, Dongxu Feng, Huixia Li, Zhuanmin Zhang, Xinxin Jin, Zhengmin Ma, Mao Xu, Fang Li, Ying Zhang, Xin Gao, Hongzhi Sun, Shufang W. Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis Through NPY2R. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 35 issue 7 2021 32101625 |
intra-articular administration of npy significantly promoted chondrocyte hypertrophy and cartilage matrix degradation, with a higher oarsi score than that of control mice, whereas inhibition of npy2r but not npy1r with its specific antagonist remarkably ameliorated npy-mediated effects. |
2021-06-29 |
2023-01-26 |
mouse |
| Cheong Hoon Seo, Hui Song Cui, June-Bum Ki. Calpastatin-Mediated Inhibition of Calpain Ameliorates Skin Scar Formation after Burn Injury. International journal of molecular sciences vol 22 issue 11 2021 34071277 |
hypertrophic scars, the most common complication of burn injuries, are characterized by excessive deposition of fibroblast-derived extracellular matrix proteins. |
2021-06-28 |
2023-01-26 |
Not clear |
| Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zhen. Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as The Chinese journal of physiology vol 64 issue 3 2021 34169921 |
then, their effects on rat glomerular mesangial cells (rgmcs, hbzy-1) proliferation, hypertrophy, extracellular matrix (ecm) proliferation, expression of fibronectin, transforming growth factor-beta (tgf-\xce\xb2), and connective tissue growth factor (ctgf) induced by high glucose were studied in vitro model of diabetic glomerulosclerosis. |
2021-06-28 |
2023-01-26 |
rat |
| Mauricio N Ferrao Blanco, Yvonne M Bastiaansen-Jenniskens, Mark G Chambers, Andrew A Pitsillides, Roberto Narcisi, Gerjo J V M van Osc. Effect of Inflammatory Signaling on Human Articular Chondrocyte Hypertrophy: Potential Involvement of Tissue Repair Macrophages. Cartilage vol issue 2021 34165367 |
in osteoarthritis, chondrocytes tend to acquire a hypertrophic phenotype, which contributes to the modification of the extracellular matrix, resulting in permanent cartilage changes. |
2021-06-24 |
2023-01-26 |
mouse |
| La\\xc3\\xa9rcia K D Paiva Ferreira, Larissa A M Paiva Ferreira, Grasiela C Bezerra Barros, Talissa Mozzini Monteiro, Luiz A de Ara\\xc3\\xbajo Silva, Ramon de A Pereira, Pedro T R Figueiredo, Adriano Francisco Alves, Lu\\xc3\\xads Cezar Rodrigues, Marcia Regina Piuveza. MHTP, a synthetic alkaloid, attenuates combined allergic rhinitis and asthma syndrome through downregulation of the p38/ERK1/2 MAPK signaling pathway in mice. International immunopharmacology vol 96 issue 2021 33857802 |
the mhtp treatment also reduced the pulmonary hyperactivity by decreasing the smooth muscle layer hypertrophy and the collagen fiber deposition in the extracellular matrix. |
2021-06-22 |
2023-01-26 |
mouse |
| Benjamin D Pope, Curtis R Warren, Madeleine O Dahl, Christina V Pizza, Douglas E Henze, Nina R Sinatra, Grant M Gonzalez, Huibin Chang, Qihan Liu, Aaron L Glieberman, John P Ferrier, Chad A Cowan, Kevin Kit Parke. Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes Lab on a chip vol 20 issue 22 2021 33034335 |
to model adaptive adipocyte hypertrophy in vitro, we designed and built fat-on-a-chip using fiber networks inspired by extracellular matrix in adipose tissue. |
2021-06-21 |
2023-01-26 |
human |
| Chrystelle V Garat, Susan M Majka, Timothy M Sullivan, Joseph T Crossno, Jane E B Reusch, Dwight J Klem. CREB depletion in smooth muscle cells promotes medial thickening, adventitial fibrosis and elicits pulmonary hypertension. Pulmonary circulation vol 10 issue 2 2021 32313640 |
isolated murine creb-null smooth muscle cells exhibited serum-independent proliferation and hypertrophy in vitro and medium conditioned by creb-null smooth muscle cells stimulated proliferation and expression of extracellular matrix proteins by adventitial fibroblasts. |
2021-06-16 |
2023-01-26 |
rat |
| D Joe Millwar. Interactions between Growth of Muscle and Stature: Mechanisms Involved and Their Nutritional Sensitivity to Dietary Protein: The Protein-Stat Revisited. Nutrients vol 13 issue 3 2021 33668846 |
cellular mechanisms of muscle growth during development are then reviewed identifying (a) the difficulties posed by the need to maintain its ultrastructure during myofibre hypertrophy within the extracellular matrix and the concept of muscle as concentric "bags" allowing growth to be conceived as bag enlargement and filling, (b) the cellular and molecular mechanisms involved in the mechanotransduction of satellite and mesenchymal stromal cells, to enable both connective tissue remodelling and provision of new myonuclei to aid myofibre hypertrophy and (c) the implications of myofibre hypertrophy for protein turnover within the myonuclear domain. |
2021-06-02 |
2023-01-26 |
rat |
