| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aykhan Yusifov, Vikram E Chhatre, Jacob M Zumo, Ross F Cook, Benjamin D McNair, Emily E Schmitt, Kathleen C Woulfe, Danielle R Brun. Cardiac response to adrenergic stress differs by sex and across the lifespan. GeroScience. vol 43. issue 4. 2021-10-28. PMID:33651247. |
adults increased myocyte cell size and deposited fibrotic matrix in response to iso, while juvenile and aged animals did not show evidence of hypertrophy or fibrosis. |
2021-10-28 |
2023-08-13 |
mouse |
| Natalya Bildyu. Integrins in cardiac hypertrophy: lessons learned from culture systems. ESC heart failure. vol 8. issue 5. 2021-10-28. PMID:34232557. |
the lessons learned from culture experiments on the models of hypertrophy induced by stretch, stimulating factors, and/or extracellular matrix components are summarized, demonstrating the major involvement of integrin-mediated signalling in cardiac hypertrophic response and its apparent crosstalk with signal pathways induced by stretch or hypertrophy stimulating factors. |
2021-10-28 |
2023-08-13 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology. vol 99. issue 4. 2021-10-27. PMID:32726570. |
p75ntr silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the pi3k/akt/mtor pathway. |
2021-10-27 |
2023-08-13 |
Not clear |
| Wen Shi, Yan Wu, Donghui Bia. p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Canadian journal of physiology and pharmacology. vol 99. issue 4. 2021-10-27. PMID:32726570. |
hypertrophic scar (hs) results from abnormal wound healing, accompanied by excessive hypercellularity, migration, and extracellular matrix (ecm) deposition. |
2021-10-27 |
2023-08-13 |
Not clear |
| Susumu Horikoshi, Mikihito Kajiya, Souta Motoike, Mai Yoshino, Shin Morimoto, Hiroki Yoshii, Tomoya Ogawa, Hisakatsu Sone, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihar. Clumps of Mesenchymal Stem Cells/Extracellular Matrix Complexes Generated with Xeno-Free Chondro-Inductive Medium Induce Bone Regeneration via Endochondral Ossification. Biomedicines. vol 9. issue 10. 2021-10-26. PMID:34680525. |
c-mscs generated with xf-cim showed enlarged round cells, cartilage matrix, and hypertrophic chondrocytes genes elevation in vitro. |
2021-10-26 |
2023-08-13 |
mouse |
| Florian A Wenzl, Samuele Ambrosini, Shafeeq A Mohammed, Simon Kraler, Thomas F Lüscher, Sarah Costantino, Francesco Panen. Inflammation in Metabolic Cardiomyopathy. Frontiers in cardiovascular medicine. vol 8. 2021-10-22. PMID:34671656. |
at the cellular level, inflammation-induced oxidative stress, mitochondrial dysfunction, impaired calcium handling, and lipotoxicity contribute to cardiomyocyte hypertrophy and dysfunction, extracellular matrix accumulation and microvascular disease. |
2021-10-22 |
2023-08-13 |
Not clear |
| Donghong Fang, Xuesi Wan, Wanping Deng, Hongyu Guan, Weijian Ke, Haipeng Xiao, Yanbing L. Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats. Experimental and therapeutic medicine. vol 4. issue 5. 2021-10-21. PMID:23226741. |
however, only middle and high doses of fxst prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. |
2021-10-21 |
2023-08-12 |
rat |
| Zhi Cong Wang, Hui Jun Sun, Kai Hua Li, Chao Fu, Mo Zhen Li. Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289054. |
icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy icariin (ica), a traditional chinese medicine, has been demonstrated to be a promoting compound for extracellular matrix synthesis and gene expression of chondrocytes. |
2021-10-21 |
2023-08-13 |
rat |
| Ning Wang, Lu Lu, Qi Feng Cao, Subo Qian, Jie Ding, Chen Wang, Huangqi Duan, Haibo Shen, Jun Q. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34237300. |
the bladder undergoes profound structural alterations after bladder outlet obstruction (boo), characterized by hypertrophy of the bladder wall and accumulation of extracellular matrix (ecm). |
2021-10-19 |
2023-08-13 |
mouse |
| Matthew Anderson-Baron, Melanie Kunze, Aillette Mulet-Sierra, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B Adesid. Nasal Chondrocyte-Derived Soluble Factors Affect Chondrogenesis of Cocultured Mesenchymal Stem Cells. Tissue engineering. Part A. vol 27. issue 1-2. 2021-10-15. PMID:32122264. |
engineered cartilage from cocultures exposed to the pure nc construct exhibited reduced chondrogenic potential relative to control constructs, shown by reduced extracellular matrix deposition and increased expression of hypertrophic markers. |
2021-10-15 |
2023-08-13 |
human |
