All Relations between microglial cell and trem2

Publication Sentence Publish Date Extraction Date Species
Luke W Bonham, Daniel W Sirkis, Jia Fan, Renan E Aparicio, Marian Tse, Eliana Marisa Ramos, Qing Wang, Giovanni Coppola, Howard J Rosen, Bruce L Miller, Jennifer S Yokoyam. Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease. Neurocase. vol 23. issue 1. 2018-02-20. PMID:28376694. trem2 encodes a receptor expressed in microglia which is thought to influence neurodegeneration by sensing damage signals and regulating neuroinflammation. 2018-02-20 2023-08-13 Not clear
Teng Jiang, Yu Wan, Ying-Dong Zhang, Jun-Shan Zhou, Qing Gao, Xi-Chen Zhu, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice. Molecular neurobiology. vol 54. issue 2. 2018-02-13. PMID:26780455. afterwards, we directly isolated microglia from middle-aged and aging appswe/ps1de9 mice and determined effects of trem2 overexpression on microglial aβ phagocytosis and aβ-binding receptors expression in vitro. 2018-02-13 2023-08-13 mouse
Teng Jiang, Yu Wan, Ying-Dong Zhang, Jun-Shan Zhou, Qing Gao, Xi-Chen Zhu, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice. Molecular neurobiology. vol 54. issue 2. 2018-02-13. PMID:26780455. meanwhile, this phagocytic deficit in microglia from aging appswe/ps1de9 mice cannot be rescued by trem2 overexpression. 2018-02-13 2023-08-13 mouse
Felix L Yeh, David V Hansen, Morgan Shen. TREM2, Microglia, and Neurodegenerative Diseases. Trends in molecular medicine. vol 23. issue 6. 2018-02-08. PMID:28442216. trem2, microglia, and neurodegenerative diseases. 2018-02-08 2023-08-13 Not clear
Felix L Yeh, David V Hansen, Morgan Shen. TREM2, Microglia, and Neurodegenerative Diseases. Trends in molecular medicine. vol 23. issue 6. 2018-02-08. PMID:28442216. genetic variants of trem2 (triggering receptor expressed on myeloid cells 2), a cell-surface receptor expressed selectively in myeloid cells, greatly increase the risk of ad, implicating microglia and the innate immune system as pivotal factors in ad pathogenesis. 2018-02-08 2023-08-13 Not clear
Felix L Yeh, David V Hansen, Morgan Shen. TREM2, Microglia, and Neurodegenerative Diseases. Trends in molecular medicine. vol 23. issue 6. 2018-02-08. PMID:28442216. recent studies have advanced our understanding of trem2 biology and microglial activities in aging and neurodegenerative brains, providing new insights into trem2 functions in amyloid plaque maintenance, microglial envelopment of plaque, microglia viability, and the identification of novel trem2 ligands. 2018-02-08 2023-08-13 Not clear
Felix L Yeh, David V Hansen, Morgan Shen. TREM2, Microglia, and Neurodegenerative Diseases. Trends in molecular medicine. vol 23. issue 6. 2018-02-08. PMID:28442216. our increased understanding of trem2 and microglia has opened new avenues for therapeutic intervention to delay or prevent the progression of ad. 2018-02-08 2023-08-13 Not clear
Jean-Vianney Haure-Mirande, Mickael Audrain, Tomas Fanutza, Soong Ho Kim, William L Klein, Charles Glabe, Ben Readhead, Joel T Dudley, Robert D Blitzer, Minghui Wang, Bin Zhang, Eric E Schadt, Sam Gandy, Michelle E Ehrlic. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta neuropathologica. vol 134. issue 5. 2018-01-31. PMID:28612290. dap12 (dnax-activating protein 12)/tyrobp, a molecule localized to microglia, is a direct partner/adapter for trem2, cd33, and cr3. 2018-01-31 2023-08-13 mouse
Yuta Yoshino, Kentaro Kawabe, Kiyohiro Yamazaki, Shinya Watanabe, Shusuke Numata, Yoko Mori, Taku Yoshida, Junichi Iga, Tetsuro Ohmori, Shu-Ichi Uen. Elevated TREM2 mRNA expression in leukocytes in schizophrenia but not major depressive disorder. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 6. 2018-01-19. PMID:27130565. we previously reported that the mrna for a protein related to activation of microglia, triggering receptor expressed on myeloid cell 2 (trem2), is expressed higher in peripheral leukocytes in scz than controls. 2018-01-19 2023-08-13 human
Paul M McKeever, TaeHyung Kim, Andrew R Hesketh, Laura MacNair, Denise Miletic, Giorgio Favrin, Stephen G Oliver, Zhaolei Zhang, Peter St George-Hyslop, Janice Robertso. Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 57. 2018-01-03. PMID:28628896. in contrast, the total transcriptome of the anterior forebrain showed upregulation in cytokine signaling, microglia, and immune system pathways, including trem2, tyrobp, and inpp5d. 2018-01-03 2023-08-13 mouse
Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haas. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Science translational medicine. vol 8. issue 369. 2017-12-29. PMID:27974666. trem2 is a transmembrane protein involved in innate immunity and is selectively expressed by microglia and genetically linked to ad and other neurodegenerative disorders. 2017-12-29 2023-08-13 human
