All Relations between microglial cell and mesencephalon

Reference Sentence Publish Date Extraction Date Species
Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry vol 13 issue 2022 36090351 most notable was the distinct transcriptional profile of midbrain microglia, with enrichment for pathways related to immune function; these midbrain microglia exhibited a profile similar to disease-associated or immune-surveillant microglia. 2022-09-12 2022-09-14 Not clear
Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry vol 13 issue 2022 36090351 we also found evidence for a gradient of expression of microglia-specific transcripts across the rostral-to-caudal axes of the brain, with microglia extracted from the striatum exhibiting a transcriptional profile intermediate between that of the pfc and midbrain. 2022-09-12 2022-09-14 Not clear
Linxiu Wu, Rongtao Xue, Jiahao Chen, Jin X. dock8 deficiency attenuates microglia colonization in early zebrafish larvae. Cell death discovery vol 8 issue 1 2022 35977943 here, we generated zebrafish dock8 mutants by crispr/cas9 genome editing and showed that dock8 mutations attenuate microglia colonization in the zebrafish midbrain at early larvae stages. 2022-08-17 2022-08-22 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 2022-03-09 2022-04-14 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 however, the absence of microglia, with their ability to remodel neuronal networks and phagocytose apoptotic cells and debris, represents a major disadvantage for the current midbrain organoid systems. 2022-03-09 2022-04-14 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 so far, no studies about the effects of human ipsc-derived microglia on midbrain organoid neural cells have been published. 2022-03-09 2022-04-14 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 here we describe an approach to derive microglia from human ipscs and integrate them into ipsc-derived midbrain organoids. 2022-03-09 2022-04-14 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 using single nuclear rna sequencing, we provide a detailed characterization of microglia in midbrain organoids as well as the influence of their presence on the other cells of the organoids. 2022-03-09 2022-04-14 Not clear
Sonia Sabate-Soler, Sarah Louise Nickels, Cl\\xc3\\xa1udia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W Shin, Sally A Cowley, Jens C Schwambor. Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. Glia vol issue 2022 35262217 finally, we show that microglia in midbrain organoids affect synaptic remodeling and increase neuronal excitability. 2022-03-09 2022-04-14 Not clear
Qi-Wen Han, Qian-Hang Shao, Xiao-Tong Wang, Kai-Li Ma, Nai-Hong Chen, Yu-He Yua. CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways. Acta pharmacologica Sinica vol issue 2022 35132190 we showed that the application of cb2 receptor agonists jwh015 (1, 10\xe2\x80\x89\xce\xbcm) significantly increased the nuclear nurr1 protein in bv-2 cells and primary midbrain microglia. 2022-02-08 2022-02-13 Not clear
Maria T Panayotacopoulou, Ismini Papageorgiou, Marianna Pagida, Alexandra E Katsogridaki, Margarita Chrysanthou-Piterou, Nektarios A Valous, Niels Halama, Efstratios Patsouris, Anastasia E Konstantinido. Microglia Activation in the Midbrain of the Human Neonate: The Effect of Perinatal Hypoxic-Ischemic Injury. Journal of neuropathology and experimental neurology vol issue 2022 35092294 microglia activation in the midbrain of the human neonate: the effect of perinatal hypoxic-ischemic injury. 2022-01-29 2022-02-06 Not clear
Le Wang, Xiaoli Gong, Yang Liu, Tianshu Du, Zhen Zhang, Ting Zhang, Xiaomin Wan. CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. Glia vol 68 issue 9 2021 32112601 cd200 maintains the region-specific phenotype of microglia in the midbrain and its role in parkinson's disease. 2021-11-30 2022-01-13 Not clear
Le Wang, Xiaoli Gong, Yang Liu, Tianshu Du, Zhen Zhang, Ting Zhang, Xiaomin Wan. CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. Glia vol 68 issue 9 2021 32112601 we hypothesized that microglia in different brain regions respond differently to neuroinflammatory stimulation and that cd200, an anti-inflammatory protein mainly originated from neurons, acts as a local cue inhibiting microglia activation in the midbrain. 2021-11-30 2022-01-13 Not clear
Nicholas J Silva, Leah C Dorman, Ilia D Vainchtein, Nadine C Horneck, Anna V Molofsk. In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications vol 12 issue 1 2021 34625548 we found that ramified microglia increased in synaptic regions of the midbrain and hindbrain between 7 and 28 days post fertilization. 2021-11-02 2022-01-13 Not clear
Oihane Uriarte Huarte, Dimitrios Kyriakis, Tony Heurtaux, Yolanda Pires-Afonso, Kamil Grzyb, Rashi Halder, Manuel Buttini, Alexander Skupin, Michel Mittelbronn, Alessandro Michelucc. Single-Cell Transcriptomics and Frontiers in immunology vol 12 issue 2021 33854507 we uncovered a microglia subset, mainly present in the midbrain, displaying an intrinsic transcriptional immune alerted signature sharing features of inflammation-induced microglia. 2021-09-21 2022-01-13 Not clear
Carla Garza-Lomb\\xc3\\xb3, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry vol 11 issue 1 2021 34253711 using the lps model of the persistent microglial pro-inflammatory response, male c57bl/6j mice injected with lps (5\xe2\x80\x89mg/kg ip) exhibited persistent changes in microglia morphology and elevated pro-inflammatory markers in the hippocampus, cortex, and midbrain 7 days after lps injection, while the peripheral immune response had resolved. 2021-08-02 2022-01-13 Not clear
Carla Garza-Lomb\\xc3\\xb3, Morrent Thang, Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Chandrama Ahmed, Emily Quinn, Kimberly Sullivan, Michelle L Bloc. Circulating HMGB1 is elevated in veterans with Gulf War Illness and triggers the persistent pro-inflammatory microglia phenotype in male C57Bl/6J mice. Translational psychiatry vol 11 issue 1 2021 34253711 microglia isolated at 7 days after lps injection revealed a unique transcriptional profile of 17 genes when compared to the acute 3 h lps response, 6 of which were also upregulated in the midbrain by rhmgb1, highlighting a distinct signature of the persistent pro-inflammatory microglia phenotype. 2021-08-02 2022-01-13 Not clear
Yichao Hou, Xingqi Li, Chang Liu, Ming Zhang, Xiaoying Zhang, Shaoyang Ge, Liang Zha. Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson's disease. Experimental gerontology vol 150 issue 2021 33905875 butyrate reached into the midbrain snpc and suppressed microglia over-activation. 2021-07-02 2022-01-13 Not clear
Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America vol 117 issue 44 2021 33060302 histological localization of neutral lipids using a fluorescent probe (bodipy) revealed that dopaminergic neurons and midbrain microglia significantly accumulated intracellular lipids in pd sn, while adjacent astrocytes had a reduced lipid load overall. 2021-01-07 2022-01-13 Not clear
Nicole Rosskothen-Kuhl, Heika Hildebrandt, Ralf Birkenh\\xc3\\xa4ger, Robert-Benjamin Illin. Astrocyte Hypertrophy and Microglia Activation in the Rat Auditory Midbrain Is Induced by Electrical Intracochlear Stimulation. Frontiers in cellular neuroscience vol 12 issue 2020 29520220 astrocyte hypertrophy and microglia activation in the rat auditory midbrain is induced by electrical intracochlear stimulation. 2020-10-01 2022-01-13 Not clear
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