All Relations between local circuit neuron and prefrontal cortex

Reference Sentence Publish Date Extraction Date Species
Eastman M Lewis, Hayli E Spence, Neha Akella, Andres Buonann. Pathway-specific contribution of parvalbumin interneuron NMDARs to synaptic currents and thalamocortical feedforward inhibition. Molecular psychiatry vol issue 2022 36075962 despite the importance of inhibitory gabaergic parvalbumin-expressing (pv+) interneurons to pfc circuit function and decades of interest in n-methyl-d-aspartate receptors (nmdars) in these neurons, examples of defined circuit functions that depend on pv+ interneuron nmdars have been elusive. 2022-09-08 2022-09-14 Not clear
Katherine J Robinson, Nicholas A Everett, Sarah J Baracz, Jennifer L Cornis. The effect of self-administered methamphetamine on GABAergic interneuron populations and functional connectivity of the nucleus accumbens and prefrontal cortex. Psychopharmacology vol issue 2022 35920922 here we investigate meth-induced changes to neuronal nitric oxide synthase (nnos), parvalbumin and calretinin-expressing gabaergic interneuron populations within the nucleus accumbens (nac), prefrontal cortex (pfc) and orbitofrontal cortex (ofc). 2022-08-03 2022-08-08 Not clear
Deborah J Luessen, Isabel Gallinger, P J Con. mGlu FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35554597 furthermore, adolescent exposure to psychostimulants impairs gaba interneuron function and inhibitory transmission in the pfc in adulthood, suggesting that enhancing pfc inhibitory transmission may be a promising strategy to mitigate drug-induced cognitive deficits observed later in life. 2022-05-13 2022-06-13 Not clear
Max E Joffe, Danny G Winder, P Jeffrey Con. Contrasting sex-dependent adaptations to synaptic physiology and membrane properties of prefrontal cortex interneuron subtypes in a mouse model of binge drinking. Neuropharmacology vol 178 issue 2021 32781000 to address this gap, we generated fluorescent reporter transgenic mice to label the two major classes of interneuron in deep layer prelimbic pfc, based on expression of parvalbumin (pv-in) or somatostatin (sst-in). 2021-08-12 2022-01-13 Not clear
Max E Joffe, Danny G Winder, P Jeffrey Con. Contrasting sex-dependent adaptations to synaptic physiology and membrane properties of prefrontal cortex interneuron subtypes in a mouse model of binge drinking. Neuropharmacology vol 178 issue 2021 32781000 essential regulation of pfc output is provided by local inhibitory interneurons, yet how drinking affects interneuron physiology remains poorly understood, particularly in female individuals. 2021-08-12 2022-01-13 Not clear
D A Maas, V D Eijsink, J A van Hulten, R Panic, P De Weerd, J R Homberg, A Vall\\xc3\\xa8s, B Nait-Oumesmar, G J M Marten. Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 46 issue 6 2021 33564104 cognitive dysfunction in schizophrenia (sz) is thought to arise from neurodevelopmental abnormalities that include interneuron hypomyelination in the prefrontal cortex (pfc). 2021-06-23 2022-01-13 Not clear
Huijeong Jeong, Dohoung Kim, Min Song, Se-Bum Paik, Min Whan Jun. Distinct roles of parvalbumin- and somatostatin-expressing neurons in flexible representation of task variables in the prefrontal cortex. Progress in neurobiology vol 187 issue 2021 32070716 to investigate roles of different interneuron subtypes in this process, we examined discharge characteristics and inactivation effects of parvalbumin (pv)- and somatostatin (sst)-expressing neurons in the mouse pfc during probabilistic classical conditioning. 2021-02-08 2022-01-13 Not clear
Matthew J Girgenti, Eric S Wohleb, Sameet Mehta, Sriparna Ghosal, Manoela V Fogaca, Ronald S Duma. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry vol 9 issue 1 2020 31712551 using sst- and parvalbumin-fluorescence tagged reporter mice and fluorescence-activated cell sorting (facs) combined with rna sequencing, we identify distinct transcriptome profiles for these interneuron subtypes in the medial pfc. 2020-08-05 2022-01-14 Not clear
Matthew J Girgenti, Eric S Wohleb, Sameet Mehta, Sriparna Ghosal, Manoela V Fogaca, Ronald S Duma. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry vol 9 issue 1 2020 31712551 here, we analyze the transcriptional profiles and the effects of chronic stress in males vs. females on gaba interneuron subtypes in the pfc. 2020-08-05 2022-01-14 Not clear
