| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jindan He, Taotao Liu, Yue Li, Xinning Mi, Dengyang Han, Ning Yang, Lei Chen, Yitong Li, Jingshu Hong, Chongshen Kuang, Yi Yuan, Yiyun Cao, Yongzheng Han, Chengmei Shi, Zhengqian Li, Xiangyang Gu. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International immunopharmacology. vol 99. 2021-09-08. PMID:34298396. |
interestingly, jnk inhibitor sp600125 significantly attenuated surgery-induced cognitive impairments through inhibiting pyroptosis, inflammatory responses, and reducing immunoreactivity of nlrp3 and gasdermin d n terminus (gsdmd-n) in hippocampal microglia. |
2021-09-08 |
2023-08-13 |
mouse |
| Nicholas E Propson, Ethan R Roy, Alexandra Litvinchuk, Jörg Köhl, Hui Zhen. Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. The Journal of clinical investigation. vol 131. issue 1. 2021-09-07. PMID:32990682. |
endothelial c3ar1 inactivation also dampened microglia reactivity and improved hippocampal and cortical volumes in the aging brain, demonstrating a crosstalk between brain vasculature dysfunction and immune cell activation and neurodegeneration. |
2021-09-07 |
2023-08-13 |
mouse |
| Tino Emanuele Poloni, Valentina Medici, Matteo Moretti, Silvia Damiana Visonà, Alice Cirrincione, Arenn Faye Carlos, Annalisa Davin, Stella Gagliardi, Orietta Pansarasa, Cristina Cereda, Livio Tronconi, Antonio Guaita, Mauro Ceron. COVID-19-related neuropathology and microglial activation in elderly with and without dementia. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-09-07. PMID:34145669. |
in covid-19 cases complicated by delirium (all with neurocognitive disorders), there was a significant enhancement of microglia in the hippocampus (p = 0.048). |
2021-09-07 |
2023-08-13 |
Not clear |
| Jieyu Liu, Rui Feng, Dan Wang, Taoguang Huo, Hong Jian. Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34416638. |
bv-2 cells were treated with 20 μm tcs for 24 h, and the conditional medium from tcs-induced activated microglia reduced the viability of the murine hippocampal neurons cell line ht22. |
2021-09-07 |
2023-08-13 |
Not clear |
| Maheedhar Kodali, Sahithi Attaluri, Leelavathi N Madhu, Bing Shuai, Raghavendra Upadhya, Jenny Jaimes Gonzalez, Xiaolan Rao, Ashok K Shett. Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus. Aging cell. vol 20. issue 2. 2021-09-06. PMID:33443781. |
quantification of microglia revealed that metformin treatment reduced the incidence of pathological microglial clusters with alternative activation of microglia into an m2 phenotype, displaying highly ramified processes in the hippocampus. |
2021-09-06 |
2023-08-13 |
mouse |
| Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang, Dong Soo Le. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-09-04. PMID:34465358. |
hippocampal glucose uptake as a surrogate of metabolic change of microglia in alzheimer's disease. |
2021-09-04 |
2023-08-13 |
Not clear |
| Hongyoon Choi, Yoori Choi, Eun Ji Lee, Hyun Kim, Youngsun Lee, Seokjun Kwon, Do Won Hwang, Dong Soo Le. Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer's disease. Journal of neuroinflammation. vol 18. issue 1. 2021-09-04. PMID:34465358. |
here, we found a close association of the metabolic reconfiguration of microglia with increased hippocampal glucose uptake on [ |
2021-09-04 |
2023-08-13 |
Not clear |
| Yong Yang, Tamaki Ishima, Xiayun Wan, Yan Wei, Lijia Chang, Jiancheng Zhang, Youge Qu, Kenji Hashimot. Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622. European archives of psychiatry and clinical neuroscience. 2021-09-04. PMID:34480631. |
repeated administration of plx5622 caused significant reductions of the expression of genes and proteins for microglial markers in the prefrontal cortex (pfc) and hippocampus compared to control mice although the elimination of brain's microglia was partial. |
2021-09-04 |
2023-08-13 |
mouse |
| Yilin Shen, Haixia Hu, Cui Fan, Quan Wang, Tianyuan Zou, Bin Ye, Mingliang Xian. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons. Neurobiology of disease. vol 156. 2021-09-03. PMID:34082124. |
activated microglia and astrocytes with increased levels of inflammatory cytokines, such as tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) were detected in the hippocampus. |
2021-09-03 |
2023-08-13 |
mouse |
| Yangping Shentu, Qiuyun Tian, Jinge Yang, Xiaoyuan Liu, Yujiao Han, Dichen Yang, Nan Zhang, Xiaofang Fan, Ping Wang, Jianshe Ma, Ran Chen, Dantong Li, Shouting Liu, Yongyu Wang, Sunzhong Mao, Yongsheng Gong, Congkuo Du, Junming Fa. Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33865886. |
