| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tina Notter, Sina M Schalbetter, Nicholas E Clifton, Daniele Mattei, Juliet Richetto, Kerrie Thomas, Urs Meyer, Jeremy Hal. Neuronal activity increases translocator protein (TSPO) levels. Molecular psychiatry. vol 26. issue 6. 2021-10-11. PMID:32398717. |
confocal laser scanning microscopy confirmed that tspo protein is present in neuronal and non-neuronal (astrocytes, microglia, vascular endothelial cells) cells of cortical (medial prefrontal cortex) and subcortical (hippocampus) brain regions. |
2021-10-11 |
2023-08-13 |
mouse |
| Kai Xiao, Yanmin Luo, Xin Liang, Jing Tang, Jin Wang, Qian Xiao, Yingqiang Qi, Yue Li, Peilin Zhu, Hao Yang, Yuhan Xie, Hong Wu, Yong Tan. Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34489395. |
beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats. |
2021-10-11 |
2023-08-13 |
rat |
| Kai Xiao, Yanmin Luo, Xin Liang, Jing Tang, Jin Wang, Qian Xiao, Yingqiang Qi, Yue Li, Peilin Zhu, Hao Yang, Yuhan Xie, Hong Wu, Yong Tan. Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34489395. |
however, the effects of running exercise on hippocampal neuroinflammation and the number and activation of microglia in depression have not been studied. |
2021-10-11 |
2023-08-13 |
rat |
| Chen Qiu, Min Wang, Wen Yu, Zheng Rong, He-Sheng Zheng, Ting Sun, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Activation of the Hippocampal LXRβ Improves Sleep-Deprived Cognitive Impairment by Inhibiting Neuroinflammation. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34278533. |
gw3965, a dual agonist for both lxrα and lxrβ, ameliorated sd-induced cognitive impairment by inhibiting microglia activation, suppressing hmgb1/tlr4/nf-κb p65 pathway, and ultimately affecting the hippocampal expression of inflammatory cytokines in sd mice. |
2021-10-08 |
2023-08-13 |
mouse |
| Yan-Ling Liao, Xiao-Yan Zhou, Mu-Huo Ji, Liang-Cheng Qiu, Xiao-Hui Chen, Can-Sheng Gong, Ying Lin, Yan-Hua Guo, Jian-Jun Yan. S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice. Inflammation. vol 44. issue 1. 2021-10-07. PMID:32918665. |
our results showed that clp-induced and lps-induced memory impairments were accompanied with increased expressions of hippocampal microglia iba1 and cd86 (m1 markers), but reduced expression of arg1 (m2 marker). |
2021-10-07 |
2023-08-13 |
mouse |
| Haoran Li, Yuhuan Xiao, Li Han, Yue Jia, Shaolei Luo, Dandan Zhang, Ling Zhang, Peng Wu, Chunjie Xiao, Weijing Kan, Jing Du, Hongkun Ba. Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system. Brain research bulletin. vol 171. 2021-10-07. PMID:33705858. |
moreover, after 5 days of treatment, glp attenuated the expression of the proinflammatory cytokines il-1β and tnf-α, enhanced the expression of the anti-inflammatory cytokine il-10 and the neurotrophic factor bdnf, and inhibited the activation of microglia and proliferation of astrocytes in the hippocampus of csds mice. |
2021-10-07 |
2023-08-13 |
mouse |
| Tunahan Kirabali, Ruslan Rust, Serena Rigotti, Alessandro Siccoli, Roger M Nitsch, Luka Kuli. Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 6. 2021-10-06. PMID:32866303. |
post-mortem human cortical and hippocampal samples derived from ad patients and non-demented elderly control individuals were immunostained using a panel of markers representing specific components of the nvu including collagen iv (basement membrane), pdgfr-β (pericytes), gfap (astrocytes), iba1 (microglia), mrc1 (perivascular macrophages) and lectin as an endothelial cell label. |
2021-10-06 |
2023-08-13 |
human |
| Ali Mohammadkhanizadeh, Farnaz Nikbakh. Investigating the potential mechanisms of depression induced-by COVID-19 infection in patients. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 91. 2021-10-04. PMID:34373041. |
the reasons for depression in infected patients may be due to social and pathological factors including social quarantine, economic problems, stress, changes in the hpa axis, inflammation due to the entry of proinflammatory cytokines into the cns, production of inflammatory cytokines by microglia, mitochondrial disorders, damage to the hippocampus, and malnutrition. |
2021-10-04 |
2023-08-13 |
Not clear |
| Yishun Hong, Wenyao Wu, Shuo Wang, Quanshui Hao, Hua Zheng, Shiyong Li, Xianwei Zhang, Rao Su. Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord. Neuropharmacology. vol 196. 2021-10-01. PMID:34252405. |
our results showed that sps exposure increased the levels of angiotensin ii in the hippocampus, prefrontal cortex (pfc) and spinal cord; intraperitoneal injection of losartan attenuated sps-induced mechanical allodynia, and suppressed sps-induced glial activation (both microglia and astrocytes) and proinflammatory cytokine expression in the pfc and spinal cord, but not in the hippocampus. |
2021-10-01 |
2023-08-13 |
rat |
| Jan Hendrik Börner, Oliver Rawashdeh, Abdelhaq Ram. Exacerbated Age-Related Hippocampal Alterations of Microglia Morphology, β-Amyloid and Lipofuscin Deposition and Presenilin Overexpression in Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572962. |
exacerbated age-related hippocampal alterations of microglia morphology, β-amyloid and lipofuscin deposition and presenilin overexpression in in humans, alterations of circadian rhythms and autophagy are linked to metabolic, cardiovascular and neurological dysfunction. |
