| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Ghahary, Y J Shen, B Nedelec, P G Scott, E E Tredge. Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblasts. Molecular and cellular biochemistry vol 148 issue 1 1995 7476930 |
hypertrophic scarring (hsc) which frequently develops in patients following severe thermal injury is characterized by accumulation of extracellular matrix (ecm) proteins including type i and type iii collagen. |
1995-12-12 |
2023-01-24 |
Not clear |
| A Panizo, J Pardo, M Hern\\xc3\\xa1ndez, M F Galindo, E Cenarruzabeitia, J D\\xc3\\xade. Quinapril decreases myocardial accumulation of extracellular matrix components in spontaneously hypertensive rats. American journal of hypertension vol 8 issue 8 1995 7576398 |
in genetic and acquired hypertension, a structural remodeling of the nonmyocyte compartment of myocardium, including the accumulation of fibrillar collagen and other components of the extracellular matrix (ecm) within the interstitium, represents a determinant of pathologic hypertrophy that leads to ventricular dysfunction. |
1995-12-07 |
2023-01-24 |
rat |
| W A Hsueh, Y S Do, P W Anderson, R E La. Angiotensin II in cell growth and matrix production. Advances in experimental medicine and biology vol 377 issue 1995 7484424 |
these effects are primarily mediated by the at1 receptor and include: 1) growth: hyperplasia in cardiac fibroblasts and hypertrophy in normal adult mesangial cells and 2) matrix production: there appears to be an early upregulation of fibronectin message which is later followed by an increase in collagens. |
1995-12-05 |
2023-01-24 |
Not clear |
| A Agrotis, J Saltis, R Dilley, P Bray, A Bobi. Transforming growth factor-beta 1 and the development of vascular hypertrophy in hypertension. Blood pressure. Supplement vol 2 issue 1995 7582073 |
in hypertension tgf-beta 1 gene transcription is most likely elevated by a combination of physical and chemical stimuli with the cytokine acting to increase the production of extracellular matrix proteins or to modulate smooth muscle cellular growth, producing hypertrophy, polyploidy or proliferation. |
1995-11-30 |
2023-01-24 |
Not clear |
| L Schafer, T Lorenz, J Daemmrich, A Heidland, R M Schaefe. Role of proteinases in renal hypertrophy and matrix accumulation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol 10 issue 6 1995 7566607 |
role of proteinases in renal hypertrophy and matrix accumulation. |
1995-11-01 |
2023-01-24 |
rat |
| K Sharma, F N Ziyade. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes vol 44 issue 10 1995 7556948 |
we have also observed that the development of renal hypertrophy in the insulin-dependent diabetic bb rat and nod mouse is associated with increased expression of tgf-beta 1 in the kidney and that short-term administration of antibodies capable of neutralizing the activity of tgf-beta in the streptozotocin mouse model of diabetes results in attenuation of whole kidney and glomerular hypertrophy and overexpression of mrnas encoding matrix components. |
1995-10-24 |
2023-01-24 |
rat |
| C W Yang, H Vlassara, G E Striker, L J Strike. Administration of AGEs in vivo induces genes implicated in diabetic glomerulosclerosis. Kidney international. Supplement vol 49 issue 1995 7674596 |
both glomerular hypertrophy and overexpression of genes coding for extracellular matrix were abrogated when aminoguanidine, an inhibitor of age cross-linking, was added to the ages injections, suggesting that the glomerular response to ages was specific. |
1995-10-19 |
2023-01-24 |
mouse |
| M Galotto, G Campanile, A Banfi, M Trugli, R Cancedd. Chondrocyte and osteoblast differentiation stage-specific monoclonal antibodies as a tool to investigate the initial bone formation in developing chick embryo. European journal of cell biology vol 67 issue 2 1995 7664760 |
when cryosections of the chondro-bone junction of developing embryo tibiae were stained, it was observed that monoclonal antibodies raised against hypertrophic chondrocytes stained frank hypertrophic and elongated chondrocytes (bd5, la5), a very discrete peripheric layer of cartilage (ad2), and cells embedded in the initial osteoid matrix (la5), but failed to stain cells in the preosteoblast and osteoblast region. |
1995-10-12 |
2023-01-24 |
chicken |
| T Barak-Shalom, M Schickler, V Knopov, R Shapira, S Hurwitz, M Pine. Synthesis and phosphorylation of osteopontin by avian epiphyseal growth-plate chondrocytes as affected by differentiation. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology vol 111 issue 1 1995 7656184 |
the gene was expressed mainly at the lower hypertrophic zone where cartilage matrix is calcified and endochondral bone formation is initiated. |
1995-10-03 |
2023-01-24 |
Not clear |
