All Relations between microglial cell and hippocampus

Publication Sentence Publish Date Extraction Date Species
Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun L. Co-exposure of chronic stress and alumina nanoparticles aggravates hippocampal microglia pyroptosis by activating cathepsin B/NLRP3 signaling pathway. Journal of hazardous materials. vol 436. 2022-05-15. PMID:35569374. these results demonstrated that co-exposure to chronic stress and alnps could aggravate hippocampal microglia pyroptosis by activating cathepsin b/nlrp3 signaling pathway, resulting in hippocampal damage and behavioral deficits. 2022-05-15 2023-08-13 rat
Chuan-Feng Tang, Cong-Ying Wang, Jun-Han Wang, Qiao-Na Wang, Shen-Jie Li, Hai-Ou Wang, Feng Zhou, Jian-Mei L. Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood-Brain Barrier Damage. Nutrients. vol 14. issue 9. 2022-05-14. PMID:35565849. of note, scfas could rescue hippocampal neurogenesis decline, improve bbb damage and suppress microglia activation and neuroinflammation, thereby ameliorate depressive-like behaviors of frud mice exposed to chronic stress. 2022-05-14 2023-08-13 mouse
Wilfred Fonseca-Ferrer, Cristina Suárez-Gomez, Lubriel Sambolin-Escobales, Kimberly Santos-Avilés, Maria Colón-Romero, Anixa Hernández-López, Adariana Feliciano-Quiñones, Lizmarie Tirado-Castro, James Porte. Infusion of C20 ceramide induces depressive-like behavior, increases microglia but not astrocyte expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555658. because of this, we hypothesize that the infusion of long-chain ceramides (c20) in the ventral hippocampus will increase the development of depressive-like behavior, will cause an increase in the level of microglia expression but not astrocyte expression. 2022-05-13 2023-08-13 rat
Samantha K Baker, Na Wang, Guojun Bu, Chia-Chen Li. Effects of Microglia APOE Expression on Tau Pathology. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35557103. phosphorylated-tau accumulation, microglia activation, and neurodegeneration of the hippocampus and piriform cortex upon specific expression of apoe3 were quantified. 2022-05-13 2023-08-13 mouse
Maria-Leonor López-Meraz, Dulce-Mariely Álvarez-Crod. Microglia and Status Epilepticus in the Immature Brain. Epilepsia open. 2022-05-09. PMID:35531942. in the developing brain, status epilepticus (se) promotes microglia activation that is associated with neuronal injury in some areas of the brain, such as the hippocampus, thalamus and amygdala. 2022-05-09 2023-08-13 Not clear
Hua-Xiang Shi, Meng-Wei Zhou, Hu Zhou, Jing-Xin Zhang, Wei-Guo Shi, Li-Yun Wan. [Time-dependent injury of mouse cerebral cortex and hippocampus by acute hypoxia]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503062. immunofluorescent staining was used to detect neuroinflammatory response of microglia in the cerebral cortex and hippocampus. 2022-05-03 2023-08-13 mouse
Jie Luo, Jing-Qiong Wang, Li-Na Xie, An-Na Meng, Si-Si Zheng, Shou-Hong Zho. [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503065. [voluntary wheel running exercise regulates microglia polarization in hippocampus through stat3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. 2022-05-03 2023-08-13 rat
Jie Luo, Jing-Qiong Wang, Li-Na Xie, An-Na Meng, Si-Si Zheng, Shou-Hong Zho. [Voluntary wheel running exercise regulates microglia polarization in hippocampus through STAT3 signal pathway to inhibit depression-like behavior induced by chronic stress in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 2. 2022-05-03. PMID:35503065. these results suggest that voluntary wheel running ameliorates the depression-like behavior induced by cwirs in rats, and the mechanism may be related to regulating hippocampal microglia polarization via stat3 signaling pathway. 2022-05-03 2023-08-13 rat
Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. strem-1 promotes the phagocytic function of microglia to induce hippocampus damage via the pi3k-akt signaling pathway. 2022-04-29 2023-08-13 mouse
Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. after intracerebroventricular (icv) injection, the damage in hippocampal neurons increased, and the loss of neuronal synapses and activation of microglia increased compared to the control mice (treated with saline). 2022-04-29 2023-08-13 mouse
