| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Jiang, Ying Deng, Wei Li, Yang L. Arctigenin suppresses fibroblast activity and extracellular matrix deposition in hypertrophic scarring by reducing inflammation and oxidative stress. Molecular medicine reports vol 22 issue 6 2021 33174021 |
hypertrophic scars (hss) are a progressive fibroproliferation disorder caused by abnormal tissue repair after deep skin injury, and are characterized by continuous activation of fibroblasts and excessive deposition of extracellular matrix. |
2021-05-25 |
2023-01-26 |
mouse |
| Chang Yeop Han, Inkyung Kang, Mohamed Omer, Shari Wang, Tomasz Wietecha, Thomas N Wight, Alan Chai. Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties. JCI insight vol 5 issue 20 2021 32970631 |
because we recently found that the major extracellular matrix proteoglycan produced by hypertrophic adipocytes is versican, whereas activated adipose tissue macrophages produce mainly biglycan, we further investigated the role of proteoglycans in determining the antiinflammatory properties of hdl. |
2021-05-19 |
2023-01-26 |
human |
| Jingting Li, Karthikeyan Narayanan, Ying Zhang, Ryan C Hill, Fan He, Kirk C Hansen, Ming Pe. Role of lineage-specific matrix in stem cell chondrogenesis. Biomaterials vol 231 issue 2021 31864016 |
interestingly, secm expanded cells had less potential for hypertrophy compared to those grown on other decms, indicating that a tissue-specific matrix might provide a superior microenvironment for stem cell chondrogenic differentiation. |
2021-05-14 |
2023-01-26 |
human |
| Rosanne M Raftery, Arlyng G Gonzalez Vazquez, Gang Chen, Fergal J O'Brie. Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification. Advanced healthcare materials vol 9 issue 10 2021 32329217 |
it is shown that delivery of the sox-trio induced mscs to over-express col2a1 and acan and deposit a sulfated and collagen type ii rich extracellular matrix while hypertrophic gene expression and collagen type x deposition is inhibited. |
2021-05-14 |
2023-01-26 |
Not clear |
| Franziska Meyer, Annalena Dittmann, Uwe Kornak, Maria Herbster, Thomas Pap, Christoph H Lohmann, Jessica Bertran. Chondrocytes From Osteoarthritic and Chondrocalcinosis Cartilage Represent Different Phenotypes. Frontiers in cell and developmental biology vol 9 issue 2021 33981699 |
patients with radiologically detectable cc presented calcification mainly on the cartilage surface, whereas oa patients showed calcification mainly in the pericellular matrix of hypertrophic chondrocytes. |
2021-05-14 |
2023-01-26 |
Not clear |
| Chen Fan, Samir El Andaloussi, Taavi Lehto, Kiat Whye Kong, Yiqi Seo. Smad\\xe2\\x80\\x91binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. Molecular medicine reports vol 22 issue 6 2021 33173952 |
smad\xe2\x80\x91binding decoy reduces extracellular matrix expression in human hypertrophic scar fibroblasts. |
2021-05-13 |
2023-01-26 |
human |
| Vivek Jeyakumar, Nedaa Amraish, Eugenia Niculescu-Morsza, Christoph Bauer, Dieter Pahr, Stefan Nehre. Decellularized Cartilage Extracellular Matrix Incorporated Silk Fibroin Hybrid Scaffolds for Endochondral Ossification Mediated Bone Regeneration. International journal of molecular sciences vol 22 issue 8 2021 33919985 |
hbmsc's were primed two weeks for chondrogenesis, followed by six weeks for hypertrophy onto hybrid cd-ecm/sf or sf alone scaffolds and evaluated for the mineralized matrix formation in vitro. |
2021-05-12 |
2023-01-26 |
Not clear |
| Xinhang Dong, Mingzi Zhang, Xiaolei Ji. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery vol issue 2021 33963427 |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-05-08 |
2023-01-26 |
Not clear |
| Ying Kui Zhong, Bao Lan Lu, Si Yun Huang, Yu Jun Chen, Zi Ping Li, Jordi Rimola, Xue Hua L. Cross-sectional imaging for assessing intestinal fibrosis in Crohn's disease. Journal of digestive diseases vol 21 issue 6 2021 32418328 |
excessive deposition of extracellular matrix components in the submucosa and smooth muscle hypertrophy or hyperplasia are the main features of fibrosis in cd. |
2021-04-30 |
2023-01-26 |
Not clear |
| Zachary M Working, Elizabeth R Morris, Jiun Chiun Chang, Ryan F Coghlan, Brian Johnstone, Theodore Miclau, William A Horton, Chelsea S Bahne. A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 39 issue 1 2021 32533783 |