we found that kdm6b, vgll4, interleukin-1β (il-1β), and ionized calcium-binding adaptor molecule-1 (iba-1, microglia marker) protein levels were increased in lps-dose dependent manner in the hippocampus but not in prefrontal cortex. |
2021-09-02 |
2023-08-13 |
mouse |
| Xiaoye Feng, Yang Fan, Chang Y Chun. Mefenamic acid can attenuate depressive symptoms by suppressing microglia activation induced upon chronic stress. Brain research. vol 1740. 2021-09-01. PMID:32325074. |
in this study, we examine the effects of inhibiting cox by ma on depressive-like behaviors and microglia activation in the hippocampus. |
2021-09-01 |
2023-08-13 |
Not clear |
| Clarissa Branco Haas, Afonso Kopczynski de Carvalho, Alexandre Pastoris Muller, Bart J L Eggen, Luis Valmor Portel. Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. Brain research. vol 1741. 2021-09-01. PMID:32422127. |
insulin activates microglia and increases cox-2/il-1β expression in young but not in aged hippocampus. |
2021-09-01 |
2023-08-13 |
rat |
| Clarissa Branco Haas, Afonso Kopczynski de Carvalho, Alexandre Pastoris Muller, Bart J L Eggen, Luis Valmor Portel. Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. Brain research. vol 1741. 2021-09-01. PMID:32422127. |
in this study we investigated whether insulin affected microglia in the hippocampus of young and aged rats. |
2021-09-01 |
2023-08-13 |
rat |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
we further demonstrated that pf administration inhibited the enhanced expression of gsdmd which mainly distributed in microglia, along with the proteins involved in pyroptosis signaling transduction including caspase (casp)-11, casp-1, nlrp3, and interleukin (il)-1β in the hippocampus of mice treated with reserpine. |
2021-09-01 |
2023-08-13 |
mouse |
| Dan-Dan Tian, Min Wang, An Liu, Mei-Rong Gao, Chen Qiu, Wen Yu, Wen-Ju Wang, Kun Zhang, Le Yang, Yan-Yan Jia, Chang-Bin Yang, Yu-Mei W. Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway. Molecular neurobiology. vol 58. issue 2. 2021-09-01. PMID:33025508. |
collectively, the data indicated that pf exerted antidepressant effects, alleviating neuroinflammation through inhibiting casp-11-dependent pyroptosis signaling transduction induced by over-activated microglia in the hippocampus of mice treated with reserpine. |
2021-09-01 |
2023-08-13 |
mouse |
| Ryan K Shahidehpour, Rebecca E Higdon, Nicole G Crawford, Janna H Neltner, Eseosa T Ighodaro, Ela Patel, Douglas Price, Peter T Nelson, Adam D Bachstette. Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain. Neurobiology of aging. vol 99. 2021-09-01. PMID:33422891. |
an age-associated increase in the number of dystrophic microglia was found in the hippocampus and frontal cortex. |
2021-09-01 |
2023-08-13 |
human |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
the prevailing phenotype of trem2 r47h knock-in mice was decreased expression levels of trem2 in microglia, which resulted in decreased density of microglia in the hippocampus. |
2021-08-30 |
2023-08-13 |
mouse |
| Min Chu, Jijun Teng, Lei Guo, Yuyang Wang, Liang Zhang, Jing Gao, Lijun Li. Mild hyperhomocysteinemia induces blood-brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice. Canadian journal of physiology and pharmacology. vol 99. issue 9. 2021-08-27. PMID:34161158. |
however, microglia were not activated and the levels of tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) were not changed in either the cerebral cortex or hippocampus of mice with mild hhcy. |
2021-08-27 |
2023-08-13 |
mouse |
| Laura Fernandez Garcia-Agudo, Agnes A Steixner-Kumar, Yasmina Curto, Nadine Barnkothe, Imam Hassouna, Sebastian Jähne, Umer Javed Butt, Katharina Grewe, Martin S Weber, Kim Green, Silvio Rizzoli, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreic. Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. Cell reports. vol 36. issue 8. 2021-08-25. PMID:34433021. |
brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus. |
2021-08-25 |
2023-08-13 |
mouse |
| Hiroshi Giga, Bin Ji, Kazuya Kikutani, Shuji Fukuda, Takashi Kitajima, Seishi Katsumata, Miho Matsumata, Tetsuya Suhara, Shigeto Yamawaki, Nobuaki Shime, Koji Hosokawa, Hidenori Aizaw. Pharmacological and Genetic Inhibition of Translocator Protein 18 kDa Ameliorated Neuroinflammation in Murine Endotoxemia Model. Shock (Augusta, Ga.). vol 56. issue 1. 2021-08-23. PMID:33351449. |
histological analysis revealed that ono-2952 pretreatment suppressed the lps-induced activation of tspo-expressing microglia in the hippocampus of mice. |
2021-08-23 |
2023-08-13 |
mouse |