| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
we found that this aie-induced decline in hippocampal microglia was mediated by both microglial activation and apoptosis, as (i) 1 day of alcohol exposure induced a distinct activation of hippocampal microglia followed by their apoptosis, and (ii) blocking the initial activation of hippocampal microglia by pretreatment with minocycline suppressed the aie-induced apoptosis and loss of hippocampal microglia as well as the aie-induced depression-like symptoms. |
2021-06-03 |
2023-08-13 |
mouse |
| Peili Hu, Dan Wang, Yaru Zhang, Zixuan Cai, Ting Ye, Lijuan Tong, Xing Xu, Jiashu Lu, Fengguo Liu, Xu Lu, Chao Huan. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32217088. |
lipopolysaccharide (lps), a classical activator of microglia, ameliorated the aie-induced depression-like symptoms by reversing the decline in the hippocampal microglia. |
2021-06-03 |
2023-08-13 |
mouse |
| Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C Ganal-Vonarburg, Andrew J Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Ern. Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32727612. |
furthermore, rna-sequencing of hippocampal microglia from spf, gf and abx-treated 5xfad mice revealed distinct microbiota-dependent gene expression profiles associated with phagocytosis and altered microglial activation states. |
2021-05-31 |
2023-08-13 |
mouse |
| J Michael, M S Unger, R Poupardin, P Schernthaner, H Mrowetz, J Attems, L Aigne. Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer's Disease mice. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32771067. |
here, we identified the leukotriene (lt) synthesis rate-limiting enzyme 5-lipoxygenase (5-lox) primarily in neurons and to a lesser extent in a subpopulation of microglia in human alzheimer´s disease (ad) hippocampus brain sections and in brains of app swedish ps1 de9 (app-ps1) mice, a transgenic model for alzheimer´s disease (ad) pathology. |
2021-05-31 |
2023-08-13 |
mouse |
| Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi X. Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice. Frontiers in pharmacology. vol 12. 2021-05-30. PMID:34045967. |
maternal nicotine exposure alters hippocampal microglia polarization and promotes anti-inflammatory signaling in juvenile offspring in mice. |
2021-05-30 |
2023-08-13 |
mouse |
| Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi X. Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice. Frontiers in pharmacology. vol 12. 2021-05-30. PMID:34045967. |
in this study, we explored the impact of nicotine on the microglia during the development of hippocampus. |
2021-05-30 |
2023-08-13 |
mouse |
| Tasuku Araki, Yuji Ikegaya, Ryuta Koyam. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology reports. vol 40. issue 1. 2021-05-28. PMID:31794154. |
microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. |
2021-05-28 |
2023-08-13 |
Not clear |
| Tasuku Araki, Yuji Ikegaya, Ryuta Koyam. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology reports. vol 40. issue 1. 2021-05-28. PMID:31794154. |
status epilepticus-induced hippocampal neuronal death, astrogliosis, and the activation of microglia are common pathological changes in mesial temporal lobe epilepsy (mtle) with resistance to antiepileptic drugs. |
2021-05-28 |
2023-08-13 |
Not clear |
| Tasuku Araki, Yuji Ikegaya, Ryuta Koyam. Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures. Neuropsychopharmacology reports. vol 40. issue 1. 2021-05-28. PMID:31794154. |
here, mainly using hippocampal slice cultures with or without the pharmacological depletion of microglia, we directly examined whether microglia, the resident immune cells of the brain that can act either neurotoxically or in a neuroprotective manner, accelerate or attenuate kainic acid (ka)-induced neuronal death in vitro. |
2021-05-28 |
2023-08-13 |
Not clear |
| Eoin O'Neill, Éadaoin W Griffin, Ruairi O'Sullivan, Carol Murray, Lucy Ryan, Justin Yssel, Andrew Harkin, Colm Cunningha. Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice. Brain, behavior, and immunity. vol 94. 2021-05-28. PMID:33307172. |
this did not significantly alter numbers of pu.1-positive microglia, iba1-positive microglial morphology or mrna expression of microglia-associated gene transcripts (tyrobp, sall1, cd68, sra2, clec7a) in the hippocampus or frontal cortex and produced modest reductions in cx3cr1 and p2ry12. |
2021-05-28 |
2023-08-13 |
mouse |
