| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. |
omvs activated astrocytes and microglia, increased secretion of inflammatory cytokines (nuclear factor κb, interleukin-1β, and tumour necrosis factor-α) in the hippocampus. |
2021-03-08 |
2023-08-13 |
Not clear |
| Kinga Gawlińska, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Fili. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. International journal of molecular sciences. vol 21. issue 21. 2021-03-08. PMID:33120991. |
in addition, downregulation of gene expression associated with oligodendrocytes (cnp, myrf) and microglia regulator of g protein signaling 1 (rgs1) was observed in the hippocampus, regardless of the type of drug abstinence, while downregulation of myelin and lymphocyte protein (mal) expression was found only in rats exposed to abstinence in the home cage. |
2021-03-08 |
2023-08-13 |
rat |
| Bernadette Basilico, Barbara Cortese, Patrizia Ratano, Silvia Di Angelantonio, Davide Ragozzin. Time-lapse Whole-field Fluorescence Imaging of Microglia ProcessesMotility in Acute Mouse Hippocampal Slices and Analysis. Bio-protocol. vol 9. issue 8. 2021-03-05. PMID:33655009. |
time-lapse whole-field fluorescence imaging of microglia processesmotility in acute mouse hippocampal slices and analysis. |
2021-03-05 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
there were no differences in hippocampal protein expression between genotypes in microglia (iba1) or astrocyte (gfap) reactivity. |
2021-03-04 |
2023-08-13 |
mouse |
| Jing Wang, Gangadhara R Sareddy, Yujiao Lu, Uday P Pratap, Fulei Tang, Karah M Greene, Pornjittra L Meyre, Rajeshwar R Tekmal, Ratna K Vadlamudi, Darrell W Bran. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 50. 2021-03-04. PMID:33158962. |
in contrast, after gci, gfap-aro-ko mice: (1) lacked the normal elevation of astrocyte aromatase and hippocampal e2 levels; (2) had significantly attenuated reactive astrogliosis; and (3) displayed enhanced neuronal damage, microglia activation, and cognitive deficits. |
2021-03-04 |
2023-08-13 |
mouse |
| Jorge Miguel Amaya, Ernst Suidgeest, Isabelle Sahut-Barnola, Typhanie Dumontet, Nathanaëlle Montanier, Guilhem Pagès, Cécile Keller, Louise van der Weerd, Alberto M Pereira, Antoine Martinez, Onno C Meije. Effects of Long-Term Endogenous Corticosteroid Exposure on Brain Volume and Glial Cells in the AdKO Mouse. Frontiers in neuroscience. vol 15. 2021-03-03. PMID:33642975. |
we also observed a decrease in the expression of glial fibrillary acidic protein (gfap, a marker for reactive astrocytes) and ionized calcium-binding adapter molecule 1 (iba1, a marker for activated microglia) in the cingulate regions of the anterior corpus callosum and the hippocampus. |
2021-03-03 |
2023-08-13 |
mouse |
| Zhang Yuan, Shi Yi-Yun, Yu Hai-Ya. Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-03-01. PMID:32460187. |
triad3a and necroptosis were triggered in mouse microglia cells treated with oxygen and glucose deprivation (ogd), and in tnfα-incubated mouse hippocampal neuronal cells treated with z-vad-fmk, known as a pan-caspase inhibitor. |
2021-03-01 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
new insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: inhibition of cort-induced microglia activation. |
2021-02-25 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
notably, microglia activation-evoked brain inflammation and inhibited neurogenesis were also observed in the hippocampus of stressed mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Zhong-Fu Mao, Shu-Hua Ouyang, Qiong-Yi Zhang, Yan-Ping Wu, Guo-En Wang, Long-Fang Tu, Zhuo Luo, Wei-Xi Li, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong H. New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32619083. |
in comparison, intragastric administration of caffeine (10 and 20 mg/kg, 28 days) significantly reverted cwirs-induced depressive behaviors, neurogenesis recession and microglia activation in the hippocampus. |
2021-02-25 |
