| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Fakir, J Wegrowski, P Bour, A Joundi, J Chanard, F X Maquar. [Synthesis of collagen in culture of endothelial cells of the human umbilical vein. Effects of cyclosporine A]. Presse medicale (Paris, France : 1983). vol 21. issue 41. 1993-04-12. PMID:1294948. |
interstitial renal fibrosis and gingival hypertrophy are frequent side-effects of cyclosporin a which have been attributed to a dysfunction of extracellular matrix synthesis. |
1993-04-12 |
2023-08-11 |
human |
| S M Austin, J S Lieberman, L D Newton, M Mejia, W A Peters, B D Myer. Slope of serial glomerular filtration rate and the progression of diabetic glomerular disease. Journal of the American Society of Nephrology : JASN. vol 3. issue 7. 1993-04-01. PMID:8439648. |
remaining open glomeruli exhibited hypertrophy, excessive extracellular matrix, and deformation of epithelial podocytes. |
1993-04-01 |
2023-08-12 |
Not clear |
| E Bonucci, G Silvestrin. Immunohistochemical investigation on the presence of chondroitin sulfate in calcification nodules of epiphyseal cartilage. European journal of histochemistry : EJH. vol 36. issue 4. 1993-03-23. PMID:1283829. |
these results show that cs-56, besides reacting with cytoplasm of maturing and hypertrophic chondrocytes, binds to crystal ghosts and other components of cartilage matrix, immunoreactivity decreasing as calcification increases. |
1993-03-23 |
2023-08-11 |
mouse |
| T Kirsch, B Swoboda, K von der Mar. Ascorbate independent differentiation of human chondrocytes in vitro: simultaneous expression of types I and X collagen and matrix mineralization. Differentiation; research in biological diversity. vol 52. issue 1. 1993-03-18. PMID:1286778. |
from these observations we conclude a sequence of events ultimately leading to matrix calcification in chondrocyte nodules in vitro that begins with chondrocyte hypertrophy and the initiation of type x collagen synthesis, followed by the increase of intracellular calcium, the deposition of calcium mineral, and finally by the onset of type i collagen synthesis. |
1993-03-18 |
2023-08-11 |
human |
| F N Ziyade. Renal tubular basement membrane and collagen type IV in diabetes mellitus. Kidney international. vol 43. issue 1. 1993-03-18. PMID:8433550. |
it has been postulated that in the earlier stages of the disease, hyperglycemia induces renal tubular hypertrophy and stimulates the synthesis of the various matrix components which are normal constituents of the tbm. |
1993-03-18 |
2023-08-12 |
Not clear |
| P LuValle, K Daniels, E D Hay, B R Olse. Type X collagen is transcriptionally activated and specifically localized during sternal cartilage maturation. Matrix (Stuttgart, Germany). vol 12. issue 5. 1993-02-12. PMID:1484507. |
type x collagen is an extracellular matrix protein which is synthesized by chondrocytes when they undergo hypertrophy. |
1993-02-12 |
2023-08-11 |
chicken |
| G L Engelmann, C A Dionne, M C Jay. Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis. Circulation research. vol 72. issue 1. 1993-01-29. PMID:7678079. |
in concert with the neonatal "transition" from proliferative to hypertrophic growth, ventricular remodeling of the nonmyocyte compartment is characterized by increased extracellular matrix synthesis/deposition and capillary angiogenesis. |
1993-01-29 |
2023-08-12 |
Not clear |
| B L Riser, P Cortes, X Zhao, J Bernstein, F Dumler, R G Narin. Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat. The Journal of clinical investigation. vol 90. issue 5. 1992-12-22. PMID:1430216. |
to define the interplay of glomerular hypertension and hypertrophy with mesangial extracellular matrix (ecm) deposition, we examined the effects of glomerular capillary distention and mesangial cell stretching on ecm synthesis. |
1992-12-22 |
2023-08-11 |
rat |
| K Ishizeki, N Kuroda, H Nagano, T Naw. Morphological modifications during long-term survival of Meckel's cartilage hypertrophic chondrocytes transplanted in the mouse spleen. Archives of histology and cytology. vol 55. issue 3. 1992-12-17. PMID:1419276. |
some remaining hypertrophic cells in the calcified matrix had transformed into osteocyte-like cells. |
1992-12-17 |
2023-08-11 |
mouse |
| K Ishizeki, N Kuroda, H Nagano, T Naw. Morphological modifications during long-term survival of Meckel's cartilage hypertrophic chondrocytes transplanted in the mouse spleen. Archives of histology and cytology. vol 55. issue 3. 1992-12-17. PMID:1419276. |
