| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Nurminskaya, T F Linsenmaye. Identification and characterization of up-regulated genes during chondrocyte hypertrophy. Developmental dynamics : an official publication of the American Association of Anatomists vol 206 issue 3 1997 8896982 |
chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type x collagen, alkaline phosphatase, and matrix metalloproteinases. |
1997-02-19 |
2023-01-24 |
chicken |
| M Nurminskaya, T F Linsenmaye. Identification and characterization of up-regulated genes during chondrocyte hypertrophy. Developmental dynamics : an official publication of the American Association of Anatomists vol 206 issue 3 1997 8896982 |
the identified genes included translational and transcriptional regulatory factors, ribosomal proteins, the enzymes transglutaminase and glycogen phosphorylase, type x collagen (highly specific for hypertrophic cartilage matrix), gelsolin, and the carbohydrate-binding protein galectin. |
1997-02-19 |
2023-01-24 |
chicken |
| M G Ehrlich, A L Armstron. Aggregate degradation by growth plate proteases. Clinical orthopaedics and related research vol issue 334 1997 9005927 |
for long bone growth to occur, calcification of the matrix must begin in the lower hypertrophic zone of the growth plate. |
1997-02-18 |
2023-01-24 |
Not clear |
| M G Ehrlich, A L Armstron. Aggregate degradation by growth plate proteases. Clinical orthopaedics and related research vol issue 334 1997 9005927 |
because the matrix constituents probably limit hypertrophic cell size and shape, this degradation may have some relationship to the rate of growth of the physis. |
1997-02-18 |
2023-01-24 |
Not clear |
| K H Choi, S W Kang, H Y Lee, D S Ha. The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells. Yonsei medical journal vol 37 issue 5 1997 8997162 |
in order to investigate whether the intracellular signaling pathways inducing proliferation, hypertrophy and matrix synthesis of mesangial cells are altered in a diabetic environment, we evaluated the effects of a high concentration of extracellular glucose(25 mm; 450 mg/dl) on [3h]thymidine uptake, hypertrophy, and [3h]proline incorporation into a collagenase-sensitive protein, induced by angiotensin ii(ang ii) or transforming growth factor(tgf)-beta, in cultured rat mesangial cells. |
1997-02-06 |
2023-01-24 |
rat |
| T Yasuda, K Shimizu, Y Nakagawa, H Ishikawa, H Nishihara, T Nakamur. Possible involvement of RGD (Arg-Gly-Asp)-containing extracellular matrix proteins in rat growth plate chondrocyte differentiation in culture. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 11 issue 10 1997 8889842 |
treatment with grgdsp from the early to late culture periods in association with the transition of chondrocytes from prehypertrophic to hypertrophic phenotypes followed by matrix mineralization resulted in suppression of mineral growth without significant effects on alkaline phosphatase levels or cellular morphology in the cultures. |
1997-01-30 |
2023-01-24 |
rat |
| R Toury, F Belqasmi, M Hauchecorne, C W Heizmann, N Balmai. Ultrastructural localization of alpha-parvalbumin in the epiphyseal plate cartilage and bone of growing rats. Bone vol 19 issue 3 1997 8873965 |
there was moderate parvalbumin immunolabeling over the dense chromatin in the nuclei of chondrocytes and bone cells, but none in the cell processes of mature and hypertrophic chondrocytes, in the matrix vesicles themselves, or in the cell processes of osteoblasts. |
1997-01-29 |
2023-01-24 |
rat |
| S M Donnelly, X P Zhou, J T Huang, C I Whitesid. Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat. Biochemistry and cell biology = Biochimie et biologie cellulaire vol 74 issue 3 1997 8883841 |
in the streptozotocin-induced diabetic rat, the effect of the aldose reductase inhibitor, tolrestat, in preventing glomerular hyperfiltration, renal hypertrophy, extracellular matrix accumulation, and mesangial cell hypocontractility was addressed. |
1997-01-28 |
2023-01-24 |
rat |
| N J Wilsman, C E Farnum, E M Leiferman, M Fry, C Barret. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 14 issue 6 1997 8982136 |
in the proximal tibia, 9% of growth is contributed by cellular division; 32%, by matrix synthesis throughout the growth plate; and 59%, by chondrocytic enlargement during hypertrophy. |
1997-01-27 |
2023-01-24 |
rat |
| N J Wilsman, C E Farnum, E M Leiferman, M Fry, C Barret. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 14 issue 6 1997 8982136 |
this study suggests that differential growth is best depicted as a complex interplay among cellular division, matrix synthesis, and cellular enlargement during hypertrophy. |