2023-08-13 |
mouse |
| Tatiana Anan'ina, Alena Kisel, Marina Kudabaeva, Galina Chernysheva, Vera Smolyakova, Konstantin Usov, Elena Krutenkova, Mark Plotnikov, Marina Khodanovic. Neurodegeneration, Myelin Loss and Glial Response in the Three-Vessel Global Ischemia Model in Rat. International journal of molecular sciences. vol 21. issue 17. 2021-02-24. PMID:32872364. |
in addition, we investigated the relationships between demyelination and changes in microglia and astrocytes, as well as oligodendrogenesis in the hippocampus; (2) methods: adult male wistar rats ( |
2021-02-24 |
2023-08-13 |
human |
| Xiali Zhong, Jingwei Wu, Weijian Ke, Yuejin Yu, Di Ji, Jianmeng Kang, Jiahuang Qiu, Can Wang, Panpan Yu, Yanhong We. Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro. Archives of toxicology. vol 94. issue 2. 2021-02-23. PMID:31894355. |
the mrna levels of pro-inflammatory factors il-1β, tnfα and ccl2 dose dependently increased in the hippocampus at both 24 h and 28 days following exposure, accompanied by microglia activation characterized by an amoeboid-like phenotype. |
2021-02-23 |
2023-08-13 |
mouse |
| Xiali Zhong, Jingwei Wu, Weijian Ke, Yuejin Yu, Di Ji, Jianmeng Kang, Jiahuang Qiu, Can Wang, Panpan Yu, Yanhong We. Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro. Archives of toxicology. vol 94. issue 2. 2021-02-23. PMID:31894355. |
neurite outgrowth of primary mouse hippocampal neurons was inhibited by treatment with the conditioned medium harvested from microglia exposed to tdcpp. |
2021-02-23 |
2023-08-13 |
mouse |
| S Alboni, C Benatti, C Colliva, G Radighieri, J M C Blom, N Brunello, F Tascedd. Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade. Frontiers in pharmacology. vol 11. 2021-02-23. PMID:33613281. |
moreover, the expressions of markers of immune activation and m1/m2 markers of microglia polarization were measured in the dorsal and ventral parts of the hippocampus. |
2021-02-23 |
2023-08-13 |
mouse |
| S Alboni, C Benatti, C Colliva, G Radighieri, J M C Blom, N Brunello, F Tascedd. Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade. Frontiers in pharmacology. vol 11. 2021-02-23. PMID:33613281. |
these results demonstrate that a chronic administration of vortioxetine specifically prevents lps-induced memory impairment, without affecting acute sickness behavior and anhedonia, and suggest that hippocampal microglia may represent a cellular target of this novel antidepressant medication. |
2021-02-23 |
2023-08-13 |
mouse |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
microglia and astrocytes in spinal dorsal horn (sdh), prefrontal cortex (pfc), anterior cingulate cortex (acc), and hippocampus were analyzed. |
2021-02-20 |
2023-08-13 |
rat |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
in addition, it reduced the activation of astrocyte but not microglia in pfc, acc, and hippocampus. |
2021-02-20 |
2023-08-13 |
rat |
| Lulin Ma, Juan Li, Junli Zhou, Dexin Zhang, Zhi Xiao, Tian Yu, Ying Li, Song Ca. Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes. iScience. vol 24. issue 2. 2021-02-20. PMID:33604528. |
intravenous lidocaine may relieve phn by inhibiting the activation of microglia and astrocyte in sdh or by reducing the neuroinflammation and astrocyte activation in pfc, acc, and hippocampus. |
2021-02-20 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
microglia polarization of hippocampus is involved in the mechanism of apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. |
2021-02-12 |
2023-08-13 |
rat |
| Shouhong Zhou, Shanshan Chen, Wenxia Xie, Xiaoxiao Guo, Jianfeng Zha. Microglia polarization of hippocampus is involved in the mechanism of Apelin-13 ameliorating chronic water immersion restraint stress-induced depression-like behavior in rats. Neuropeptides. vol 81. 2021-02-12. PMID:31932110. |
chronic stress induces the activation of hippocampal microglia, which produces many inflammatory mediators and mediates the occurrence of depression. |
2021-02-12 |
2023-08-13 |
rat |