| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaomi Ding, Jing Zhou, Li Zhao, Mingyue Chen, Shenglin Wang, Ming Zhang, Xiaodong Zhang, Guohui Jian. Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress. Frontiers in cellular and infection microbiology. vol 12. 2022-03-31. PMID:35356535. |
the seizure grade, duration, latency, hippocampal potential, and energy density were used to evaluate seizures, and the changes in the polarization of microglia were detected by western blot. |
2022-03-31 |
2023-08-13 |
mouse |
| Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexak. ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses. Biomolecules. vol 12. issue 3. 2022-03-25. PMID:35327616. |
in addition, ent-a010 pretreatment partially restored homeostatic features of microglia in the hippocampus of lipopolysaccharide (lps)-treated mice, enhanced aβ phagocytosis, and increased |
2022-03-25 |
2023-08-13 |
mouse |
| Urszula Hohmann, Chalid Ghadban, Tim Hohmann, Joshua Kleine, Miriam Schmidt, Christian Scheller, Christian Strauss, Faramarz Dehghan. Nimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328753. |
direct effects of nimodipine on neurons amongst others were observed in the hippocampus as well as its influence on both microglia and astrocytes. |
2022-03-25 |
2023-08-13 |
Not clear |
| Rita Gaspar, Carina Soares-Cunha, Ana Verónica Domingues, Bárbara Coimbra, Filipa I Baptista, Luísa Pinto, António F Ambrósio, Ana João Rodrigues, Catarina A Gome. The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia. Frontiers in behavioral neuroscience. vol 16. 2022-03-25. PMID:35330844. |
here, we examine the effects of short and long unpredictable chronic mild stress (ucms) protocols on behavior, evaluating in parallel microglia and neurons morphology in the dorsal hippocampus (dhip) and in the |
2022-03-25 |
2023-08-13 |
Not clear |
| Mary Beth Hall, Nicola M Habash, Nicole A Haas, Jaclyn M Schwar. A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain. Journal of neuroscience methods. 2022-03-20. PMID:35306037. |
a method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain. |
2022-03-20 |
2023-08-13 |
rat |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
furthermore, how the nature of the hippocampal local pathological imprint is associated with microglia responses needs to be elucidated. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
to this purpose, we employed an automated pipeline for analysis of 3d confocal microscopy images to assess ca1, ca3 and dg/ca4 subfields microglia responses in post-mortem hippocampal samples from late-onset ad (n = 10), dlb (n = 8) and age-matched control (ctl) (n = 11) individuals. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
our findings suggest that combinations and severity of subregional ptau, aβ and psyn pathologies transform local microglia phenotypic composition in the hippocampus. |
2022-03-17 |
2023-08-13 |
Not clear |
| Chihiro Kurematsu, Masato Sawada, Masaki Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, Mami Matsumoto, Hisashi Oishi, Hiroyuki Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, Truc Quynh Thai, Shinichi Kohsaka, Nobuhiko Ohno, Maki K Yamada, Masato Asai, Masahiro Sokabe, Junichi Nabekura, Kenichi Asano, Masato Tanaka, Kazunobu Sawamot. Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine. The Journal of experimental medicine. vol 219. issue 4. 2022-03-17. PMID:35297954. |
in this transgenic mouse, the spine pruning of adult-born neurons by microglia is impaired in the ob and hippocampus. |
2022-03-17 |
2023-08-13 |
mouse |
| Amal Alachkar, Sudhanshu Agrawal, Melica Baboldashtian, Khawla Nuseir, Jon Salazar, Anshu Agrawa. L-methionine enhances neuroinflammation and impairs neurogenesis: Implication for Alzheimer's disease. Journal of neuroimmunology. vol 366. 2022-03-17. PMID:35299077. |
we found that repeated administration of l-met at a dose equivalent to two-fold of daily dietary intake for seven days enhanced the activation of microglia and inflammation in the brain, and decreased neurogenesis in the hippocampus without affecting degeneration. |
2022-03-17 |
2023-08-13 |
mouse |
