| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dahae Lee, Hyejung Jo, Cheolhyeon Go, Yoojin Jang, Naghyung Chu, Suhyun Bae, Dongmin Kang, Yejin Kim, Jae Seung Kan. The Roles of IL-22 and Its Receptor in the Regulation of Inflammatory Responses in the Brain. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054942. |
here, we used rt-pcr, western blotting, flow cytometry, immunohistochemical, and microarray analyses to examine the role of il-22 and expression of il-22rα in the brain, using the microglial cell line, hippocampal neuronal cell line, and inflamed mouse brain tissue. |
2022-01-21 |
2023-08-13 |
mouse |
| Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U Shin, Min-Soo Kwo. Possible role of arginase 1 positive microglia on depressive/anxiety-like behaviors in atopic dermatitis mouse model. Archives of pharmacal research. 2022-01-21. PMID:35060088. |
in addition, ad mice showed microglia with a shortened branch of de-ramified form and astrocytes with longer processes and decreased branching in the hippocampus, especially in the dentate gyrus (dg). |
2022-01-21 |
2023-08-13 |
mouse |
| Shane M O'Neil, Emma E Hans, Starr Jiang, Lynde M Wangler, Jonathan P Godbou. Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation. Glia. 2022-01-21. PMID:35061297. |
using single-cell rna-sequencing, we confirmed hippocampal microglia of aged mice (18 m.o.) |
2022-01-21 |
2023-08-13 |
mouse |
| Shane M O'Neil, Emma E Hans, Starr Jiang, Lynde M Wangler, Jonathan P Godbou. Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation. Glia. 2022-01-21. PMID:35061297. |
moreover, microglia in the aged hippocampus failed to turn over during the resolving phase of neuroinflammation. |
2022-01-21 |
2023-08-13 |
mouse |
| Christiane Kruse Fæste, Anita Solhaug, Marion Gaborit, Florian Pierre, Dominique Massott. Neurotoxic Potential of Deoxynivalenol in Murine Brain Cell Lines and Primary Hippocampal Cultures. Toxins. vol 14. issue 1. 2022-01-20. PMID:35051025. |
here, we have investigated the impact of don on mouse astrocyte and microglia cell lines, as well as on primary hippocampal cultures by analysing different toxicological endpoints. |
2022-01-20 |
2023-08-13 |
mouse |
| Yasir H Qureshi, Diego E Berman, Samuel E Marsh, Ronald L Klein, Vivek M Patel, Sabrina Simoes, Suvarnambiga Kannan, Gregory A Petsko, Beth Stevens, Scott A Smal. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease. Cell reports. vol 38. issue 3. 2022-01-19. PMID:35045281. |
moreover, the studies show that the neuronal retromer can regulate a distinct, dystrophic, microglia morphology, phenotypic of hippocampal microglia in ad. |
2022-01-19 |
2023-08-13 |
mouse |
| Qing Tian, Hui-Ling Tang, Yi-Yun Tang, Ping Zhang, Xuan Kang, Wei Zou, Xiao-Qing Tan. Hydrogen Sulfide Attenuates the Cognitive Dysfunction in Parkinson's Disease Rats via Promoting Hippocampal Microglia M2 Polarization by Enhancement of Hippocampal Warburg Effect. Oxidative medicine and cellular longevity. vol 2022. 2022-01-14. PMID:35028004. |
hydrogen sulfide attenuates the cognitive dysfunction in parkinson's disease rats via promoting hippocampal microglia m2 polarization by enhancement of hippocampal warburg effect. |
2022-01-14 |
2023-08-13 |
rat |
| Suresh B Rangasamy, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Improves Cognitive Functions in Mice after Controlled Cortical Impact Injury. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008615. |
oral treatment with nab, but not sodium formate (nafo), was found to decrease the activation of microglia and astrocytes and to inhibit the expression of inducible nitric oxide synthase (inos) in the hippocampus and cortex of cci-insulted mice. |
2022-01-11 |
2023-08-13 |
mouse |
| Adelaide Fernandes, Cláudia Caldeira, Carolina Cunha, Elisabete Ferreiro, Ana Rita Vaz, Dora Brite. Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice. Cells. vol 11. issue 1. 2022-01-11. PMID:35011699. |
we examined the temporal profile of inflammatory mediators and microglia deactivation/activation in the brain cortex and hippocampus of 3xtg-ad mice at 3- and 9-month-old. |
2022-01-11 |
2023-08-13 |
mouse |
| Henrique C Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Deborah Y Hukuda, Christiane Gimenes, Simone A A Romariz, Qing Ye, Yong Tang, Henning Ulrich, Beatriz Monteiro Long. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. Stem cell reviews and reports. 2022-01-08. PMID:34997526. |