1997-01-27 |
2023-01-24 |
rat |
| L Z Sailor, R M Hewick, E A Morri. Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 14 issue 6 1997 8982137 |
the present study was performed to determine if the addition of human recombinant bone morphogenetic protein-2 to a long-term monolayer articular chondrocyte cell culture system affected the ability of the chondrocytes to divide in vitro, whether the cytokine altered expression of the articular chondrocyte phenotype and synthesis of matrix proteoglycans, and whether the cytokine was capable of inducing differentiation to a hypertrophic chondrocyte. |
1997-01-27 |
2023-01-24 |
human |
| N Ashizawa, K Graf, Y S Do, T Nunohiro, C M Giachelli, W P Meehan, T L Tuan, W A Hsue. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. The Journal of clinical investigation vol 98 issue 10 1997 8941637 |
angiotensin ii (aii) is a critical factor in cardiac remodeling which involves hypertrophy, fibroblast proliferation, and extracellular matrix production. |
1997-01-23 |
2023-01-24 |
rat |
| H Claassen, T Kirsch, G Simon. Cartilage canals in human thyroid cartilage characterized by immunolocalization of collagen types I, II, pro-III, IV and X. Anatomy and embryology vol 194 issue 2 1997 8827323 |
the extracellular matrix of hypertrophic chondrocytes adjacent to cartilage canals showed strong immunoreactivity for type x collagen. |
1997-01-16 |
2023-01-24 |
human |
| P W Anderson, X Y Zhang, J Tian, J D Correale, X P Xi, D Yang, K Graf, R E Law, W A Hsue. Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney international vol 50 issue 3 1997 8872947 |
angiotensin ii (ang ii) and insulin are implicated in the mesangial cell hypertrophy and excessive accumulation of mesangial matrix seen in glomerulosclerosis. |
1997-01-06 |
2023-01-24 |
rat |
| A L Bronckers, W Goei, G Luo, G Karsenty, R N D'Souza, D M Lyaruu, E H Burge. DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 11 issue 9 1996 8864903 |
we conclude that some of the osteocytes in deeper layers of bone die within their lacuna and disperse nuclear fragments over the extracellular matrix, that a majority of the osteocytes are phagocytosed and degraded by osteoclasts at sites of intense bone resorption, and that during endochondral ossification, substantial numbers of late hypertrophic chondrocyte cells undergo cell death. |
1996-12-26 |
2023-01-24 |
rat |
| K Lee, B Lanske, A C Karaplis, J D Deeds, H Kohno, R A Nissenson, H M Kronenberg, G V Segr. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology vol 137 issue 11 1996 8895385 |
terminal differentiation of chondrocytes, which was characterized by cell hypertrophy, apoptosis (dna fragmentation and decreased bcl-2 mrna expression), and matrix mineralization, was more advanced in growth cartilage of pthrp(-/-), compared with pthrp(+/+) animals. |
1996-12-17 |
2023-01-24 |
mouse |
| J Sesin, J Tamarg. [Effect of cilazapril, a converting enzyme inhibitor, on cardiovascular hypertrophy in the hypertensive patient]. Medicina vol 56 issue 1 1996 8734937 |
this is the result of a vascular tone increase and/or structural changes which imply hypertrophy as well as hyperplasia of the vascular smooth muscle fibers, hypertrophy of the cardiac cells and an increase in the constituent synthesis of the extracellular matrix. |
1996-12-10 |
2023-01-24 |
Not clear |
| P Pavasant, T Shizari, C B Underhil. Hyaluronan contributes to the enlargement of hypertrophic lacunae in the growth plate. Journal of cell science vol 109 ( Pt 2) issue 1996 8838656 |
since hyaluronan can adsorb large amounts of water, it is possible that it exerted a hydrostatic pressure on the surrounding territorial matrix and thereby caused the expansion of hypertrophic lacunae. |
1996-12-05 |
2023-01-24 |
Not clear |
| E H Morrison, M W Ferguson, M T Bayliss, C W Arche. The development of articular cartilage: I. The spatial and temporal patterns of collagen types. Journal of anatomy vol 189 ( Pt 1) issue 1996 8771392 |
interestingly, generalised matrix immunopositivity was only retained in the hypertrophic cartilage of the secondary centre of ossification. |
1996-11-25 |
2023-01-24 |
Not clear |
| H Karam, D Heudes, P Bruneval, M F Gonzales, B M L\\xc3\\xb6ffler, M Clozel, J P Cloze. Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension (Dallas, Tex. : 1979) vol 28 issue 3 1996 8794820 |
cardiac hypertrophy and fibrosis, aortic medial thickness, and extracellular matrix content were evaluated by quantitative morphometry. |
1996-11-22 |
2023-01-24 |
rat |