All Relations between local circuit neuron and prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Dorien A Maas, Vivian D Eijsink, Marcia Spoelder, Josephus A van Hulten, Peter De Weerd, Judith R Homberg, Astrid Vallès, Brahim Nait-Oumesmar, Gerard J M Marten. Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia. Nature communications. vol 11. issue 1. 2020-08-05. PMID:32393757. impaired cognitive functioning is a core feature of schizophrenia, and is hypothesized to be due to myelination as well as interneuron defects during adolescent prefrontal cortex (pfc) development. 2020-08-05 2023-08-13 rat
Adith Mohan, Anbupalam Thalamuthu, Karen A Mather, Yiru Zhang, Vibeke S Catts, Cynthia Shannon Weickert, Perminder S Sachde. Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. Neurobiology of aging. vol 70. 2019-09-27. PMID:30031232. differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. 2019-09-27 2023-08-13 human
Adith Mohan, Anbupalam Thalamuthu, Karen A Mather, Yiru Zhang, Vibeke S Catts, Cynthia Shannon Weickert, Perminder S Sachde. Differential expression of synaptic and interneuron genes in the aging human prefrontal cortex. Neurobiology of aging. vol 70. 2019-09-27. PMID:30031232. we hypothesized that expression of 14 genes encoding proteins localized to synapses or interneurons would show age-related changes relative to 1 another in postmortem tissue from the prefrontal cortex of 37 individuals (18-78 years) and that synaptic or interneuron markers would be differentially correlated with human brain volumes across aging. 2019-09-27 2023-08-13 human
Atheir I Abbas, Marina J M Sundiang, Britt Henoch, Mitchell P Morton, Scott S Bolkan, Alan J Park, Alexander Z Harris, Christoph Kellendonk, Joshua A Gordo. Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding. Neuron. vol 100. issue 4. 2019-08-12. PMID:30318409. these findings suggest that interneuron dysfunction may contribute to cognitive deficits associated with schizophrenia by disrupting long-range synchrony between the hpc and pfc. 2019-08-12 2023-08-13 mouse
Robert W Green. Defining the Role of Interneuron N-Methyl-D-Aspartate Receptors in Prefrontal Cortex Inhibition. Biological psychiatry. vol 84. issue 6. 2019-06-19. PMID:30165951. defining the role of interneuron n-methyl-d-aspartate receptors in prefrontal cortex inhibition. 2019-06-19 2023-08-13 Not clear
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro. vol 6. issue 1. 2019-05-21. PMID:30809588. a common feature of these psychiatric disorders is prefrontal cortex (pfc) inhibitory circuit disruption due to gabaergic interneuron alteration. 2019-05-21 2023-08-13 mouse
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro. vol 6. issue 1. 2019-05-21. PMID:30809588. based on the changes seen, a new preterm encephalopathy mouse model was developed to produce similar pfc interneuron loss. 2019-05-21 2023-08-13 mouse
Helene Lacaille, Claire-Marie Vacher, Dana Bakalar, Jiaqi J O'Reilly, Jacquelyn Salzbank, Anna A Pen. Impaired Interneuron Development in a Novel Model of Neonatal Brain Injury. eNeuro. vol 6. issue 1. 2019-05-21. PMID:30809588. this pattern of interneuron loss in upper cortical layers was mimicked in the mouse pfc following the combination of mia and csh, but not after either insult alone. 2019-05-21 2023-08-13 mouse
Luke Joseph Bogart, Patricio O'Donnel. Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 10. 2019-02-21. PMID:29483660. the observation that multiple long-range inputs to mpfc fsi elicit nmdar currents suggests that the nmdar-hypofunction model of schizophrenia may still imply a loss of interneuron inputs, but the sources of reduced excitation may originate from sites upstream of the pfc. 2019-02-21 2023-08-13 mouse
Jennifer J Donegan, Angela M Boley, Daniel J Lodg. Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 8. 2019-02-14. PMID:29453447. specifically, people with autism have a reduction in parvalbumin (pv)-containing interneurons in the pfc, leading to the suggestion that restoring interneuron function in this region may be a novel therapeutic approach for asd. 2019-02-14 2023-08-13 Not clear
Suijuan Zhong, Shu Zhang, Xiaoying Fan, Qian Wu, Liying Yan, Ji Dong, Haofeng Zhang, Long Li, Le Sun, Na Pan, Xiaohui Xu, Fuchou Tang, Jun Zhang, Jie Qiao, Xiaoqun Wan. A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex. Nature. vol 555. issue 7697. 2018-08-16. PMID:29539641. we also map the timeline of neurogenesis of excitatory neurons in the prefrontal cortex and detect the presence of interneuron progenitors in early developing prefrontal cortex. 2018-08-16 2023-08-13 human