hypertrophic chondrocytes, now exposed from cellular lacunae, and the osteocyte-like cells in the calcified matrix displayed involutional changes. |
1992-12-17 |
2023-08-11 |
mouse |
| R Quarto, G Campanile, R Cancedda, B Dozi. Thyroid hormone, insulin, and glucocorticoids are sufficient to support chondrocyte differentiation to hypertrophy: a serum-free analysis. The Journal of cell biology. vol 119. issue 4. 1992-12-04. PMID:1429844. |
when ascorbic acid is added to the hormone-supplemented medium, differentiating chondrocytes organize their matrix leading to a cartilage-like structure with hypertrophic chondrocytes embedded in lacunae. |
1992-12-04 |
2023-08-11 |
chicken |
| H I Roac. Trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix. Bone and mineral. vol 19. issue 1. 1992-12-03. PMID:1422302. |
trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix. |
1992-12-03 |
2023-08-11 |
chicken |
| Y Ben-Ami, D Lewinson, M Silberman. Structural characterization of the mandibular condyle in human fetuses: light and electron microscopy studies. Acta anatomica. vol 145. issue 1. 1992-11-25. PMID:1414216. |
the matrix in the hypertrophic cell layer reveals distinct matrix vesicles that undergo mineralization and subsequently coalesce to form larger sheets of mineralized extracellular matrix. |
1992-11-25 |
2023-08-11 |
human |
| S Jingushi, M E Joyce, M E Bolande. Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 7. issue 9. 1992-11-19. PMID:1414497. |
messenger rnas for these proteins in the soft callus were detected at low levels during chondrogenesis (day 9) but increased to 80% of maximal levels with chondrocyte hypertrophy and mineralization of the cartilage matrix (day 13). |
1992-11-19 |
2023-08-11 |
rat |
| F Shapir. Vertebral development of the chick embryo during days 3-19 of incubation. Journal of morphology. vol 213. issue 3. 1992-11-03. PMID:1404404. |
clumps of growth plate cartilage cells and matrix are surrounded occasionally by newly synthesized bone, but invasion of individual hypertrophic chondrocyte lacunae by vessels with bone deposition by accompanying osteoblasts on single trabeculae of cartilage does not occur. |
1992-11-03 |
2023-08-11 |
chicken |
| M R Coe, T A Summers, S J Parsons, A L Boskey, G Balia. Matrix mineralization in hypertrophic chondrocyte cultures. Beta glycerophosphate increases type X collagen messenger RNA and the specific activity of pp60c-src kinase. Bone and mineral. vol 18. issue 2. 1992-10-20. PMID:1381978. |
matrix mineralization in hypertrophic chondrocyte cultures. |
1992-10-20 |
2023-08-11 |
Not clear |
| M R Coe, T A Summers, S J Parsons, A L Boskey, G Balia. Matrix mineralization in hypertrophic chondrocyte cultures. Beta glycerophosphate increases type X collagen messenger RNA and the specific activity of pp60c-src kinase. Bone and mineral. vol 18. issue 2. 1992-10-20. PMID:1381978. |
the phenomenon of chondrocyte hypertrophy is accompanied by the expression of type x collagen and the appearance of matrix mineralization. |
1992-10-20 |
2023-08-11 |
Not clear |
| T Kirsch, K von der Mar. Remodelling of collagen types I, II and X and calcification of human fetal cartilage. Bone and mineral. vol 18. issue 2. 1992-10-20. PMID:1525593. |
by immunofluorescence double staining we demonstrate codistribution of type ii and x collagen in the hypertrophic zone, while type i collagen was absent from hypertrophic cartilage matrix; it was detected only in the perichondrium, in vascular cavities, and in osteoid and bone. |
1992-10-20 |
2023-08-11 |
human |
| F J Villarreal, W H Dillman. Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen. The American journal of physiology. vol 262. issue 6 Pt 2. 1992-08-04. PMID:1535758. |
cardiac hypertrophy induced by pressure overload is accompanied by increases in the deposition of extracellular matrix (ecm) proteins. |
1992-08-04 |
2023-08-11 |
rat |
| M Miyamoto, H Koike, T Sada, Y Ijima, J Fukushige, N Nakamur. The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats. Lipids. vol 26. issue 12. 1992-07-30. PMID:1819723. |
histological changes in this model (glomerular hypertrophy, proliferation of mesangial matrix and interstitial fibrosis) were also ameliorated by the r-75,317 treatment. |
1992-07-30 |
2023-08-11 |
human |