| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fumihiro Saika, Yohji Fukazawa, Yu Hatano, Shiroh Kishioka, Yuko Hino, Shinjiro Hino, Kentaro Suzuki, Norikazu Kiguch. Sexually dimorphic effects of pexidartinib on nerve injury-induced neuropathic pain in mice. Glia. 2024-04-09. PMID:38591338. |
sex- and androgen-dependent differences in the plx3397-mediated preventive effects were observed on spinal microglia and dorsal root ganglia (drg) macrophages, as well as in expression patterns of pain-related inflammatory mediators in these cells. |
2024-04-09 |
2024-04-11 |
mouse |
| Fumihiro Saika, Yohji Fukazawa, Yu Hatano, Shiroh Kishioka, Yuko Hino, Shinjiro Hino, Kentaro Suzuki, Norikazu Kiguch. Sexually dimorphic effects of pexidartinib on nerve injury-induced neuropathic pain in mice. Glia. 2024-04-09. PMID:38591338. |
collectively, these findings demonstrate the presence of considerable sex- and androgen-dependent differences in the etiology of neuropathic pain in spinal microglia and drg macrophages but not in sciatic nerve macrophages. |
2024-04-09 |
2024-04-11 |
mouse |
| Ri Chen, Xueru Xu, Youfen Yu, Yanqin Chen, Chun Lin, Rongguo Li. High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI. Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402335. |
four different voltages (45 v, 65 v, 85 v, and 100 v) of prf on drg significantly alleviated the sni-induced nep, reduced the levels of activating transcription factor 3 (atf3) in drg, improved the ultrastructure of drg, and promoted autophagy in spinal microglia to varying degrees and partially reversed the increased expression of tnf-α and the reduced expression of il-10 in spinal cord dorsal horn (scdh). |
2024-02-24 |
2024-02-27 |
rat |
| Lunhao Chen, Chao Jiang, Qian Xu, Jiale Jin, Sigen A, Xi Wang, Xiaolin Li, Yaling Hu, Huankun Sun, Xuan Lu, Shumin Duan, Zhihua Gao, Wenxin Wang, Yue Wan. Biphasic release of betamethasone from an injectable HA hydrogel implant for alleviating lumbar disc herniation induced sciatica. Acta biomaterialia. 2024-01-20. PMID:38244658. |
in a mouse model of ldh, the epidural administration of bd/bp@ha efficiently alleviated ldh-induced sciatica for at least 10 days by inhibiting the activation of macrophages and microglia in dorsal root ganglion and spinal dorsal horn, respectively. |
2024-01-20 |
2024-01-23 |
mouse |
| Akhilesh, Deepak Chouhan, Obulapathi Ummadisetty, Nivedita Verma, Vinod Tiwar. Bergenin ameliorates chemotherapy-induced neuropathic pain in rats by modulating TRPA1/TRPV1/NR2B signalling. International immunopharmacology. vol 125. issue Pt A. 2023-12-27. PMID:38149571. |
we also measured alterations in tight junction proteins, pro-inflammatory cytokines, microglia activity, transient receptor potential (trp) channels (trpv1, trpa1 and trpm8) and n-methyl-d-aspartate receptor subtype 2 (nr2b) in dorsal root ganglion (drg) and spinal tissues of neuropathic rats. |
2023-12-27 |
2023-12-29 |
rat |
| Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wan. HK2 in microglia and macrophages contribute to the development of neuropathic pain. Glia. 2023-11-01. PMID:37909251. |
deletion of hk2 in myeloid cells, including both drg macrophages and spinal microglia, led to the alleviation of mechanical pain during the first week after injury, along with attenuated microgliosis in the ipsilateral sdh, macrophage proliferation in drgs, and suppressed inflammatory responses in drgs. |
2023-11-01 |
2023-11-08 |
Not clear |
| Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wan. HK2 in microglia and macrophages contribute to the development of neuropathic pain. Glia. 2023-11-01. PMID:37909251. |
these data suggest that hk2 plays an important role in regulating neuropathic pain-related immune cell responses at acute phase and that hk2 contributes to neuropathic pain onset primarily through peripheral monocytes and drg macrophages rather than spinal microglia. |
2023-11-01 |
2023-11-08 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. |
2023-08-14 |
2023-08-16 |
Not clear |
| Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. |
moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. |
2023-08-14 |
2023-08-16 |
Not clear |
| Songbin Wu, Shaomin Yang, Rongzhen Li, Xiyuan Ba, Changyu Jiang, Donglin Xiong, Lizu Xiao, Wuping Su. HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism. Journal of medical virology. vol 95. issue 4. 2023-05-16. PMID:37185840. |
besides, hsv-1 inoculation induced an up-regulation of atf3, cgrp, and gal in drg and activation of astrocytes and microglia in the spinal cord. |