Li Lu, Xuan Liu, Juanhua Fu, Jun Liang, Yayi Hou, Huan Do. sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. Scientific reports. vol 12. issue 1. 2022-04-29. PMID:35487953. pi3k-akt pathway inhibitor ly294002 reversed the excessive activation and phagocytosis of microglia caused by strem-1 in vivo and in vitro, which in turn improved the hippocampus damage. 2022-04-29 2023-08-13 mouse
Jeimmy Cerón, Julieta Troncos. Facial nerve injury-associated hippocampal microglial activation Biomedica : revista del Instituto Nacional de Salud. vol 42. issue 1. 2022-04-28. PMID:35471181. the animals were sacrificed at specific times after injury to evaluate hippocampal microglial cell proliferation (cell density) and activation (cell area); sham-operated animals were compared to lesioned animals sacrificed 1, 3, 7, 21, or 35 days after injury.results: facial nerve-injured rats’ hippocampal microglial cells proliferated and adopted an activated phenotype 3- to 21-days post-lesion. 2022-04-28 2023-08-16 rat
Ying-Ying Wang, Yu-Sen Deng, Shang-Kun Dai, Ting-Wei Mi, Rui-Yang Li, Pei-Pei Liu, Cong Liu, Bao-Dong He, Xuan-Cheng He, Hong-Zhen Du, Han-Chen Yang, Yi Tang, Chang-Mei Liu, Zhao-Qian Ten. Loss of microglial EED impairs synapse density, learning, and memory. Molecular psychiatry. 2022-04-28. PMID:35484239. the absence of microglial eed at early postnatal stages resulted in reduced spines and impaired synapse density in the hippocampus at adulthood, accompanied by upregulated expression of phagocytosis-related genes in microglia. 2022-04-28 2023-08-13 mouse
T A McCorkle, Z L Romm, R Raghupath. Repeated mild TBI in adolescent rats reveals sex differences in acute and chronic behavioral deficits. Neuroscience. 2022-04-26. PMID:35469970. histological analysis at 6 weeks after injury revealed that repeated mild tbi in male and female adolescent rats resulted in increased reactivity of astrocytes and microglia within the corpus callosum below the impact site and in the stratum oriens and stratum pyramidale of the ca2 region of the dorsal hippocampus. 2022-04-26 2023-08-13 rat
Yu Ren, Qing Wang, Zexian Yang, Linyin Feng, Yu Zhan. MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal α-synuclein accumulation. Biochemical and biophysical research communications. vol 611. 2022-04-26. PMID:35472607. furthermore, immunostaining or immunoblotting experiments on the hippocampal tissue were performed, and the results suggested that mcc950 not only inhibited the expression of nlrp3, and suppressed the activation of astrocytes and microglia, but also promoted the mtor-mediated autophagy pathway to reduce human α-synuclein accumulation. 2022-04-26 2023-08-13 mouse
Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wi. Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain. Toxics. vol 10. issue 4. 2022-04-21. PMID:35448455. serum and brain homogenates were examined by enzyme-linked immunosorbent assay (elisa), and neurons, microglia, and astrocytes in the hippocampal region were examined with immunohistochemical analysis. 2022-04-21 2023-08-13 rat
Yao Zhao, Jiawei Zhang, Yaxuan Zhang, Yueqi Zhang, Xiaojie Zhang, Yaling Zheng, Hongmei Wang, Xiuzhe Wang, Jianliang F. Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment. International immunopharmacology. vol 108. 2022-04-09. PMID:35397390. immunohistochemistry study revealed that andro could reduce neuronal damage and activation of microglia in the cortex and hippocampus in bccao rats. 2022-04-09 2023-08-13 rat
Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. microglia maintain the normal structure and function of the hippocampal astrocyte network. 2022-04-08 2023-08-13 mouse
Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. here, we explored a role for microglia in regulating the structure and function of the astrocyte syncytium in mouse hippocampus. 2022-04-08 2023-08-13 mouse
Yixing Du, Faith H Brennan, Phillip G Popovich, Min Zho. Microglia maintain the normal structure and function of the hippocampal astrocyte network. Glia. 2022-04-08. PMID:35394085. because neuronal function requires intact astrocyte coupling, we also evaluated the effects of microglia depletion on synaptic transmission in the hippocampus. 2022-04-08 2023-08-13 mouse