| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naveen Nagarajan, Mario R Capecch. Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both. Molecular psychiatry. 2023-04-10. PMID:37037872. |
optogenetic stimulation of hoxb8 microglia in the ventral ca1 region of the hippocampus (vca1) induces both behaviors as well as freezing. |
2023-04-10 |
2023-08-14 |
mouse |
| Michael Nugent, Mark St Pierre, Ashley Brown, Salma Nassar, Pritika Parmar, Yuma Kitase, Sarah Ann Duck, Charles Pinto, Lauren Jantzie, Camille Fung, Raul Chavez-Valde. Sexual dimorphism in the closure of the hippocampal postnatal critical period of synaptic plasticity after intrauterine growth restriction - link to oligodendrocyte and glial dysregulation. Developmental neuroscience. 2023-04-05. PMID:37019088. |
lastly, activated microglia was only detected in iugr female ca1 and ca3 sub-regions. |
2023-04-05 |
2023-08-14 |
mouse |
| Peiyan Jiang, Lianyu Zhou, Zhulin Du, Linyang Zhao, Yexi Tang, Xinghang Fei, Lian Wang, Dabing Li, Song Li, Hui Yang, Xiaotang Fan, Huiling Lia. Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice. Behavioural brain research. 2023-03-08. PMID:36889463. |
furthermore, ica treatment inhibited neuroinflammation via decreasing microglia number and the soma size in the ca1 region of the hippocampus, as well as the protein levels of proinflammatory cytokines in the hippocampus of btbr mice. |
2023-03-08 |
2023-08-14 |
mouse |
| Kyu Ri Hahn, Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, In Koo Hwang, Dae Won Kim, Yeo Sung Yoo. Cu,Zn-Superoxide Dismutase has Minimal Effects Against Cuprizone-Induced Demyelination, Microglial Activation, and Neurogenesis Defects in the C57BL/6 Mouse Hippocampus. Neurochemical research. 2023-02-22. PMID:36808020. |
eight weeks feeding of cuprizone-supplemented (0.2%) diets caused a significant decrease in myelin basic protein (mbp) expression in the stratum lacunosum-moleculare of the ca1 region, the polymorphic layer of the dentate gyrus, and the corpus callosum, while ionized calcium-binding adapter molecule 1 (iba-1)-immunoreactive microglia showed activated and phagocytic phenotypes. |
2023-02-22 |
2023-08-14 |
mouse |
| Iván Ballasch, Esther García-García, Cristina Vila, Anna Pérez-González, Anna Sancho-Balsells, Jéssica Fernández, David Soto, Mar Puigdellívol, Xavier Gasull, Jordi Alberch, Manuel J Rodríguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
by characterizing the ikzf1 deficient mice, we observed that these mice displayed spatial learning deficits, impaired hippocampal ca3-ca1 long-term potentiation, and decreased spine density in pyramidal neurons of the ca1, which correlates with an increased expression of synaptic markers within microglia. |
2023-01-26 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
cleaved gsdmd was detected in microglia, but also in astrocytes and in few pyramidal neurons in the first sector of the cornu ammonis (ca1) of the hippocampus and the temporal cortex of brodmann area 36. |
2022-12-09 |
2023-08-14 |
human |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
in ca1, nlrp3-positive microglia and cleaved gsdmd-positive neurons were associated with local neuronal loss, indicating a possible contribution of nlrp3 inflammasome and pyroptosis activation to ad-related neurodegeneration. |
2022-12-09 |
2023-08-14 |
human |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
we characterized in depth the features of microglia in the two hippocampal poles and investigated their contribution to ca1 plasticity under physiological conditions. |
2022-12-09 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
this was recapitulated in cx3cr1 knockout mice, indicating that microglia have a key role in setting the conditions for plasticity processes in a region-specific manner, and that the cx3cl1-cx3cr1 pathway is a key element in determining the basal level of ca1 ltp in the two regions. |
2022-12-09 |
2023-08-14 |
mouse |
| E De Felice, E Gonçalves de Andrade, M T Golia, F González Ibáñez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
furthermore, microglia in the ca1 sr region showed an increase in soma and a more extensive arborization, an increased prevalence of immature lysosomes accompanied by an elevation in mrna expression of phagocytic markers mertk and cd68 and a surge in the expression of microglial outward k |
2022-12-09 |
2023-08-14 |
mouse |