| K S Chung, H H Park, K Ting, H Takita, S S Apte, Y Kuboki, I Nishimur. Modulated expression of type X collagen in Meckel's cartilage with different developmental fates. Developmental biology vol 170 issue 2 1995 7649371 |
since the entire meckel's cartilage develops up to chondrocyte hypertrophy, the regional extracellular matrix components in the hypertrophic meckel's cartilage may differ in association with the diverse developmental fates. |
1995-09-25 |
2023-01-24 |
rat |
| V Knopov, R M Leach, T Barak-Shalom, S Hurwitz, M Pine. Osteopontin gene expression and alkaline phosphatase activity in avian tibial dyschondroplasia. Bone vol 16 issue 4 Suppl 1995 7542900 |
in the normal growth plate, opn gene was expressed by a) cells of the subperichondrial zone surrounding the articular cartilage, b) a narrow layer of hypertrophic chondrocytes at the hypertrophic zone, and c) lower hypertrophic chondrocytes at the zone of matrix calcification and endochondral bone formation. |
1995-09-01 |
2023-01-24 |
Not clear |
| M J Morgan, A J Madgwick, B Charleston, J M Pell, P T Loughn. The developmental regulation of a novel muscle LIM-protein. Biochemical and biophysical research communications vol 212 issue 3 1995 7626119 |
this period corresponds to the period of greatest muscle fibre hypertrophy and suggests a role for this homologue in either the elaboration of muscle fibre matrix anchorage or the regulation of muscle fibre hypertrophy itself. |
1995-08-25 |
2023-01-24 |
human |
| N J Mayer, S A Rubi. The molecular and cellular biology of heart failure. Current opinion in cardiology vol 10 issue 3 1995 7612972 |
in animal models, the hypothesis that the devolution from hypertrophy to heart failure includes alterations in the molecular direction of extracellular matrix production gained some support. |
1995-08-18 |
2023-01-24 |
Not clear |
| J H Omens, D E Milkes, J W Covel. Effects of pressure overload on the passive mechanics of the rat left ventricle. Annals of biomedical engineering vol 23 issue 2 1995 7605052 |
thus, in this model of pressure-overload hypertrophy, the decreases in compliance and circumferential strain of the passive lv are not due to changes in the percentage of extracellular matrix, but rather to global geometric changes. |
1995-08-07 |
2023-01-24 |
rat |
| H A Struijker-Boudier, J F Smits, J G De Me. Pharmacology of cardiac and vascular remodeling. Annual review of pharmacology and toxicology vol 35 issue 1995 7598505 |
the most distinguished features of this process are phenotypic modulation of various cell types in the cardiovascular system; cellular hyperplasia and hypertrophy; and extracellular matrix production, deposition, and degradation. |
1995-08-01 |
2023-01-24 |
Not clear |
| A Ghahary, Y J Shen, P G Scott, E E Tredge. Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissues. Cytokine vol 7 issue 2 1995 7780038 |
following severe thermal injury and other injuries to the deep dermis of the skin, patients frequently develop hypertrophic scarring (hsc) which is characterized by an over-abundance of extracellular matrix (ecm) proteins including collagen. |
1995-07-18 |
2023-01-24 |
human |
| M Ketteler, N A Noble, W A Borde. Transforming growth factor-beta and angiotensin II: the missing link from glomerular hyperfiltration to glomerulosclerosis? Annual review of physiology vol 57 issue 1995 7778869 |
recent studies reveal that angiotensin ii is a potent inducer of tgf-beta synthesis in a variety of cells and that this mechanism exerts important biological effects including extracellular matrix accumulation, cell proliferation, and hypertrophy. |
1995-07-13 |
2023-01-24 |
Not clear |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology vol 66 issue 1 1995 7538466 |
supernatants from dedifferentiated cells undergoing maturation to hypertrophic chondrocytes in suspension progressively inhibited vascular cell random migration and invasion of basement membrane matrix by endothelial cells. |
1995-06-20 |
2023-01-24 |
mouse |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology vol 66 issue 1 1995 7538466 |
medium conditioned by osteoblast-like cells derived from hypertrophic chondrocytes also induced vascular cell migration and invasion of basement membrane matrix. |
1995-06-20 |
2023-01-24 |
mouse |
| F Descalzi Cancedda, A Melchiori, R Benelli, C Gentili, L Masiello, G Campanile, R Cancedda, A Albin. Production of angiogenesis inhibitors and stimulators is modulated by cultured growth plate chondrocytes during in vitro differentiation: dependence on extracellular matrix assembly. European journal of cell biology vol 66 issue 1 1995 7538466 |
therefore, interactions of chondrocytes with their extracellular matrix are an absolute requirement for the expression of angiogenic activities by hypertrophic chondrocytes at late developmental stages. |
1995-06-20 |
2023-01-24 |
mouse |