| Hyunbum Kim, Laurensia Danis Anggradita, Sun-Jae Lee, Sung Sik Hur, Joonsuk Bae, Nathaniel Suk-Yeon Hwang, Seung Min Nam, Yongsung Hwan. Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling. International journal of molecular sciences vol 22 issue 4 2021 33672186 |
keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ecm) in the dermis. |
2021-06-01 |
2023-01-26 |
Not clear |
| Grasiela Costa Bezerra Barros, La\\xc3\\xa9rcia K D Paiva Ferreira, Larissa A M P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Ramon de Alencar Pereira, Marcia Regina Piuveza. 4-Carvomenthenol ameliorates the murine combined allergic rhinitis and asthma syndrome by inhibiting IL-13 and mucus production via p38MAPK/NF-\\xce\\xbaB signaling pathway axis. International immunopharmacology vol 88 issue 2021 33182052 |
in addition, the histological analyzes demonstrated that sick mice presented hyperplasia and hypertrophy of the lung smooth muscle layer followed by increasing of extracellular matrix and carvo (50\xc2\xa0mg/kg) inhibited these asthmatic parameters. |
2021-05-27 |
2023-01-26 |
mouse |
| Ling Jiang, Ying Deng, Wei Li, Yang L. Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. Molecular medicine reports vol 22 issue 6 2021 33174021 |
arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. |
2021-05-25 |
2023-01-26 |
mouse |
| Ling Jiang, Ying Deng, Wei Li, Yang L. Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. Molecular medicine reports vol 22 issue 6 2021 33174021 |
hypertrophic scars (hss) are a progressive fibroproliferation disorder caused by abnormal tissue repair after deep skin injury, and are characterized by continuous activation of fibroblasts and excessive deposition of extracellular matrix. |
2021-05-25 |
2023-01-26 |
mouse |
| Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N Wight, Alan Chai. Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties. JCI insight vol 5 issue 20 2021 32970631 |
because we recently found that the major extracellular matrix proteoglycan produced by hypertrophic adipocytes is versican, whereas activated adipose tissue macrophages produce mainly biglycan, we further investigated the role of proteoglycans in determining the antiinflammatory properties of hdl. |
2021-05-19 |
2023-01-26 |
human |
| Jingting Li, Karthikeyan Narayanan, Ying Zhang, Ryan C Hill, Fan He, Kirk C Hansen, Ming Pe. Role of lineage-specific matrix in stem cell chondrogenesis. Biomaterials vol 231 issue 2021 31864016 |
interestingly, secm expanded cells had less potential for hypertrophy compared to those grown on other decms, indicating that a tissue-specific matrix might provide a superior microenvironment for stem cell chondrogenic differentiation. |
2021-05-14 |
2023-01-26 |
human |
| Rosanne M Raftery, Arlyng G Gonzalez Vazquez, Gang Chen, Fergal J O'Brie. Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification. Advanced healthcare materials vol 9 issue 10 2021 32329217 |
it is shown that delivery of the sox-trio induced mscs to over-express col2a1 and acan and deposit a sulfated and collagen type ii rich extracellular matrix while hypertrophic gene expression and collagen type x deposition is inhibited. |
2021-05-14 |
2023-01-26 |
Not clear |
| Franziska Meyer, Annalena Dittmann, Uwe Kornak, Maria Herbster, Thomas Pap, Christoph H Lohmann, Jessica Bertran. Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes. Frontiers in cell and developmental biology vol 9 issue 2021 33981699 |
patients with radiologically detectable cc presented calcification mainly on the cartilage surface, whereas oa patients showed calcification mainly in the pericellular matrix of hypertrophic chondrocytes. |
2021-05-14 |
2023-01-26 |
Not clear |
| Chen Fan, Samir El Andaloussi, Taavi Lehto, Kiat Whye Kong, Yiqi Seo. Smad\\xe2\\x80\\x91binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. Molecular medicine reports vol 22 issue 6 2021 33173952 |
smad\xe2\x80\x91binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. |
2021-05-13 |
2023-01-26 |
human |
| Vivek Jeyakumar, Nedaa Amraish, Eugenia Niculescu-Morsza, Christoph Bauer, Dieter Pahr, Stefan Nehre. Decellularized Cartilage Extracellular Matrix Incorporated Silk Fibroin Hybrid Scaffolds for Endochondral Ossification Mediated Bone Regeneration. International journal of molecular sciences vol 22 issue 8 2021 33919985 |
hbmsc's were primed two weeks for chondrogenesis, followed by six weeks for hypertrophy onto hybrid cd-ecm/sf or sf alone scaffolds and evaluated for the mineralized matrix formation in vitro. |
2021-05-12 |
2023-01-26 |
Not clear |
| Xinhang Dong, Mingzi Zhang, Xiaolei Ji. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery vol issue 2021 33963427 |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-05-08 |
2023-01-26 |
Not clear |