2023-05-16 |
2023-08-14 |
mouse |
| Po-Yu Yang, Meei-Ling Tsau. NS5806 reduces carrageenan-evoked inflammation by suppressing extracellular signal-regulated kinase activation in primary sensory neurons and immune cells. European journal of pain (London, England). 2023-05-12. PMID:37172202. |
ns5806 also reduces the expansion of drg macrophages and spinal microglia several days after peripheral nerve injury, implying an anti-inflammatory effect. |
2023-05-12 |
2023-08-14 |
Not clear |
| Qi Li, Rui Li, Xiaoxi Zhu, Xiaolei Chu, Xiaoqiong An, Ming Chen, Lei Zhang, Mingwei Gao, Long Che. EphA1 aggravates neuropathic pain by activating CXCR4/RhoA/ROCK2 pathway in mice. Human cell. 2023-05-10. PMID:37162645. |
subsequently, knockdown of epha1 expression levels using adenovirus short hairpin rna (aav-shepha1) revealed an increase in mechanical stimulation withdrawal threshold (pwt) and withdrawal latency (pwl) when epha1 expression was decreased, accompanied by improved dorsal root ganglion injury, increased leukocytosis, decreased microglia, and decreased levels of pro-inflammatory factors. |
2023-05-10 |
2023-08-14 |
mouse |
| Ping-Heng Tan, Jasmine Ji, Chung-Hsi Hsing, Radika Tan, Ru-Rong J. Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430870. |
microglia, astrocytes, as well as neurons in the central and peripheral nervous systems, including spinal cord neurons and dorsal root ganglion neurons, express type i ifn receptors (ifnars). |
2022-11-26 |
2023-08-14 |
Not clear |
| Lunhao Chen, Yaling Hu, Siyuan Wang, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Ga. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI insight. 2022-10-04. PMID:36194480. |
however, selective ablation of mtor in drg neurons, rather than microglia, alleviated acute neuropathic pain in mice. |
2022-10-04 |
2023-08-14 |
mouse |
| Lunhao Chen, Yaling Hu, Siyuan Wang, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Ga. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI insight. 2022-10-04. PMID:36194480. |
using the spared nerve injury-induced neuropathic pain model, we found that mtor was preferentially activated in large-diameter dorsal root ganglion (drg) neurons and spinal microglia. |
2022-10-04 |
2023-08-14 |
mouse |
| Xuan Lu, Lunhao Chen, Chao Jiang, Kelei Cao, Zhihua Gao, Yue Wan. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2022-09-28. PMID:36170151. |
we found that nerve root compression using degenerated np tissues can initiate remarkable and persistent sciatica, with increased and prolonged macrophage infiltration in dorsal root ganglia (drg) and significant activation of microglia in the spinal dorsal horn. |
2022-09-28 |
2023-08-14 |
mouse |
| Roland G W Staal, Adarsh Gandhi, Hua Zhou, Manuel Cajina, Anne-Marie Jacobsen, Sara Hestehave, Allen Hopper, Suresh Poda, Gamini Chandresana, Stevin H Zorn, Brian Campbell, Marta Segerdahl, Thomas Mӧller, Gordon Munr. Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain. Purinergic signalling. 2022-08-24. PMID:36001278. |
the p2x7 receptor is expressed by multiple cell types including dorsal root ganglion satellite glial cells, macrophages, and spinal microglia, all of which have been implicated in nociceptive sensitization. |
2022-08-24 |
2023-08-14 |
rat |
| Ankit Uniyal, Anagha Gadepalli, Ajay Modi, Vinod Tiwar. Modulation of KIF17/NR2B crosstalk by tozasertib attenuates inflammatory pain in rats. Inflammopharmacology. 2022-03-04. PMID:35243557. |
moreover, tozasertib treatment significantly attenuated cfa-induced oxido-nitrosative stress and macrophage activation in drg and microglia activation in spinal cord of rats. |
2022-03-04 |
2023-08-13 |
rat |
| Jing Wang, Feng Zhou, Susu Zhang, Mao Mao, Shanwu Feng, Xian Wan. Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain. Neuroscience letters. 2022-02-12. PMID:35149198. |
additionally, ptx increased cgrp and substance p (sp) expression in the drg and sdh, induced sdh microglia and astrocyte activation, and upregulated spinal tumor necrosis factor-α (tnf-α) but not il-1β or il-10 expression. |
2022-02-12 |
2023-08-13 |
rat |
| Liren Li, Liying Bai, Kangli Yang, Jian Zhang, Yan Gao, Mingjun Jiang, Yin Yang, Xuan Zhang, Li Wang, Xueli Wang, Yiming Qiao, Ji-Tian X. KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34464689. |
double immunofluorescence staining revealed that the kdm6b expressed in myelinated a- and unmyelinated c-fibers in the drg; and located in neuronal cells, astrocytes, and microglia in the dorsal horn. |
2021-12-09 |
2023-08-13 |
rat |