| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
however, the mechanisms of the crosstalk between microglia and adult hippocampal neurogenesis in depression are not yet fully understood. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
therefore, in this review, we first introduce recent discoveries regarding the roles of microglia and adult hippocampal neurogenesis in the etiology of depression. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
then, we systematically discuss the possible mechanisms of how microglia regulate adult hippocampal neurogenesis in depression according to recent studies, which involve toll-like receptors, microglial polarization, fractalkine-c-x3-c motif chemokine receptor 1, hypothalamic-pituitary-adrenal axis, cytokines, brain-derived neurotrophic factor, and the microbiota-gut-brain axis, etc. |
2023-10-26 |
2023-11-08 |
Not clear |
| Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Che. Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics. Frontiers in immunology. vol 14. 2023-10-26. PMID:37881439. |
in addition, we summarize the promising drugs that could improve the adult hippocampal neurogenesis by regulating the microglia. |
2023-10-26 |
2023-11-08 |
Not clear |
| Jonathan C Vincent, Colleen N Garnett, James B Watson, Emma K Higgins, Teresa Macheda, Lydia Sanders, Kelly N Roberts, Ryan K Shahidehpour, Eric M Blalock, Ning Qaun, Adam D Bachstette. IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury. Journal of neuroinflammation. vol 20. issue 1. 2023-10-26. PMID:37884959. |
we found that il-1r1 gko attenuated behavioral impairments 14 weeks post-injury and reduced reactive microglia and astrocyte staining in the neocortex, corpus callosum, and hippocampus. |
2023-10-26 |
2023-11-08 |
mouse |
| Chiara Orciani, Sonia Do Carmo, Morgan K Foret, Helene Hall, Quentin Bonomo, Agustina Lavagna, Chunwei Huang, A Claudio Cuell. Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology. Neurobiology of aging. vol 132. 2023-10-21. PMID:37864952. |
af710b treatment also reduced microglia and astrocyte recruitment toward ca1 hippocampal aβ-burdened neurons compared to vehicle-treated mcgill-r-thy1-app rats, also altering the inflammatory cytokines profile. |
2023-10-21 |
2023-11-08 |
rat |
| Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hu, Lei Xie, Cheng Peng, Zili Yo. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress. European journal of pharmacology. 2023-10-20. PMID:37863415. |
grg1 exert antidepressant effects by preventing stress from activating the nlrp3 inflammasome in microglia, promoting a proneurogenic phenotype and allowing adult hippocampal neurogenesis. |
2023-10-20 |
2023-11-08 |
mouse |
| Meng Meng Shi, Xiao Fan Xu, Qiu Min Sun, Mingying Luo, Dan Dan Liu, Dong Min Guo, Ling Chen, Xiao Lin Zhong, Yang Xu, Wen Yu Ca. Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice. Phytotherapy research : PTR. vol 37. issue 10. 2023-10-17. PMID:37846157. |
moreover, long-term betaine administration inhibited hippocampal microglia over-activation and polarized microglia toward the m2 phenotype, which effectively inhibited the expression of inflammatory factors in si mice. |
2023-10-17 |
2023-11-08 |
mouse |
| Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. |
the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. |
2023-10-09 |
2023-10-15 |
rat |
| Fang Qiu, Yueming Liu, Yang Liu, Zhuyun Zhao, Lile Zhou, Pengfei Chen, Yunbo Du, Yanmei Wang, Huimin Sun, Changchun Zeng, Xiaokang Wang, Yuqiang Liu, Haobo Pan, Changneng K. CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. Neuromolecular medicine. 2023-10-05. PMID:37796401. |
immunofluorescence and rt-qpcr analyses showed that hippocampal expression of cd137l was upregulated in activated microglia following lps treatment. |
2023-10-05 |
2023-10-07 |
mouse |
| Giulia Galimberti, Giada Amodeo, Giulia Magni, Benedetta Riboldi, Gianfranco Balboni, Valentina Onnis, Stefania Ceruti, Paola Sacerdote, Silvia Franch. Prokineticin System Is a Pharmacological Target to Counteract Pain and Its Comorbid Mood Alterations in an Osteoarthritis Murine Model. Cells. vol 12. issue 18. 2023-09-28. PMID:37759478. |