Peter J Amos, Susan Fung, Amanda Case, Jerusalem Kifelew, Leah Osnis, Carole L Smith, Kevin Green, Alipi Naydenov, Macarena Aloi, Jesse J Hubbard, Aravind Ramakrishnan, Gwenn A Garden, Suman Jayade. Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. ASN neuro. vol 9. issue 4. 2017-12-08. PMID:28683563. using immunofluorescence microscopy, flow cytometry, and reverse transcription polymerase chain reaction, we observed cells with microglia morphology expressing a repertoire of markers associated with microglia: iba1, cx3cr1, cd11b, trem2, hexb, and p2ry12. 2017-12-08 2023-08-13 human
Daniel W Sirkis, Renan E Aparicio, Randy Schekma. Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Molecular biology of the cell. vol 28. issue 20. 2017-11-29. PMID:28768830. triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein expressed on microglia within the brain. 2017-11-29 2023-08-13 Not clear
Sara Belloli, Maria Pannese, Cecilia Buonsanti, Chiara Maiorino, Giuseppe Di Grigoli, Assunta Carpinelli, Cristina Monterisi, Rosa Maria Moresco, Paola Panina-Bordigno. Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice. Neurobiology of aging. vol 53. 2017-11-16. PMID:28189343. we evaluated the effect of trem2 deletion in a 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (mptp)-induced pd mouse model, measuring neurodegeneration and microglia activation using a combined in vivo imaging and postmortem molecular approach. 2017-11-16 2023-08-13 mouse
Sami Piirainen, Andrew Youssef, Cai Song, Allan V Kalueff, Gary E Landreth, Tarja Malm, Li Tia. Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia? Neuroscience and biobehavioral reviews. vol 77. 2017-10-26. PMID:28185874. moreover, genome-wide association studies have linked variants in several immune genes, such as trem2 and cd33, the expression of which in the brain is restricted to microglia, with cognitive dysfunctions in load. 2017-10-26 2023-08-13 Not clear
Daniel W Sirkis, Luke W Bonham, Renan E Aparicio, Ethan G Geier, Eliana Marisa Ramos, Qing Wang, Anna Karydas, Zachary A Miller, Bruce L Miller, Giovanni Coppola, Jennifer S Yokoyam. Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression. Acta neuropathologica communications. vol 4. issue 1. 2017-10-25. PMID:27589997. trem2 encodes a cell surface receptor expressed on microglia and related cells, and the r47h variant associated with ad appears to affect the ability of trem2 to bind extracellular ligands. 2017-10-25 2023-08-13 Not clear
Susanne Krasemann, Charlotte Madore, Ron Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, Lien Beckers, Elaine O'Loughlin, Yang Xu, Zain Fanek, David J Greco, Scott T Smith, George Tweet, Zachary Humulock, Tobias Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Zhiping Weng, Hao Chen, Emily Tjon, Fargol Mazaheri, Kristin Hartmann, Asaf Madi, Jason D Ulrich, Markus Glatzel, Anna Worthmann, Joerg Heeren, Bogdan Budnik, Cynthia Lemere, Tsuneya Ikezu, Frank L Heppner, Vladimir Litvak, David M Holtzman, Hans Lassmann, Howard L Weiner, Jordi Ochando, Christian Haass, Oleg Butovsk. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. vol 47. issue 3. 2017-10-18. PMID:28930663. trem2 (triggering receptor expressed on myeloid cells 2) induced apoe signaling, and targeting the trem2-apoe pathway restored the homeostatic signature of microglia in als and ad mouse models and prevented neuronal loss in an acute model of neurodegeneration. 2017-10-18 2023-08-13 mouse
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K Ulland, Yaming Wang, Rudolph E Tanzi, Marco Colonn. Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 4. 2017-10-06. PMID:27520774. trem2 is a lipid-sensing activating receptor on microglia known to be important for alzheimer's disease (ad), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. 2017-10-06 2023-08-13 Not clear
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haas. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO molecular medicine. vol 8. issue 9. 2017-09-25. PMID:27402340. recently, heterozygous mutations in the triggering receptor expressed on myeloid cells 2 (trem2), a microglial gene involved in phagocytosis, were genetically linked to late onset ad loss of trem2 reduces the ability of microglia to engulf aβ. 2017-09-25 2023-08-13 Not clear
Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. consistent with this in vivo result, lps or oligomeric amyloid-β treatment down regulated trem2 but up-regulated treml2 expression in primary microglia. 2017-09-19 2023-08-13 mouse