| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in addition, mscs treatment can significantly inhibit the over-activation of hippocampal microglia in heat stroke rats and the levels of pro-inflammatory factors and chemokines in the hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
| Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in conclusion, the application of mscs in the treatment of heat stroke in rats can significantly reduce mortality and neurological deficits and improve hippocampal damage, possibly by inhibiting the excessive activation of hippocampal microglia in heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
| Dimitrios Kleidonas, Andreas Vlacho. Scavenging Tumor Necrosis Factor α Does Not Affect Inhibition of Dentate Granule Cells Following In Vitro Entorhinal Cortex Lesion. Cells. vol 10. issue 11. 2021-12-07. PMID:34831454. |
these functional changes were accompanied by a recruitment of microglia in the denervated hippocampus, and experiments in tissue cultures prepared from tnf-reporter mice [ |
2021-12-07 |
2023-08-13 |
mouse |
| Jian Shi, Huan Xu, María José Cavagnaro, Xingmei Li, Jia Fan. Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867376. |
reduced expression levels of tnf-α, il-1α, and c1qa were exhibited in the hippocampus of the berberine treatment group, and attenuated effect of declining neo-neuron, activation of microglia and astrocytes in the hippocampus of mice with sepsis were also found. |
2021-12-07 |
2023-08-13 |
mouse |
| Ilia G Komoltsev, Liya V Tret'yakova, Stepan O Frankevich, Natalia I Shirobokova, Aleksandra A Volkova, Alexey V Butuzov, Margarita R Novikova, Alexey A Kvichansky, Yulia V Moiseeva, Mikhail V Onufriev, Alexey P Bolshakov, Natalia V Gulyaev. Neuroinflammatory Cytokine Response, Neuronal Death, and Microglial Proliferation in the Hippocampus of Rats During the Early Period After Lateral Fluid Percussion-Induced Traumatic Injury of the Neocortex. Molecular neurobiology. 2021-12-02. PMID:34855115. |
activation of microglia was observed from day 7 in different hippocampal areas of both hemispheres. |
2021-12-02 |
2023-08-13 |
rat |
| Ilia G Komoltsev, Liya V Tret'yakova, Stepan O Frankevich, Natalia I Shirobokova, Aleksandra A Volkova, Alexey V Butuzov, Margarita R Novikova, Alexey A Kvichansky, Yulia V Moiseeva, Mikhail V Onufriev, Alexey P Bolshakov, Natalia V Gulyaev. Neuroinflammatory Cytokine Response, Neuronal Death, and Microglial Proliferation in the Hippocampus of Rats During the Early Period After Lateral Fluid Percussion-Induced Traumatic Injury of the Neocortex. Molecular neurobiology. 2021-12-02. PMID:34855115. |
the data suggest that tbi results in distant hippocampal damage (delayed neurodegeneration in the dentate gyrus and microglia proliferation in both the ipsilateral and contralateral hippocampus), the time course of this damage being different from that of the neuroinflammatory response. |
2021-12-02 |
2023-08-13 |
rat |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged tupaia belangeri. |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
to further understand the process of microglia dysfunction during the aging process, we used hippocampal sections from tupaia belangeri (tree shrews). |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
adult (mean age 3.8 years), old (mean age 6 years), and aged (mean age 7.5 years) tree shrews were used for histochemical and immunostaining techniques to determine ferritin and iba1 positive microglia, iron tissue content, tau hyperphosphorylation and oxidized-rna in dentate gyrus, subiculum, and ca1-ca3 hippocampal regions. |
2021-11-30 |
2023-08-13 |
Not clear |
| Dan Luo, Lu Han, Shengqiao Gao, Zhiyong Xiao, Qingru Zhou, Xiaorui Cheng, Yongxiang Zhang, Wenxia Zho. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827410. |
the results showed that dutasteride significantly reduced the levels of il-6 and tnf-α in the supernatants of lps-stimulated bv2 cells, and decreased the levels of il-6 in the hippocampus and plasma, and the number of activated microglia in the brain of lps administration mice. |
2021-11-30 |
2023-08-13 |
mouse |
| Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li, Zhaowei Li. Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. Journal of neuroinflammation. vol 18. issue 1. 2021-11-30. PMID:34836549. |
upregulation of trpc5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout il-10 mice. |
2021-11-30 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
| Ke Wang, Yongquan Shi, Wei Liu, Shuqing Liu, Ming-Zhong Su. Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson's disease model through inhibition of microglial activation. Neurotoxicology. vol 83. 2021-11-26. PMID:33450328. |
clinical and experimental findings support the view that activation of hippocampus microglia through nadph oxidase contributes to cognitive impairment in parkinson's disease (pd). |
2021-11-26 |
2023-08-13 |
mouse |
| Ke Wang, Yongquan Shi, Wei Liu, Shuqing Liu, Ming-Zhong Su. Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson's disease model through inhibition of microglial activation. Neurotoxicology. vol 83. 2021-11-26. PMID:33450328. |
then the ability of learning and memory was observed by morris water maze, neuron loss was evaluated by immunohistochemistry in hippocampus, the level of postsynaptic density 95 (psd95) and microglia activation was assessed by immunostaining, the molecules (gp91 |
2021-11-26 |
2023-08-13 |
mouse |
| Zeyi Huang, Sijie Ta. P2X7 Receptor as a Potential Target for Major Depressive Disorder. Current drug targets. vol 22. issue 10. 2021-11-26. PMID:33494675. |
chronic stress activates microglia in the hippocampus by secreting interleukin- 1β (il-1β) and other inflammatory cytokines, and increasing the bbb permeability, thus promoting the occurrence and development of mdd, which indicated that p2x7r might be a promising therapeutic target for mdd. |
2021-11-26 |
2023-08-13 |
Not clear |
| A V Morgun, E D Osipova, E B Boitsova, A N Shuvaev, N A Malinovskaya, A I Mosiagina, A B Salmin. Neurogenic Potential of Implanted Neurospheres Is Regulated by Optogenetic Stimulation of Hippocampal Astrocytes Ex Vivo. Bulletin of experimental biology and medicine. vol 170. issue 6. 2021-11-26. PMID:33893948. |
the electrophysiological characteristics of the hippocampus and expression of molecules involved in the mechanisms of activation of astrocytes and microglia (gfap, cd38, c3/c3b, cx43, cd11b, and cd18) were evaluated. |
2021-11-26 |
2023-08-13 |
mouse |
| Changming Tan, Feng Xu, Qiong Xie, Feng L. Deficiency of cGAS signaling protects against sepsis-associated encephalopathy. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507063. |
the restoration may attribute to the recovery of neo-neuron decline that associated with the decrease of activated microglia and astrocytes in the hippocampus of cgas-deficient mice. |
2021-11-26 |
2023-08-13 |
mouse |
| Mariya Tsyglakova, Alisa M Huskey, Emily H Hurst, Natalie M Telep, Mary C Wilding, Meghan E Babington, Jennifer R Rainville, Georgia E Hode. Sex and region-specific effects of variable stress on microglia morphology. Brain, behavior, & immunity - health. vol 18. 2021-11-26. PMID:34820640. |
here we report changes in microglia morphology in the nucleus accumbens (nac) and subregions of the hippocampus (hpc) in both male and female mice following variable stress of 6 or 28 days in duration. |
2021-11-26 |
2023-08-13 |
mouse |