| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G L Engelmann, S E Campbell, K Rakusa. Immediate postnatal rat heart development modified by abdominal aortic banding: analysis of gene expression. Molecular and cellular biochemistry. vol 163-164. 1997-04-08. PMID:8974039. |
as the newborn myocyte undergoes a 'transition' from proliferative to hypertrophic growth, ventricular remodeling of the non-myocyte compartment is characterized by increased extracellular matrix (ecm) formation and coronary capillary angiogenesis. |
1997-04-08 |
2023-08-12 |
rat |
| K Amann, B Wolf, C Nichols, J Törnig, U Schwarz, M Zeier, G Mall, E Rit. Aortic changes in experimental renal failure: hyperplasia or hypertrophy of smooth muscle cells? Hypertension (Dallas, Tex. : 1979). vol 29. issue 3. 1997-03-26. PMID:9052894. |
it is currently unknown whether such increases result from hyperplasia of vascular smooth muscle cells, hypertrophy, or a combination of both or from an increase in aortic extracellular matrix. |
1997-03-26 |
2023-08-12 |
rat |
| K Amann, B Wolf, C Nichols, J Törnig, U Schwarz, M Zeier, G Mall, E Rit. Aortic changes in experimental renal failure: hyperplasia or hypertrophy of smooth muscle cells? Hypertension (Dallas, Tex. : 1979). vol 29. issue 3. 1997-03-26. PMID:9052894. |
in contrast, wall thickness, cross-sectional media, total number of aortic vascular smooth muscle cells, and volume of extracellular matrix including collagen were significantly increased after subtotal nephrectomy, whereas cellular hypertrophy was only modest and an increase in elastic fibers did not occur. |
1997-03-26 |
2023-08-12 |
rat |
| S Kim, K Ohta, A Hamaguchi, K Miura, T Yukimura, H Iwa. Suppression of vascular transforming growth factor-beta1 and extracellular matrix gene expressions by cilazapril and nifedipine in hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement. vol 22. issue 1. 1997-03-25. PMID:9072426. |
these results suggest that tgf-beta1 may be responsible for smooth muscle cell hypertrophy and the increased deposition of extracellular matrix in hypertensive blood vessels. |
1997-03-25 |
2023-08-12 |
rat |
| I S Park, H Kiyomoto, S L Abboud, H E Abbou. Expression of transforming growth factor-beta and type IV collagen in early streptozotocin-induced diabetes. Diabetes. vol 46. issue 3. 1997-03-14. PMID:9032105. |
the earliest manifestations of type i diabetic nephropathy include mesangial matrix expansion, basement membrane thickening, and renal hypertrophy. |
1997-03-14 |
2023-08-12 |
rat |
| I Girkontaite, S Frischholz, P Lammi, K Wagner, B Swoboda, T Aigner, K Von der Mar. Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix biology : journal of the International Society for Matrix Biology. vol 15. issue 4. 1997-03-03. PMID:8892223. |
mab x 53 stained the peri- and extracellular matrix of hypertrophic chondrocytes in the lower hypertrophic zone and in the calcified cartilage core in endochondral bone trabecules, while clone x 34 stained intracellularly and the pericellular matrix. |
1997-03-03 |
2023-08-12 |
human |
| G Nguyen, F Delarue, J Berrou, E Rondeau, J D Srae. Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen. Kidney international. vol 50. issue 6. 1997-02-28. PMID:8943472. |
the role of this receptor remains to be determined in nephropathies and hypertensive states associated with high plasma/tissue renin concentrations, hypertrophy of mesangial or smooth muscle cells and extracellular matrix remodeling. |
1997-02-28 |
2023-08-12 |
human |
| L N Wu, M G Wuthier, B R Genge, R E Wuthie. In situ levels of intracellular Ca2+ and pH in avian growth plate cartilage. Clinical orthopaedics and related research. issue 335. 1997-02-27. PMID:9020233. |
ca2+ was elevated intensely near the periphery of cells in the zones of maturation and hypertrophy, and many ca2+ rich particles were seen in the matrix near these cells. |
1997-02-27 |
2023-08-12 |
Not clear |
| L N Wu, M G Wuthier, B R Genge, R E Wuthie. In situ levels of intracellular Ca2+ and pH in avian growth plate cartilage. Clinical orthopaedics and related research. issue 335. 1997-02-27. PMID:9020233. |
however, after repeated ca2+ cycling, in the zones of maturation and hypertrophy, ca2+ rich particles were shed from the cell surface, forming what appeared to be matrix vesicles. |
1997-02-27 |
2023-08-12 |
Not clear |
| M Nurminskaya, T F Linsenmaye. Identification and characterization of up-regulated genes during chondrocyte hypertrophy. Developmental dynamics : an official publication of the American Association of Anatomists. vol 206. issue 3. 1997-02-19. PMID:8896982. |
chondrocyte hypertrophy involves de novo acquisition and/or increased expression of certain gene products including, among others, type x collagen, alkaline phosphatase, and matrix metalloproteinases. |
1997-02-19 |
2023-08-12 |
chicken |
| M Nurminskaya, T F Linsenmaye. Identification and characterization of up-regulated genes during chondrocyte hypertrophy. Developmental dynamics : an official publication of the American Association of Anatomists. vol 206. issue 3. 1997-02-19. PMID:8896982. |