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornis. Behavioral sensitization to methamphetamine induces specific interneuronal mRNA pathology across the prelimbic and orbitofrontal cortices. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28351548. schizophrenia is associated with significant pathophysiological changes to interneurons within the prefrontal cortex (pfc), with mrna and protein changes associated with the gaba network localized to specific interneuron subtypes. 2018-03-05 2023-08-13 Not clear
Travis A Wearne, Lindsay M Parker, Jane L Franklin, Ann K Goodchild, Jennifer L Cornis. Behavioral sensitization to methamphetamine induces specific interneuronal mRNA pathology across the prelimbic and orbitofrontal cortices. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28351548. the aim of this study, therefore, was to examine mrna expression of interneuron markers across two regions of the pfc (prelimbic (prl) and orbitofrontal cortices (ofc)) following meth sensitization, an animal model of meth psychosis. 2018-03-05 2023-08-13 Not clear
Jennifer J Donegan, Daniel J Lodg. Cell-based therapies for the treatment of schizophrenia. Brain research. vol 1655. 2017-08-08. PMID:27544423. therefore, it has been hypothesized that restoring interneuron function in the hippocampus and/or prefrontal cortex may be an effective treatment strategy for schizophrenia. 2017-08-08 2023-08-13 Not clear
Carine H do Prado, Tanya Narahari, Freedom H Holland, Ha-Neul Lee, Shashi K Murthy, Heather C Brenhous. Effects of early adolescent environmental enrichment on cognitive dysfunction, prefrontal cortex development, and inflammatory cytokines after early life stress. Developmental psychobiology. vol 58. issue 4. 2017-01-17. PMID:26688108. significant correlations indicated that adolescents with higher oxidative damage and less prefrontal cortex parvalbumin in adolescence committed more errors on the win-shift task; therefore, maternal separation may affect cognitive dysfunction via aberrant interneuron development. 2017-01-17 2023-08-13 rat
Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. this analysis suggests that 5-ht and ssris will have markedly different effects within the pfc, where they will induce mixed effects on gaba and glutamate neurotransmission, compared to the striatum, where they will enhance gabaergic interneuron activity and drive down the activity of medium spiny neurons. 2016-07-19 2023-08-13 Not clear
Alan L Pehrson, Theepica Jeyarajah, Connie Sanche. Regional distribution of serotonergic receptors: a systems neuroscience perspective on the downstream effects of the multimodal-acting antidepressant vortioxetine on excitatory and inhibitory neurotransmission. CNS spectrums. vol 21. issue 2. 2016-07-19. PMID:26250622. vortioxetine is expected to reduce gabaergic interneuron activity in the pfc and concomitantly increase cortical pyramidal neuron firing. 2016-07-19 2023-08-13 Not clear
Luc Estebanez, Jens Kremkow, James F A Poule. Matching Cell Type to Function in Cortical Circuits. Neuron. vol 87. issue 2. 2015-09-29. PMID:26182411. in this issue of neuron, pinto and dan (2015) performed single-cell calcium imaging in the mouse dorsomedial prefrontal cortex to reveal correlated, cell-type-specific responses in three major gaba-ergic interneuron subtypes during a goal-directed sensory discrimination task. 2015-09-29 2023-08-13 mouse
Dipesh Joshi, Janice M Fullerton, Cynthia Shannon Weicker. Elevated ErbB4 mRNA is related to interneuron deficit in prefrontal cortex in schizophrenia. Journal of psychiatric research. vol 53. 2014-11-24. PMID:24636039. elevated erbb4 mrna is related to interneuron deficit in prefrontal cortex in schizophrenia. 2014-11-24 2023-08-12 human
Xanthippi Konstantoudaki, Athanasia Papoutsi, Kleanthi Chalkiadaki, Panayiota Poirazi, Kyriaki Sidiropoulo. Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24550786. to this end, we constructed a pfc microcircuit, consisting of pyramidal neuron models and all three different interneuron types: fast-spiking (fs), regular-spiking (rs), and irregular-spiking (is) interneurons. 2014-09-24 2023-08-12 Not clear