Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
microglia are brain-resident innate immune cells and execute inflammatory and phagocytic functions upon environmental stimulation, during which processes triggering receptor expressed on myeloid cells 2 (trem2) plays an important regulatory role. |
2023-12-26 |
2023-12-29 |
mouse |
Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
however, although microglia are known to exhibit innate immune memory related to inflammation when subjected to continuous inflammatory stimuli, whether microglia exhibit innate immune memory related to phagocytosis and whether trem2 participates in innate immune memory of microglia remain unknown. |
2023-12-26 |
2023-12-29 |
mouse |
Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
while 4xlps had no effect on reducing synapse phagocytosis in trem2 ko microglia. |
2023-12-26 |
2023-12-29 |
mouse |
Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
our results demonstrate that microglia also exhibit immune tolerance related to phagocytosis of synapses and that trem2 plays a crucial role in this process possibly through regulating complement system and phagosome-related gene expressions. |
2023-12-26 |
2023-12-29 |
mouse |
Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Correction to: Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2023-12-22. PMID:38129702. |
correction to: cyanidin-3-o-glucoside regulates the m1/m2 polarization of microglia via pparγ and aβ42 phagocytosis through trem2 in an alzheimer's disease model. |
2023-12-22 |
2023-12-24 |
Not clear |
Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
deferoxamine induces autophagy following traumatic brain injury via trem2 on microglia. |
2023-12-19 |
2023-12-21 |
mouse |
Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
however, the role of trem2 in modulating the microglia response in tbi has been rarely investigated. |
2023-12-19 |
2023-12-21 |
mouse |
Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
trem2 expression was up-regulated in cortex of tbi mice model and in microglia stretching model, which was attenuated by dfo. |
2023-12-19 |
2023-12-21 |
mouse |
Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane receptor protein predominantly expressed in microglia within the central nervous system (cns). |
2023-12-02 |
2023-12-10 |
mouse |
Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
recent studies have found that trem2 is highly expressed in activated microglia after ischemic stroke. |
2023-12-02 |
2023-12-10 |
mouse |
Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
meanwhile, in a neuron-microglia co-culture system under hypoxic conditions, we found that microglia lost their protective effect against neuronal injury and apoptosis when trem2 was knocked down. |
2023-12-02 |
2023-12-10 |
mouse |
Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
under in vivo conditions, trem2 knockdown mice express lower tgf-β1 expression levels and a lower number of anti-inflammatory m2 phenotype microglia, resulting in increased cerebral infarct size, exacerbated neuronal apoptosis, and aggravated neuronal impairment. |
2023-12-02 |
2023-12-10 |
mouse |
Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-12-01 |
2023-12-10 |
Not clear |
Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-11-29 |
2023-12-10 |
Not clear |
Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Ki. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014048. |
proximity proteome analysis reveals novel trem2 interactors in the er-mitochondria interface of human microglia. |
2023-11-28 |
2023-11-29 |
human |
Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Ki. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014048. |
trem2 deficiency alters the thickness (inter-organelle distance) of mercs, a structural parameter of metabolic state, in microglia derived from human induced pluripotent stem cells. |
2023-11-28 |
2023-11-29 |
human |
Yanxia Peng, Genmeng Yang, Shangwen Wang, Wanrong Lin, Lihua Zhu, Wenjuan Dong, Baoyu Shen, Qianyun Nie, Shijun Hong, Lihua L. Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation. International journal of toxicology. 2023-11-25. PMID:38006258. |
triggering receptor expressed on myeloid cells 2 (trem2) is reported to play a key role in activation of microglia and neuroinflammation. |
2023-11-25 |
2023-11-28 |
mouse |
Oliver Cousins, Julia J Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O'Neill, David Collier, Ramla Awais, Kerstin Sander, Erik Årstad, Oliver Howes, Federico Turkheimer, Angela Hodge. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge. Journal of neuroinflammation. vol 20. issue 1. 2023-11-22. PMID:37990275. |
trem2 is a microglial cell surface receptor. |
2023-11-22 |
2023-11-29 |
Not clear |
Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
ipsc-derived microglia carrying the trem2 r47h/+ mutation are proinflammatory and promote synapse loss. |
2023-11-16 |
2023-11-20 |
mouse |
Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
we employed gene editing and stem cell models to gain insight into the effects of the trem2 r47h/+ mutation on human-induced pluripotent stem cell-derived microglia. |
2023-11-16 |
2023-11-20 |
mouse |