| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. |
microglia, and specifically those expressing the ad risk gene trem2, are considered important players in ad, but their exact contribution to pathology remains unclear. |
2024-04-18 |
2024-04-21 |
mouse |
| Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. |
in this study, using high-throughput mass cytometry in the 5×fad mouse model of amyloidosis, we identified senescent microglia that express high levels of trem2 but also exhibit a distinct signature from trem2-dependent disease-associated microglia (dam). |
2024-04-18 |
2024-04-21 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
microglia play a pivotal role in the pathology of alzheimer's disease (ad), with the triggering receptor expressed on myeloid cells 2 (trem2) central to their neuroprotective functions. |
2024-04-13 |
2024-04-16 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
in summary, our findings offer a deeper understanding of the relationship between trem2 variants and ship1 in microglial functions, and emphasize the therapeutic potential of targeting the trem2 and ship1 pathways in microglia for neurodegenerative diseases. |
2024-04-13 |
2024-04-16 |
mouse |
| Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fu. Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation. American journal of Alzheimer's disease and other dementias. vol 39. 2024-04-09. PMID:38592304. |
triggering receptor expressed on myeloid cells 2 (trem2) is upregulated in activated microglia and may be related to cognitive decline in patients with alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of trem2. |
2024-03-29 |
2024-03-31 |
mouse |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
in conclusion, the present study suggests that taurine treatment may upregulate trem2 to protect against microglia over-activation by decreasing the accumulation of phospho-tau and aβ; providing an insight into a novel preventive strategy in ad. |
2024-03-29 |
2024-03-31 |
mouse |
| Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wan. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury. European journal of pharmacology. 2024-03-01. PMID:38428662. |
the triggering receptor expressed on myeloid cells 2 (trem2), primarily expressed on microglial cell membranes, plays a critical role in reducing inflammation and oxidative stress in ais. |
2024-03-01 |
2024-03-04 |
mouse |
| Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wan. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury. European journal of pharmacology. 2024-03-01. PMID:38428662. |
in this study, we employed a high-throughput screening (hts) strategy to evaluate 2625 compounds from the (food and drug administration) fda library in vitro to identify compounds that upregulate the trem2 receptor on microglia. |
2024-03-01 |
2024-03-04 |
mouse |
| Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai, Xiaoping Zh. TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway. Molecular brain. vol 17. issue 1. 2024-02-28. PMID:38409127. |
trem2 improves microglia function and synaptic development in autism spectrum disorders by regulating p38 mapk signaling pathway. |
2024-02-28 |
2024-03-01 |
Not clear |
| Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai, Xiaoping Zh. TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway. Molecular brain. vol 17. issue 1. 2024-02-28. PMID:38409127. |
this study aim to explore the potential mechanism of trem2 in regulating microglia function in asd. |
2024-02-28 |
2024-03-01 |
Not clear |
| Ryan Arsenault, Steven Marshall, Patrick Salois, Qiao Li, Wandong Zhan. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology. vol 13. issue 2. 2024-02-23. PMID:38392305. |
trem2 is a critical innate immune receptor primarily expressed on myeloid-derived cells, such as microglia and macrophages. |
2024-02-23 |
2024-02-25 |
Not clear |
| Guoyu Lan, Xuhui Chen, Jie Yang, Pan Sun, Yue Cai, Anqi Li, Yalin Zhu, Zhen Liu, Shaohua Ma, Tengfei Gu. Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau. Annals of neurology. 2024-02-15. PMID:38356322. |
triggering receptor expressed on myeloid cells-2 (trem2) and progranulin (pgrn) are critical regulators of microglia activation and can be detected in cerebrospinal fluid (csf). |
2024-02-15 |
2024-02-17 |
Not clear |
| Tao Yin, Metin Yesiltepe, Luciano D'Adami. Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias. EMBO reports. 2024-02-12. PMID:38347225. |
we observe heightened itm2b/bri2 expression in microglia, a pivotal cell type in ad due to risk-increasing variants in the microglial gene trem2. |
2024-02-12 |
2024-02-15 |
mouse |
| Tao Yin, Metin Yesiltepe, Luciano D'Adami. Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias. EMBO reports. 2024-02-12. PMID:38347225. |
constitutive and microglial-specific itm2b-knock-out mice, and itm2b-knock-out primary microglia provide evidence that bri2 reduces trem2 processing, boosts trem2 mrna expression, and influences trem2 protein levels through α-secretase-independent pathways, revealing a multifaceted bri2-trem2 functional interaction. |
2024-02-12 |
2024-02-15 |
mouse |
| Lin Li, Yu-Lin He, Nan Xu, Xiu-Fen Wang, Bing Song, Ben-Qin Tang, Simon Ming-Yuen Le. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox biology. vol 70. 2024-02-07. PMID:38325196. |
the triggering receptor expressed on myeloid cells 2 (trem2), highly expressed by microglia in the central nervous system (cns), can modulate neuroinflammatory responses. |
2024-02-07 |
2024-02-10 |
zebrafish |
| Lin Li, Yu-Lin He, Nan Xu, Xiu-Fen Wang, Bing Song, Ben-Qin Tang, Simon Ming-Yuen Le. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox biology. vol 70. 2024-02-07. PMID:38325196. |
knockdown of trem2 mrna expression significantly abolished the anti-inflammatory and antioxidant effects of hecubine on lps-stimulated proinflammatory mediators (no, tnf-α, il-6, and il-1β) and oxidative stress in microglia cells. |
2024-02-07 |
2024-02-10 |
zebrafish |
| Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saba. Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine. vol 221. issue 3. 2024-01-30. PMID:38289348. |
microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and trem2. |
2024-01-30 |
2024-02-01 |
mouse |
| André F Batista, Khyrul A Khan, Maria-Tzousi Papavergi, Cynthia A Lemer. The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255891. |
in this review, we provide an overview of previously known and newly established roles for the complement cascade in the cns and we explore how complement interactions with microglia, astrocytes, and other risk factors such as trem2 and apoe4 modulate the processes of neurodegeneration in both amyloid and tau models of ad. |
2024-01-23 |
2024-01-25 |
Not clear |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Aastha Dheer, Jadyn F Perry, Manling Xie, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Impaired microglial phagocytosis promotes seizure development. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260601. |
in the central nervous system, triggering receptor expressed on myeloid cells 2 (trem2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. |
2024-01-23 |
2024-01-25 |
mouse |