| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
triggering receptor expressed on myeloid cells 2 (trem2) confers strong neuroprotective effects in pd by regulating the phenotype of microglia. |
2023-11-02 |
2023-11-08 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
in an in vitro experiment, lentivirus was used to interfere with the expression of trem2 in bv2 microglia, and then lipopolysaccharide (lps) and adenopterin nucleoside triphosphate (atp) were used to stimulate inflammation to construct a cellular inflammation model. |
2023-11-02 |
2023-11-08 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1β, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhan. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-10-21. PMID:37865646. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein that is predominantly expressed by microglia in the brain. |
2023-10-21 |
2023-11-08 |
mouse |
| Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Rege. Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer's patients. Immunity & ageing : I & A. vol 20. issue 1. 2023-10-14. PMID:37833781. |
monocyte-derived macrophages (mo-mФs) infiltrating the brain alongside microglia are postulated to play a modulatory role in load and both express triggering receptor expressed on myeloid cells 2 (trem2). |
2023-10-14 |
2023-10-15 |
Not clear |
| Xiao-Wei Pang, Yun-Hui Chu, Luo-Qi Zhou, Man Chen, Yun-Fan You, Yue Tang, Sheng Yang, Hang Zhang, Jun Xiao, Gang Deng, Wei Wang, Ke Shang, Chuan Qin, Dai-Shi Tia. Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion. Journal of neurochemistry. 2023-10-12. PMID:37823326. |
triggering receptor expressed on myeloid cells 2 (trem2), which is expressed exclusively on microglia in the central nervous system (cns), plays an essential role in microglial response in various cns disorders. |
2023-10-12 |
2023-10-15 |
mouse |
| Xiao-Wei Pang, Yun-Hui Chu, Luo-Qi Zhou, Man Chen, Yun-Fan You, Yue Tang, Sheng Yang, Hang Zhang, Jun Xiao, Gang Deng, Wei Wang, Ke Shang, Chuan Qin, Dai-Shi Tia. Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion. Journal of neurochemistry. 2023-10-12. PMID:37823326. |
furthermore, trem2 knockout inhibited lipid droplet accumulation in microglia in vitro. |
2023-10-12 |
2023-10-15 |
mouse |
| Ernest K J Pauwels, Gerard J Boe. Friends and Foes in Alzheimer's Disease. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2023-10-03. PMID:37788649. |
apart from the function of astrocytes and microglia, molecular entities such as trem2, syk, c22 and c33 play a role in the physiopathology of ad. |
2023-10-03 |
2023-10-07 |
Not clear |
| Qin Fan, Yue-Zhang Wu, Xiao-Xi Jia, Ruhan A, Chu-Mou Liu, Wei-Wei Zhang, Zhi-Yue Chao, Dong-Hua Zhou, Yuan Wang, Jia Chen, Kang Xiao, Cao Chen, Qi Shi, Xiao-Ping Don. Increased Gal-3 Mediates Microglia Activation and Neuroinflammation via the TREM2 Signaling Pathway in Prion Infection. ACS chemical neuroscience. 2023-09-28. PMID:37769016. |
increased gal-3 mediates microglia activation and neuroinflammation via the trem2 signaling pathway in prion infection. |
2023-09-28 |
2023-10-07 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
finally, a series of molecular biological experiments including knock-down of triggering receptor expressed on myeloid cells 2 (trem2) and analysis of the level of apolipoprotein e (apoe) expression were performed to investigate the underlying mechanism of involvement of ccm-activated oecs in modulating microglia polarization, leading to neural regeneration and function recovery. |
2023-09-02 |
2023-09-07 |
rat |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
in addition, microglial polarization to m2 elicited by aoecs-cm in lps-induced microglia was effectively reversed when trem2 expression was downregulated. |
2023-09-02 |
2023-09-07 |
rat |
| Xuezhen Chen, Yue Zhao, Yimin Huang, Kaichuan Zhu, Fan Zeng, Junyi Zhao, Huaqiu Zhang, Xinzhou Zhu, Helmut Kettenmann, Xianyuan Xian. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia. 2023-08-29. PMID:37641212. |
triggering receptor expressed on myeloid cell 2 (trem2), a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2023-08-29 |
2023-09-07 |
Not clear |
| Fabrizio Biundo, Violeta Chitu, Şölen Gökhan, Edward Chen, Jude Oppong-Asare, E Richard Stanle. Trem2 Enhances Demyelination in the Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626591. |
triggering receptor expressed on myeloid cells-2 (trem2) is a microglial receptor that promotes the activation of microglia and phagocytic clearance of apoptotic neurons and myelin debris. |
2023-08-26 |
2023-09-07 |
Not clear |
| Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R Paluda. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Science advances. vol 9. issue 33. 2023-08-21. PMID:37595041. |
trem2 is down-regulated by hsv1 in microglia and involved in antiviral defense in the brain. |
2023-08-21 |
2023-09-07 |
human |
| Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R Paluda. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Science advances. vol 9. issue 33. 2023-08-21. PMID:37595041. |
here, we report that herpes simplex virus type 1 (hsv1) infection of human induced pluripotent stem cell (hipsc)-derived microglia down-regulates expression of genes in the trem2 pathway. |
2023-08-21 |
2023-09-07 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hon. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. The EMBO journal. 2023-08-14. PMID:37575021. |
these apoptotic-like spines are targeted by microglia for engulfment via trem2 leading to amelioration of aβ oligomer-induced synaptic hyperactivity. |
2023-08-14 |
2023-08-16 |
mouse |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
for example, loss of function of the microglial gene trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and trem2 variants are among the strongest genetic risk factors for ad. |
2023-08-04 |
2023-08-14 |
mouse |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a trem2 mutant mouse model of ad. |
2023-08-04 |
2023-08-14 |
mouse |