| Irma Bernadette Simbolon Sitohang, Sondang Aemilia P Sirait, Fadhila Dea Safir. Fractional carbon dioxide laser for treating hypertrophic scars: A systematic review of randomised trials. The Australasian journal of dermatology. 2021-10-12. PMID:34628639. |
hypertrophic scars present collagen deposition and an abnormal extracellular matrix that cause abnormal shape changes and limit normal movement. |
2021-10-12 |
2023-08-13 |
Not clear |
| Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Le. SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression. NPJ Regenerative medicine. vol 6. issue 1. 2021-10-06. PMID:34535669. |
the knockdown of spry4 in healthy chondrocytes caused an increase in hypertrophy, senescence, reactive oxygen species (ros) production, and extracellular matrix (ecm) protease expression. |
2021-10-06 |
2023-08-13 |
human |
| Song Tian, Yongjun Zheng, Shichu Xiao, Pengfei Luo, Rongju Sun, Jun Liu, Zhaofan Xi. Ivermectin inhibits cell proliferation and the expression levels of type I collagen, α‑SMA and CCN2 in hypertrophic scar fibroblasts. Molecular medicine reports. vol 24. issue 1. 2021-10-05. PMID:33955514. |
a hypertrophic scar (hps) is characterized by abnormal cell proliferation and the overproduction of extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |
| Fred S Lamb, Hyehun Choi, Michael R Miller, Ryan J Star. TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis. American journal of hypertension. vol 33. issue 10. 2021-09-29. PMID:32498083. |
this "phenotypic switching" promotes proliferation and production of extracellular matrix proteins which are associated with medial hypertrophy. |
2021-09-29 |
2023-08-13 |
mouse |
| Cheong Hoon Seo, Hui Song Cui, June-Bum Ki. Altered K Translational research : the journal of laboratory and clinical medicine. vol 236. 2021-09-29. PMID:33905948. |
altered k hypertrophic scars are the most common post-burn complications characterized by fibroblast proliferation and excessive extracellular matrix deposition. |
2021-09-29 |
2023-08-13 |
Not clear |
| Wenjie Guo, Weijing Feng, Xianglin Fan, Jing Huang, Caiwen Ou, Minsheng Che. Osteomodulin is a Potential Genetic Target for Hypertrophic Cardiomyopathy. Biochemical genetics. vol 59. issue 5. 2021-09-28. PMID:33715137. |
its features include abnormal cardiomyocyte hypertrophy, microvascular dysfunction, and increased accumulation of intercellular matrix. |
2021-09-28 |
2023-08-13 |
Not clear |
| Yongsheng Li, Wei Chen, Yao Dai, Yuting Huang, Zongming Chen, Tingfei Xi, Zheng Zhou, Hairong Li. Decellularized sturgeon cartilage extracellular matrix scaffold inhibits chondrocyte hypertrophy in vitro and in vivo. Journal of tissue engineering and regenerative medicine. vol 15. issue 8. 2021-09-14. PMID:34032003. |
decellularized sturgeon cartilage extracellular matrix scaffold inhibits chondrocyte hypertrophy in vitro and in vivo. |
2021-09-14 |
2023-08-13 |
mouse |
| João Santos-Faria, Cristina Gavina, Patrícia Rodrigues, João Coelho, Paula da Costa Martins, Adelino Leite-Moreira, Inês Falcão-Pire. MicroRNAs and ventricular remodeling in aortic stenosis. Revista portuguesa de cardiologia. vol 39. issue 7. 2021-08-31. PMID:32682570. |
we hypothesized that their expression in myocardial biopsies from patients with as could be linked with the degree of left ventricular (lv) hypertrophy and remodeling and to plasma levels of important biomarkers of extracellular matrix turnover. |
2021-08-31 |
2023-08-13 |
Not clear |
| Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Le. Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis. Pharmaceutics. vol 13. issue 8. 2021-08-31. PMID:34452101. |
as the pathological processes in the oa cartilage microenvironment, such as the alterations in the extracellular matrix, are initiated and dictated by the physiological state of the chondrocytes, in-depth knowledge of chondrocyte hypertrophy is necessary to enhance our understanding of the disease pathology and develop therapeutic agents. |
2021-08-31 |
2023-08-13 |
Not clear |
| Falguni Das, Amit Bera, Nandini Ghosh-Choudhury, Kavitha Sataranatarajan, Amrita Kamat, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose-stimulated enhancer of zeste homolog-2 (EZH2) forces suppression of deptor to cause glomerular mesangial cell pathology. Cellular signalling. vol 86. 2021-08-30. PMID:34224844. |
together, our findings provide a novel mechanism for mtor activation via ezh2 to induce mesangial cell hypertrophy and matrix expansion during early progression of diabetic nephropathy. |
2021-08-30 |
2023-08-13 |
mouse |