All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
Mengjun Geng, Qiujing Shao, Jiacheng Fu, Jingyang Gu, Laipeng Feng, Liqin Zhao, Cong Liu, Junlin Mu, Xiaoli Zhang, Mingjun Zhao, Xinsheng Guo, Cai Song, Yan Li, Huiying Wang, Changhong Wan. Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation. Translational psychiatry. vol 14. issue 1. 2024-02-29. PMID:38424085. rats exposed to cums exhibited mkp-1 overexpression, greater numbers of activated microglia, and enhanced expressions of neuroinflammatory markers (interleukin [il]-6, [il]-1β, tumor necrosis factor [tnf]-ɑ, and decreased phosphorylation levels of erk and p38 in the hippocampus as well as anhedonia in the sucrose preference test, motor retardation in the open field, and greater immobility (despair) in the forced swimming tests. 2024-02-29 2024-03-03 rat
Sahabuddin Ahmed, Baruh Polis, Sumit Jamwal, Basavaraju G Sanganahalli, Zoe MacDowell Kaswan, Rafiad Islam, Dana Kim, Christian Bowers, Lauryn Giuliano, Thomas Biederer, Fahmeed Hyder, Arie Kaffma. Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405887. this is linked to altered developmental refinement of connectivity, with lb severely impairing microglial-mediated synaptic pruning in the hippocampus of male and female pups on postnatal day 17 (p17), but not in adolescent p33 mice when levels of synaptic engulfment by microglia are substantially lower. 2024-02-26 2024-02-28 mouse
Sahabuddin Ahmed, Baruh Polis, Sumit Jamwal, Basavaraju G Sanganahalli, Zoe MacDowell Kaswan, Rafiad Islam, Dana Kim, Christian Bowers, Lauryn Giuliano, Thomas Biederer, Fahmeed Hyder, Arie Kaffma. Transient Impairment in Microglial Function Causes Sex-Specific Deficits in Synaptic and Hippocampal Function in Mice Exposed to Early Adversity. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405887. since the hippocampus undergoes intense synaptic pruning during the second and third weeks of life, we investigated whether microglia are required for the synaptic and behavioral aberrations observed in adolescent lb mice. 2024-02-26 2024-02-28 mouse
Assunta Virtuoso, Christos Galanis, Maximilian Lenz, Michele Papa, Andreas Vlacho. Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397023. microglia responses varied depending on their anatomical location, underscoring the complexity of the hippocampal neuroglial network post-injury. 2024-02-24 2024-02-26 mouse
Yuka Kusui, Naotaka Izuo, Reika Tokuhara, Takashi Asano, Atsumi Nitt. Neuronal activation of nucleus accumbens by local methamphetamine administration induces cognitive impairment through microglial inflammation in mice. Journal of pharmacological sciences. vol 154. issue 3. 2024-02-23. PMID:38395513. in the hippocampus of mice with meth (nac), activated microglia, but not astroglia, and upregulated microglia-related genes, il1b and c1qa were observed. 2024-02-23 2024-02-26 mouse
Renu Heir, Zahra Abbasi, Pragya Komal, Haider F Altimimi, Marie Franquin, Dionysia Moschou, Julien Chambon, David Stellwage. Astrocytes are the source of TNF mediating homeostatic synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-02-23. PMID:38395613. hippocampal cultures from rats of both sexes depleted of microglia still will increase tnf levels following activity deprivation, and still express ttx-driven hsp. 2024-02-23 2024-02-26 mouse
Gangjing Li, Li Hu, Xiangcheng Gu, Weijun Zhu, Xuechu Zhen, Xiaohui Su. Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Neurochemical research. 2024-02-22. PMID:38383879. ), a specific bk channel blocker, or bk shrna-aav effectively inhibited the activation of microglia, reduced the production of il-1β in the hippocampus and suppressed the expression and activity of ido in the hippocampus and prefrontal cortex, resulting in the amelioration of depressive-like behavior in mice. 2024-02-22 2024-02-24 mouse
Kelsey E Kline, Ashley L Russell, Jason P Stezoski, Ian G Gober, Emma G Dimeo, Keri Janesko-Feldman, Tomas Drabek, Patrick M Kochanek, Amy K Wagne. Differential Effects of Targeted Temperature Management on Sex-Dependent Outcomes After Experimental Asphyxial Cardiac Arrest. Therapeutic hypothermia and temperature management. 2024-02-22. PMID:38386544. hippocampal pathology was assessed for cell death, degenerating neurons, and microglia on day 14. 2024-02-22 2024-02-25 rat
Palkin Arora, Richa Trivedi, Megha Kumari, Kavita Singh, Rajat Sandhir, Maria M D'Souza, Poonam Ran. Altered DTI scalars in the hippocampus are associated with morphological and structural changes after traumatic brain injury. Brain structure & function. 2024-02-21. PMID:38381381. the perturbed dti scalars accompanied histological changes in the hippocampus, wherein both the microglia and astrocytes showed changes in the morphometric parameters at all timepoints. 2024-02-21 2024-02-23 rat
Qingquan Li, Xiaokui Gan, Ming Zhang, Guangmin Zhang, Yingbin Li, Liang Ga. Erianin promotes endogenous neurogenesis in traumatic brain injury rats. Scientific reports. vol 14. issue 1. 2024-02-19. PMID:38374284. additionally, there was an increase in neuronal regeneration in the cortex and hippocampus, inhibition of pro-inflammatory microglial cell transformation in the cortex, improvement in learning and memory function in tbi rats, and simultaneous inhibition of the activation of the erk1/c-jun signal pathway. 2024-02-19 2024-02-22 rat
