| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryosuke Kamei, Shinji Urata, Hisato Maruoka, Shigeo Okab. In vivo Chronic Two-Photon Imaging of Microglia in the Mouse Hippocampus. Journal of visualized experiments : JoVE. issue 185. 2022-07-25. PMID:35876553. |
here, a method is presented that enables the chronic observation of microglia in all layers of the hippocampal ca1 through an imaging window. |
2022-07-25 |
2023-08-14 |
mouse |
| Jing Li, Peilin Zhu, Yue Li, Kai Xiao, Jing Tang, Xin Liang, Yanmin Luo, Jin Wang, Yuhui Deng, Lin Jiang, Qian Xiao, Yijing Guo, Yong Tang, Chunxia Huan. The liver X receptors agonist GW3965 attenuates depressive-like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model. The Journal of comparative neurology. 2022-06-27. PMID:35758275. |
moreover, cus intervention significantly increased the number of microglia in the ca1 region, ca2/3 region, and dentate gyrus and the density of activated microglia in the ca2/3 region and dentate gyrus and significantly decreased the endpoints of microglial branches and process length of microglia in the dentate gyrus, while 4 weeks of injections with gw3965 reversed these changes. |
2022-06-27 |
2023-08-14 |
mouse |
| Lu Chen, Huili Jiang, Tuya Bao, Yu Wang, Hong Meng, Yang Sun, Pengfei Liu, Songxiao Quan, Wenshan Li, Simin Qi, Xiujun Re. Acupuncture Ameliorates Depressive Behaviors by Modulating the Expression of Hippocampal Iba-1 and HMGB1 in Rats Exposed to Chronic Restraint Stress. Frontiers in psychiatry. vol 13. 2022-06-23. PMID:35733802. |
the results have also shown that acupuncture ameliorated the crs-induced activation of microglia and hmgb1 in the hippocampus ca1 region. |
2022-06-23 |
2023-08-14 |
rat |
| Tamás Oroszi, Sietse F de Boer, Csaba Nyakas, Regien G Schoemaker, Eddy A van der Ze. Chronic whole body vibration ameliorates hippocampal neuroinflammation, anxiety-like behavior, memory functions and motor performance in aged male rats dose dependently. Scientific reports. vol 12. issue 1. 2022-05-31. PMID:35637277. |
microglia activation showed a significant decrease in the ca1 and dentate gyrus subregions by both dose of wbv. |
2022-05-31 |
2023-08-13 |
rat |
| Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E Barclay, Ramona M Rodriguiz, William C Wetsel, Ting Yang, Mari L Shinohara, Niccolò Terrand. Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. Frontiers in immunology. vol 13. 2022-05-23. PMID:35603196. |
surgery triggered asc specks formation in ca1 hippocampal microglia, but without inducing significant morphological changes in nlrp3 and asc knockout mice. |
2022-05-23 |
2023-08-13 |
mouse |
| Di Liu, Feng Lv, Su Min, You Yang, Lihao Che. Inhibition of NLRP3 inflammasome-mediated neuroinflammation alleviates electroconvulsive shock-induced memory impairment via regulation of hippocampal synaptic plasticity in depressive rats. Behavioural brain research. 2022-04-07. PMID:35390431. |
the hippocampal ca1 region was immunohistochemically and electron-microscopically examined, respectively, for the activation of iba-1 positive microglia and the ultrastructure of synapses. |
2022-04-07 |
2023-08-13 |
rat |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
to this purpose, we employed an automated pipeline for analysis of 3d confocal microscopy images to assess ca1, ca3 and dg/ca4 subfields microglia responses in post-mortem hippocampal samples from late-onset ad (n = 10), dlb (n = 8) and age-matched control (ctl) (n = 11) individuals. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
we identified two distinct microglia clusters enriched in disease conditions and particularly increased in ca1 and dg/ca4 of ad and ca3 of dlb. |
2022-03-17 |
2023-08-13 |
Not clear |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
hypoxia/ischemia-induced rod microglia phenotype in ca1 hippocampal slices. |
2022-02-15 |
2023-08-13 |
rat |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
twenty-four h following ogd, many rod microglia formed trains of elongated cells spanning from the sr throughout the ca1, reaching the sp outer layer where they acquired a round-shaped amoeboid phagocytic head and phagocytosed most of the pyknotic, damaged neurons. |
2022-02-15 |
2023-08-13 |
rat |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