Dorien A Maas, Vivian D Eijsink, Marcia Spoelder, Josephus A van Hulten, Peter De Weerd, Judith R Homberg, Astrid Vall\\xc3\\xa8s, Brahim Nait-Oumesmar, Gerard J M Marten. Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia. Nature communications vol 11 issue 1 2020 32393757 impaired cognitive functioning is a core feature of schizophrenia, and is hypothesized to be due to myelination as well as interneuron defects during adolescent prefrontal cortex (pfc) development. 2020-08-05 2022-01-13 Not clear
Atheir I Abbas, Marina J M Sundiang, Britt Henoch, Mitchell P Morton, Scott S Bolkan, Alan J Park, Alexander Z Harris, Christoph Kellendonk, Joshua A Gordo. Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding. Neuron vol 100 issue 4 2019 30318409 these findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the hpc and pfc. 2019-08-12 2022-01-13 Not clear
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro vol 6 issue 1 2019 30809588 this pattern of interneuron loss in upper cortical layers was mimicked in the mouse pfc following the combination of mia and csh, but not after either insult alone. 2019-05-21 2022-01-13 Not clear
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro vol 6 issue 1 2019 30809588 a common feature of these psychiatric disorders is prefrontal cortex (pfc) inhibitory circuit disruption due to gabaergic interneuron alteration. 2019-05-21 2022-01-13 Not clear
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro vol 6 issue 1 2019 30809588 based on the changes seen, a new preterm encephalopathy mouse model was developed to produce similar pfc interneuron loss. 2019-05-21 2022-01-13 Not clear
Luke Joseph Bogart, Patricio O'Donnel. Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 43 issue 10 2019 29483660 the observation that multiple long-range inputs to mpfc fsi elicit nmdar currents suggests that the nmdar-hypofunction model of schizophrenia may still imply a loss of interneuron inputs, but the sources of reduced excitation may originate from sites upstream of the pfc. 2019-02-21 2022-01-13 Not clear
Jennifer J Donegan, Angela M Boley, Daniel J Lodg. Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 43 issue 8 2019 29453447 specifically, people with autism have a reduction in parvalbumin (pv)-containing interneurons in the pfc, leading to the suggestion that restoring interneuron function in this region may be a novel therapeutic approach for asd. 2019-02-14 2022-01-13 Not clear
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornis. Behavioral sensitization to methamphetamine induces specific interneuronal mRNA pathology across the prelimbic and orbitofrontal cortices. Progress in neuro-psychopharmacology & biological psychiatry vol 77 issue 2018 28351548 schizophrenia is associated with significant pathophysiological changes to interneurons within the prefrontal cortex (pfc), with mrna and protein changes associated with the gaba network localized to specific interneuron subtypes. 2018-03-05 2022-01-13 Not clear
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornis. Behavioral sensitization to methamphetamine induces specific interneuronal mRNA pathology across the prelimbic and orbitofrontal cortices. Progress in neuro-psychopharmacology & biological psychiatry vol 77 issue 2018 28351548 the aim of this study, therefore, was to examine mrna expression of interneuron markers across two regions of the pfc (prelimbic (prl) and orbitofrontal cortices (ofc)) following meth sensitization, an animal model of meth psychosis. 2018-03-05 2022-01-13 Not clear
Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums vol 21 issue 2 2016 26250622 vortioxetine is expected to reduce gabaergic interneuron activity in the pfc and concomitantly increase cortical pyramidal neuron firing. 2016-07-19 2022-01-12 Not clear
Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums vol 21 issue 2 2016 26250622 this analysis suggests that 5-ht and ssris will have markedly different effects within the pfc, where they will induce mixed effects on gaba and glutamate neurotransmission, compared to the striatum, where they will enhance gabaergic interneuron activity and drive down the activity of medium spiny neurons. 2016-07-19 2022-01-12 Not clear
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