prior to converting to the bone, cartilage undergoes hypertrophic maturation, characterized by the deposition of a provisional collagen x matrix. |
2021-04-30 |
2023-01-26 |
Not clear |
| Kathrin Maly, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, Frank Zauck. COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis. International journal of molecular sciences vol 22 issue 5 2021 33668140 |
the usually quiescent chondrocytes become reactivated and accumulate in cell clusters, become hypertrophic, and intensively produce not only degrading enzymes, but also ecm proteins, like the cartilage oligomeric matrix protein (comp) and thrombospondin-4 (tsp-4). |
2021-04-29 |
2023-01-26 |
Not clear |
| Yi Zhang, Wei-Long Hong, Zhi-Ming Li, Qi-Yu Zhang, Kang Zen. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery vol 45 issue 2 2021 32350561 |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-04-19 |
2023-01-26 |
Not clear |
| Yanping Wei, Tingting Wang, Ningning Zhang, Yunyun Ma, Siji Shi, Ruxing Zhang, Xianzhao Zheng, Lindong Zha. LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis. Journal of molecular histology vol 52 issue 2 2021 33675502 |
hypertrophic scar (hs), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. |
2021-04-17 |
2023-01-26 |
Not clear |
| Gabriela S Kronemberger, Gisele M L Dalm\\xc3\\xb4nico, Andr\\xc3\\xa9 L Rossi, Paulo Em\\xc3\\xadlio Correa Leite, Antonio M Saraiva, Anderson Beatrici, Karina Ribeiro Silva, Jos\\xc3\\xa9 Mauro Granjeiro, Leandra Santos Baptist. Scaffold- and serum-free hypertrophic cartilage tissue engineering as an alternative approach for bone repair. Artificial organs vol 44 issue 7 2021 31950507 |
human adipose stem/stromal cell (asc) spheroids were used as a serum-free in vitro model to recapitulate the molecular events and extracellular matrix organization that orchestrate a hypertrophic cartilage phenotype. |
2021-04-12 |
2023-01-26 |
human |
| Danying Wang, Bo Che. The Mechanism of miR-222 Targets Matrix Metalloproteinase 1 in Regulating Fibroblast Proliferation in Hypertrophic Scars. Aesthetic plastic surgery vol issue 2021 33768305 |
the mechanism of mir-222 targets matrix metalloproteinase 1 in regulating fibroblast proliferation in hypertrophic scars. |
2021-03-26 |
2023-01-26 |
Not clear |
| Jinxia Zhang, Zhikuan Xia, Shuanglin Zhou, Wanting Luo, Zhuoying Peng, Rongya Yan. Effect of Artesunate Combined With Fractional CO Lasers in surgery and medicine vol issue 2021 33644924 |
effect of artesunate combined with fractional co hypertrophic scar (hs), a common complication in wound healing, is characterized by the disarrangement of collagen, fibers, and extracellular matrix. |
2021-03-18 |
2023-01-26 |
Not clear |
| Marietta Herrmann, Klaus Engelke, Regina Ebert, Sigrid M\\xc3\\xbcller-Deubert, Maximilian Rudert, Fani Ziouti, Franziska Jundt, Dieter Felsenberg, Franz Jako. Interactions between Muscle and Bone-Where Physics Meets Biology. Biomolecules vol 10 issue 3 2021 32164381 |
this may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. |
2021-03-17 |
2023-01-26 |
Not clear |
| Yuyan Pan, Zhiwei Chen, Fazhi Qi, Jiaqi Li. Identification of drug compounds for keloids and hypertrophic scars: drug discovery based on text mining and DeepPurpose. Annals of translational medicine vol 9 issue 4 2021 33708974 |
keloids (kl) and hypertrophic scars (hs) are forms of abnormal cutaneous scarring characterized by excessive deposition of extracellular matrix and fibroblast proliferation. |
2021-03-13 |
2023-01-26 |
Not clear |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine vol 21 issue 4 2021 33680106 |
hypertrophic scars (hss) are characterized by excessive extracellular matrix deposition and excessive growth of dense fibrous tissues. |
2021-03-10 |
2023-01-26 |
human |
| Ugo E Pazzaglia, Marcella Reguzzoni, Lavinia Casati, Valeria Sibilia, Guido Zarattini, Mario Raspant. New morphological evidence of the 'fate' of growth plate hypertrophic chondrocytes in the general context of endochondral ossification. Journal of anatomy vol 236 issue 2 2021 31820452 |
furthermore, the study provided evidence that the metaphyseal capillaries could advance inside the columns of stacked hypertrophic chondrocytes (delimited by the intercolumnar septa) without the need for calcified matrix resorption because the thin transverse septa between the stacked chondrocyte (below the mineral deposition line) were not calcified. |
2021-03-09 |
2023-01-26 |
Not clear |