in addition, pk upregulation and reactive astrogliosis in the hippocampus and microglia reactivity in the prefrontal cortex were detected. |
2023-09-28 |
2023-10-07 |
mouse |
| Cristina Ibáñez, Tirso Acuña, María Elena Quintanilla, Diliana Pérez-Reytor, Paola Morales, Eduardo Karahania. Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism. Antioxidants (Basel, Switzerland). vol 12. issue 9. 2023-09-28. PMID:37760061. |
animals treated with fenofibrate showed an increase m2-type microglia (with anti-inflammatory proprieties) and a decrease in phagocytic microglia in the hippocampus. |
2023-09-28 |
2023-10-07 |
rat |
| Daniele Lana, Giada Magni, Elisa Landucci, Gary L Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannin. Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761971. |
phenomic microglia diversity as a druggable target in the hippocampus in neurodegenerative diseases. |
2023-09-28 |
2023-10-07 |
rat |
| Daniele Lana, Giada Magni, Elisa Landucci, Gary L Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannin. Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761971. |
in this review, we discuss the recent literature on the alterations in microglia phenomics in the hippocampus of animal models of normal brain aging, acute neuroinflammation, ischemia, and neurodegenerative disorders, such as ad. |
2023-09-28 |
2023-10-07 |
rat |
| Daniele Lana, Giada Magni, Elisa Landucci, Gary L Wenk, Domenico Edoardo Pellegrini-Giampietro, Maria Grazia Giovannin. Phenomic Microglia Diversity as a Druggable Target in the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761971. |
for instance, in contiguous and highly interconnected regions of the rat hippocampus, microglia show a differential, finely regulated, and region-specific reactivity, demonstrating that microglia responses are not uniform, but vary significantly from area to area in response to insults. |
2023-09-28 |
2023-10-07 |
rat |
| Xidan Li, Haijing Liu, Chao Han, Jianglin Luo, Xin Guan, Liang Wang, Ying Li, Jiayi Wang, Hua Piao, Wei Zou, Jing Li. A Human Brain Model Mimicking Umbilical Cord Mesenchymal Stem Cells for the Treatment of Hypoxic-Ischemic Brain Injury. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762511. |
a co-culture system, termed hname, consisted of human hippocampal neurons (n), astrocytes (a), microglia (m), and brain microvascular endothelial cells (e). |
2023-09-28 |
2023-10-07 |
human |
| Noriko Itoh, Yuichiro Itoh, Cassandra E Meyer, Timothy Takazo Suen, Diego Cortez-Delgado, Michelle Rivera Lomeli, Sophia Wendin, Sri Sanjana Somepalli, Lisa C Golden, Allan MacKenzie-Graham, Rhonda R Voskuh. Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice. Nature communications. vol 14. issue 1. 2023-09-27. PMID:37758709. |
here, we identify a sex hormone by age interaction whereby loss of ovarian hormones in female mice at midlife, but not young age, induced hippocampal-dependent cognitive impairment, dorsal hippocampal atrophy, and astrocyte and microglia activation with synaptic loss. |
2023-09-27 |
2023-10-07 |
mouse |
| Xing-Dong Chen, Jing-Xiang Wei, Hai-Yan Wang, Yu-Yuan Peng, Can Tang, Yang Ding, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wan. Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats. Neuropharmacology. 2023-09-24. PMID:37742716. |
additionally, sal inhibited the activation of the nf-κb/inos/cox-2 signaling pathway in the hippocampus of ptsd rats, thereby suppressing the release of inflammatory factors (tnf-α and il-1β) and the activation of microglia. |
2023-09-24 |
2023-10-07 |
rat |
| Ricardo Schmidt, Björn Welzel, Wolfgang Lösche. Effects of season, daytime, sex, and stress on the incidence, latency, frequency, severity, and duration of neonatal seizures in a rat model of birth asphyxia. Epilepsy & behavior : E&B. vol 147. 2023-09-20. PMID:37729684. |
acute stress induced an increase in hippocampal microglia density in sham-exposed rat pups, which may have an additive effect on microglia activation induced by asphyxia. |
2023-09-20 |
2023-10-07 |
human |