2021-10-01 |
2023-08-13 |
Not clear |
| Caitlin K Posillic. Three's Company: Neuroimmune activation, sex, and memory at the tripartite synapse. Brain, behavior, & immunity - health. vol 16. 2021-10-01. PMID:34589812. |
understanding the functional convergence of neurons, astrocytes, and microglia at the synapse, particularly in the hippocampus, is key to understanding the nuances of such diverse roles. |
2021-10-01 |
2023-08-13 |
Not clear |
| Fábio J Sousa, Raquel G Correia, Alexandra F Cruz, Joana M Martins, Matilde S Rodrigues, Catarina A Gomes, António F Ambrósio, Filipa I Baptist. Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy. Brain, behavior, & immunity - health. vol 5. 2021-10-01. PMID:34589855. |
notably, insulin administration to diabetic dams may also modulate offspring development in a way that differs from what is observed in physiological conditions, since it promoted the expedited acquisition of developmental milestones and of discrimination ability at memory test, also inducing a hyper-ramification of male and female hippocampal microglia. |
2021-10-01 |
2023-08-13 |
Not clear |
| Morgana D da Silva, Giselle Guginski, Karina L Sato, Luciana Sayuri Sanada, Kathleen A Sluka, Adair R S Santo. Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells. Brain, behavior, & immunity - health. vol 7. 2021-10-01. PMID:34589875. |
further, in our data was a decrease in the density of microglia and astrocytes in the hippocampus and increased microglial density in the prefrontal cortex, areas associated with neuropathic pain conditions. |
2021-10-01 |
2023-08-13 |
mouse |
| Reem A Mohamed, Dalaal M Abdallah, Amany I El-Brairy, Kawkab A Ahmed, Hanan S El-Abha. Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation. Molecules (Basel, Switzerland). vol 26. issue 16. 2021-09-30. PMID:34443654. |
palonosetron/methyllycaconitine deactivate hippocampal microglia 1, inflammasome assembly and pyroptosis to enhance cognition in a novel model of neuroinflammation. |
2021-09-30 |
2023-08-13 |
rat |
| Reem A Mohamed, Dalaal M Abdallah, Amany I El-Brairy, Kawkab A Ahmed, Hanan S El-Abha. Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation. Molecules (Basel, Switzerland). vol 26. issue 16. 2021-09-30. PMID:34443654. |
in the hippocampus, all regimens reduced the expression of glial fibrillary acidic protein and skewed microglia m1 to m2 phenotype, indicated by the decreased m1 markers and the enhanced m2 related parameters. |
2021-09-30 |
2023-08-13 |
rat |
| Guangchi Sun, Zong Miao, Yangfan Ye, Pengzhan Zhao, Liang Fan, Zhongyuan Bao, Yiming Tu, Chong Li, Honglu Chao, Xiupeng Xu, Jing J. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. Brain research bulletin. vol 162. 2021-09-29. PMID:32502596. |
neuroinflammation was evaluated by astrocyte hypertrophy, activated microglia, and inflammatory factors in the hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Guangchi Sun, Zong Miao, Yangfan Ye, Pengzhan Zhao, Liang Fan, Zhongyuan Bao, Yiming Tu, Chong Li, Honglu Chao, Xiupeng Xu, Jing J. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. Brain research bulletin. vol 162. 2021-09-29. PMID:32502596. |
treatment with cur ameliorated the spatial memory of tbi rats, reduced tbi-induced chronic inflammation, typified by diminished astrocyte hypertrophy, reduction in activated microglia, declined inflammatory factors, and increased neurogenesis in the hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Yihua He, Yuqin Peng, Yuan Chang, Juan Zhu, Zheqi Li, Kaibin Huang, Suyue Pa. Utilizing the Faxitron MultiRad 225 X-ray irradiation system for the construction of mouse chronic whole brain radiation model. Journal of radiation research. 2021-09-29. PMID:34585253. |
however, two months later, the results of immunofluorescence showed that astrocytes and microglia were activated continuously, and the number of immature neurons in dentate gyrus (dg) area of hippocampus was significantly reduced, in accordance with the features of chronic pathophysiological changes. |
2021-09-29 |
2023-08-13 |
mouse |
| Qingfen Qiang, Jeanne M Manalo, Hong Sun, Yujin Zhang, Anren Song, Alexander Q Wen, Y Edward Wen, Changhan Chen, Hong Liu, Ying Cui, Travis Nemkov, Julie A Reisz, George Edwards Iii, Fred A Perreira, Rodney E Kellems, Claudio Soto, Angelo D'Alessandro, Yang Xi. Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS biology. vol 19. issue 6. 2021-09-28. PMID:34138843. |
eadora2b-/- mice display the early aging-like cellular and molecular features including the proliferation and activation of microglia and macrophages, elevation of pro-inflammatory cytokines, and attenuation of hypoxia-induced glycolytic gene expression to counteract hypoxia in the hippocampus (hip), cortex, or cochlea. |
2021-09-28 |
2023-08-13 |
mouse |
| Lei Niu, Shi Shi Luo, Yang Xu, Zhen Wang, Dan Luo, Hui Yang, Wei Li, Jie He, Xiao Lin Zhong, Zheng Hai Liu, Jia Yu Zeng, Wen Yu Cao, Wei Wa. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiology of learning and memory. vol 175. 2021-09-27. PMID:32882398. |
minocycline also prevented expression of the hippocampal nlrp3 inflammasome, indicating that microglia might be the primary contributor to si-induced hippocampal nlrp3 inflammasome activation. |
2021-09-27 |
2023-08-13 |
mouse |