| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangchi Sun, Zong Miao, Yangfan Ye, Pengzhan Zhao, Liang Fan, Zhongyuan Bao, Yiming Tu, Chong Li, Honglu Chao, Xiupeng Xu, Jing J. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. Brain research bulletin. vol 162. 2021-09-29. PMID:32502596. |
treatment with cur ameliorated the spatial memory of tbi rats, reduced tbi-induced chronic inflammation, typified by diminished astrocyte hypertrophy, reduction in activated microglia, declined inflammatory factors, and increased neurogenesis in the hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Yihua He, Yuqin Peng, Yuan Chang, Juan Zhu, Zheqi Li, Kaibin Huang, Suyue Pa. Utilizing the Faxitron MultiRad 225 X-ray irradiation system for the construction of mouse chronic whole brain radiation model. Journal of radiation research. 2021-09-29. PMID:34585253. |
however, two months later, the results of immunofluorescence showed that astrocytes and microglia were activated continuously, and the number of immature neurons in dentate gyrus (dg) area of hippocampus was significantly reduced, in accordance with the features of chronic pathophysiological changes. |
2021-09-29 |
2023-08-13 |
mouse |
| Qingfen Qiang, Jeanne M Manalo, Hong Sun, Yujin Zhang, Anren Song, Alexander Q Wen, Y Edward Wen, Changhan Chen, Hong Liu, Ying Cui, Travis Nemkov, Julie A Reisz, George Edwards Iii, Fred A Perreira, Rodney E Kellems, Claudio Soto, Angelo D'Alessandro, Yang Xi. Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS biology. vol 19. issue 6. 2021-09-28. PMID:34138843. |
eadora2b-/- mice display the early aging-like cellular and molecular features including the proliferation and activation of microglia and macrophages, elevation of pro-inflammatory cytokines, and attenuation of hypoxia-induced glycolytic gene expression to counteract hypoxia in the hippocampus (hip), cortex, or cochlea. |
2021-09-28 |
2023-08-13 |
mouse |
| Lei Niu, Shi Shi Luo, Yang Xu, Zhen Wang, Dan Luo, Hui Yang, Wei Li, Jie He, Xiao Lin Zhong, Zheng Hai Liu, Jia Yu Zeng, Wen Yu Cao, Wei Wa. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiology of learning and memory. vol 175. 2021-09-27. PMID:32882398. |
minocycline also prevented expression of the hippocampal nlrp3 inflammasome, indicating that microglia might be the primary contributor to si-induced hippocampal nlrp3 inflammasome activation. |
2021-09-27 |
2023-08-13 |
mouse |
| Ye Wang, Amy K Y Fu, Nancy Y I. IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry. DNA and cell biology. vol 40. issue 9. 2021-09-23. PMID:34297618. |
glial cells, including astrocytes and microglia, actively regulate hippocampal synaptic plasticity by coordinating the neuronal activity-induced synaptic changes at the circuit level. |
2021-09-23 |
2023-08-13 |
Not clear |
| Maheedhar Kodali, Vikas Mishra, Bharathi Hattiangady, Sahithi Attaluri, Jenny Jaimes Gonzalez, Bing Shuai, Ashok K Shett. Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34245811. |
moderate, intermittent voluntary exercise in a model of gulf war illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus. |
2021-09-22 |
2023-08-13 |
rat |
| Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi, Marie-Ève Trembla. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343616. |
microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. |
2021-09-22 |
2023-08-13 |
mouse |
| Katherine Picard, Kanchan Bisht, Silvia Poggini, Stefano Garofalo, Maria Teresa Golia, Bernadette Basilico, Fatima Abdallah, Naomi Ciano Albanese, Irmgard Amrein, Nathalie Vernoux, Kaushik Sharma, Chin Wai Hui, Julie C Savage, Cristina Limatola, Davide Ragozzino, Laura Maggi, Igor Branchi, Marie-Ève Trembla. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343616. |
we first confirmed that microglia were depleted in gr in our model in males and females among the cingulate cortex and the hippocampus, both stress-sensitive brain regions. |
2021-09-22 |
2023-08-13 |
mouse |
| Lourdes Fernández de Cossío, Chloé Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Ève Trembla. Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34343619. |
the current study sought to evaluate the origin and impact of this reduced hippocampal cx3cr1 mrna expression on microglia and cognition. |
2021-09-22 |
2023-08-13 |
Not clear |
| Caner Günaydin, Z Betül Çelik, S Sırrı Bilge, Bahattin Avci, Nurten Kar. SAHA attenuates rotenone-induced toxicity in primary microglia and HT-22 cells. Toxicology and industrial health. vol 37. issue 1. 2021-09-21. PMID:33300458. |
therefore, we here investigated the effects of histone acetylation on rotenone-induced inflammation and oxidative stress in both primary mouse microglia and hippocampal ht-22 cells using the pan-histone deacetylase (hdac) inhibitor, suberoylanilide hydroxamic acid (saha). |
