| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alita Soch, Luba Sominsky, Simin Younesi, Simone N De Luca, Maneesha Gunasekara, Steven Bozinovski, Sarah J Spence. The role of microglia in the second and third postnatal weeks of life in rat hippocampal development and memory. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32360602. |
neonatal microglia may be dispensable in the establishment of hippocampal brain function. |
2021-04-06 |
2023-08-13 |
rat |
| Bruno Chausse, Andrea Lewen, Gernot Poschet, Oliver Kan. Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32446944. |
employing postnatal organotypic hippocampal slice cultures, we describe that microglia transformed into a mild reactive phenotype by single tlr4 stimulation with lipopolysaccharide (lps), which was boosted into a severe neurotoxic phenotype by ifn-γ (lps + inf-γ). |
2021-04-06 |
2023-08-13 |
Not clear |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
priming of microglia with ifn-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. |
2021-04-06 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
however, the effects of ifn-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. |
2021-04-06 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
microglia isolated from the hippocampus of ifn-γ-injected mice suppressed nspcs proliferation and stimulated apoptosis of immature neurons. |
2021-04-06 |
2023-08-13 |
mouse |
| Jinqiang Zhang, Hui He, Yan Qiao, Tao Zhou, Haili He, Saini Yi, Lijuan Zhang, Li Mo, Yahui Li, Weike Jiang, Zili Yo. Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. Glia. vol 68. issue 12. 2021-04-06. PMID:32652855. |
collectively, these findings suggested that priming of microglia with ifn-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects. |
2021-04-06 |
2023-08-13 |
mouse |
| Nicole Scott-Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteol. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO journal. vol 39. issue 16. 2021-04-06. PMID:32657463. |
in hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed ps using annexin v or through microglial loss of trem2. |
2021-04-06 |
2023-08-13 |
mouse |
| Nicole Scott-Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteol. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO journal. vol 39. issue 16. 2021-04-06. PMID:32657463. |
in vivo, ps exposure at both hippocampal and retinogeniculate synapses and engulfment of ps-labeled material by microglia occurs during established developmental periods of microglial-mediated synapse elimination. |
2021-04-06 |
2023-08-13 |
mouse |
| Suchen Qu, Mengqiu Liu, Cheng Cao, Chongqi Wei, Xue-Er Meng, Qianyin Lou, Bin Wang, Xuan Li, Yuyan She, Qingqing Wang, Zhichao Song, Zhengxiang Han, Yue Zhu, Fei Huang, Jin-Ao Dua. Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells. Frontiers in pharmacology. vol 12. 2021-04-02. PMID:33790789. |
meanwhile, kxs also inhibited the activation of microglia and significantly reduced the expression of pro-inflammatory cytokines such as il-1β, il-2, and tnf-α in the hippocampus of mice. |
2021-04-02 |
2023-08-13 |
mouse |
| Phi T Nguyen, Leah C Dorman, Simon Pan, Ilia D Vainchtein, Rafael T Han, Hiromi Nakao-Inoue, Sunrae E Taloma, Jerika J Barron, Ari B Molofsky, Mazen A Kheirbek, Anna V Molofsk. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. vol 182. issue 2. 2021-04-01. PMID:32615087. |
here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. |
2021-04-01 |
2023-08-13 |
mouse |
| Dan Xu, Yujing Zhang, Bing Xie, Hua Yao, Yin Yuan, Shiying Yuan, Jiancheng Zhan. The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior. Aging. vol 12. issue 15. 2021-03-30. PMID:32741775. |
crsr increased plasma proinflammatory cytokine levels, blood-brain barrier permeability, hippocampal proinflammatory cytokine levels, and transition of microglia to the m1 phenotype 24 h after lps treatment. |
2021-03-30 |
2023-08-13 |
mouse |
| Jiajia Zhang, Lijuan Ning, Junping Wan. Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress. Biochemical and biophysical research communications. vol 533. issue 4. 2021-03-25. PMID:33059918. |
a1-specific astrocyte reactivity was markedly suppressed in the microglia and astrocytes isolated from the mpfc and hippocampus of mice fed the long-term quercetin-enriched diet, but not in those who received quercetin supplementation concurrently or after csds. |
2021-03-25 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
although cocaine treatment had little effect on microglial abundance, plx3397 treatment dramatically decreased the number of microglia in the nucleus accumbens and hippocampus in control mice and in mice subjected to cocaine sensitization. |
2021-03-21 |
2023-08-13 |
mouse |
| João Paulo Brás, Joana Bravo, Jaime Freitas, Mário Adolfo Barbosa, Susana Gomes Santos, Teresa Summavielle, Maria Inês Almeid. TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell death & disease. vol 11. issue 6. 2021-03-19. PMID:32488063. |
co-cultures of microglia with hippocampal neurons, using a microfluidic system, were performed to understand the impact on neurotoxicity. |
2021-03-19 |
2023-08-13 |
rat |
| Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Tae Hyeong Kim, Jong Whi Kim, Dae Young Yoo, Dae Won Kim, Jung Hoon Choi, Yeo Sung Yoon, In Koo Hwan. Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia. Cells. vol 9. issue 6. 2021-03-18. PMID:32531881. |
cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. |
2021-03-18 |
2023-08-13 |
Not clear |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Una Avdic, Matilda Ahl, My Andersson, Christine T Ekdah. Levetiracetam and N-Cadherin Antibody Alleviate Brain Pathology Without Reducing Early Epilepsy Development After Focal Non-convulsive Status Epilepticus in Rats. Frontiers in neurology. vol 12. 2021-03-16. PMID:33716930. |
continuous levetiracetam treatment for 4 weeks post-fncse reduced microglia activation, including cell numbers and morphological changes, partly decreased neuronal cell loss, and excitatory post-synaptic scaffold protein psd-95 expression in selective hippocampal structures. |
2021-03-16 |
2023-08-13 |
rat |
| Daniele Lana, Filippo Ugolini, Maria Grazia Giovannin. Space-Dependent Glia-Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition. International journal of molecular sciences. vol 21. issue 24. 2021-03-15. PMID:33322419. |
differential crosstalk between astrocytes and microglia in ca1 and ca3 areas of the hippocampus can be responsible for the differential sensitivity of the two areas to insults. |
2021-03-15 |
2023-08-13 |
Not clear |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
poly i:c activated microglia disrupt perineuronal nets and modulate synaptic balance in primary hippocampal neurons perineuronal nets (pnns) are specialized, reticular structures of the extracellular matrix (ecm) that can be found covering the soma and proximal dendrites of a neuronal subpopulation. |
2021-03-13 |
2023-08-13 |
Not clear |
| David Wegrzyn, Nadja Freund, Andreas Faissner, Georg Jucke. Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons Frontiers in synaptic neuroscience. vol 13. 2021-03-13. PMID:33708102. |
based on this knowledge, we analyzed the impact of activated microglia on hippocampal neuronal networks |
2021-03-13 |
2023-08-13 |
Not clear |