the identified genes included translational and transcriptional regulatory factors, ribosomal proteins, the enzymes transglutaminase and glycogen phosphorylase, type x collagen (highly specific for hypertrophic cartilage matrix), gelsolin, and the carbohydrate-binding protein galectin. |
1997-02-19 |
2023-08-12 |
chicken |
| M G Ehrlich, A L Armstron. Aggregate degradation by growth plate proteases. Clinical orthopaedics and related research. issue 334. 1997-02-18. PMID:9005927. |
for long bone growth to occur, calcification of the matrix must begin in the lower hypertrophic zone of the growth plate. |
1997-02-18 |
2023-08-12 |
Not clear |
| M G Ehrlich, A L Armstron. Aggregate degradation by growth plate proteases. Clinical orthopaedics and related research. issue 334. 1997-02-18. PMID:9005927. |
because the matrix constituents probably limit hypertrophic cell size and shape, this degradation may have some relationship to the rate of growth of the physis. |
1997-02-18 |
2023-08-12 |
Not clear |
| K H Choi, S W Kang, H Y Lee, D S Ha. The effects of high glucose concentration on angiotensin II- or transforming growth factor-beta-induced DNA synthesis, hypertrophy and collagen synthesis in cultured rat mesangial cells. Yonsei medical journal. vol 37. issue 5. 1997-02-06. PMID:8997162. |
in order to investigate whether the intracellular signaling pathways inducing proliferation, hypertrophy and matrix synthesis of mesangial cells are altered in a diabetic environment, we evaluated the effects of a high concentration of extracellular glucose(25 mm; 450 mg/dl) on [3h]thymidine uptake, hypertrophy, and [3h]proline incorporation into a collagenase-sensitive protein, induced by angiotensin ii(ang ii) or transforming growth factor(tgf)-beta, in cultured rat mesangial cells. |
1997-02-06 |
2023-08-12 |
rat |
| T Yasuda, K Shimizu, Y Nakagawa, H Ishikawa, H Nishihara, T Nakamur. Possible involvement of RGD (Arg-Gly-Asp)-containing extracellular matrix proteins in rat growth plate chondrocyte differentiation in culture. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 11. issue 10. 1997-01-30. PMID:8889842. |
treatment with grgdsp from the early to late culture periods in association with the transition of chondrocytes from prehypertrophic to hypertrophic phenotypes followed by matrix mineralization resulted in suppression of mineral growth without significant effects on alkaline phosphatase levels or cellular morphology in the cultures. |
1997-01-30 |
2023-08-12 |
rat |
| R Toury, F Belqasmi, M Hauchecorne, C W Heizmann, N Balmai. Ultrastructural localization of alpha-parvalbumin in the epiphyseal plate cartilage and bone of growing rats. Bone. vol 19. issue 3. 1997-01-29. PMID:8873965. |
there was moderate parvalbumin immunolabeling over the dense chromatin in the nuclei of chondrocytes and bone cells, but none in the cell processes of mature and hypertrophic chondrocytes, in the matrix vesicles themselves, or in the cell processes of osteoblasts. |
1997-01-29 |
2023-08-12 |
rat |
| S M Donnelly, X P Zhou, J T Huang, C I Whitesid. Prevention of early glomerulopathy with tolrestat in the streptozotocin-induced diabetic rat. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 74. issue 3. 1997-01-28. PMID:8883841. |
in the streptozotocin-induced diabetic rat, the effect of the aldose reductase inhibitor, tolrestat, in preventing glomerular hyperfiltration, renal hypertrophy, extracellular matrix accumulation, and mesangial cell hypocontractility was addressed. |
1997-01-28 |
2023-08-12 |
rat |
| N J Wilsman, C E Farnum, E M Leiferman, M Fry, C Barret. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 14. issue 6. 1997-01-27. PMID:8982136. |
in the proximal tibia, 9% of growth is contributed by cellular division; 32%, by matrix synthesis throughout the growth plate; and 59%, by chondrocytic enlargement during hypertrophy. |
1997-01-27 |
2023-08-12 |
rat |
| N J Wilsman, C E Farnum, E M Leiferman, M Fry, C Barret. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 14. issue 6. 1997-01-27. PMID:8982136. |
this study suggests that differential growth is best depicted as a complex interplay among cellular division, matrix synthesis, and cellular enlargement during hypertrophy. |
1997-01-27 |
2023-08-12 |
rat |
| L Z Sailor, R M Hewick, E A Morri. Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 14. issue 6. 1997-01-27. PMID:8982137. |
the present study was performed to determine if the addition of human recombinant bone morphogenetic protein-2 to a long-term monolayer articular chondrocyte cell culture system affected the ability of the chondrocytes to divide in vitro, whether the cytokine altered expression of the articular chondrocyte phenotype and synthesis of matrix proteoglycans, and whether the cytokine was capable of inducing differentiation to a hypertrophic chondrocyte. |
1997-01-27 |
2023-08-12 |
human |