therefore, the present study aimed to investigate whether transplantation of nsc or msc into the hippocampus of app/ps1 mice reverses ad-induced pathological alterations, evaluated by the locomotor activity (open field test), short- and long-term memory (object recognition) tests, Αβ plaques (6-e10), microglia distribution (iba-1), m1 (inos) and m2 (arg-1) microglial phenotype frequencies. |
2022-01-08 |
2023-08-13 |
mouse |
| Henrique C Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Deborah Y Hukuda, Christiane Gimenes, Simone A A Romariz, Qing Ye, Yong Tang, Henning Ulrich, Beatriz Monteiro Long. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. Stem cell reviews and reports. 2022-01-08. PMID:34997526. |
nsc and msc engraftment reduced the number of Αβ plaques and produced an increase in m2 microglia polarization in the hippocampus of app/ps1 mice, suggesting an anti-inflammatory effect of stem cell transplantation. |
2022-01-08 |
2023-08-13 |
mouse |
| Henrique C Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Deborah Y Hukuda, Christiane Gimenes, Simone A A Romariz, Qing Ye, Yong Tang, Henning Ulrich, Beatriz Monteiro Long. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. Stem cell reviews and reports. 2022-01-08. PMID:34997526. |
nsc also reversed the hyperlocomotor activity and increased the number of microglia in the hippocampus of app/ps1 mice. |
2022-01-08 |
2023-08-13 |
mouse |
| James C Nelson, Eva Greengrove, Kala N Nwachukwu, Isabella R Grifasi, S Alex Marshal. Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997716. |
this paper extends that research by examining the impact of binge-like consumption on microglia in the hippocampus and the amygdala. |
2022-01-08 |
2023-08-13 |
mouse |
| James C Nelson, Eva Greengrove, Kala N Nwachukwu, Isabella R Grifasi, S Alex Marshal. Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997716. |
however, after three drinking-in-the-dark cycles, the number of microglia decreased in the hippocampus. |
2022-01-08 |
2023-08-13 |
mouse |
| Risako Fujikawa, Jun Yamada, Kyoko M Iinuma, Shozo Jinn. Phytoestrogen genistein modulates neuron-microglia signaling in a mouse model of chronic social defeat stress. Neuropharmacology. 2022-01-06. PMID:34990615. |
the numerical densities of microglia in the hippocampus were increased by csds, and they were decreased by gen. |
2022-01-06 |
2023-08-13 |
mouse |
| Ming Wang, Yangmei Xie, Yiye Shao, Yinghui Che. LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980782. |
the nissl stain and immunohistochemical stain were performed to observe hippocampal damage and microglia proliferation. |
2022-01-04 |
2023-08-13 |
rat |
| Ming Wang, Yangmei Xie, Yiye Shao, Yinghui Che. LncRNA Snhg5 Attenuates Status Epilepticus Induced Inflammation through Regulating NF-κΒ Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 1. 2022-01-04. PMID:34980782. |
moreover, down-regulation of snhg5 attenuated se-induced inflammation and reduced the number of microglia in hippocampus. |
2022-01-04 |
2023-08-13 |
rat |
| Daria Zamolodchikov, Michael Duffield, Lynn E Macdonald, Nicole Alessandri-Habe. Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978145. |
we show increased levels of hk in the hippocampus of ad patients, which colocalized with amyloid beta (aβ) deposits and activated microglia. |
2022-01-03 |
2023-08-13 |
Not clear |
| Daria Zamolodchikov, Michael Duffield, Lynn E Macdonald, Nicole Alessandri-Habe. Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-01-03. PMID:34978145. |
we demonstrate that microglia internalize hk and traffic it to lysosomes, which is accompanied by reduced activity of lysosomal cathepsins l and s. our results suggest that hk accumulation in the ad hippocampus may alter microglial uptake and degradation of aβ fibrils, possibly contributing to microglial dysfunction in ad. |
2022-01-03 |
2023-08-13 |
Not clear |
| Francesca Logiacco, Pengfei Xia, Svilen Veselinov Georgiev, Celeste Franconi, Yi-Jen Chang, Bilge Ugursu, Anje Sporbert, Ralf Kühn, Helmut Kettenmann, Marcus Semtne. Microglia sense neuronal activity via GABA in the early postnatal hippocampus. Cell reports. vol 37. issue 13. 2021-12-29. PMID:34965412. |
microglia sense neuronal activity via gaba in the early postnatal hippocampus. |
2021-12-29 |
2023-08-13 |
Not clear |