| Pamela M Maras, Elaine K Hebda-Bauer, Megan H Hagenauer, Kathryn L Hilde, Peter Blandino, Stanley J Watson, Huda Aki. Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model. Translational psychiatry. vol 12. issue 1. 2022-03-16. PMID:35292624. |
using detailed anatomical analyses, we compared hippocampal microglia profiles of bhrs and blrs and found that although the lines had similar numbers of microglia, selective breeding was associated with a shift in the morphological features of these cells. |
2022-03-16 |
2023-08-13 |
rat |
| Rui Huang, Yuyuan Gao, Jianing Chen, Qingrui Duan, Peikun He, Jiahui Zhang, Heling Huang, Qingxi Zhang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wan. TGR5 agonist INT-777 alleviates inflammatory neurodegeneration in parkinson's disease mouse model by modulating mitochondrial dynamics in microglia. Neuroscience. 2022-03-08. PMID:35257795. |
int-777 prevented mptp-induced neurodegeneration and microglia activation in the substantia nigra pars compacta, hippocampus, and cortical layer v. based on bioinformatics and wet lab data, int-777 inhibited microglia activation by suppressing the release of tumor necrosis factor alpha (tnf-α) in the hippocampus, along with secondary chemokines (c-c motif ligand 3 (ccl3) and ccl6) in these three brain regions. |
2022-03-08 |
2023-08-13 |
mouse |
| Rui Huang, Yuyuan Gao, Jianing Chen, Qingrui Duan, Peikun He, Jiahui Zhang, Heling Huang, Qingxi Zhang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wan. TGR5 agonist INT-777 alleviates inflammatory neurodegeneration in parkinson's disease mouse model by modulating mitochondrial dynamics in microglia. Neuroscience. 2022-03-08. PMID:35257795. |
therefore, pd cognitive impairment is associated with hippocampal tnf-α elevation as a result of mitochondrial damage in microglia. |
2022-03-08 |
2023-08-13 |
mouse |
| Jiamei Guo, Tian Qiu, Lixia Wang, Lei Shi, Ming Ai, Zhu Xia, Zhiping Peng, Anhai Zheng, Xiao Li, Li Kuan. Microglia Loss and Astrocyte Activation Cause Dynamic Changes in Hippocampal [ Frontiers in cellular neuroscience. vol 16. 2022-03-07. PMID:35250485. |
microglia loss and astrocyte activation cause dynamic changes in hippocampal [ major depression is a serious and chronic mental illness. |
2022-03-07 |
2023-08-13 |
mouse |
| Zhuo Fan, Wendi Zhang, Qi Cao, Lingyun Zou, Xiaobei Fan, Changcun Qi, Yuandong Yan, Bo Song, Bailin W. JAK2/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure. Ecotoxicology and environmental safety. vol 234. 2022-03-06. PMID:35248926. |
jak2/stat3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure. |
2022-03-06 |
2023-08-13 |
Not clear |
| Zhuo Fan, Wendi Zhang, Qi Cao, Lingyun Zou, Xiaobei Fan, Changcun Qi, Yuandong Yan, Bo Song, Bailin W. JAK2/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure. Ecotoxicology and environmental safety. vol 234. 2022-03-06. PMID:35248926. |
to explore the effects of acute paraquat (pq) exposure on the phenotypic polarization of hippocampal microglia and its mechanism. |
2022-03-06 |
2023-08-13 |
Not clear |
| Teresa Cramer, Raminder Gill, Zahra S Thirouin, Markus Vaas, Suchita Sampath, Fanny Martineau, Sara B Noya, Patrizia Panzanelli, Tania J J Sudharshan, David Colameo, Philip K-Y Chang, Pei You Wu, Roy Shi, Philip A Barker, Steven A Brown, Rosa C Paolicelli, Jan Klohs, Rebecca Anne McKinney, Shiva K Tyagaraja. Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia. Science advances. vol 8. issue 9. 2022-03-04. PMID:35245123. |
here, using in vitro organotypic hippocampal slice cultures and transient middle cerebral artery occlusion (mcao) in genetically engineered mice in vivo, we report that at 24 hours after ischemia, microglia release brain-derived neurotrophic factor (bdnf) to downregulate glutamatergic and gabaergic synapses within the peri-infarct area. |
2022-03-04 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
hippocampal overexpression of trem2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. |
2022-02-28 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
furthermore, trem2 markedly increased the number of iba-1/arg-1-positive microglia in the hippocampus, suppressed neuroinflammation and microglial activation. |
2022-02-28 |
2023-08-13 |
mouse |