| Li Wu, Yuqiu Han, Zhipeng Zheng, Shuai Zhu, Jun Chen, Yuanyuan Yao, Siqing Yue, Andreas Teufel, Honglei Weng, Lanjuan Li, Baohong Wan. Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice. Nutrients. vol 13. issue 3. 2021-05-28. PMID:33803974. |
we found that oca treatment inhibited the initiation and progression of anxiety in hfhs diet-mds mice via a microbiota-bas-brain axis: oca decreased the neuroinflammatory microglia and il-1β expression in the hippocampus, reversed intestinal barrier dysfunction and serum proinflammatory lps to a normal level, modified the microbial community, including the known anxiety-related rikenellaceae and |
2021-05-28 |
2023-08-13 |
mouse |
| Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M D Carneiro, Chang Y Chun. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33176182. |
minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. |
2021-05-27 |
2023-08-13 |
mouse |
| Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M D Carneiro, Chang Y Chun. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis. Brain, behavior, and immunity. vol 91. 2021-05-27. PMID:33176182. |
the effect of minocycline on microglia activation in different areas of the dorsal or ventral hippocampus in stressed mice was examined by immunohistochemistry. |
2021-05-27 |
2023-08-13 |
mouse |
| He-Tao Bian, Gao-Hua Wang, Jun-Jie Huang, Liang Liang, Ling Xiao, Hui-Ling Wan. Scutellarin protects against lipopolysaccharide-induced behavioral deficits by inhibiting neuroinflammation and microglia activation in rats. International immunopharmacology. vol 88. 2021-05-27. PMID:33182053. |
furthermore, immunostaining results showed that scutellarin pretreatment inhibited lps-induced microglia activation in the hippocampus of rats. |
2021-05-27 |
2023-08-13 |
rat |
| Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wan. Inhibition of phosphodiesterase-4 suppresses HMGB1/RAGE signaling pathway and NLRP3 inflammasome activation in mice exposed to chronic unpredictable mild stress. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33221489. |
simultaneously, rof inhibited cums-induced microglial activation and restored the morphology of microglial cells in the hippocampus, as evidenced by reduced total process length, area, volume, number of branching points, number of terminal points and total sholl intersections of microglia. |
2021-05-27 |
2023-08-13 |
mouse |
| Dragos Inta, Raphael Guzman, Peter Gas. Microglia activation and adult neurogenesis in the hippocampus: New clues about the antidepressant effect of minocycline. Brain, behavior, and immunity. vol 94. 2021-05-27. PMID:33571629. |
microglia activation and adult neurogenesis in the hippocampus: new clues about the antidepressant effect of minocycline. |
2021-05-27 |
2023-08-13 |
Not clear |
| Aria W Tarudji, Connor C Gee, Sarah M Romereim, Anthony J Convertine, Forrest M Kievi. Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury. Biomaterials. vol 272. 2021-05-27. PMID:33819812. |
this protection was likely a result of np1-mediated reduction in oxidative stress in the ipsilateral hemisphere as determined by immunofluorescence imaging of markers of oxidative stress and the spread of neuroinflammation into the contralateral hippocampus as determined by immunofluorescence imaging of activated microglia and neuron-astrocyte-microglia triad formation. |
2021-05-27 |
2023-08-13 |
mouse |
| Shu-Ming Li, Bin Li, Ling Zhang, Guang-Fen Zhang, Jie Sun, Mu-Huo Ji, Jian-Jun Yan. A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment. International immunopharmacology. vol 87. 2021-05-26. PMID:32707491. |
in the present study, we showed that hippocampal complement c3 levels in astrocytes and c3a receptor expressions in microglia were specifically up-regulated after lipopolysaccharide (lps) injection. |
2021-05-26 |
2023-08-13 |
Not clear |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
gaba-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the nlrp3 inflammasome and nf-κb signaling pathways. |
2021-05-25 |
2023-08-13 |
mouse |
| Limin Lang, Bin Xu, Jianbin Yuan, Shize Li, Shuai Lian, Yan Chen, Jingru Guo, Huanmin Yan. GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways. International immunopharmacology. vol 89. issue Pt B. 2021-05-25. PMID:33166810. |
we demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of gaba-mediated activation of nod-like receptor protein 3 (nlrp3) inflammasome and the nuclear factor kappa b (nf-κb) signaling pathway. |
2021-05-25 |
2023-08-13 |
mouse |