Li Liu, Jing Tang, Xin Liang, Yue Li, Peilin Zhu, Mei Zhou, Lu Qin, Yuhui Deng, Jing Li, Yiying Wang, Lin Jiang, Dujuan Huang, Yuning Zhou, Shun Wang, Qian Xiao, Yanmin Luo, Yong Tan. Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1/M2 polarization through adiponectin/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress. Molecular psychiatry. 2024-02-16. PMID:38361125. when an adeno-associated virus was used to knock down hippocampal adipor1, mice showed depressive-like behaviors and alterations in microglia and inflammatory factor expression in the hippocampus that were similar to those observed in cus-exposed mice. 2024-02-16 2024-02-18 mouse
Karen Krukowski, Katherine Grue, McKenna Becker, Edward Elizarraras, Elma S Frias, Aaron Halvorsen, McKensie Koenig-Zanoff, Valentina Frattini, Hasitha Nimmagadda, Xi Feng, Tamako Jones, Gregory Nelson, Adam R Ferguson, Susanna Ros. The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures. Science advances. vol 7. issue 42. 2024-02-14. PMID:34652936. mechanistically, these gcrsim-induced learning impairments corresponded with chronic microglia activation and synaptic alterations in the hippocampus. 2024-02-14 2024-02-16 mouse
Aaron Y Lai, Dustin Loren V Almanza, Jessica A Ribeiro, Mary E Hill, Matthew Mandrozos, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv : the preprint server for biology. 2024-02-08. PMID:38328066. pathological analyses of prefrontal cortex and hippocampus showed that obesity in tgf344-ad rats produced varied effects, with increased density of myelin and oligodendrocytes, lowered density and activation of microglia that we propose contributes to the cognitive improvement. 2024-02-08 2024-02-10 human
Longfei Du, Xuyuan Fan, Yi Yang, Shusheng Wu, Yuan Li. Quercetin Ameliorates Cognitive Impairment in Depression by Targeting HSP90 to Inhibit NLRP3 Inflammasome Activation. Molecular neurobiology. 2024-02-08. PMID:38329680. besides, quercetin inhibited the increased level of cytokines (il-6, il-1β, mcp-1, and tnf-α) in the hippocampus of the depressive model mouse and the increased level of cytokines (il-6, il-1β, and mcp-1) in microglia. 2024-02-08 2024-02-10 mouse
Ling Wang, Haoran Sha, Xiaoyi He, Yinyin Xie, Jiapeng Deng, Jiexuan Chen, Guoying Li, Junhua Yan. Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF. Cellular and molecular neurobiology. vol 44. issue 1. 2024-02-05. PMID:38315435. more microglia numbers/activation and higher m-csf level in the hippocampus in il-4 over-exposed rats were also observed. 2024-02-05 2024-02-09 rat
Hiroko Ikeda, Aimi Yamagishi, Naomi Yonemochi, Shogo Yamamoto, Takatsune Shimizu, Akihiro Muto, John L Waddington, Junzo Kame. Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice. Molecular neurobiology. 2024-02-03. PMID:38308664. in tb mice kc mrna was increased in both astrocytes and microglia of the amygdala and hippocampus. 2024-02-03 2024-02-06 mouse
Hiroko Ikeda, Aimi Yamagishi, Naomi Yonemochi, Shogo Yamamoto, Takatsune Shimizu, Akihiro Muto, John L Waddington, Junzo Kame. Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice. Molecular neurobiology. 2024-02-03. PMID:38308664. these findings indicate that tb mice show an increase in serum cytokines, including il-1β, that increases kc production in microglia of the hippocampus, which then disrupts extinction of fear memory. 2024-02-03 2024-02-06 mouse
Dan-Dan Xu, Zhi-Qi Hou, Ya-Yun Xu, Jun Liang, Ye-Jun Gao, Chen Zhang, Fan Guo, Dan-Dan Huang, Jin-Fang Ge, Qing-Rong Xi. Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm". Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 19. issue 1. 2024-02-02. PMID:38305948. furthermore, protein expression levels of the circadian locomotor output cycles kaput, cryptochrome 2, and period 2 was significantly reduced in the hippocampus of lps-challenged rats, whereas bmal1 expression was significantly increased in the hippocampus but decreased in the hypothalamus, where it was co-located with neurons, microglia, and astrocytes. 2024-02-02 2024-02-04 rat
Changcun Qi, Yuandong Yan, Qi Cao, Lingyun Zou, Shanshan Li, Qiuyu Yang, Qing Deng, Bailin Wu, Bo Son. Elucidating the mechanisms underlying astrocyte-microglia crosstalk in hippocampal neuroinflammation induced by acute diquat exposure. Environmental science and pollution research international. 2024-02-02. PMID:38305974. these results indicate that astrocytes can activate the p2x4/nlrp3 signaling pathway in microglia through the dq-induced extracellular release of atp to promote neuroinflammation in rat hippocampal tissue. 2024-02-02 2024-02-04 rat
Yingsi Cao, Wenjing Zhao, Yanqi Zhong, Xiaofan Jiang, Huiya Mei, Yuanjin Chang, Dongqin Wu, JianRui Dou, Emely Vasquez, Xian Shi, Jiatao Yang, Zhongtang Jia, Xiaochao Tan, Qian Li, Yuying Dong, Ruijin Xie, Ju Gao, Yu Wu, Yueying Li. Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation. The Science of the total environment. 2024-02-01. PMID:38301787. in conclusion, our study indicates that chronic low-level lead exposure may activate microglia, leading to the promotion of ferroptosis in hippocampal neurons. 2024-02-01 2024-02-04 Not clear