2021-09-21 |
2023-08-13 |
mouse |
| Di Wu, Jay Prakash P Kumal, Xiaodi Lu, Yixuan Li, Dongsheng Mao, Xudong Tang, Meitong Nie, Xin Liu, Liang Sun, Bin Liu, Yafang Zhan. Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer's-Like Pathology in the Hippocampus by Altering the Phenotype of Microglia in the APP/PS1 Mouse Model. Frontiers in neurology. vol 12. 2021-09-21. PMID:34539542. |
traumatic brain injury accelerates the onset of cognitive dysfunction and aggravates alzheimer's-like pathology in the hippocampus by altering the phenotype of microglia in the app/ps1 mouse model. |
2021-09-21 |
2023-08-13 |
mouse |
| Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyam. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia. vol 69. issue 4. 2021-09-20. PMID:33119934. |
here, we examined the effects of bdnf on the properties of microglia in the ca3 region of the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Junya Onodera, Hidetaka Nagata, Ai Nakashima, Yuji Ikegaya, Ryuta Koyam. Neuronal brain-derived neurotrophic factor manipulates microglial dynamics. Glia. vol 69. issue 4. 2021-09-20. PMID:33119934. |
thus, neuronal bdnf prevents microglia from engulfing mossy fiber synapses in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Viktoriya Maystrenko, Irina Ivleva, Darya Krytskaya, Alexander Zubov, Andrey Ivlev, Marina Karpenk. Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin. Metabolic brain disease. vol 36. issue 7. 2021-09-20. PMID:34014442. |
we showed, that in the hippocampus the day after lps administration an increase in production of il-1β and tnf-α mrna, followed by elevated mrna expression and activity of µ- and m-calpains without signs of microglia activation is observed. |
2021-09-20 |
2023-08-13 |
rat |
| Marcia G Honig, Conor C Dorian, John D Worthen, Anthony C Micetich, Isabelle A Mulder, Katelyn B Sanchez, William F Pierce, Nobel A Del Mar, Anton Reine. Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities. The European journal of neuroscience. vol 54. issue 5. 2021-09-17. PMID:32090401. |
hierarchical cluster analysis of dorsal hippocampal microglia across the three groups based on morphology and expression of mhcii, cx3cr1, cd68 and iba1 revealed five distinct phenotypes. |
2021-09-17 |
2023-08-13 |
mouse |
| Andrea Lewen, Thuy-Truc Ta, Tiziana Cesetti, Jan-Oliver Hollnagel, Ismini E Papageorgiou, Bruno Chausse, Oliver Kan. Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue. Journal of neuroscience research. vol 98. issue 10. 2021-09-17. PMID:32638411. |
the slice cultures featured well-preserved hippocampal cytoarchitecture and parvalbumin-positive interneuron networks, microglia with ramified morphology, and low basal levels of il-6, tnf-α, and nitric oxide (no). |
2021-09-17 |
2023-08-13 |
rat |
| Kazuki Nakanishi, Harutoshi Sakakima, Kosuke Norimatsu, Shotaro Otsuka, Seiya Takada, Akira Tani, Kiyoshi Kikuch. Effect of low-intensity motor balance and coordination exercise on cognitive functions, hippocampal Aβ deposition, neuronal loss, neuroinflammation, and oxidative stress in a mouse model of Alzheimer's disease. Experimental neurology. vol 337. 2021-09-13. PMID:33388314. |
our findings suggest that low-intensity motor balance and coordination exercise prevented age-related cognitive decline in the early stage of ad progression, possibly through the suppression of hippocampal aβ deposition, neuronal loss, oxidative stress, and neuroinflammation, including reduced m1 and a1 phenotypes microglia and astrocytes. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaoyue Qiao, Hailin Wang, Li Lu, Jinglei Chen, Qinpei Cheng, Meng Guo, Yayi Hou, Huan Do. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. Journal of neuroimmunology. vol 357. 2021-09-13. PMID:34062352. |
hippocampal microglia cd40 mediates npsle cognitive dysfunction in mice. |
2021-09-13 |
2023-08-13 |
mouse |
| Xiaoyue Qiao, Hailin Wang, Li Lu, Jinglei Chen, Qinpei Cheng, Meng Guo, Yayi Hou, Huan Do. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. Journal of neuroimmunology. vol 357. 2021-09-13. PMID:34062352. |
this study aimed to investigate whether hippocampal microglia cd40 of mrl/mpj-fas |
2021-09-13 |
2023-08-13 |
mouse |
| Yunpeng Liu, Danya Sanderson, M Firoz Mian, Karen-Anne McVey Neufeld, Paul Forsyth. Loss of vagal integrity disrupts immune components of the microbiota-gut-brain axis and inhibits the effect of Lactobacillus rhamnosus on behavior and the corticosterone stress response. Neuropharmacology. vol 195. 2021-09-13. PMID:34175326. |
these effects were associated with an increase in splenic t regulatory cells and a decrease in activated microglia in the hippocampus. |
2021-09-13 |
2023-08-13 |
mouse |