| Yingjuan Xu, Jiling Zhang, Zeman Fang, Handi Zhan. The effects of social defeat stress on hippocampal glial cells and interleukin-6 in adolescence and adulthood. Neuroreport. vol 33. issue 18. 2022-11-11. PMID:36367792. |
microglia activation characterized by increased ionized calcium-binding adapter molecule 1 positive cell numbers or staining area in the ca1 and ca3 regions of the hippocampus were observed 24 h after the end of stress, which did not last into the adulthood. |
2022-11-11 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1β pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
microglial proliferation was first observed in the dentate gyrus on day 3, while the number of microglia in cornu ammonis 1 grew the most. |
2022-11-04 |
2023-08-14 |
mouse |
| Mojtaba Ehsanifar, Zeinab Montazeri, Mahmoud Salami Zavareh, Mehravar Rafati, Jie Wan. Cognitive impairment, depressive-like behaviors and hippocampal microglia activation following exposure to air pollution nanoparticles. Environmental science and pollution research international. 2022-11-03. PMID:36327074. |
the number of activated microglia increased in the dentate gyrus (dg) and ca1 regions of the hippocampus in dep-exposed mice. |
2022-11-03 |
2023-08-14 |
mouse |
| Yangming Zhang, Yuqiao Xie, Zishuo Cheng, Kaiwen Xi, Xin Huang, Fang Kuang, Wenting Wang, Tiaotiao Liu, Baolin Guo, Shengxi W. Quercetin ameliorates memory impairment by inhibiting abnormal microglial activation in a mouse model of paradoxical sleep deprivation. Biochemical and biophysical research communications. vol 632. 2022-10-03. PMID:36191372. |
morphological analysis showed that quercetin, by targeting the hippocampal ca1 region, strikingly ameliorated the overactivation of microglia induced by psd. |
2022-10-03 |
2023-08-14 |
mouse |
| Chenlu Xu, Jia Zhang, Qinfeng Zhou, Juling Wang, Chenyang Liu, Yu Tian, Danni Huang, Huaizhuang Ye, Yongtang Ji. Exposure to a real traffic environment impairs brain cognition in aged mice. Environmental research. 2022-09-16. PMID:36113572. |
trap exposure increased the number of activated microglia in the hippocampal dg, ca1, ca3 regions and dorsolateral prefrontal cortex (dpfc). |
2022-09-16 |
2023-08-14 |
mouse |
| Tingting Zhou, Suli He, Xin Ye, Zhaolan Wei, Jian Wan, Hongmao Zhang, Shumao Din. Exposure to dibutyl phthalate adsorbed to multi-walled carbon nanotubes causes neurotoxicity in mice by inducing the release of BDNF. The Science of the total environment. 2022-08-30. PMID:36041608. |
staining of hippocampal sections of mouse brain tissue showed that, in the ca1, ca2, and dg areas, the number of neurons decreased, the nucleus was pyknotic, the cell body was atrophied, and levels of the microglia marker iba-1 increased. |
2022-08-30 |
2023-08-14 |
mouse |
| Takayuki Nakajima, Yuki Tanaka, Yusuke Takahashi, Tomohiro Kondo, Shigeo Takenak. The expression and phosphorylation of SMAD3 protein in microglia and astrocytes of the rat hippocampus after transient global cerebral ischemia. Journal of chemical neuroanatomy. 2022-08-27. PMID:36030021. |
the number of smad3- or phosphorylated smad3 (p-smad3)-immunopositive microglia or astrocytes increased in the ca1 region 7 days after ischemia. |
2022-08-27 |
2023-08-14 |
rat |
| Risako Fujikawa, Shozo Jinn. Identification of hyper-ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience. The European journal of neuroscience. 2022-08-26. PMID:36017697. |
identification of hyper-ramified microglia in the ca1 region of the mouse hippocampus potentially associated with stress resilience. |
2022-08-26 |
2023-08-14 |
mouse |
| Risako Fujikawa, Shozo Jinn. Identification of hyper-ramified microglia in the CA1 region of the mouse hippocampus potentially associated with stress resilience. The European journal of neuroscience. 2022-08-26. PMID:36017697. |
the morphological characteristics of microglia in the ca1 region of the dorsal hippocampus in non-stressed controls and resilient mice differed from those in vulnerable mice. |
2022-08-26 |
2023-08-14 |
mouse |
| Cheng Ju, Yue Wang, Caixia Zang, Hui Liu, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Xiuqi Bao, Dan Zhan. Inhibition of Dyrk1A Attenuates LPS-Induced Neuroinflammation via the TLR4/NF-κB P65 Signaling Pathway. Inflammation. 2022-08-02. PMID:35917097. |
in addition, immunohistochemical detection of ionized calcium-binding adapter molecule 1 (iba1) and nissl staining showed that harmine significantly attenuated microglia activation and neuronal damage in the ca1 region of hippocampus. |
2022-08-02 |
2023-08-14 |
mouse |