thirty-six h after ogd, neuronal damage was more pronounced in sp outer and inner layers of ca1, rod microglia cells were no longer detectable, and most microglia were amoeboid/phagocytic. |
2022-02-15 |
2023-08-13 |
rat |
| Daniele Lana, Elisabetta Gerace, Giada Magni, Francesca Cialdai, Monica Monici, Guido Mannaioni, Maria Grazia Giovannin. Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163344. |
damaged neurons, more numerous 36 h after ogd, were phagocytosed by amoeboid microglia in both inner and outer layers of ca1. |
2022-02-15 |
2023-08-13 |
rat |
| Étienne Gervais, Parisa Iloun, Ekaterina Martianova, Ana Claudia Gonçalves Bessa, Serge Rivest, Lisa Topolni. Structural analysis of the microglia-interneuron interactions in the CA1 hippocampal area of the APP/PS1 mouse model of Alzheimer's disease. The Journal of comparative neurology. 2021-12-17. PMID:34919273. |
here, we compared the interactions between microglia and parvalbumin (pv+) and somatostatin (som+) expressing interneurons in the ca1 hippocampal area of app/ps1 transgenic mice that mimic certain aspects of the alzheimer's disease (ad). |
2021-12-17 |
2023-08-13 |
mouse |
| Yukitoshi Izumi, Anil G Cashikar, Kathiresan Krishnan, Steven M Paul, Douglas F Covey, Steven J Mennerick, Charles F Zorumsk. A Proinflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 49. 2021-12-12. PMID:34725187. |
here, we examined the effects of lipopolysaccharide (lps), an activator of innate immunity, on 25hc production in microglia, and the effects of lps and 25hc on ca1 hippocampal synaptic plasticity and learning. |
2021-12-12 |
2023-08-13 |
Not clear |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Francesca Romana Rizzo, Livia Guadalupi, Krizia Sanna, Valentina Vanni, Diego Fresegna, Francesca De Vito, Alessandra Musella, Silvia Caioli, Sara Balletta, Silvia Bullitta, Antonio Bruno, Ettore Dolcetti, Mario Stampanoni Bassi, Fabio Buttari, Luana Gilio, Georgia Mandolesi, Diego Centonze, Antonietta Gentil. Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34391817. |
indeed, exercise significantly reduced microgliosis in the ca1 area, the expression of tumour necrosis factor (tnf) in microglia and, to a lesser extent, the hippocampal level of interleukin 1 beta (il-1β), previously shown to contribute to aberrant synaptic plasticity in the eae hippocampus. |
2021-12-09 |
2023-08-13 |
mouse |
| Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityate. Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice. Cells. vol 10. issue 8. 2021-11-15. PMID:34440631. |
although the elimination of microglia did not alter the overall number or intensity of pnns in the ca1 region of the hippocampus, it decreased the size of pnn holes and elevated the expression of the surrounding ecm. |
2021-11-15 |
2023-08-13 |
mouse |
| Mola Mohammadi, Homa Manaheji, Nader Maghsoudi, Samira Danyali, Mansoureh Baniasadi, Jalal Zaringhala. Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain. Behavioural brain research. vol 390. 2021-10-25. PMID:32442548. |
taking together, the results of the current study for the first time revealed that an increase in the microglia dependent probdnf/bdnf ratio following persistent inflammatory pain leads to cell death of the ca1 and dg neurons that subsequently causes a cognitive deficit in the learning and spatial memory functions. |
2021-10-25 |
2023-08-13 |
rat |
| Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Le. CD200 Change Is Involved in Neuronal Death in Gerbil Hippocampal CA1 Field Following Transient Forebrain Ischemia and Postischemic Treatment with Risperidone Displays Neuroprotection without CD200 Change. International journal of molecular sciences. vol 22. issue 3. 2021-09-03. PMID:33498705. |
however, in the ca3 field, the change in cd200 immunoreactivity in pyramidal neurons was markedly weaker than that in the ca1 field, showing there was no expression of cd 200 in microglia and gabaergic neurons. |
2021-09-03 |
2023-08-13 |
Not clear |
| Paula Ortiz-Romero, Alejandro González-Simón, Gustavo Egea, Luis A Pérez-Jurado, Victoria Campuzan. Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression. Frontiers in pharmacology. vol 12. 2021-08-21. PMID:34413771. |
cd mice showed an increased density of activated microglia in the motor cortex and ca1 hippocampal region, which was prevented by co-treatment. |
2021-08-21 |
2023-08-13 |
mouse |